Putative cardiolipin synthetase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cardiolipin synthetase - putative

Species:

Leishmania infantum

UniProt:

A4IAM8_LEIIN

TriTrypDb:

LINF_340026200

Length:

752

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0020023	kinetoplast	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4IAM8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAM8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0016740	transferase activity	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	447	451	PF00656	0.778
CLV_C14_Caspase3-7	742	746	PF00656	0.606
CLV_NRD_NRD_1	180	182	PF00675	0.497
CLV_NRD_NRD_1	187	189	PF00675	0.455
CLV_NRD_NRD_1	22	24	PF00675	0.631
CLV_NRD_NRD_1	248	250	PF00675	0.410
CLV_NRD_NRD_1	314	316	PF00675	0.564
CLV_NRD_NRD_1	326	328	PF00675	0.532
CLV_NRD_NRD_1	353	355	PF00675	0.646
CLV_NRD_NRD_1	498	500	PF00675	0.598
CLV_NRD_NRD_1	505	507	PF00675	0.555
CLV_NRD_NRD_1	526	528	PF00675	0.525
CLV_NRD_NRD_1	572	574	PF00675	0.410
CLV_NRD_NRD_1	577	579	PF00675	0.339
CLV_NRD_NRD_1	589	591	PF00675	0.293
CLV_NRD_NRD_1	601	603	PF00675	0.357
CLV_PCSK_KEX2_1	107	109	PF00082	0.606
CLV_PCSK_KEX2_1	180	182	PF00082	0.497
CLV_PCSK_KEX2_1	186	188	PF00082	0.459
CLV_PCSK_KEX2_1	22	24	PF00082	0.631
CLV_PCSK_KEX2_1	240	242	PF00082	0.556
CLV_PCSK_KEX2_1	314	316	PF00082	0.602
CLV_PCSK_KEX2_1	326	328	PF00082	0.560
CLV_PCSK_KEX2_1	353	355	PF00082	0.634
CLV_PCSK_KEX2_1	498	500	PF00082	0.598
CLV_PCSK_KEX2_1	505	507	PF00082	0.555
CLV_PCSK_KEX2_1	518	520	PF00082	0.458
CLV_PCSK_KEX2_1	526	528	PF00082	0.521
CLV_PCSK_KEX2_1	577	579	PF00082	0.357
CLV_PCSK_KEX2_1	601	603	PF00082	0.391
CLV_PCSK_PC1ET2_1	107	109	PF00082	0.606
CLV_PCSK_PC1ET2_1	240	242	PF00082	0.533
CLV_PCSK_PC1ET2_1	518	520	PF00082	0.643
CLV_PCSK_PC7_1	18	24	PF00082	0.613
CLV_PCSK_PC7_1	573	579	PF00082	0.438
CLV_PCSK_SKI1_1	156	160	PF00082	0.535
CLV_PCSK_SKI1_1	223	227	PF00082	0.432
CLV_PCSK_SKI1_1	249	253	PF00082	0.392
CLV_PCSK_SKI1_1	326	330	PF00082	0.707
CLV_PCSK_SKI1_1	37	41	PF00082	0.635
CLV_PCSK_SKI1_1	413	417	PF00082	0.610
CLV_PCSK_SKI1_1	470	474	PF00082	0.664
CLV_PCSK_SKI1_1	499	503	PF00082	0.617
CLV_PCSK_SKI1_1	506	510	PF00082	0.532
CLV_PCSK_SKI1_1	590	594	PF00082	0.357
DEG_APCC_DBOX_1	505	513	PF00400	0.452
DEG_COP1_1	532	539	PF00400	0.589
DEG_MDM2_SWIB_1	115	123	PF02201	0.423
DEG_MDM2_SWIB_1	148	155	PF02201	0.408
DOC_CDC14_PxL_1	525	533	PF14671	0.639
DOC_CKS1_1	581	586	PF01111	0.357
DOC_CYCLIN_RxL_1	246	255	PF00134	0.481
DOC_CYCLIN_RxL_1	587	594	PF00134	0.391
DOC_CYCLIN_RxL_1	709	720	PF00134	0.496
DOC_CYCLIN_RxL_1	8	17	PF00134	0.629
DOC_CYCLIN_yClb5_NLxxxL_5	670	679	PF00134	0.438
DOC_CYCLIN_yCln2_LP_2	476	482	PF00134	0.735
DOC_MAPK_gen_1	246	254	PF00069	0.399
DOC_MAPK_gen_1	372	380	PF00069	0.607
DOC_MAPK_gen_1	573	581	PF00069	0.430
DOC_MAPK_gen_1	601	608	PF00069	0.415
DOC_MAPK_gen_1	631	639	PF00069	0.492
DOC_MAPK_gen_1	710	718	PF00069	0.464
DOC_MAPK_MEF2A_6	601	608	PF00069	0.391
DOC_MAPK_MEF2A_6	710	718	PF00069	0.493
DOC_PP1_RVXF_1	159	165	PF00149	0.470
DOC_PP1_RVXF_1	233	240	PF00149	0.574
DOC_PP1_RVXF_1	730	736	PF00149	0.431
DOC_USP7_MATH_1	147	151	PF00917	0.519
DOC_USP7_MATH_1	359	363	PF00917	0.673
DOC_USP7_MATH_1	421	425	PF00917	0.689
DOC_USP7_MATH_1	492	496	PF00917	0.566
DOC_USP7_MATH_1	80	84	PF00917	0.687
DOC_USP7_MATH_2	479	485	PF00917	0.594
DOC_WW_Pin1_4	110	115	PF00397	0.601
DOC_WW_Pin1_4	239	244	PF00397	0.465
DOC_WW_Pin1_4	4	9	PF00397	0.516
DOC_WW_Pin1_4	454	459	PF00397	0.615
DOC_WW_Pin1_4	475	480	PF00397	0.791
DOC_WW_Pin1_4	580	585	PF00397	0.357
DOC_WW_Pin1_4	746	751	PF00397	0.598
DOC_WW_Pin1_4	76	81	PF00397	0.740
LIG_14-3-3_CanoR_1	108	114	PF00244	0.605
LIG_14-3-3_CanoR_1	131	139	PF00244	0.460
LIG_14-3-3_CanoR_1	227	233	PF00244	0.558
LIG_14-3-3_CanoR_1	385	394	PF00244	0.715
LIG_14-3-3_CanoR_1	400	408	PF00244	0.735
LIG_14-3-3_CanoR_1	493	501	PF00244	0.626
LIG_14-3-3_CanoR_1	519	528	PF00244	0.555
LIG_14-3-3_CanoR_1	578	584	PF00244	0.357
LIG_14-3-3_CanoR_1	717	722	PF00244	0.435
LIG_14-3-3_CanoR_1	732	736	PF00244	0.498
LIG_AP2alpha_2	617	619	PF02296	0.357
LIG_APCC_ABBA_1	138	143	PF00400	0.496
LIG_BIR_II_1	1	5	PF00653	0.609
LIG_BIR_III_4	745	749	PF00653	0.617
LIG_BIR_III_4	87	91	PF00653	0.594
LIG_BRCT_BRCA1_1	111	115	PF00533	0.597
LIG_BRCT_BRCA1_1	60	64	PF00533	0.597
LIG_BRCT_BRCA1_1	719	723	PF00533	0.428
LIG_deltaCOP1_diTrp_1	617	622	PF00928	0.357
LIG_eIF4E_1	627	633	PF01652	0.391
LIG_eIF4E_1	724	730	PF01652	0.488
LIG_FHA_1	190	196	PF00498	0.394
LIG_FHA_1	207	213	PF00498	0.457
LIG_FHA_1	229	235	PF00498	0.565
LIG_FHA_1	323	329	PF00498	0.710
LIG_FHA_1	434	440	PF00498	0.734
LIG_FHA_1	520	526	PF00498	0.551
LIG_FHA_1	53	59	PF00498	0.542
LIG_FHA_1	531	537	PF00498	0.412
LIG_FHA_1	548	554	PF00498	0.329
LIG_FHA_1	587	593	PF00498	0.430
LIG_FHA_1	627	633	PF00498	0.391
LIG_FHA_1	650	656	PF00498	0.391
LIG_FHA_1	690	696	PF00498	0.438
LIG_FHA_1	717	723	PF00498	0.409
LIG_FHA_2	100	106	PF00498	0.597
LIG_FHA_2	111	117	PF00498	0.542
LIG_FHA_2	414	420	PF00498	0.819
LIG_FHA_2	425	431	PF00498	0.783
LIG_LIR_Apic_2	582	588	PF02991	0.357
LIG_LIR_Gen_1	116	127	PF02991	0.510
LIG_LIR_Gen_1	14	24	PF02991	0.591
LIG_LIR_Gen_1	149	158	PF02991	0.497
LIG_LIR_Gen_1	46	54	PF02991	0.533
LIG_LIR_Gen_1	61	72	PF02991	0.484
LIG_LIR_Gen_1	656	665	PF02991	0.357
LIG_LIR_Gen_1	713	723	PF02991	0.448
LIG_LIR_Nem_3	116	122	PF02991	0.462
LIG_LIR_Nem_3	14	19	PF02991	0.584
LIG_LIR_Nem_3	149	155	PF02991	0.473
LIG_LIR_Nem_3	339	344	PF02991	0.646
LIG_LIR_Nem_3	46	50	PF02991	0.574
LIG_LIR_Nem_3	61	67	PF02991	0.562
LIG_LIR_Nem_3	656	662	PF02991	0.357
LIG_LIR_Nem_3	713	718	PF02991	0.487
LIG_LIR_Nem_3	719	724	PF02991	0.443
LIG_LIR_Nem_3	734	738	PF02991	0.408
LIG_PCNA_yPIPBox_3	170	183	PF02747	0.494
LIG_Pex14_2	115	119	PF04695	0.427
LIG_Pex14_2	148	152	PF04695	0.407
LIG_PTB_Apo_2	553	560	PF02174	0.517
LIG_PTB_Apo_2	722	729	PF02174	0.498
LIG_PTB_Phospho_1	553	559	PF10480	0.511
LIG_REV1ctd_RIR_1	223	231	PF16727	0.561
LIG_RPA_C_Fungi	500	512	PF08784	0.622
LIG_RPA_C_Fungi	596	608	PF08784	0.391
LIG_SH2_CRK	724	728	PF00017	0.495
LIG_SH2_GRB2like	109	112	PF00017	0.559
LIG_SH2_NCK_1	27	31	PF00017	0.466
LIG_SH2_STAP1	47	51	PF00017	0.564
LIG_SH2_STAP1	521	525	PF00017	0.587
LIG_SH2_STAP1	562	566	PF00017	0.477
LIG_SH2_STAT3	562	565	PF00017	0.475
LIG_SH2_STAT3	640	643	PF00017	0.415
LIG_SH2_STAT5	167	170	PF00017	0.417
LIG_SH2_STAT5	232	235	PF00017	0.475
LIG_SH2_STAT5	27	30	PF00017	0.475
LIG_SH2_STAT5	270	273	PF00017	0.424
LIG_SH2_STAT5	521	524	PF00017	0.592
LIG_SH2_STAT5	542	545	PF00017	0.576
LIG_SH2_STAT5	586	589	PF00017	0.391
LIG_SH2_STAT5	627	630	PF00017	0.391
LIG_SH2_STAT5	95	98	PF00017	0.593
LIG_SH3_1	218	224	PF00018	0.519
LIG_SH3_3	134	140	PF00018	0.493
LIG_SH3_3	218	224	PF00018	0.519
LIG_SH3_3	285	291	PF00018	0.423
LIG_SH3_3	72	78	PF00018	0.719
LIG_SH3_3	741	747	PF00018	0.621
LIG_Sin3_3	593	600	PF02671	0.438
LIG_SUMO_SIM_anti_2	124	130	PF11976	0.508
LIG_SUMO_SIM_par_1	250	255	PF11976	0.390
LIG_SUMO_SIM_par_1	651	657	PF11976	0.390
LIG_TRAF2_1	102	105	PF00917	0.468
LIG_TRAF2_1	343	346	PF00917	0.710
LIG_TYR_ITIM	722	727	PF00017	0.489
LIG_WRC_WIRS_1	735	740	PF05994	0.522
LIG_WRPW_2	222	225	PF00400	0.509
MOD_CDK_SPxxK_3	239	246	PF00069	0.453
MOD_CDK_SPxxK_3	4	11	PF00069	0.517
MOD_CK1_1	228	234	PF00069	0.508
MOD_CK1_1	386	392	PF00069	0.660
MOD_CK1_1	424	430	PF00069	0.643
MOD_CK1_1	461	467	PF00069	0.726
MOD_CK1_1	510	516	PF00069	0.624
MOD_CK1_1	612	618	PF00069	0.360
MOD_CK1_1	657	663	PF00069	0.358
MOD_CK1_1	68	74	PF00069	0.674
MOD_CK1_1	689	695	PF00069	0.492
MOD_CK1_1	76	82	PF00069	0.627
MOD_CK2_1	11	17	PF00069	0.621
MOD_CK2_1	413	419	PF00069	0.692
MOD_CK2_1	424	430	PF00069	0.780
MOD_CK2_1	475	481	PF00069	0.739
MOD_CK2_1	99	105	PF00069	0.654
MOD_CMANNOS	313	316	PF00535	0.587
MOD_CMANNOS	619	622	PF00535	0.357
MOD_Cter_Amidation	351	354	PF01082	0.674
MOD_GlcNHglycan	143	146	PF01048	0.494
MOD_GlcNHglycan	202	205	PF01048	0.574
MOD_GlcNHglycan	28	31	PF01048	0.655
MOD_GlcNHglycan	350	353	PF01048	0.689
MOD_GlcNHglycan	359	362	PF01048	0.690
MOD_GlcNHglycan	385	388	PF01048	0.656
MOD_GlcNHglycan	41	44	PF01048	0.549
MOD_GlcNHglycan	427	430	PF01048	0.794
MOD_GlcNHglycan	454	457	PF01048	0.781
MOD_GlcNHglycan	465	468	PF01048	0.720
MOD_GlcNHglycan	484	487	PF01048	0.740
MOD_GlcNHglycan	490	493	PF01048	0.635
MOD_GlcNHglycan	494	497	PF01048	0.564
MOD_GlcNHglycan	593	596	PF01048	0.494
MOD_GlcNHglycan	67	70	PF01048	0.690
MOD_GlcNHglycan	82	85	PF01048	0.731
MOD_GSK3_1	318	325	PF00069	0.666
MOD_GSK3_1	383	390	PF00069	0.610
MOD_GSK3_1	39	46	PF00069	0.553
MOD_GSK3_1	421	428	PF00069	0.738
MOD_GSK3_1	450	457	PF00069	0.822
MOD_GSK3_1	458	465	PF00069	0.765
MOD_GSK3_1	488	495	PF00069	0.708
MOD_GSK3_1	547	554	PF00069	0.426
MOD_GSK3_1	609	616	PF00069	0.357
MOD_GSK3_1	622	629	PF00069	0.357
MOD_GSK3_1	654	661	PF00069	0.361
MOD_GSK3_1	76	83	PF00069	0.727
MOD_LATS_1	517	523	PF00433	0.622
MOD_N-GLC_1	110	115	PF02516	0.523
MOD_N-GLC_1	200	205	PF02516	0.492
MOD_N-GLC_1	612	617	PF02516	0.438
MOD_NEK2_1	141	146	PF00069	0.491
MOD_NEK2_1	225	230	PF00069	0.509
MOD_NEK2_1	26	31	PF00069	0.605
MOD_NEK2_1	281	286	PF00069	0.408
MOD_NEK2_1	381	386	PF00069	0.728
MOD_NEK2_1	463	468	PF00069	0.828
MOD_NEK2_1	609	614	PF00069	0.385
MOD_NEK2_1	65	70	PF00069	0.695
MOD_NEK2_1	716	721	PF00069	0.426
MOD_NEK2_2	175	180	PF00069	0.434
MOD_NEK2_2	359	364	PF00069	0.676
MOD_NEK2_2	404	409	PF00069	0.700
MOD_PIKK_1	318	324	PF00454	0.607
MOD_PIKK_1	399	405	PF00454	0.797
MOD_PIKK_1	547	553	PF00454	0.428
MOD_PIKK_1	59	65	PF00454	0.618
MOD_PIKK_1	689	695	PF00454	0.438
MOD_PIKK_1	73	79	PF00454	0.466
MOD_PK_1	560	566	PF00069	0.443
MOD_PKA_2	130	136	PF00069	0.476
MOD_PKA_2	206	212	PF00069	0.535
MOD_PKA_2	281	287	PF00069	0.408
MOD_PKA_2	300	306	PF00069	0.470
MOD_PKA_2	399	405	PF00069	0.763
MOD_PKA_2	492	498	PF00069	0.718
MOD_PKA_2	510	516	PF00069	0.531
MOD_PKA_2	545	551	PF00069	0.561
MOD_PKA_2	716	722	PF00069	0.443
MOD_PKA_2	731	737	PF00069	0.559
MOD_PKB_1	558	566	PF00069	0.504
MOD_Plk_1	560	566	PF00069	0.430
MOD_Plk_4	11	17	PF00069	0.604
MOD_Plk_4	147	153	PF00069	0.496
MOD_Plk_4	163	169	PF00069	0.275
MOD_Plk_4	228	234	PF00069	0.502
MOD_Plk_4	376	382	PF00069	0.605
MOD_Plk_4	389	395	PF00069	0.653
MOD_Plk_4	439	445	PF00069	0.716
MOD_Plk_4	649	655	PF00069	0.364
MOD_Plk_4	717	723	PF00069	0.437
MOD_ProDKin_1	110	116	PF00069	0.597
MOD_ProDKin_1	239	245	PF00069	0.459
MOD_ProDKin_1	4	10	PF00069	0.518
MOD_ProDKin_1	454	460	PF00069	0.615
MOD_ProDKin_1	475	481	PF00069	0.792
MOD_ProDKin_1	580	586	PF00069	0.357
MOD_ProDKin_1	746	752	PF00069	0.605
MOD_ProDKin_1	76	82	PF00069	0.741
MOD_SUMO_rev_2	298	306	PF00179	0.505
TRG_DiLeu_BaLyEn_6	604	609	PF01217	0.438
TRG_DiLeu_BaLyEn_6	628	633	PF01217	0.422
TRG_ENDOCYTIC_2	222	225	PF00928	0.531
TRG_ENDOCYTIC_2	341	344	PF00928	0.666
TRG_ENDOCYTIC_2	47	50	PF00928	0.640
TRG_ENDOCYTIC_2	521	524	PF00928	0.592
TRG_ENDOCYTIC_2	724	727	PF00928	0.409
TRG_ER_diArg_1	179	181	PF00400	0.567
TRG_ER_diArg_1	186	188	PF00400	0.586
TRG_ER_diArg_1	205	208	PF00400	0.434
TRG_ER_diArg_1	22	24	PF00400	0.631
TRG_ER_diArg_1	313	315	PF00400	0.633
TRG_ER_diArg_1	326	328	PF00400	0.548
TRG_ER_diArg_1	332	335	PF00400	0.456
TRG_ER_diArg_1	353	355	PF00400	0.651
TRG_ER_diArg_1	366	369	PF00400	0.597
TRG_ER_diArg_1	497	499	PF00400	0.578
TRG_ER_diArg_1	525	527	PF00400	0.529
TRG_ER_diArg_1	543	546	PF00400	0.569
TRG_ER_diArg_1	577	579	PF00400	0.357
TRG_NES_CRM1_1	693	708	PF08389	0.435
TRG_Pf-PMV_PEXEL_1	180	184	PF00026	0.566
TRG_Pf-PMV_PEXEL_1	353	357	PF00026	0.662
TRG_Pf-PMV_PEXEL_1	696	700	PF00026	0.504

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IC19	Leptomonas seymouri	67%	89%
A0A0S4J7Q2	Bodo saltans	42%	100%
A0A3Q8III3	Leishmania donovani	99%	100%
A0A3R7MZ93	Trypanosoma rangeli	47%	100%
E9AI68	Leishmania braziliensis	82%	100%
E9B4Z6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q2Z0	Leishmania major	93%	100%