Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IAN5_LEIIN

TriTrypDb:

LINF_340038400

Length:

425

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4IAN5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAN5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	365	369	PF00656	0.452
CLV_NRD_NRD_1	12	14	PF00675	0.723
CLV_NRD_NRD_1	304	306	PF00675	0.740
CLV_PCSK_KEX2_1	12	14	PF00082	0.703
CLV_PCSK_KEX2_1	145	147	PF00082	0.726
CLV_PCSK_KEX2_1	306	308	PF00082	0.697
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.726
CLV_PCSK_PC1ET2_1	306	308	PF00082	0.565
CLV_PCSK_SKI1_1	168	172	PF00082	0.720
CLV_PCSK_SKI1_1	226	230	PF00082	0.645
CLV_PCSK_SKI1_1	264	268	PF00082	0.635
CLV_PCSK_SKI1_1	307	311	PF00082	0.619
DEG_Nend_UBRbox_2	1	3	PF02207	0.591
DEG_SCF_FBW7_1	35	41	PF00400	0.456
DEG_SPOP_SBC_1	38	42	PF00917	0.418
DOC_CKS1_1	35	40	PF01111	0.447
DOC_MAPK_FxFP_2	187	190	PF00069	0.352
DOC_MAPK_gen_1	196	205	PF00069	0.466
DOC_MAPK_gen_1	226	236	PF00069	0.519
DOC_MAPK_gen_1	303	311	PF00069	0.487
DOC_MAPK_gen_1	376	384	PF00069	0.399
DOC_MAPK_MEF2A_6	196	205	PF00069	0.432
DOC_MAPK_MEF2A_6	281	290	PF00069	0.479
DOC_PP2B_PxIxI_1	174	180	PF00149	0.402
DOC_PP4_FxxP_1	187	190	PF00568	0.352
DOC_USP7_MATH_1	166	170	PF00917	0.553
DOC_USP7_MATH_1	250	254	PF00917	0.623
DOC_WW_Pin1_4	171	176	PF00397	0.465
DOC_WW_Pin1_4	269	274	PF00397	0.331
DOC_WW_Pin1_4	315	320	PF00397	0.401
DOC_WW_Pin1_4	339	344	PF00397	0.359
DOC_WW_Pin1_4	34	39	PF00397	0.430
DOC_WW_Pin1_4	5	10	PF00397	0.458
LIG_14-3-3_CanoR_1	136	142	PF00244	0.426
LIG_14-3-3_CanoR_1	168	177	PF00244	0.401
LIG_14-3-3_CanoR_1	226	236	PF00244	0.401
LIG_14-3-3_CanoR_1	281	288	PF00244	0.490
LIG_14-3-3_CanoR_1	305	310	PF00244	0.476
LIG_14-3-3_CanoR_1	67	73	PF00244	0.557
LIG_14-3-3_CanoR_1	94	99	PF00244	0.466
LIG_BRCT_BRCA1_1	398	402	PF00533	0.353
LIG_eIF4E_1	204	210	PF01652	0.462
LIG_FHA_1	229	235	PF00498	0.419
LIG_FHA_1	391	397	PF00498	0.479
LIG_FHA_1	418	424	PF00498	0.502
LIG_FHA_2	159	165	PF00498	0.543
LIG_FHA_2	39	45	PF00498	0.595
LIG_GBD_Chelix_1	409	417	PF00786	0.421
LIG_LIR_Apic_2	314	319	PF02991	0.400
LIG_LIR_Gen_1	378	389	PF02991	0.419
LIG_LIR_Nem_3	104	109	PF02991	0.400
LIG_LIR_Nem_3	265	271	PF02991	0.417
LIG_LIR_Nem_3	289	295	PF02991	0.381
LIG_LIR_Nem_3	310	316	PF02991	0.376
LIG_LIR_Nem_3	378	384	PF02991	0.440
LIG_NRBOX	384	390	PF00104	0.358
LIG_NRBOX	413	419	PF00104	0.450
LIG_PDZ_Class_2	420	425	PF00595	0.613
LIG_Pex14_1	184	188	PF04695	0.346
LIG_Pex14_1	263	267	PF04695	0.448
LIG_Pex14_2	383	387	PF04695	0.328
LIG_SH2_CRK	20	24	PF00017	0.534
LIG_SH2_CRK	316	320	PF00017	0.381
LIG_SH2_CRK	33	37	PF00017	0.411
LIG_SH2_PTP2	381	384	PF00017	0.404
LIG_SH2_STAT3	141	144	PF00017	0.481
LIG_SH2_STAT5	154	157	PF00017	0.505
LIG_SH2_STAT5	185	188	PF00017	0.426
LIG_SH2_STAT5	204	207	PF00017	0.463
LIG_SH2_STAT5	269	272	PF00017	0.389
LIG_SH2_STAT5	316	319	PF00017	0.410
LIG_SH2_STAT5	381	384	PF00017	0.352
LIG_SH3_1	316	322	PF00018	0.404
LIG_SH3_1	32	38	PF00018	0.405
LIG_SH3_3	12	18	PF00018	0.451
LIG_SH3_3	231	237	PF00018	0.525
LIG_SH3_3	267	273	PF00018	0.370
LIG_SH3_3	316	322	PF00018	0.358
LIG_SH3_3	32	38	PF00018	0.405
LIG_SH3_3	337	343	PF00018	0.365
LIG_SUMO_SIM_anti_2	308	314	PF11976	0.301
LIG_TYR_ITIM	266	271	PF00017	0.396
LIG_UBA3_1	413	421	PF00899	0.380
MOD_CDK_SPK_2	315	320	PF00069	0.411
MOD_CDK_SPxxK_3	171	178	PF00069	0.490
MOD_CDK_SPxxK_3	5	12	PF00069	0.461
MOD_CK1_1	253	259	PF00069	0.579
MOD_CK1_1	353	359	PF00069	0.432
MOD_CK1_1	40	46	PF00069	0.542
MOD_CK2_1	107	113	PF00069	0.372
MOD_CK2_1	158	164	PF00069	0.559
MOD_CK2_1	166	172	PF00069	0.570
MOD_CK2_1	47	53	PF00069	0.594
MOD_GlcNHglycan	168	171	PF01048	0.753
MOD_GlcNHglycan	25	28	PF01048	0.647
MOD_GlcNHglycan	256	259	PF01048	0.735
MOD_GlcNHglycan	282	285	PF01048	0.670
MOD_GlcNHglycan	397	401	PF01048	0.636
MOD_GlcNHglycan	49	52	PF01048	0.783
MOD_GlcNHglycan	53	57	PF01048	0.771
MOD_GlcNHglycan	59	62	PF01048	0.785
MOD_GlcNHglycan	79	82	PF01048	0.510
MOD_GSK3_1	166	173	PF00069	0.511
MOD_GSK3_1	246	253	PF00069	0.621
MOD_GSK3_1	307	314	PF00069	0.419
MOD_GSK3_1	34	41	PF00069	0.514
MOD_GSK3_1	371	378	PF00069	0.452
MOD_GSK3_1	57	64	PF00069	0.564
MOD_N-GLC_2	131	133	PF02516	0.664
MOD_NEK2_1	228	233	PF00069	0.492
MOD_NEK2_1	244	249	PF00069	0.570
MOD_NEK2_1	291	296	PF00069	0.451
MOD_NEK2_1	311	316	PF00069	0.360
MOD_NEK2_1	396	401	PF00069	0.491
MOD_NEK2_1	93	98	PF00069	0.401
MOD_NEK2_2	262	267	PF00069	0.348
MOD_PIKK_1	123	129	PF00454	0.402
MOD_PK_1	305	311	PF00069	0.331
MOD_PKA_1	145	151	PF00069	0.438
MOD_PKA_1	305	311	PF00069	0.469
MOD_PKA_2	137	143	PF00069	0.418
MOD_PKA_2	145	151	PF00069	0.503
MOD_PKA_2	156	162	PF00069	0.374
MOD_PKA_2	280	286	PF00069	0.483
MOD_PKA_2	375	381	PF00069	0.498
MOD_PKA_2	66	72	PF00069	0.475
MOD_PKA_2	93	99	PF00069	0.469
MOD_PKB_1	303	311	PF00069	0.406
MOD_PKB_1	45	53	PF00069	0.481
MOD_Plk_4	262	268	PF00069	0.436
MOD_Plk_4	286	292	PF00069	0.395
MOD_Plk_4	307	313	PF00069	0.396
MOD_Plk_4	94	100	PF00069	0.466
MOD_ProDKin_1	171	177	PF00069	0.454
MOD_ProDKin_1	269	275	PF00069	0.336
MOD_ProDKin_1	315	321	PF00069	0.398
MOD_ProDKin_1	339	345	PF00069	0.358
MOD_ProDKin_1	34	40	PF00069	0.439
MOD_ProDKin_1	5	11	PF00069	0.460
MOD_SUMO_rev_2	342	349	PF00179	0.477
MOD_SUMO_rev_2	365	372	PF00179	0.488
TRG_DiLeu_LyEn_5	172	177	PF01217	0.434
TRG_ENDOCYTIC_2	185	188	PF00928	0.381
TRG_ENDOCYTIC_2	268	271	PF00928	0.388
TRG_ENDOCYTIC_2	381	384	PF00928	0.404
TRG_ER_diArg_1	12	14	PF00400	0.522
TRG_ER_diArg_1	135	138	PF00400	0.373
TRG_ER_diArg_1	29	32	PF00400	0.436
TRG_ER_diArg_1	336	339	PF00400	0.436
TRG_NLS_MonoExtN_4	303	309	PF00514	0.443
TRG_Pf-PMV_PEXEL_1	178	182	PF00026	0.645

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHK0	Leptomonas seymouri	47%	96%
A0A3R7MRN0	Trypanosoma rangeli	21%	100%
A0A3S7X898	Leishmania donovani	99%	100%
A4HB34	Leishmania braziliensis	70%	100%
E9B5A4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q2M9	Leishmania major	86%	100%
V5BQG2	Trypanosoma cruzi	23%	100%