Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IAP2_LEIIN

TriTrypDb:

LINF_340012900

Length:

486

Annotations

Annotations by Jardim et al.

Metal Binding, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IAP2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAP2

PDB structure(s): 7ane_y

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0004784	superoxide dismutase activity	2	4
GO:0005488	binding	1	4
GO:0016209	antioxidant activity	1	4
GO:0016491	oxidoreductase activity	2	4
GO:0016721	oxidoreductase activity, acting on superoxide radicals as acceptor	3	4
GO:0043167	ion binding	2	4
GO:0043169	cation binding	3	4
GO:0046872	metal ion binding	4	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	216	220	PF00656	0.568
CLV_C14_Caspase3-7	465	469	PF00656	0.413
CLV_C14_Caspase3-7	474	478	PF00656	0.427
CLV_NRD_NRD_1	11	13	PF00675	0.482
CLV_NRD_NRD_1	22	24	PF00675	0.633
CLV_NRD_NRD_1	292	294	PF00675	0.476
CLV_NRD_NRD_1	300	302	PF00675	0.618
CLV_PCSK_KEX2_1	11	13	PF00082	0.408
CLV_PCSK_KEX2_1	201	203	PF00082	0.376
CLV_PCSK_KEX2_1	22	24	PF00082	0.498
CLV_PCSK_PC1ET2_1	201	203	PF00082	0.376
CLV_PCSK_SKI1_1	11	15	PF00082	0.428
CLV_PCSK_SKI1_1	46	50	PF00082	0.652
DEG_APCC_DBOX_1	10	18	PF00400	0.488
DEG_APCC_DBOX_1	75	83	PF00400	0.456
DEG_SCF_FBW7_1	160	167	PF00400	0.393
DEG_SPOP_SBC_1	352	356	PF00917	0.619
DOC_CKS1_1	161	166	PF01111	0.384
DOC_CYCLIN_RxL_1	57	65	PF00134	0.388
DOC_CYCLIN_RxL_1	9	20	PF00134	0.496
DOC_MAPK_DCC_7	11	19	PF00069	0.450
DOC_MAPK_FxFP_2	455	458	PF00069	0.529
DOC_MAPK_gen_1	11	19	PF00069	0.405
DOC_MAPK_gen_1	60	66	PF00069	0.561
DOC_MAPK_MEF2A_6	11	19	PF00069	0.465
DOC_PP2B_LxvP_1	177	180	PF13499	0.463
DOC_PP4_FxxP_1	455	458	PF00568	0.529
DOC_USP7_MATH_1	146	150	PF00917	0.331
DOC_USP7_MATH_1	208	212	PF00917	0.507
DOC_USP7_MATH_1	27	31	PF00917	0.433
DOC_USP7_MATH_1	352	356	PF00917	0.762
DOC_USP7_MATH_1	377	381	PF00917	0.795
DOC_USP7_MATH_1	389	393	PF00917	0.598
DOC_USP7_MATH_1	44	48	PF00917	0.558
DOC_WW_Pin1_4	151	156	PF00397	0.511
DOC_WW_Pin1_4	160	165	PF00397	0.475
DOC_WW_Pin1_4	229	234	PF00397	0.568
DOC_WW_Pin1_4	337	342	PF00397	0.658
LIG_14-3-3_CanoR_1	231	237	PF00244	0.555
LIG_14-3-3_CanoR_1	256	264	PF00244	0.466
LIG_14-3-3_CanoR_1	471	476	PF00244	0.402
LIG_14-3-3_CanoR_1	76	86	PF00244	0.323
LIG_Actin_WH2_2	303	319	PF00022	0.572
LIG_BRCT_BRCA1_1	333	337	PF00533	0.614
LIG_BRCT_BRCA1_1	90	94	PF00533	0.300
LIG_deltaCOP1_diTrp_1	441	448	PF00928	0.331
LIG_EH1_1	28	36	PF00400	0.508
LIG_FHA_1	118	124	PF00498	0.432
LIG_FHA_1	161	167	PF00498	0.443
LIG_FHA_1	26	32	PF00498	0.597
LIG_FHA_1	280	286	PF00498	0.364
LIG_FHA_1	324	330	PF00498	0.522
LIG_FHA_1	371	377	PF00498	0.695
LIG_FHA_1	442	448	PF00498	0.457
LIG_FHA_1	459	465	PF00498	0.399
LIG_FHA_2	239	245	PF00498	0.679
LIG_FHA_2	294	300	PF00498	0.484
LIG_FHA_2	451	457	PF00498	0.432
LIG_FHA_2	472	478	PF00498	0.403
LIG_LIR_Apic_2	452	458	PF02991	0.400
LIG_LIR_LC3C_4	33	36	PF02991	0.294
LIG_LIR_Nem_3	132	138	PF02991	0.402
LIG_LIR_Nem_3	326	331	PF02991	0.409
LIG_LIR_Nem_3	91	97	PF02991	0.454
LIG_Pex14_1	418	422	PF04695	0.391
LIG_Pex14_2	94	98	PF04695	0.437
LIG_SH2_CRK	135	139	PF00017	0.420
LIG_SH2_CRK	162	166	PF00017	0.483
LIG_SH2_SRC	475	478	PF00017	0.561
LIG_SH2_STAP1	288	292	PF00017	0.445
LIG_SH2_STAP1	40	44	PF00017	0.502
LIG_SH2_STAT5	162	165	PF00017	0.378
LIG_SH2_STAT5	88	91	PF00017	0.436
LIG_SH2_STAT5	97	100	PF00017	0.472
LIG_SH3_3	158	164	PF00018	0.494
LIG_SH3_3	335	341	PF00018	0.602
LIG_SH3_3	373	379	PF00018	0.642
LIG_Sin3_3	32	39	PF02671	0.297
LIG_TRAF2_1	241	244	PF00917	0.572
LIG_WRC_WIRS_1	16	21	PF05994	0.488
MOD_CDC14_SPxK_1	154	157	PF00782	0.482
MOD_CDK_SPK_2	229	234	PF00069	0.515
MOD_CDK_SPxK_1	151	157	PF00069	0.503
MOD_CK1_1	134	140	PF00069	0.473
MOD_CK1_1	259	265	PF00069	0.467
MOD_CK1_1	30	36	PF00069	0.485
MOD_CK1_1	333	339	PF00069	0.621
MOD_CK1_1	340	346	PF00069	0.589
MOD_CK1_1	355	361	PF00069	0.497
MOD_CK1_1	442	448	PF00069	0.498
MOD_CK1_1	90	96	PF00069	0.375
MOD_CK2_1	164	170	PF00069	0.621
MOD_CK2_1	238	244	PF00069	0.697
MOD_CK2_1	293	299	PF00069	0.488
MOD_CK2_1	450	456	PF00069	0.402
MOD_CK2_1	476	482	PF00069	0.434
MOD_Cter_Amidation	20	23	PF01082	0.584
MOD_GlcNHglycan	166	169	PF01048	0.643
MOD_GlcNHglycan	210	213	PF01048	0.527
MOD_GlcNHglycan	261	264	PF01048	0.559
MOD_GlcNHglycan	269	272	PF01048	0.516
MOD_GlcNHglycan	282	285	PF01048	0.438
MOD_GlcNHglycan	318	321	PF01048	0.509
MOD_GlcNHglycan	347	350	PF01048	0.730
MOD_GlcNHglycan	357	360	PF01048	0.486
MOD_GlcNHglycan	362	366	PF01048	0.518
MOD_GlcNHglycan	379	382	PF01048	0.724
MOD_GlcNHglycan	391	394	PF01048	0.688
MOD_GlcNHglycan	40	43	PF01048	0.591
MOD_GSK3_1	147	154	PF00069	0.476
MOD_GSK3_1	160	167	PF00069	0.312
MOD_GSK3_1	17	24	PF00069	0.679
MOD_GSK3_1	255	262	PF00069	0.565
MOD_GSK3_1	30	37	PF00069	0.337
MOD_GSK3_1	323	330	PF00069	0.496
MOD_GSK3_1	333	340	PF00069	0.568
MOD_GSK3_1	351	358	PF00069	0.465
MOD_GSK3_1	377	384	PF00069	0.718
MOD_GSK3_1	385	392	PF00069	0.697
MOD_GSK3_1	40	47	PF00069	0.468
MOD_GSK3_1	437	444	PF00069	0.518
MOD_N-GLC_1	196	201	PF02516	0.356
MOD_N-GLC_1	345	350	PF02516	0.560
MOD_N-GLC_1	423	428	PF02516	0.417
MOD_N-GLC_1	458	463	PF02516	0.415
MOD_N-GLC_1	49	54	PF02516	0.550
MOD_NEK2_1	141	146	PF00069	0.466
MOD_NEK2_1	147	152	PF00069	0.466
MOD_NEK2_1	17	22	PF00069	0.681
MOD_NEK2_1	279	284	PF00069	0.475
MOD_NEK2_1	316	321	PF00069	0.501
MOD_NEK2_1	34	39	PF00069	0.491
MOD_NEK2_2	443	448	PF00069	0.314
MOD_PIKK_1	293	299	PF00454	0.398
MOD_PIKK_1	311	317	PF00454	0.558
MOD_PIKK_1	368	374	PF00454	0.725
MOD_PK_1	248	254	PF00069	0.525
MOD_PK_1	256	262	PF00069	0.370
MOD_PKA_1	293	299	PF00069	0.370
MOD_PKA_2	21	27	PF00069	0.609
MOD_PKA_2	255	261	PF00069	0.376
MOD_PKA_2	470	476	PF00069	0.361
MOD_Plk_1	131	137	PF00069	0.498
MOD_Plk_1	361	367	PF00069	0.708
MOD_Plk_1	381	387	PF00069	0.505
MOD_Plk_1	458	464	PF00069	0.412
MOD_Plk_1	69	75	PF00069	0.449
MOD_Plk_4	172	178	PF00069	0.352
MOD_Plk_4	30	36	PF00069	0.489
MOD_Plk_4	333	339	PF00069	0.654
MOD_Plk_4	443	449	PF00069	0.487
MOD_Plk_4	450	456	PF00069	0.363
MOD_Plk_4	459	465	PF00069	0.340
MOD_Plk_4	62	68	PF00069	0.368
MOD_ProDKin_1	151	157	PF00069	0.503
MOD_ProDKin_1	160	166	PF00069	0.487
MOD_ProDKin_1	229	235	PF00069	0.575
MOD_ProDKin_1	337	343	PF00069	0.657
MOD_SUMO_for_1	359	362	PF00179	0.613
MOD_SUMO_rev_2	93	103	PF00179	0.463
TRG_DiLeu_BaEn_1	9	14	PF01217	0.349
TRG_DiLeu_BaLyEn_6	12	17	PF01217	0.374
TRG_DiLeu_LyEn_5	9	14	PF01217	0.462
TRG_ENDOCYTIC_2	135	138	PF00928	0.412
TRG_ER_diArg_1	10	12	PF00400	0.391
TRG_Pf-PMV_PEXEL_1	201	205	PF00026	0.421

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P312	Leptomonas seymouri	49%	95%
A0A1X0PA30	Trypanosomatidae	36%	100%
A0A3Q8IHA9	Leishmania donovani	100%	100%
A0A3R7K8T3	Trypanosoma rangeli	37%	100%
A4HAI1	Leishmania braziliensis	80%	100%
C9ZN11	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9B4P2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q3D4	Leishmania major	92%	100%
V5DAY1	Trypanosoma cruzi	36%	100%