Trk system potassium uptake protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Trk system potassium uptake protein

Species:

Leishmania infantum

UniProt:

A4IAQ9_LEIIN

TriTrypDb:

LINF_350005900

Length:

579

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

A4IAQ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAQ9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	11
GO:0006811	monoatomic ion transport	4	11
GO:0006812	monoatomic cation transport	5	11
GO:0006813	potassium ion transport	7	11
GO:0030001	metal ion transport	6	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	11
GO:0008324	monoatomic cation transmembrane transporter activity	4	11
GO:0015075	monoatomic ion transmembrane transporter activity	3	11
GO:0022857	transmembrane transporter activity	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	303	307	PF00656	0.644
CLV_C14_Caspase3-7	338	342	PF00656	0.511
CLV_C14_Caspase3-7	518	522	PF00656	0.251
CLV_C14_Caspase3-7	563	567	PF00656	0.547
CLV_NRD_NRD_1	184	186	PF00675	0.359
CLV_NRD_NRD_1	284	286	PF00675	0.317
CLV_NRD_NRD_1	450	452	PF00675	0.396
CLV_PCSK_KEX2_1	179	181	PF00082	0.288
CLV_PCSK_KEX2_1	184	186	PF00082	0.299
CLV_PCSK_KEX2_1	284	286	PF00082	0.311
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.346
CLV_PCSK_PC7_1	180	186	PF00082	0.331
CLV_PCSK_SKI1_1	13	17	PF00082	0.459
CLV_PCSK_SKI1_1	131	135	PF00082	0.449
CLV_PCSK_SKI1_1	159	163	PF00082	0.383
CLV_PCSK_SKI1_1	171	175	PF00082	0.417
CLV_PCSK_SKI1_1	284	288	PF00082	0.364
CLV_PCSK_SKI1_1	454	458	PF00082	0.377
CLV_PCSK_SKI1_1	463	467	PF00082	0.228
CLV_PCSK_SKI1_1	501	505	PF00082	0.436
DEG_SCF_FBW7_1	24	31	PF00400	0.647
DEG_SPOP_SBC_1	141	145	PF00917	0.404
DEG_SPOP_SBC_1	567	571	PF00917	0.565
DOC_CDC14_PxL_1	44	52	PF14671	0.582
DOC_CDC14_PxL_1	91	99	PF14671	0.367
DOC_CKS1_1	25	30	PF01111	0.648
DOC_CKS1_1	8	13	PF01111	0.576
DOC_CYCLIN_RxL_1	495	508	PF00134	0.254
DOC_MAPK_gen_1	546	554	PF00069	0.449
DOC_MAPK_MEF2A_6	546	554	PF00069	0.443
DOC_PP1_RVXF_1	466	472	PF00149	0.349
DOC_PP2B_LxvP_1	134	137	PF13499	0.335
DOC_PP2B_LxvP_1	517	520	PF13499	0.251
DOC_PP4_FxxP_1	45	48	PF00568	0.650
DOC_SPAK_OSR1_1	495	499	PF12202	0.331
DOC_USP7_MATH_1	106	110	PF00917	0.243
DOC_USP7_MATH_1	190	194	PF00917	0.404
DOC_USP7_MATH_1	327	331	PF00917	0.603
DOC_USP7_MATH_1	347	351	PF00917	0.516
DOC_USP7_MATH_1	415	419	PF00917	0.280
DOC_USP7_MATH_1	567	571	PF00917	0.565
DOC_WW_Pin1_4	166	171	PF00397	0.623
DOC_WW_Pin1_4	193	198	PF00397	0.289
DOC_WW_Pin1_4	24	29	PF00397	0.731
DOC_WW_Pin1_4	296	301	PF00397	0.661
DOC_WW_Pin1_4	7	12	PF00397	0.676
LIG_14-3-3_CanoR_1	310	318	PF00244	0.757
LIG_14-3-3_CanoR_1	328	334	PF00244	0.534
LIG_14-3-3_CanoR_1	39	45	PF00244	0.568
LIG_14-3-3_CanoR_1	458	462	PF00244	0.563
LIG_14-3-3_CanoR_1	463	472	PF00244	0.426
LIG_APCC_ABBA_1	478	483	PF00400	0.351
LIG_BRCT_BRCA1_1	234	238	PF00533	0.311
LIG_BRCT_BRCA1_1	466	470	PF00533	0.271
LIG_deltaCOP1_diTrp_1	276	281	PF00928	0.483
LIG_FHA_1	194	200	PF00498	0.326
LIG_FHA_1	249	255	PF00498	0.353
LIG_FHA_1	285	291	PF00498	0.573
LIG_FHA_1	313	319	PF00498	0.693
LIG_FHA_1	364	370	PF00498	0.436
LIG_FHA_1	38	44	PF00498	0.645
LIG_FHA_1	457	463	PF00498	0.566
LIG_FHA_1	464	470	PF00498	0.279
LIG_FHA_1	472	478	PF00498	0.265
LIG_FHA_1	498	504	PF00498	0.243
LIG_FHA_1	79	85	PF00498	0.400
LIG_FHA_2	167	173	PF00498	0.615
LIG_FHA_2	500	506	PF00498	0.280
LIG_GBD_Chelix_1	461	469	PF00786	0.292
LIG_IRF3_LxIS_1	439	445	PF10401	0.353
LIG_LIR_Gen_1	101	110	PF02991	0.194
LIG_LIR_Gen_1	196	204	PF02991	0.351
LIG_LIR_Gen_1	221	231	PF02991	0.310
LIG_LIR_Gen_1	276	283	PF02991	0.576
LIG_LIR_Gen_1	330	337	PF02991	0.553
LIG_LIR_Gen_1	494	504	PF02991	0.249
LIG_LIR_Gen_1	530	541	PF02991	0.388
LIG_LIR_Gen_1	555	565	PF02991	0.497
LIG_LIR_Gen_1	81	90	PF02991	0.400
LIG_LIR_Nem_3	101	107	PF02991	0.293
LIG_LIR_Nem_3	128	133	PF02991	0.350
LIG_LIR_Nem_3	143	149	PF02991	0.254
LIG_LIR_Nem_3	196	201	PF02991	0.350
LIG_LIR_Nem_3	221	226	PF02991	0.330
LIG_LIR_Nem_3	263	268	PF02991	0.283
LIG_LIR_Nem_3	276	280	PF02991	0.462
LIG_LIR_Nem_3	330	334	PF02991	0.543
LIG_LIR_Nem_3	355	359	PF02991	0.556
LIG_LIR_Nem_3	365	371	PF02991	0.509
LIG_LIR_Nem_3	387	392	PF02991	0.323
LIG_LIR_Nem_3	397	403	PF02991	0.243
LIG_LIR_Nem_3	418	422	PF02991	0.353
LIG_LIR_Nem_3	467	473	PF02991	0.271
LIG_LIR_Nem_3	502	507	PF02991	0.249
LIG_LIR_Nem_3	525	529	PF02991	0.299
LIG_LIR_Nem_3	530	536	PF02991	0.349
LIG_LIR_Nem_3	555	561	PF02991	0.496
LIG_LIR_Nem_3	81	85	PF02991	0.430
LIG_MYND_1	24	28	PF01753	0.641
LIG_MYND_1	48	52	PF01753	0.578
LIG_MYND_3	420	424	PF01753	0.368
LIG_NRBOX	207	213	PF00104	0.448
LIG_Pex14_1	453	457	PF04695	0.583
LIG_Pex14_2	268	272	PF04695	0.304
LIG_Pex14_2	529	533	PF04695	0.281
LIG_Pex14_2	66	70	PF04695	0.520
LIG_PTAP_UEV_1	29	34	PF05743	0.639
LIG_REV1ctd_RIR_1	64	73	PF16727	0.551
LIG_SH2_CRK	188	192	PF00017	0.349
LIG_SH2_CRK	331	335	PF00017	0.510
LIG_SH2_GRB2like	425	428	PF00017	0.292
LIG_SH2_SRC	438	441	PF00017	0.404
LIG_SH2_STAP1	188	192	PF00017	0.293
LIG_SH2_STAP1	244	248	PF00017	0.358
LIG_SH2_STAT5	200	203	PF00017	0.271
LIG_SH2_STAT5	396	399	PF00017	0.401
LIG_SH2_STAT5	403	406	PF00017	0.342
LIG_SH2_STAT5	438	441	PF00017	0.404
LIG_SH2_STAT5	71	74	PF00017	0.271
LIG_SH2_STAT5	78	81	PF00017	0.271
LIG_SH3_2	8	13	PF14604	0.576
LIG_SH3_3	158	164	PF00018	0.545
LIG_SH3_3	2	8	PF00018	0.768
LIG_SH3_3	22	28	PF00018	0.719
LIG_SH3_3	437	443	PF00018	0.271
LIG_SH3_3	46	52	PF00018	0.554
LIG_SH3_3	89	95	PF00018	0.259
LIG_SH3_5	33	37	PF00018	0.626
LIG_SUMO_SIM_par_1	476	484	PF11976	0.386
LIG_TRFH_1	133	137	PF08558	0.270
LIG_TYR_ITIM	186	191	PF00017	0.463
LIG_UBA3_1	60	69	PF00899	0.588
LIG_WRC_WIRS_1	230	235	PF05994	0.244
MOD_CDK_SPK_2	166	171	PF00069	0.488
MOD_CDK_SPxK_1	7	13	PF00069	0.688
MOD_CK1_1	193	199	PF00069	0.404
MOD_CK1_1	218	224	PF00069	0.317
MOD_CK1_1	232	238	PF00069	0.284
MOD_CK1_1	38	44	PF00069	0.622
MOD_CK1_1	522	528	PF00069	0.276
MOD_CK1_1	560	566	PF00069	0.644
MOD_CK2_1	166	172	PF00069	0.619
MOD_CK2_1	302	308	PF00069	0.693
MOD_CK2_1	346	352	PF00069	0.628
MOD_CK2_1	499	505	PF00069	0.236
MOD_CK2_1	566	572	PF00069	0.676
MOD_GlcNHglycan	123	126	PF01048	0.625
MOD_GlcNHglycan	192	195	PF01048	0.356
MOD_GlcNHglycan	2	5	PF01048	0.460
MOD_GlcNHglycan	205	208	PF01048	0.327
MOD_GlcNHglycan	220	223	PF01048	0.533
MOD_GlcNHglycan	308	313	PF01048	0.462
MOD_GlcNHglycan	316	321	PF01048	0.494
MOD_GlcNHglycan	507	510	PF01048	0.436
MOD_GSK3_1	121	128	PF00069	0.323
MOD_GSK3_1	203	210	PF00069	0.443
MOD_GSK3_1	211	218	PF00069	0.335
MOD_GSK3_1	229	236	PF00069	0.244
MOD_GSK3_1	24	31	PF00069	0.678
MOD_GSK3_1	248	255	PF00069	0.388
MOD_GSK3_1	308	315	PF00069	0.755
MOD_GSK3_1	442	449	PF00069	0.522
MOD_GSK3_1	515	522	PF00069	0.242
MOD_GSK3_1	556	563	PF00069	0.563
MOD_GSK3_1	568	575	PF00069	0.643
MOD_N-GLC_1	215	220	PF02516	0.565
MOD_N-GLC_1	522	527	PF02516	0.523
MOD_NEK2_1	211	216	PF00069	0.299
MOD_NEK2_1	226	231	PF00069	0.227
MOD_NEK2_1	233	238	PF00069	0.249
MOD_NEK2_1	260	265	PF00069	0.293
MOD_NEK2_1	423	428	PF00069	0.295
MOD_NEK2_1	456	461	PF00069	0.569
MOD_NEK2_1	464	469	PF00069	0.286
MOD_NEK2_1	491	496	PF00069	0.259
MOD_NEK2_1	499	504	PF00069	0.245
MOD_NEK2_1	515	520	PF00069	0.220
MOD_NEK2_1	529	534	PF00069	0.251
MOD_NEK2_1	556	561	PF00069	0.532
MOD_NEK2_2	125	130	PF00069	0.270
MOD_PIKK_1	38	44	PF00454	0.568
MOD_PKA_1	284	290	PF00069	0.496
MOD_PKA_2	284	290	PF00069	0.588
MOD_PKA_2	327	333	PF00069	0.613
MOD_PKA_2	361	367	PF00069	0.599
MOD_PKA_2	38	44	PF00069	0.595
MOD_PKA_2	457	463	PF00069	0.584
MOD_PKA_2	572	578	PF00069	0.679
MOD_Plk_1	215	221	PF00069	0.345
MOD_Plk_1	446	452	PF00069	0.580
MOD_Plk_1	522	528	PF00069	0.322
MOD_Plk_2-3	302	308	PF00069	0.746
MOD_Plk_4	125	131	PF00069	0.363
MOD_Plk_4	207	213	PF00069	0.403
MOD_Plk_4	233	239	PF00069	0.279
MOD_Plk_4	276	282	PF00069	0.462
MOD_Plk_4	329	335	PF00069	0.620
MOD_Plk_4	374	380	PF00069	0.357
MOD_Plk_4	415	421	PF00069	0.266
MOD_Plk_4	430	436	PF00069	0.271
MOD_Plk_4	457	463	PF00069	0.566
MOD_Plk_4	522	528	PF00069	0.249
MOD_Plk_4	78	84	PF00069	0.358
MOD_ProDKin_1	166	172	PF00069	0.619
MOD_ProDKin_1	193	199	PF00069	0.289
MOD_ProDKin_1	24	30	PF00069	0.733
MOD_ProDKin_1	296	302	PF00069	0.666
MOD_ProDKin_1	7	13	PF00069	0.678
TRG_DiLeu_BaEn_1	46	51	PF01217	0.590
TRG_DiLeu_BaLyEn_6	145	150	PF01217	0.271
TRG_DiLeu_BaLyEn_6	418	423	PF01217	0.357
TRG_DiLeu_BaLyEn_6	460	465	PF01217	0.467
TRG_ENDOCYTIC_2	188	191	PF00928	0.374
TRG_ENDOCYTIC_2	200	203	PF00928	0.293
TRG_ENDOCYTIC_2	331	334	PF00928	0.602
TRG_ENDOCYTIC_2	403	406	PF00928	0.270
TRG_ER_diArg_1	184	186	PF00400	0.532
TRG_ER_diArg_1	283	285	PF00400	0.517
TRG_ER_diArg_1	546	549	PF00400	0.531
TRG_NLS_MonoExtN_4	448	455	PF00514	0.596
TRG_Pf-PMV_PEXEL_1	501	505	PF00026	0.450
TRG_Pf-PMV_PEXEL_1	58	62	PF00026	0.344

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD62	Leptomonas seymouri	68%	100%
A0A1X0NIY1	Trypanosomatidae	53%	88%
A0A3Q8IIM6	Leishmania donovani	100%	100%
A0A3R7RF53	Trypanosoma rangeli	51%	98%
A4HM47	Leishmania braziliensis	82%	100%
D0A2F4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	97%
E9AEI5	Leishmania major	94%	100%
E9B5P6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5B392	Trypanosoma cruzi	50%	98%