Pyruvate kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Pyruvate kinase

Gene product:

pyruvate kinase

Species:

Leishmania infantum

UniProt:

A4IAQ0_LEIIN

TriTrypDb:

LINF_350005300

Length:

167

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IAQ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAQ0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0000287	magnesium ion binding	5	2
GO:0003824	catalytic activity	1	2
GO:0004743	pyruvate kinase activity	5	2
GO:0005488	binding	1	2
GO:0005524	ATP binding	5	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	2
GO:0017076	purine nucleotide binding	4	2
GO:0030554	adenyl nucleotide binding	5	2
GO:0030955	potassium ion binding	6	2
GO:0031420	alkali metal ion binding	5	2
GO:0032553	ribonucleotide binding	3	2
GO:0032555	purine ribonucleotide binding	4	2
GO:0032559	adenyl ribonucleotide binding	5	2
GO:0035639	purine ribonucleoside triphosphate binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2
GO:0097159	organic cyclic compound binding	2	2
GO:0097367	carbohydrate derivative binding	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	112	116	PF00082	0.224
DEG_Nend_Nbox_1	1	3	PF02207	0.464
DOC_MAPK_gen_1	142	152	PF00069	0.425
DOC_MAPK_MEF2A_6	11	20	PF00069	0.327
LIG_14-3-3_CanoR_1	3	8	PF00244	0.421
LIG_14-3-3_CanoR_1	58	68	PF00244	0.425
LIG_FHA_1	113	119	PF00498	0.425
LIG_FHA_1	15	21	PF00498	0.336
LIG_FHA_1	28	34	PF00498	0.425
LIG_FHA_1	38	44	PF00498	0.425
LIG_KLC1_Yacidic_2	131	136	PF13176	0.425
LIG_LIR_Gen_1	136	144	PF02991	0.425
LIG_LIR_Gen_1	148	157	PF02991	0.425
LIG_LIR_Nem_3	131	137	PF02991	0.425
LIG_LIR_Nem_3	148	152	PF02991	0.425
LIG_LIR_Nem_3	19	24	PF02991	0.344
LIG_SH2_CRK	137	141	PF00017	0.425
LIG_SH2_GRB2like	137	140	PF00017	0.425
LIG_SH2_PTP2	149	152	PF00017	0.425
LIG_SH2_SRC	149	152	PF00017	0.425
LIG_SH2_STAT5	117	120	PF00017	0.425
LIG_SH2_STAT5	134	137	PF00017	0.425
LIG_SH2_STAT5	149	152	PF00017	0.425
LIG_SH3_3	140	146	PF00018	0.425
LIG_SUMO_SIM_anti_2	153	160	PF11976	0.425
LIG_SUMO_SIM_par_1	16	22	PF11976	0.341
LIG_TYR_ITIM	135	140	PF00017	0.425
MOD_CK1_1	39	45	PF00069	0.425
MOD_CK1_1	52	58	PF00069	0.425
MOD_CK1_1	62	68	PF00069	0.425
MOD_CK2_1	16	22	PF00069	0.341
MOD_GlcNHglycan	51	54	PF01048	0.224
MOD_GSK3_1	112	119	PF00069	0.425
MOD_GSK3_1	3	10	PF00069	0.401
MOD_GSK3_1	32	39	PF00069	0.425
MOD_N-GLC_1	138	143	PF02516	0.224
MOD_N-GLC_1	14	19	PF02516	0.327
MOD_N-GLC_1	59	64	PF02516	0.224
MOD_NEK2_1	16	21	PF00069	0.341
MOD_NEK2_1	49	54	PF00069	0.425
MOD_NEK2_1	59	64	PF00069	0.425
MOD_NEK2_1	7	12	PF00069	0.361
MOD_PIKK_1	37	43	PF00454	0.425
MOD_PKA_2	27	33	PF00069	0.224
MOD_PKA_2	69	75	PF00069	0.425
MOD_PKB_1	3	11	PF00069	0.394
MOD_Plk_1	14	20	PF00069	0.331
MOD_Plk_4	145	151	PF00069	0.425
MOD_Plk_4	16	22	PF00069	0.341
TRG_ENDOCYTIC_2	137	140	PF00928	0.425
TRG_ENDOCYTIC_2	149	152	PF00928	0.425
TRG_ER_diArg_1	2	5	PF00400	0.440

Homologs


Protein	Taxonomy	Sequence identity	Coverage
B0B7Q0	CHLT2	38%	34%
B8BJ39	ORYSI	32%	32%
B8BM17	ORYSI	33%	32%
O05118	METEA	35%	35%
O08309	CLOAB	38%	35%
O44006	EIMTE	42%	31%
O51323	BORBU	34%	35%
O62619	DROME	47%	31%
O65595	ARATH	44%	34%
O94122	AGABI	45%	31%
P00548	CHICK	48%	32%
P00549	YEAST	44%	33%
P0AD61	ECOLI	39%	36%
P0AD62	ECO57	39%	36%
P0CE21	CHLTR	38%	34%
P11974	RABIT	48%	31%
P11979	FELCA	48%	31%
P11980	RAT	48%	31%
P14618	HUMAN	48%	31%
P19680	SPICI	46%	87%
P21599	ECOLI	39%	35%
P22200	SOLTU	42%	33%
P22360	EMENI	48%	32%
P30614	YARLI	43%	32%
P30615	TRYBB	71%	33%
P30616	TRYBB	70%	33%
P31865	HYPJE	51%	31%
P32044	THEAC	29%	31%
P43924	HAEIN	37%	35%
P46614	CANAL	46%	33%
P47458	MYCGE	32%	33%
P52480	MOUSE	48%	31%
P52489	YEAST	43%	33%
P57404	BUCAI	34%	35%
P70789	AGRVI	32%	35%
P77983	SALTY	39%	36%
P78031	MYCPN	28%	33%
P94939	MYCIT	36%	35%
P9WKE4	MYCTO	36%	35%
P9WKE5	MYCTU	36%	35%
Q04668	LEIBR	89%	100%
Q07637	LACLA	27%	33%
Q10208	SCHPO	50%	33%
Q12669	ASPNG	48%	32%
Q27686	LEIME	94%	33%
Q27788	TRYBO	57%	34%
Q2QXR8	ORYSJ	33%	32%
Q2RAK2	ORYSJ	32%	32%
Q42806	SOYBN	43%	33%
Q42954	TOBAC	43%	33%
Q44473	AGRVI	32%	35%
Q46078	CORGL	42%	35%
Q46289	CLOPE	38%	35%
Q54RF5	DICDI	45%	33%
Q55863	SYNY3	39%	35%
Q56301	THELN	38%	35%
Q5NVN0	PONAB	48%	31%
Q6BS75	DEBHA	44%	33%
Q6FIS9	CANGA	46%	33%
Q6FV12	CANGA	46%	33%
Q759A9	ASHGO	45%	33%
Q7RVA8	NEUCR	50%	32%
Q875M9	KLULA	46%	33%
Q875S4	LACK1	46%	33%
Q875Z9	NAUCC	44%	33%
Q89AI8	BUCBP	35%	35%
Q8FP04	COREF	43%	35%
Q8K9M3	BUCAP	31%	35%
Q8SQP0	ENCCU	38%	39%
Q8Z6K2	SALTI	39%	36%
Q8ZNW0	SALTY	39%	35%
Q92122	XENLA	50%	32%
Q9PK61	CHLMU	38%	35%
Q9WY51	THEMA	31%	36%
Q9YEU2	AERPE	28%	36%
Q9Z984	CHLPN	39%	35%