Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IAM4_LEIIN

TriTrypDb:

LINF_340026300

Length:

306

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0016020	membrane	2	9
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4IAM4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAM4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	230	234	PF00656	0.646
CLV_NRD_NRD_1	173	175	PF00675	0.340
CLV_NRD_NRD_1	280	282	PF00675	0.393
CLV_NRD_NRD_1	295	297	PF00675	0.395
CLV_NRD_NRD_1	53	55	PF00675	0.340
CLV_PCSK_FUR_1	51	55	PF00082	0.330
CLV_PCSK_KEX2_1	172	174	PF00082	0.334
CLV_PCSK_KEX2_1	280	282	PF00082	0.392
CLV_PCSK_KEX2_1	295	297	PF00082	0.395
CLV_PCSK_KEX2_1	53	55	PF00082	0.340
CLV_PCSK_PC1ET2_1	295	297	PF00082	0.450
CLV_PCSK_SKI1_1	176	180	PF00082	0.336
CLV_PCSK_SKI1_1	201	205	PF00082	0.362
CLV_PCSK_SKI1_1	54	58	PF00082	0.426
DEG_APCC_DBOX_1	53	61	PF00400	0.521
DOC_MAPK_FxFP_2	123	126	PF00069	0.330
DOC_MAPK_gen_1	172	179	PF00069	0.522
DOC_MAPK_gen_1	215	223	PF00069	0.623
DOC_MAPK_MEF2A_6	172	179	PF00069	0.540
DOC_PP1_RVXF_1	88	94	PF00149	0.322
DOC_PP4_FxxP_1	123	126	PF00568	0.330
DOC_USP7_UBL2_3	297	301	PF12436	0.682
DOC_WW_Pin1_4	190	195	PF00397	0.538
DOC_WW_Pin1_4	239	244	PF00397	0.636
LIG_14-3-3_CanoR_1	13	20	PF00244	0.633
LIG_14-3-3_CanoR_1	280	286	PF00244	0.619
LIG_14-3-3_CanoR_1	94	100	PF00244	0.267
LIG_BIR_II_1	1	5	PF00653	0.610
LIG_deltaCOP1_diTrp_1	247	255	PF00928	0.590
LIG_deltaCOP1_diTrp_1	49	56	PF00928	0.529
LIG_FHA_1	240	246	PF00498	0.640
LIG_FHA_2	228	234	PF00498	0.652
LIG_FHA_2	261	267	PF00498	0.591
LIG_FHA_2	282	288	PF00498	0.623
LIG_FHA_2	6	12	PF00498	0.580
LIG_GBD_Chelix_1	135	143	PF00786	0.389
LIG_LIR_Apic_2	121	126	PF02991	0.461
LIG_LIR_Gen_1	106	115	PF02991	0.305
LIG_LIR_Gen_1	24	35	PF02991	0.573
LIG_LIR_Gen_1	244	252	PF02991	0.592
LIG_LIR_Gen_1	96	105	PF02991	0.306
LIG_LIR_Nem_3	106	112	PF02991	0.305
LIG_LIR_Nem_3	121	127	PF02991	0.460
LIG_LIR_Nem_3	244	249	PF02991	0.596
LIG_LIR_Nem_3	253	257	PF02991	0.591
LIG_LIR_Nem_3	64	69	PF02991	0.330
LIG_LIR_Nem_3	96	102	PF02991	0.306
LIG_LYPXL_yS_3	125	128	PF13949	0.286
LIG_MYND_1	194	198	PF01753	0.556
LIG_Pex14_1	52	56	PF04695	0.630
LIG_Pex14_2	151	155	PF04695	0.394
LIG_Pex14_2	251	255	PF04695	0.586
LIG_Pex14_2	72	76	PF04695	0.416
LIG_SH2_CRK	66	70	PF00017	0.330
LIG_SH2_GRB2like	205	208	PF00017	0.567
LIG_SH2_STAP1	95	99	PF00017	0.279
LIG_SH2_STAT5	47	50	PF00017	0.565
LIG_SH2_STAT5	85	88	PF00017	0.327
LIG_SH2_STAT5	95	98	PF00017	0.274
LIG_SH3_3	246	252	PF00018	0.592
LIG_SUMO_SIM_par_1	135	141	PF11976	0.306
LIG_TRAF2_1	209	212	PF00917	0.603
LIG_TRAF2_1	263	266	PF00917	0.586
LIG_TYR_ITSM	62	69	PF00017	0.347
MOD_CK1_1	138	144	PF00069	0.559
MOD_CK1_1	18	24	PF00069	0.682
MOD_CK1_1	239	245	PF00069	0.671
MOD_CK2_1	260	266	PF00069	0.595
MOD_CK2_1	281	287	PF00069	0.621
MOD_CK2_1	43	49	PF00069	0.497
MOD_CK2_1	76	82	PF00069	0.365
MOD_GlcNHglycan	106	109	PF01048	0.416
MOD_GlcNHglycan	17	20	PF01048	0.494
MOD_GSK3_1	138	145	PF00069	0.413
MOD_GSK3_1	14	21	PF00069	0.637
MOD_GSK3_1	219	226	PF00069	0.696
MOD_GSK3_1	281	288	PF00069	0.623
MOD_N-GLC_1	239	244	PF02516	0.436
MOD_NEK2_1	104	109	PF00069	0.311
MOD_NEK2_1	14	19	PF00069	0.640
MOD_NEK2_1	56	61	PF00069	0.447
MOD_NEK2_1	76	81	PF00069	0.291
MOD_PIKK_1	138	144	PF00454	0.409
MOD_PKA_1	281	287	PF00069	0.621
MOD_PKA_2	76	82	PF00069	0.379
MOD_PKA_2	93	99	PF00069	0.214
MOD_Plk_1	227	233	PF00069	0.649
MOD_Plk_2-3	43	49	PF00069	0.539
MOD_Plk_4	146	152	PF00069	0.240
MOD_Plk_4	165	171	PF00069	0.442
MOD_Plk_4	233	239	PF00069	0.684
MOD_Plk_4	281	287	PF00069	0.621
MOD_Plk_4	43	49	PF00069	0.563
MOD_Plk_4	56	62	PF00069	0.407
MOD_ProDKin_1	190	196	PF00069	0.531
MOD_ProDKin_1	239	245	PF00069	0.635
MOD_SUMO_rev_2	211	217	PF00179	0.636
TRG_DiLeu_BaEn_1	265	270	PF01217	0.634
TRG_DiLeu_BaEn_1	289	294	PF01217	0.660
TRG_DiLeu_BaEn_4	265	271	PF01217	0.671
TRG_ENDOCYTIC_2	124	127	PF00928	0.288
TRG_ENDOCYTIC_2	200	203	PF00928	0.559
TRG_ENDOCYTIC_2	27	30	PF00928	0.550
TRG_ENDOCYTIC_2	303	306	PF00928	0.662
TRG_ENDOCYTIC_2	66	69	PF00928	0.307
TRG_ENDOCYTIC_2	89	92	PF00928	0.335
TRG_ER_diArg_1	115	118	PF00400	0.556
TRG_ER_diArg_1	172	174	PF00400	0.540
TRG_ER_diArg_1	52	54	PF00400	0.538
TRG_NLS_Bipartite_1	280	300	PF00514	0.687
TRG_NLS_MonoExtC_3	294	299	PF00514	0.686
TRG_NLS_MonoExtN_4	295	300	PF00514	0.648
TRG_Pf-PMV_PEXEL_1	208	212	PF00026	0.385

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8X7	Leptomonas seymouri	86%	100%
A0A0S4J844	Bodo saltans	53%	96%
A0A1X0P9K7	Trypanosomatidae	64%	100%
A0A3Q8II60	Leishmania donovani	100%	100%
A4HAS3	Leishmania braziliensis	89%	100%
C9ZMP7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	100%
E9B4Z7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q2Y9	Leishmania major	98%	100%
V5BQ04	Trypanosoma cruzi	68%	100%