Flagellar attachment zone protein

Quick info Annotations Localization Phosphorylation Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

flagellar attachment zone protein - putative

Species:

Leishmania infantum

UniProt:

A4IAN8_LEIIN

TriTrypDb:

LINF_340031200

Length:

1529

Annotations

LeishMANIAdb annotations

A family of very long coiled-coil proteins, likely performing cytoskeletal functions.. Two varieties have evolved, one with an N-terminal FYVE domain (Non-TM) and another with a C-terminal PDZ domain (might be TM)

Annotations by Jardim et al.

Flagella, flagellar attachment zone Uncharacterized (Fragment)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Phosphorylation

Promastigote/Amastigote: 657

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4IAN8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAN8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	241	245	PF00656	0.262
CLV_NRD_NRD_1	123	125	PF00675	0.281
CLV_NRD_NRD_1	1499	1501	PF00675	0.398
CLV_NRD_NRD_1	166	168	PF00675	0.257
CLV_NRD_NRD_1	745	747	PF00675	0.418
CLV_NRD_NRD_1	94	96	PF00675	0.311
CLV_PCSK_KEX2_1	237	239	PF00082	0.271
CLV_PCSK_KEX2_1	361	363	PF00082	0.273
CLV_PCSK_KEX2_1	744	746	PF00082	0.421
CLV_PCSK_KEX2_1	94	96	PF00082	0.311
CLV_PCSK_PC1ET2_1	237	239	PF00082	0.271
CLV_PCSK_PC1ET2_1	361	363	PF00082	0.273
CLV_PCSK_PC1ET2_1	744	746	PF00082	0.356
CLV_PCSK_SKI1_1	1032	1036	PF00082	0.351
CLV_PCSK_SKI1_1	1088	1092	PF00082	0.353
CLV_PCSK_SKI1_1	1144	1148	PF00082	0.348
CLV_PCSK_SKI1_1	1186	1190	PF00082	0.343
CLV_PCSK_SKI1_1	124	128	PF00082	0.270
CLV_PCSK_SKI1_1	1242	1246	PF00082	0.354
CLV_PCSK_SKI1_1	1298	1302	PF00082	0.354
CLV_PCSK_SKI1_1	1354	1358	PF00082	0.360
CLV_PCSK_SKI1_1	1410	1414	PF00082	0.343
CLV_PCSK_SKI1_1	259	263	PF00082	0.269
CLV_PCSK_SKI1_1	39	43	PF00082	0.284
CLV_PCSK_SKI1_1	444	448	PF00082	0.377
CLV_PCSK_SKI1_1	62	66	PF00082	0.299
CLV_PCSK_SKI1_1	735	739	PF00082	0.338
CLV_PCSK_SKI1_1	864	868	PF00082	0.361
CLV_PCSK_SKI1_1	920	924	PF00082	0.366
CLV_PCSK_SKI1_1	976	980	PF00082	0.364
DEG_APCC_DBOX_1	86	94	PF00400	0.256
DOC_CYCLIN_yClb5_NLxxxL_5	618	626	PF00134	0.302
DOC_MAPK_gen_1	110	117	PF00069	0.270
DOC_MAPK_MEF2A_6	284	293	PF00069	0.263
DOC_MAPK_RevD_3	346	362	PF00069	0.279
DOC_USP7_MATH_1	446	450	PF00917	0.228
DOC_USP7_MATH_1	558	562	PF00917	0.320
DOC_USP7_MATH_1	812	816	PF00917	0.330
DOC_USP7_UBL2_3	110	114	PF12436	0.267
DOC_USP7_UBL2_3	200	204	PF12436	0.310
DOC_WW_Pin1_4	130	135	PF00397	0.272
DOC_WW_Pin1_4	207	212	PF00397	0.268
DOC_WW_Pin1_4	295	300	PF00397	0.294
DOC_WW_Pin1_4	465	470	PF00397	0.231
DOC_WW_Pin1_4	654	659	PF00397	0.457
LIG_14-3-3_CanoR_1	100	108	PF00244	0.496
LIG_14-3-3_CanoR_1	1024	1033	PF00244	0.386
LIG_14-3-3_CanoR_1	1080	1089	PF00244	0.393
LIG_14-3-3_CanoR_1	1136	1145	PF00244	0.383
LIG_14-3-3_CanoR_1	1178	1187	PF00244	0.381
LIG_14-3-3_CanoR_1	1234	1243	PF00244	0.388
LIG_14-3-3_CanoR_1	124	132	PF00244	0.287
LIG_14-3-3_CanoR_1	1290	1299	PF00244	0.389
LIG_14-3-3_CanoR_1	1346	1355	PF00244	0.397
LIG_14-3-3_CanoR_1	1402	1411	PF00244	0.383
LIG_14-3-3_CanoR_1	1452	1460	PF00244	0.371
LIG_14-3-3_CanoR_1	1494	1502	PF00244	0.380
LIG_14-3-3_CanoR_1	284	288	PF00244	0.354
LIG_14-3-3_CanoR_1	494	502	PF00244	0.298
LIG_14-3-3_CanoR_1	856	865	PF00244	0.376
LIG_14-3-3_CanoR_1	912	921	PF00244	0.379
LIG_14-3-3_CanoR_1	968	977	PF00244	0.408
LIG_Actin_WH2_2	111	126	PF00022	0.273
LIG_Actin_WH2_2	54	69	PF00022	0.293
LIG_APCC_ABBA_1	453	458	PF00400	0.243
LIG_BIR_II_1	1	5	PF00653	0.366
LIG_CaM_IQ_9	703	718	PF13499	0.309
LIG_Clathr_ClatBox_1	567	571	PF01394	0.314
LIG_CSK_EPIYA_1	665	669	PF00017	0.468
LIG_FHA_1	1438	1444	PF00498	0.351
LIG_FHA_1	1452	1458	PF00498	0.349
LIG_FHA_1	1494	1500	PF00498	0.356
LIG_FHA_1	176	182	PF00498	0.285
LIG_FHA_1	270	276	PF00498	0.496
LIG_FHA_1	283	289	PF00498	0.384
LIG_FHA_1	348	354	PF00498	0.497
LIG_FHA_1	419	425	PF00498	0.266
LIG_FHA_1	43	49	PF00498	0.249
LIG_FHA_1	53	59	PF00498	0.315
LIG_FHA_2	1033	1039	PF00498	0.354
LIG_FHA_2	1089	1095	PF00498	0.366
LIG_FHA_2	1145	1151	PF00498	0.351
LIG_FHA_2	1187	1193	PF00498	0.346
LIG_FHA_2	1243	1249	PF00498	0.357
LIG_FHA_2	1299	1305	PF00498	0.357
LIG_FHA_2	1355	1361	PF00498	0.362
LIG_FHA_2	1411	1417	PF00498	0.350
LIG_FHA_2	150	156	PF00498	0.265
LIG_FHA_2	310	316	PF00498	0.251
LIG_FHA_2	35	41	PF00498	0.297
LIG_FHA_2	387	393	PF00498	0.337
LIG_FHA_2	485	491	PF00498	0.379
LIG_FHA_2	513	519	PF00498	0.291
LIG_FHA_2	660	666	PF00498	0.482
LIG_FHA_2	669	675	PF00498	0.370
LIG_FHA_2	781	787	PF00498	0.530
LIG_FHA_2	800	806	PF00498	0.398
LIG_FHA_2	865	871	PF00498	0.344
LIG_FHA_2	921	927	PF00498	0.349
LIG_FHA_2	977	983	PF00498	0.363
LIG_Integrin_isoDGR_2	73	75	PF01839	0.266
LIG_LIR_Apic_2	165	169	PF02991	0.236
LIG_LIR_Gen_1	158	166	PF02991	0.455
LIG_LIR_Gen_1	367	374	PF02991	0.314
LIG_LIR_Gen_1	411	420	PF02991	0.330
LIG_LIR_Gen_1	43	48	PF02991	0.253
LIG_LIR_Gen_1	431	440	PF02991	0.244
LIG_LIR_Nem_3	158	162	PF02991	0.357
LIG_LIR_Nem_3	367	373	PF02991	0.308
LIG_LIR_Nem_3	411	417	PF02991	0.343
LIG_LIR_Nem_3	43	47	PF02991	0.262
LIG_LIR_Nem_3	431	435	PF02991	0.258
LIG_LIR_Nem_3	438	443	PF02991	0.217
LIG_LIR_Nem_3	532	538	PF02991	0.272
LIG_LIR_Nem_3	786	791	PF02991	0.413
LIG_LYPXL_SIV_4	225	233	PF13949	0.230
LIG_NRBOX	565	571	PF00104	0.315
LIG_Pex14_1	410	414	PF04695	0.336
LIG_PTB_Apo_2	5	12	PF02174	0.343
LIG_PTB_Apo_2	501	508	PF02174	0.289
LIG_PTB_Phospho_1	501	507	PF10480	0.283
LIG_SH2_CRK	166	170	PF00017	0.246
LIG_SH2_CRK	22	26	PF00017	0.252
LIG_SH2_CRK	230	234	PF00017	0.273
LIG_SH2_CRK	44	48	PF00017	0.241
LIG_SH2_NCK_1	414	418	PF00017	0.337
LIG_SH2_SRC	24	27	PF00017	0.284
LIG_SH2_SRC	341	344	PF00017	0.296
LIG_SH2_SRC	434	437	PF00017	0.245
LIG_SH2_STAP1	354	358	PF00017	0.278
LIG_SH2_STAP1	44	48	PF00017	0.241
LIG_SH2_STAP1	559	563	PF00017	0.319
LIG_SH2_STAP1	668	672	PF00017	0.426
LIG_SH2_STAP1	799	803	PF00017	0.398
LIG_SH2_STAT3	640	643	PF00017	0.354
LIG_SH2_STAT5	24	27	PF00017	0.318
LIG_SH2_STAT5	341	344	PF00017	0.290
LIG_SH2_STAT5	354	357	PF00017	0.313
LIG_SH2_STAT5	364	367	PF00017	0.426
LIG_SH2_STAT5	369	372	PF00017	0.508
LIG_SH2_STAT5	434	437	PF00017	0.462
LIG_SH2_STAT5	44	47	PF00017	0.205
LIG_SH2_STAT5	505	508	PF00017	0.292
LIG_SH2_STAT5	552	555	PF00017	0.420
LIG_SH2_STAT5	582	585	PF00017	0.330
LIG_SH3_3	286	292	PF00018	0.309
LIG_SH3_3	293	299	PF00018	0.238
LIG_SH3_3	6	12	PF00018	0.308
LIG_SH3_3	655	661	PF00018	0.453
LIG_SH3_3	784	790	PF00018	0.462
LIG_SUMO_SIM_anti_2	113	120	PF11976	0.278
LIG_SUMO_SIM_anti_2	565	571	PF11976	0.315
LIG_SUMO_SIM_par_1	349	355	PF11976	0.285
LIG_SUMO_SIM_par_1	565	571	PF11976	0.315
LIG_TRAF2_1	1040	1043	PF00917	0.422
LIG_TRAF2_1	1054	1057	PF00917	0.353
LIG_TRAF2_1	1096	1099	PF00917	0.419
LIG_TRAF2_1	1110	1113	PF00917	0.368
LIG_TRAF2_1	1152	1155	PF00917	0.380
LIG_TRAF2_1	1194	1197	PF00917	0.379
LIG_TRAF2_1	1208	1211	PF00917	0.419
LIG_TRAF2_1	1250	1253	PF00917	0.430
LIG_TRAF2_1	1264	1267	PF00917	0.388
LIG_TRAF2_1	1306	1309	PF00917	0.391
LIG_TRAF2_1	1320	1323	PF00917	0.358
LIG_TRAF2_1	1362	1365	PF00917	0.427
LIG_TRAF2_1	1376	1379	PF00917	0.430
LIG_TRAF2_1	1418	1421	PF00917	0.409
LIG_TRAF2_1	1474	1477	PF00917	0.411
LIG_TRAF2_1	1516	1519	PF00917	0.408
LIG_TRAF2_1	662	665	PF00917	0.473
LIG_TRAF2_1	816	819	PF00917	0.322
LIG_TRAF2_1	830	833	PF00917	0.372
LIG_TRAF2_1	872	875	PF00917	0.405
LIG_TRAF2_1	886	889	PF00917	0.352
LIG_TRAF2_1	928	931	PF00917	0.411
LIG_TRAF2_1	942	945	PF00917	0.370
LIG_TRAF2_1	984	987	PF00917	0.420
LIG_TRAF2_1	998	1001	PF00917	0.361
LIG_TYR_ITIM	20	25	PF00017	0.224
LIG_UBA3_1	502	508	PF00899	0.285
LIG_UBA3_1	566	572	PF00899	0.312
LIG_UBA3_1	82	89	PF00899	0.225
LIG_WRC_WIRS_1	279	284	PF05994	0.259
MOD_CK1_1	187	193	PF00069	0.283
MOD_CK1_1	2	8	PF00069	0.357
MOD_CK1_1	269	275	PF00069	0.433
MOD_CK1_1	352	358	PF00069	0.357
MOD_CK1_1	418	424	PF00069	0.277
MOD_CK1_1	770	776	PF00069	0.512
MOD_CK2_1	1025	1031	PF00069	0.397
MOD_CK2_1	1032	1038	PF00069	0.396
MOD_CK2_1	1081	1087	PF00069	0.408
MOD_CK2_1	1088	1094	PF00069	0.442
MOD_CK2_1	1137	1143	PF00069	0.381
MOD_CK2_1	1144	1150	PF00069	0.367
MOD_CK2_1	1179	1185	PF00069	0.378
MOD_CK2_1	1186	1192	PF00069	0.362
MOD_CK2_1	1235	1241	PF00069	0.479
MOD_CK2_1	1242	1248	PF00069	0.405
MOD_CK2_1	1291	1297	PF00069	0.385
MOD_CK2_1	1298	1304	PF00069	0.372
MOD_CK2_1	1347	1353	PF00069	0.408
MOD_CK2_1	1354	1360	PF00069	0.404
MOD_CK2_1	1403	1409	PF00069	0.398
MOD_CK2_1	1410	1416	PF00069	0.389
MOD_CK2_1	149	155	PF00069	0.256
MOD_CK2_1	309	315	PF00069	0.251
MOD_CK2_1	34	40	PF00069	0.228
MOD_CK2_1	386	392	PF00069	0.345
MOD_CK2_1	484	490	PF00069	0.385
MOD_CK2_1	659	665	PF00069	0.492
MOD_CK2_1	668	674	PF00069	0.370
MOD_CK2_1	780	786	PF00069	0.458
MOD_CK2_1	799	805	PF00069	0.406
MOD_CK2_1	812	818	PF00069	0.330
MOD_CK2_1	857	863	PF00069	0.372
MOD_CK2_1	864	870	PF00069	0.392
MOD_CK2_1	913	919	PF00069	0.438
MOD_CK2_1	920	926	PF00069	0.396
MOD_CK2_1	969	975	PF00069	0.420
MOD_CK2_1	976	982	PF00069	0.407
MOD_GlcNHglycan	186	189	PF01048	0.296
MOD_GlcNHglycan	293	296	PF01048	0.274
MOD_GlcNHglycan	375	378	PF01048	0.379
MOD_GlcNHglycan	585	589	PF01048	0.301
MOD_GlcNHglycan	726	729	PF01048	0.317
MOD_GlcNHglycan	746	749	PF01048	0.334
MOD_GlcNHglycan	769	772	PF01048	0.477
MOD_GlcNHglycan	814	817	PF01048	0.314
MOD_GSK3_1	187	194	PF00069	0.306
MOD_GSK3_1	265	272	PF00069	0.317
MOD_GSK3_1	27	34	PF00069	0.296
MOD_GSK3_1	278	285	PF00069	0.311
MOD_GSK3_1	287	294	PF00069	0.293
MOD_GSK3_1	329	336	PF00069	0.503
MOD_GSK3_1	369	376	PF00069	0.363
MOD_GSK3_1	415	422	PF00069	0.471
MOD_GSK3_1	493	500	PF00069	0.402
MOD_GSK3_1	576	583	PF00069	0.311
MOD_GSK3_1	724	731	PF00069	0.316
MOD_GSK3_1	763	770	PF00069	0.456
MOD_GSK3_1	808	815	PF00069	0.317
MOD_GSK3_1	89	96	PF00069	0.301
MOD_LATS_1	742	748	PF00433	0.344
MOD_N-GLC_1	576	581	PF02516	0.307
MOD_N-GLC_1	654	659	PF02516	0.417
MOD_N-GLC_1	767	772	PF02516	0.465
MOD_NEK2_1	282	287	PF00069	0.259
MOD_NEK2_1	629	634	PF00069	0.288
MOD_PIKK_1	386	392	PF00454	0.345
MOD_PIKK_1	493	499	PF00454	0.270
MOD_PIKK_1	542	548	PF00454	0.278
MOD_PIKK_1	629	635	PF00454	0.281
MOD_PIKK_1	705	711	PF00454	0.317
MOD_PK_1	333	339	PF00069	0.291
MOD_PK_1	89	95	PF00069	0.270
MOD_PKA_1	124	130	PF00069	0.287
MOD_PKA_1	744	750	PF00069	0.353
MOD_PKA_2	1451	1457	PF00069	0.349
MOD_PKA_2	1493	1499	PF00069	0.352
MOD_PKA_2	283	289	PF00069	0.332
MOD_PKA_2	493	499	PF00069	0.355
MOD_PKA_2	744	750	PF00069	0.353
MOD_PKA_2	93	99	PF00069	0.326
MOD_Plk_1	42	48	PF00069	0.256
MOD_Plk_1	576	582	PF00069	0.310
MOD_Plk_4	283	289	PF00069	0.275
MOD_Plk_4	349	355	PF00069	0.279
MOD_Plk_4	369	375	PF00069	0.325
MOD_ProDKin_1	130	136	PF00069	0.262
MOD_ProDKin_1	207	213	PF00069	0.258
MOD_ProDKin_1	295	301	PF00069	0.305
MOD_ProDKin_1	465	471	PF00069	0.240
MOD_ProDKin_1	654	660	PF00069	0.455
MOD_SUMO_for_1	263	266	PF00179	0.272
MOD_SUMO_for_1	816	819	PF00179	0.354
MOD_SUMO_rev_2	194	201	PF00179	0.314
MOD_SUMO_rev_2	317	326	PF00179	0.278
MOD_SUMO_rev_2	357	363	PF00179	0.277
MOD_SUMO_rev_2	376	384	PF00179	0.393
MOD_SUMO_rev_2	531	536	PF00179	0.281
MOD_SUMO_rev_2	804	808	PF00179	0.359
TRG_DiLeu_BaEn_1	113	118	PF01217	0.270
TRG_DiLeu_BaEn_1	431	436	PF01217	0.251
TRG_DiLeu_BaEn_1	562	567	PF01217	0.310
TRG_DiLeu_BaEn_1	819	824	PF01217	0.331
TRG_DiLeu_BaEn_4	1000	1006	PF01217	0.364
TRG_DiLeu_BaEn_4	1042	1048	PF01217	0.418
TRG_DiLeu_BaEn_4	1056	1062	PF01217	0.423
TRG_DiLeu_BaEn_4	1098	1104	PF01217	0.415
TRG_DiLeu_BaEn_4	1112	1118	PF01217	0.374
TRG_DiLeu_BaEn_4	1154	1160	PF01217	0.409
TRG_DiLeu_BaEn_4	1196	1202	PF01217	0.384
TRG_DiLeu_BaEn_4	1210	1216	PF01217	0.423
TRG_DiLeu_BaEn_4	1252	1258	PF01217	0.428
TRG_DiLeu_BaEn_4	1266	1272	PF01217	0.393
TRG_DiLeu_BaEn_4	1308	1314	PF01217	0.419
TRG_DiLeu_BaEn_4	1322	1328	PF01217	0.373
TRG_DiLeu_BaEn_4	1364	1370	PF01217	0.422
TRG_DiLeu_BaEn_4	1378	1384	PF01217	0.432
TRG_DiLeu_BaEn_4	1420	1426	PF01217	0.418
TRG_DiLeu_BaEn_4	1476	1482	PF01217	0.405
TRG_DiLeu_BaEn_4	1518	1524	PF01217	0.440
TRG_DiLeu_BaEn_4	832	838	PF01217	0.382
TRG_DiLeu_BaEn_4	874	880	PF01217	0.403
TRG_DiLeu_BaEn_4	888	894	PF01217	0.358
TRG_DiLeu_BaEn_4	930	936	PF01217	0.408
TRG_DiLeu_BaEn_4	944	950	PF01217	0.424
TRG_DiLeu_BaEn_4	986	992	PF01217	0.414
TRG_ENDOCYTIC_2	22	25	PF00928	0.236
TRG_ENDOCYTIC_2	230	233	PF00928	0.267
TRG_ENDOCYTIC_2	414	417	PF00928	0.343
TRG_ENDOCYTIC_2	44	47	PF00928	0.249
TRG_ENDOCYTIC_2	79	82	PF00928	0.277
TRG_ER_diArg_1	713	716	PF00400	0.313
TRG_ER_diArg_1	774	777	PF00400	0.493
TRG_ER_diArg_1	93	95	PF00400	0.437
TRG_Pf-PMV_PEXEL_1	1024	1029	PF00026	0.367
TRG_Pf-PMV_PEXEL_1	1080	1085	PF00026	0.380
TRG_Pf-PMV_PEXEL_1	1136	1141	PF00026	0.371
TRG_Pf-PMV_PEXEL_1	1178	1183	PF00026	0.367
TRG_Pf-PMV_PEXEL_1	1234	1239	PF00026	0.372
TRG_Pf-PMV_PEXEL_1	1290	1295	PF00026	0.374
TRG_Pf-PMV_PEXEL_1	1346	1351	PF00026	0.386
TRG_Pf-PMV_PEXEL_1	1402	1407	PF00026	0.372
TRG_Pf-PMV_PEXEL_1	1500	1505	PF00026	0.383
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.390
TRG_Pf-PMV_PEXEL_1	856	861	PF00026	0.363
TRG_Pf-PMV_PEXEL_1	912	917	PF00026	0.366
TRG_Pf-PMV_PEXEL_1	968	973	PF00026	0.397

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4H7T4	Leishmania braziliensis	32%	100%
A4HBI8	Leishmania braziliensis	60%	100%
E9B4N8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
V5BAB9	Trypanosoma cruzi	40%	100%