LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Phosphorylation Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
NmrA-like family/NADH(P)-binding/NAD dependent epimerase/dehydratase family/3-beta hydroxysteroid dehydrogenase/isomerase family - putative
Species:
Leishmania infantum
UniProt:
A4IAN1_LEIIN
TriTrypDb:
LINF_340038800
Length:
510

Annotations

Annotations by Jardim et al.

Oxidoreductase, NAD dependent epimerase/dehydratase family Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0005739 mitochondrion 5 1
GO:0005741 mitochondrial outer membrane 5 1
GO:0016020 membrane 2 9
GO:0019867 outer membrane 3 1
GO:0031090 organelle membrane 3 1
GO:0031966 mitochondrial membrane 4 1
GO:0031968 organelle outer membrane 4 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0098588 bounding membrane of organelle 4 1
GO:0110165 cellular anatomical entity 1 9

Phosphorylation

Promastigote: 60, 72

Expansion

Sequence features

A4IAN1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAN1

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 1
GO:0016853 isomerase activity 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 143 147 PF00656 0.311
CLV_C14_Caspase3-7 179 183 PF00656 0.303
CLV_C14_Caspase3-7 340 344 PF00656 0.355
CLV_NRD_NRD_1 417 419 PF00675 0.313
CLV_NRD_NRD_1 424 426 PF00675 0.318
CLV_NRD_NRD_1 472 474 PF00675 0.556
CLV_NRD_NRD_1 508 510 PF00675 0.707
CLV_PCSK_KEX2_1 229 231 PF00082 0.451
CLV_PCSK_KEX2_1 419 421 PF00082 0.342
CLV_PCSK_KEX2_1 424 426 PF00082 0.354
CLV_PCSK_KEX2_1 472 474 PF00082 0.556
CLV_PCSK_KEX2_1 508 510 PF00082 0.687
CLV_PCSK_PC1ET2_1 229 231 PF00082 0.458
CLV_PCSK_PC1ET2_1 419 421 PF00082 0.356
CLV_PCSK_PC1ET2_1 472 474 PF00082 0.549
CLV_PCSK_PC1ET2_1 508 510 PF00082 0.726
CLV_PCSK_PC7_1 420 426 PF00082 0.402
CLV_PCSK_SKI1_1 108 112 PF00082 0.401
CLV_PCSK_SKI1_1 214 218 PF00082 0.478
CLV_PCSK_SKI1_1 230 234 PF00082 0.405
CLV_PCSK_SKI1_1 273 277 PF00082 0.508
CLV_PCSK_SKI1_1 373 377 PF00082 0.585
CLV_PCSK_SKI1_1 424 428 PF00082 0.362
CLV_PCSK_SKI1_1 450 454 PF00082 0.463
CLV_PCSK_SKI1_1 505 509 PF00082 0.681
CLV_Separin_Metazoa 42 46 PF03568 0.677
DEG_APCC_DBOX_1 441 449 PF00400 0.625
DEG_Nend_Nbox_1 1 3 PF02207 0.639
DOC_CKS1_1 261 266 PF01111 0.355
DOC_CKS1_1 381 386 PF01111 0.413
DOC_CYCLIN_RxL_1 211 218 PF00134 0.301
DOC_CYCLIN_yCln2_LP_2 484 490 PF00134 0.333
DOC_MAPK_gen_1 106 114 PF00069 0.566
DOC_MAPK_gen_1 282 291 PF00069 0.249
DOC_MAPK_gen_1 424 434 PF00069 0.559
DOC_MAPK_MEF2A_6 108 116 PF00069 0.606
DOC_MAPK_MEF2A_6 282 291 PF00069 0.252
DOC_MAPK_MEF2A_6 425 434 PF00069 0.542
DOC_MAPK_MEF2A_6 483 491 PF00069 0.526
DOC_PP1_RVXF_1 271 277 PF00149 0.254
DOC_PP2B_LxvP_1 382 385 PF13499 0.316
DOC_PP2B_PxIxI_1 295 301 PF00149 0.258
DOC_USP7_MATH_1 236 240 PF00917 0.302
DOC_USP7_MATH_1 319 323 PF00917 0.284
DOC_USP7_MATH_1 477 481 PF00917 0.738
DOC_USP7_MATH_1 69 73 PF00917 0.770
DOC_USP7_UBL2_3 225 229 PF12436 0.269
DOC_WW_Pin1_4 196 201 PF00397 0.322
DOC_WW_Pin1_4 260 265 PF00397 0.355
DOC_WW_Pin1_4 380 385 PF00397 0.354
DOC_WW_Pin1_4 432 437 PF00397 0.533
DOC_WW_Pin1_4 483 488 PF00397 0.548
DOC_WW_Pin1_4 77 82 PF00397 0.725
LIG_14-3-3_CanoR_1 141 145 PF00244 0.269
LIG_Actin_WH2_2 167 183 PF00022 0.269
LIG_BRCT_BRCA1_1 249 253 PF00533 0.258
LIG_BRCT_BRCA1_1 321 325 PF00533 0.265
LIG_BRCT_BRCA1_1 331 335 PF00533 0.340
LIG_EH1_1 127 135 PF00400 0.329
LIG_FHA_1 208 214 PF00498 0.288
LIG_FHA_1 392 398 PF00498 0.305
LIG_FHA_1 77 83 PF00498 0.720
LIG_FHA_2 141 147 PF00498 0.269
LIG_FHA_2 242 248 PF00498 0.282
LIG_FHA_2 261 267 PF00498 0.355
LIG_FHA_2 438 444 PF00498 0.582
LIG_FHA_2 98 104 PF00498 0.641
LIG_LIR_Gen_1 255 264 PF02991 0.276
LIG_LIR_Gen_1 332 342 PF02991 0.302
LIG_LIR_Gen_1 388 398 PF02991 0.289
LIG_LIR_Gen_1 52 61 PF02991 0.709
LIG_LIR_LC3C_4 290 293 PF02991 0.269
LIG_LIR_Nem_3 255 261 PF02991 0.264
LIG_LIR_Nem_3 321 327 PF02991 0.335
LIG_LIR_Nem_3 332 338 PF02991 0.302
LIG_LIR_Nem_3 388 393 PF02991 0.282
LIG_LIR_Nem_3 52 56 PF02991 0.712
LIG_MLH1_MIPbox_1 321 325 PF16413 0.340
LIG_MYND_1 380 384 PF01753 0.340
LIG_Pex14_2 53 57 PF04695 0.731
LIG_Rb_pABgroove_1 211 219 PF01858 0.269
LIG_SH2_SRC 189 192 PF00017 0.242
LIG_SH2_STAP1 138 142 PF00017 0.258
LIG_SH2_STAP1 209 213 PF00017 0.321
LIG_SH2_STAT5 124 127 PF00017 0.313
LIG_SH2_STAT5 189 192 PF00017 0.258
LIG_SH2_STAT5 209 212 PF00017 0.340
LIG_SH2_STAT5 324 327 PF00017 0.317
LIG_SH2_STAT5 506 509 PF00017 0.514
LIG_SH3_1 323 329 PF00018 0.317
LIG_SH3_3 21 27 PF00018 0.627
LIG_SH3_3 258 264 PF00018 0.355
LIG_SH3_3 290 296 PF00018 0.249
LIG_SH3_3 323 329 PF00018 0.248
LIG_SH3_3 363 369 PF00018 0.367
LIG_SH3_3 40 46 PF00018 0.608
LIG_SH3_3 85 91 PF00018 0.704
LIG_SUMO_SIM_anti_2 290 297 PF11976 0.258
LIG_SUMO_SIM_par_1 115 122 PF11976 0.419
LIG_SUMO_SIM_par_1 204 210 PF11976 0.332
LIG_SUMO_SIM_par_1 290 297 PF11976 0.249
LIG_SUMO_SIM_par_1 306 316 PF11976 0.247
LIG_SUMO_SIM_par_1 489 495 PF11976 0.416
LIG_UBA3_1 216 225 PF00899 0.329
MOD_CDK_SPxxK_3 196 203 PF00069 0.430
MOD_CK1_1 196 202 PF00069 0.428
MOD_CK1_1 223 229 PF00069 0.428
MOD_CK1_1 260 266 PF00069 0.428
MOD_CK1_1 492 498 PF00069 0.399
MOD_CK1_1 8 14 PF00069 0.560
MOD_CK2_1 364 370 PF00069 0.353
MOD_CK2_1 97 103 PF00069 0.489
MOD_Cter_Amidation 470 473 PF01082 0.686
MOD_GlcNHglycan 121 124 PF01048 0.400
MOD_GlcNHglycan 196 199 PF01048 0.426
MOD_GlcNHglycan 222 225 PF01048 0.361
MOD_GlcNHglycan 249 252 PF01048 0.314
MOD_GlcNHglycan 39 42 PF01048 0.636
MOD_GlcNHglycan 450 453 PF01048 0.547
MOD_GlcNHglycan 5 8 PF01048 0.581
MOD_GlcNHglycan 57 60 PF01048 0.591
MOD_GSK3_1 136 143 PF00069 0.308
MOD_GSK3_1 14 21 PF00069 0.645
MOD_GSK3_1 172 179 PF00069 0.329
MOD_GSK3_1 220 227 PF00069 0.379
MOD_GSK3_1 231 238 PF00069 0.329
MOD_GSK3_1 253 260 PF00069 0.310
MOD_GSK3_1 296 303 PF00069 0.305
MOD_N-GLC_1 319 324 PF02516 0.396
MOD_N-GLC_1 329 334 PF02516 0.396
MOD_N-GLC_2 363 365 PF02516 0.396
MOD_NEK2_1 253 258 PF00069 0.291
MOD_NEK2_1 318 323 PF00069 0.426
MOD_NEK2_1 402 407 PF00069 0.387
MOD_NEK2_1 411 416 PF00069 0.280
MOD_NEK2_1 430 435 PF00069 0.429
MOD_NEK2_1 437 442 PF00069 0.375
MOD_NEK2_1 448 453 PF00069 0.343
MOD_NEK2_1 5 10 PF00069 0.567
MOD_NEK2_1 57 62 PF00069 0.571
MOD_NEK2_2 136 141 PF00069 0.306
MOD_NEK2_2 224 229 PF00069 0.340
MOD_PKA_2 140 146 PF00069 0.314
MOD_PKA_2 165 171 PF00069 0.321
MOD_PKA_2 220 226 PF00069 0.352
MOD_PKA_2 465 471 PF00069 0.606
MOD_Plk_1 329 335 PF00069 0.428
MOD_Plk_2-3 364 370 PF00069 0.477
MOD_Plk_4 14 20 PF00069 0.669
MOD_Plk_4 165 171 PF00069 0.344
MOD_Plk_4 236 242 PF00069 0.329
MOD_Plk_4 396 402 PF00069 0.338
MOD_Plk_4 489 495 PF00069 0.381
MOD_Plk_4 90 96 PF00069 0.512
MOD_ProDKin_1 196 202 PF00069 0.403
MOD_ProDKin_1 260 266 PF00069 0.450
MOD_ProDKin_1 380 386 PF00069 0.444
MOD_ProDKin_1 432 438 PF00069 0.423
MOD_ProDKin_1 483 489 PF00069 0.439
MOD_ProDKin_1 77 83 PF00069 0.686
TRG_DiLeu_BaEn_1 25 30 PF01217 0.629
TRG_DiLeu_BaEn_1 290 295 PF01217 0.428
TRG_ENDOCYTIC_2 324 327 PF00928 0.428
TRG_ER_diArg_1 281 284 PF00400 0.423
TRG_ER_diArg_1 417 420 PF00400 0.445
TRG_Pf-PMV_PEXEL_1 214 218 PF00026 0.365

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P451 Leptomonas seymouri 82% 100%
A0A0S4ILP0 Bodo saltans 53% 100%
A0A0S4KPM4 Bodo saltans 30% 84%
A0A1X0PAG0 Trypanosomatidae 25% 100%
A0A1X0PAW0 Trypanosomatidae 53% 98%
A0A3S5IRZ5 Trypanosoma rangeli 24% 100%
A0A3S7X885 Leishmania donovani 100% 100%
A0A422NNP8 Trypanosoma rangeli 56% 100%
A4HB38 Leishmania braziliensis 91% 100%
C9ZM09 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 57% 100%
E9B5A8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
P53111 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 22% 100%
P53183 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 100%
P83775 Candida albicans (strain SC5314 / ATCC MYA-2876) 22% 100%
Q12068 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 100%
Q4Q2M5 Leishmania major 98% 100%
Q9S9N9 Arabidopsis thaliana 28% 100%
V5B687 Trypanosoma cruzi 26% 100%
V5DLY1 Trypanosoma cruzi 58% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS