Stc1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uncharacterized conserved protein (DUF2039) - putative

Species:

Leishmania infantum

UniProt:

A4IAN9_LEIIN

TriTrypDb:

LINF_340012600

Length:

282

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4IAN9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAN9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	271	275	PF00656	0.571
CLV_NRD_NRD_1	121	123	PF00675	0.344
CLV_NRD_NRD_1	143	145	PF00675	0.331
CLV_NRD_NRD_1	242	244	PF00675	0.527
CLV_NRD_NRD_1	245	247	PF00675	0.530
CLV_NRD_NRD_1	262	264	PF00675	0.469
CLV_NRD_NRD_1	266	268	PF00675	0.498
CLV_NRD_NRD_1	92	94	PF00675	0.446
CLV_PCSK_FUR_1	243	247	PF00082	0.595
CLV_PCSK_FUR_1	260	264	PF00082	0.465
CLV_PCSK_FUR_1	73	77	PF00082	0.537
CLV_PCSK_KEX2_1	121	123	PF00082	0.328
CLV_PCSK_KEX2_1	143	145	PF00082	0.365
CLV_PCSK_KEX2_1	244	246	PF00082	0.575
CLV_PCSK_KEX2_1	262	264	PF00082	0.474
CLV_PCSK_KEX2_1	75	77	PF00082	0.539
CLV_PCSK_KEX2_1	92	94	PF00082	0.446
CLV_PCSK_PC1ET2_1	244	246	PF00082	0.565
CLV_PCSK_PC1ET2_1	75	77	PF00082	0.566
CLV_PCSK_PC1ET2_1	92	94	PF00082	0.268
CLV_PCSK_PC7_1	241	247	PF00082	0.407
CLV_PCSK_PC7_1	258	264	PF00082	0.475
CLV_PCSK_SKI1_1	214	218	PF00082	0.441
CLV_PCSK_SKI1_1	263	267	PF00082	0.486
CLV_PCSK_SKI1_1	76	80	PF00082	0.585
DEG_APCC_DBOX_1	250	258	PF00400	0.602
DEG_COP1_1	183	192	PF00400	0.562
DOC_USP7_MATH_1	178	182	PF00917	0.676
DOC_USP7_MATH_1	275	279	PF00917	0.631
DOC_USP7_UBL2_3	75	79	PF12436	0.614
DOC_WW_Pin1_4	195	200	PF00397	0.533
DOC_WW_Pin1_4	79	84	PF00397	0.600
LIG_14-3-3_CanoR_1	109	115	PF00244	0.412
LIG_14-3-3_CanoR_1	262	266	PF00244	0.452
LIG_14-3-3_CanoR_1	48	55	PF00244	0.433
LIG_BRCT_BRCA1_1	58	62	PF00533	0.568
LIG_FHA_1	109	115	PF00498	0.412
LIG_FHA_1	233	239	PF00498	0.535
LIG_FHA_1	55	61	PF00498	0.534
LIG_FHA_2	181	187	PF00498	0.617
LIG_FHA_2	269	275	PF00498	0.638
LIG_LIR_Gen_1	213	222	PF02991	0.463
LIG_LIR_Gen_1	66	74	PF02991	0.527
LIG_LIR_Nem_3	132	136	PF02991	0.328
LIG_LIR_Nem_3	213	218	PF02991	0.432
LIG_LIR_Nem_3	66	70	PF02991	0.646
LIG_OCRL_FandH_1	21	33	PF00620	0.421
LIG_PDZ_Class_3	277	282	PF00595	0.639
LIG_Pex14_1	129	133	PF04695	0.328
LIG_Pex14_1	58	62	PF04695	0.533
LIG_Pex14_2	63	67	PF04695	0.522
LIG_SH2_CRK	157	161	PF00017	0.449
LIG_SH2_GRB2like	89	92	PF00017	0.385
LIG_SH2_STAT3	136	139	PF00017	0.449
LIG_SH2_STAT5	205	208	PF00017	0.599
LIG_SH2_STAT5	24	27	PF00017	0.569
LIG_TRAF2_1	137	140	PF00917	0.449
LIG_TRAF2_1	194	197	PF00917	0.729
LIG_TRAF2_1	222	225	PF00917	0.480
LIG_WRC_WIRS_1	67	72	PF05994	0.556
MOD_CDK_SPxxK_3	195	202	PF00069	0.528
MOD_CDK_SPxxK_3	79	86	PF00069	0.602
MOD_CK1_1	108	114	PF00069	0.440
MOD_CK1_1	191	197	PF00069	0.657
MOD_CK1_1	253	259	PF00069	0.620
MOD_CK1_1	38	44	PF00069	0.531
MOD_CK1_1	66	72	PF00069	0.420
MOD_CK2_1	180	186	PF00069	0.564
MOD_CK2_1	191	197	PF00069	0.665
MOD_CK2_1	253	259	PF00069	0.633
MOD_CMANNOS	55	58	PF00535	0.542
MOD_GlcNHglycan	180	183	PF01048	0.717
MOD_GlcNHglycan	190	193	PF01048	0.507
MOD_GlcNHglycan	40	43	PF01048	0.435
MOD_GSK3_1	135	142	PF00069	0.465
MOD_GSK3_1	178	185	PF00069	0.619
MOD_GSK3_1	191	198	PF00069	0.707
MOD_GSK3_1	228	235	PF00069	0.576
MOD_GSK3_1	31	38	PF00069	0.425
MOD_GSK3_1	44	51	PF00069	0.509
MOD_GSK3_1	54	61	PF00069	0.647
MOD_N-GLC_1	79	84	PF02516	0.614
MOD_N-GLC_2	146	148	PF02516	0.328
MOD_NEK2_1	31	36	PF00069	0.421
MOD_NEK2_2	58	63	PF00069	0.532
MOD_PIKK_1	135	141	PF00454	0.447
MOD_PIKK_1	268	274	PF00454	0.556
MOD_PIKK_1	36	42	PF00454	0.431
MOD_PK_1	56	62	PF00069	0.432
MOD_PKA_1	267	273	PF00069	0.636
MOD_PKA_2	105	111	PF00069	0.437
MOD_PKA_2	228	234	PF00069	0.521
MOD_PKA_2	250	256	PF00069	0.628
MOD_PKA_2	261	267	PF00069	0.302
MOD_Plk_4	58	64	PF00069	0.528
MOD_ProDKin_1	195	201	PF00069	0.530
MOD_ProDKin_1	79	85	PF00069	0.601
TRG_DiLeu_BaEn_4	225	231	PF01217	0.490
TRG_ENDOCYTIC_2	157	160	PF00928	0.328
TRG_ENDOCYTIC_2	215	218	PF00928	0.433
TRG_ER_diArg_1	242	245	PF00400	0.600
TRG_Pf-PMV_PEXEL_1	16	20	PF00026	0.401
TRG_Pf-PMV_PEXEL_1	236	240	PF00026	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAJ2	Leptomonas seymouri	63%	100%
A0A0S4KI64	Bodo saltans	40%	100%
A0A1X0PAK0	Trypanosomatidae	40%	100%
A0A3S7X7J4	Leishmania donovani	100%	100%
A0A422MR74	Trypanosoma rangeli	42%	100%
A4HAH9	Leishmania braziliensis	77%	100%
C9ZN14	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	98%
E9B4N9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q3D7	Leishmania major	91%	100%
V5BJE2	Trypanosoma cruzi	40%	96%