Amastin-like surface protein, putative

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Amastin surface glycoprotein - putative

Species:

Leishmania infantum

UniProt:

A4IAM1_LEIIN

TriTrypDb:

LINF_340034900

Length:

192

Annotations

LeishMANIAdb annotations

Publication identifier(s): 26641088 15760660
Part of the greater amastin family, a cell adhesion protein critical for intracellular parasitism. Localization: Cell surface (experimental)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 12, no: 204
NetGPI	no	yes: 0, no: 216

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	192
GO:0110165	cellular anatomical entity	1	192

Expansion

Sequence features

A4IAM1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAM1

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016485	protein processing	5	1
GO:0016540	protein autoprocessing	6	1
GO:0019538	protein metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0051604	protein maturation	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004175	endopeptidase activity	4	1
GO:0004197	cysteine-type endopeptidase activity	5	1
GO:0008233	peptidase activity	3	1
GO:0008234	cysteine-type peptidase activity	4	1
GO:0016787	hydrolase activity	2	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	175	177	PF00675	0.367
CLV_NRD_NRD_1	71	73	PF00675	0.480
CLV_PCSK_KEX2_1	49	51	PF00082	0.400
CLV_PCSK_KEX2_1	70	72	PF00082	0.487
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.399
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.402
CLV_PCSK_SKI1_1	64	68	PF00082	0.536
DOC_CKS1_1	23	28	PF01111	0.350
DOC_MAPK_MEF2A_6	107	115	PF00069	0.565
DOC_PP2B_LxvP_1	170	173	PF13499	0.561
DOC_WW_Pin1_4	22	27	PF00397	0.353
LIG_14-3-3_CanoR_1	176	181	PF00244	0.496
LIG_14-3-3_CanoR_1	40	46	PF00244	0.340
LIG_Actin_RPEL_3	100	119	PF02755	0.203
LIG_Actin_WH2_2	91	109	PF00022	0.368
LIG_EH1_1	9	17	PF00400	0.394
LIG_eIF4E_1	10	16	PF01652	0.387
LIG_eIF4E_1	151	157	PF01652	0.202
LIG_FHA_1	110	116	PF00498	0.368
LIG_FHA_1	118	124	PF00498	0.382
LIG_FHA_1	182	188	PF00498	0.598
LIG_FHA_1	4	10	PF00498	0.493
LIG_FHA_2	23	29	PF00498	0.387
LIG_Integrin_RGD_1	31	33	PF01839	0.395
LIG_LIR_Apic_2	185	191	PF02991	0.661
LIG_LIR_Gen_1	124	133	PF02991	0.286
LIG_LIR_Gen_1	166	174	PF02991	0.378
LIG_LIR_Nem_3	124	130	PF02991	0.277
LIG_LIR_Nem_3	166	172	PF02991	0.407
LIG_LIR_Nem_3	6	10	PF02991	0.355
LIG_Pex14_2	149	153	PF04695	0.379
LIG_SH2_CRK	10	14	PF00017	0.367
LIG_SH2_CRK	53	57	PF00017	0.201
LIG_SH2_NCK_1	188	192	PF00017	0.548
LIG_SH2_NCK_1	53	57	PF00017	0.197
LIG_SH2_STAP1	53	57	PF00017	0.296
LIG_SH2_STAT5	132	135	PF00017	0.288
LIG_SH2_STAT5	188	191	PF00017	0.702
LIG_SH2_STAT5	89	92	PF00017	0.377
LIG_SH3_3	135	141	PF00018	0.364
LIG_SUMO_SIM_anti_2	163	169	PF11976	0.414
LIG_SUMO_SIM_par_1	160	166	PF11976	0.242
LIG_TRFH_1	169	173	PF08558	0.263
LIG_TYR_ITIM	8	13	PF00017	0.461
LIG_Vh1_VBS_1	88	106	PF01044	0.386
MOD_CK2_1	186	192	PF00069	0.597
MOD_GSK3_1	117	124	PF00069	0.292
MOD_GSK3_1	182	189	PF00069	0.572
MOD_NEK2_1	101	106	PF00069	0.323
MOD_NEK2_1	121	126	PF00069	0.376
MOD_NEK2_1	51	56	PF00069	0.336
MOD_NMyristoyl	1	7	PF02799	0.622
MOD_PK_1	176	182	PF00069	0.491
MOD_PKA_1	176	182	PF00069	0.491
MOD_PKA_1	70	76	PF00069	0.240
MOD_PKA_2	70	76	PF00069	0.281
MOD_Plk_4	101	107	PF00069	0.356
MOD_Plk_4	17	23	PF00069	0.327
MOD_Plk_4	41	47	PF00069	0.315
MOD_Plk_4	51	57	PF00069	0.305
MOD_ProDKin_1	22	28	PF00069	0.353
MOD_SUMO_rev_2	60	66	PF00179	0.273
TRG_ENDOCYTIC_2	10	13	PF00928	0.427
TRG_ENDOCYTIC_2	151	154	PF00928	0.457
TRG_ENDOCYTIC_2	53	56	PF00928	0.274
TRG_ER_diArg_1	71	74	PF00400	0.347
TRG_NLS_MonoExtC_3	69	74	PF00514	0.195

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2C4	Leptomonas seymouri	26%	100%
A0A0N0P547	Leptomonas seymouri	41%	100%
A0A0N0P6P9	Leptomonas seymouri	25%	83%
A0A0N0P993	Leptomonas seymouri	26%	86%
A0A0N1HWY5	Leptomonas seymouri	27%	98%
A0A0N1PAD5	Leptomonas seymouri	23%	76%
A0A0N1PDH0	Leptomonas seymouri	38%	95%
A0A1X0NQ58	Trypanosomatidae	30%	100%
A0A1X0NUH1	Trypanosomatidae	29%	85%
A0A1X0NVN5	Trypanosomatidae	27%	100%
A0A1X0NVT7	Trypanosomatidae	28%	100%
A0A1X0NX02	Trypanosomatidae	28%	100%
A0A1X0NX81	Trypanosomatidae	29%	100%
A0A1X0P2R3	Trypanosomatidae	31%	91%
A0A1X0P988	Trypanosomatidae	40%	100%
A0A381MTA7	Leishmania infantum	43%	100%
A0A381MTB8	Leishmania infantum	47%	100%
A0A381MTC7	Leishmania infantum	44%	100%
A0A381MTN2	Leishmania infantum	66%	100%
A0A381MVY0	Leishmania infantum	45%	100%
A0A3Q8ID16	Leishmania donovani	26%	100%
A0A3Q8IE85	Leishmania donovani	55%	100%
A0A3Q8IEC2	Leishmania donovani	43%	99%
A0A3Q8IEI1	Leishmania donovani	84%	100%
A0A3Q8IF65	Leishmania donovani	40%	97%
A0A3Q8IFB9	Leishmania donovani	34%	95%
A0A3Q8IFH7	Leishmania donovani	44%	94%
A0A3Q8IH65	Leishmania donovani	47%	99%
A0A3Q8IHN2	Leishmania donovani	78%	100%
A0A3Q8IHW7	Leishmania donovani	46%	100%
A0A3Q8IHZ6	Leishmania donovani	51%	91%
A0A3Q8IIH1	Leishmania donovani	49%	99%
A0A3Q8IL03	Leishmania donovani	41%	100%
A0A3Q8IMR4	Leishmania donovani	21%	100%
A0A3Q8IUK8	Leishmania donovani	40%	100%
A0A3Q8IUR5	Leishmania donovani	66%	98%
A0A3S5H662	Leishmania donovani	44%	95%
A0A3S5H663	Leishmania donovani	43%	95%
A0A3S5H665	Leishmania donovani	43%	95%
A0A3S5H666	Leishmania donovani	56%	99%
A0A3S5H667	Leishmania donovani	43%	95%
A0A3S5H7D2	Leishmania donovani	27%	100%
A0A3S5H7L2	Leishmania donovani	47%	94%
A0A3S5H7V9	Leishmania donovani	42%	97%
A0A3S5H7W2	Leishmania donovani	29%	99%
A0A3S5H7W6	Leishmania donovani	45%	96%
A0A3S7WQA0	Leishmania donovani	43%	95%
A0A3S7WQA8	Leishmania donovani	53%	100%
A0A3S7WQC1	Leishmania donovani	47%	99%
A0A3S7X2E6	Leishmania donovani	47%	99%
A0A3S7X357	Leishmania donovani	26%	86%
A0A3S7X453	Leishmania donovani	39%	97%
A0A3S7X472	Leishmania donovani	42%	96%
A0A3S7X7E5	Leishmania donovani	49%	77%
A0A3S7X7M4	Leishmania donovani	52%	91%
A0A3S7X7U1	Leishmania donovani	45%	91%
A0A3S7X7U4	Leishmania donovani	45%	74%
A0A3S7X7W2	Leishmania donovani	37%	91%
A0A3S7X7Y0	Leishmania donovani	46%	99%
A4H595	Leishmania braziliensis	45%	100%
A4H596	Leishmania braziliensis	45%	100%
A4H597	Leishmania braziliensis	45%	100%
A4H5D1	Leishmania braziliensis	47%	100%
A4H5D2	Leishmania braziliensis	38%	100%
A4H5G0	Leishmania braziliensis	50%	100%
A4H5G4	Leishmania braziliensis	46%	100%
A4H5G6	Leishmania braziliensis	44%	100%
A4H5G7	Leishmania braziliensis	44%	100%
A4H5G9	Leishmania braziliensis	45%	99%
A4H5H0	Leishmania braziliensis	46%	100%
A4H5H1	Leishmania braziliensis	46%	100%
A4H5H2	Leishmania braziliensis	50%	100%
A4H5H3	Leishmania braziliensis	46%	100%
A4H6C8	Leishmania braziliensis	45%	100%
A4H7D7	Leishmania braziliensis	46%	100%
A4H9E8	Leishmania braziliensis	47%	100%
A4H9E9	Leishmania braziliensis	47%	100%
A4HAJ4	Leishmania braziliensis	48%	100%
A4HAJ5	Leishmania braziliensis	43%	100%
A4HAJ6	Leishmania braziliensis	45%	100%
A4HAL1	Leishmania braziliensis	46%	100%
A4HAL2	Leishmania braziliensis	28%	100%
A4HAM2	Leishmania braziliensis	48%	100%
A4HAM4	Leishmania braziliensis	48%	100%
A4HAR1	Leishmania braziliensis	46%	100%
A4HAZ8	Leishmania braziliensis	46%	100%
A4HB00	Leishmania braziliensis	46%	100%
A4HB02	Leishmania braziliensis	42%	100%
A4HB47	Leishmania braziliensis	36%	100%
A4HBJ0	Leishmania braziliensis	43%	100%
A4HBJ1	Leishmania braziliensis	47%	100%
A4HBJ2	Leishmania braziliensis	48%	100%
A4HDI2	Leishmania braziliensis	23%	100%
A4HDI3	Leishmania braziliensis	30%	100%
A4HDI4	Leishmania braziliensis	25%	100%
A4HDL3	Leishmania braziliensis	27%	100%
A4HDL4	Leishmania braziliensis	25%	100%
A4HTM3	Leishmania infantum	50%	100%
A4HTM4	Leishmania infantum	53%	100%
A4HTM5	Leishmania infantum	50%	100%
A4I0W3	Leishmania infantum	21%	100%
A4I0W4	Leishmania infantum	27%	100%
A4I0W5	Leishmania infantum	26%	100%
A4I4J2	Leishmania infantum	46%	100%
A4I4J3	Leishmania infantum	50%	100%
A4I5B9	Leishmania infantum	26%	100%
A4I6E5	Leishmania infantum	41%	100%
A4I9Q4	Leishmania infantum	47%	100%
A4I9R4	Leishmania infantum	29%	99%
A4I9R5	Leishmania infantum	35%	100%
A4I9R7	Leishmania infantum	50%	100%
A4I9W8	Leishmania infantum	45%	100%
A4I9X0	Leishmania infantum	37%	100%
A4IA59	Leishmania infantum	66%	100%
A4IAL7	Leishmania infantum	46%	100%
A4IAM2	Leishmania infantum	77%	100%
C6K3X5	Leptomonas seymouri	25%	96%
C6K3X9	Leptomonas seymouri	25%	100%
E8NHC3	Leishmania infantum	43%	96%
E8NHD3	Leishmania infantum	47%	94%
E8NHD6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	100%
E8NHD9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E8NHE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E8NHF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E8NHF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	99%
E8NHF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E8NHG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E8NHH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E8NHH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E8NHI3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E8NHI5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E8NHK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E8NHK9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E8NHL7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E8NHL9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E8NHM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	99%
E8NHM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E8NHM3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E8NHM5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E8NHM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E8NHM7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E8NHP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E8NHQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E8NHQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E8NHR7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E8NHR8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E8NHS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E9AG81	Leishmania infantum	44%	94%
E9AG82	Leishmania infantum	44%	94%
E9AG83	Leishmania infantum	52%	96%
E9AG85	Leishmania infantum	44%	95%
E9AHI9	Leishmania infantum	47%	99%
E9AHT2	Leishmania infantum	55%	91%
E9AME9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E9AMF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AMF1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
E9AMF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E9AMF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9AMF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E9AMF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
E9AMF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9AMF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E9AMF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	100%
E9ASP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9AWW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9AWW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	99%
E9AWW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AWX0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9B0L6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B1J3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
E9B1J4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
E9B1J5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E9B4L9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
E9B4R7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
E9B4R8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
E9B4R9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9B4S0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B4Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%
Q4Q1U9	Leishmania major	44%	98%
Q4Q305	Leishmania major	46%	99%
Q4Q309	Leishmania major	46%	100%
Q4Q313	Leishmania major	48%	100%
Q4Q317	Leishmania major	46%	100%
Q4Q325	Leishmania major	48%	100%
Q4Q327	Leishmania major	43%	100%
Q4Q329	Leishmania major	46%	99%
Q4Q333	Leishmania major	46%	99%
Q4Q335	Leishmania major	49%	100%
Q4Q337	Leishmania major	45%	98%
Q4Q339	Leishmania major	48%	100%
Q4Q341	Leishmania major	51%	100%
Q4Q397	Leishmania major	48%	100%
Q4Q3A7	Leishmania major	30%	99%
Q4Q3A8	Leishmania major	34%	100%
Q4Q3A9	Leishmania major	48%	100%
Q4Q3F7	Leishmania major	50%	100%
Q4Q6L8	Leishmania major	41%	100%
Q4Q7L6	Leishmania major	25%	100%
Q4Q7L7	Leishmania major	25%	100%
Q4Q7L8	Leishmania major	25%	100%
Q4QAK4	Leishmania major	20%	100%
Q4QAK5	Leishmania major	25%	100%
Q4QAK6	Leishmania major	29%	97%
Q4QAK7	Leishmania major	21%	100%
Q4QI84	Leishmania major	51%	100%
Q4QI85	Leishmania major	53%	100%
Q4QI86	Leishmania major	52%	100%
Q4QI87	Leishmania major	52%	100%
Q4QI88	Leishmania major	50%	100%
Q4QI92	Leishmania major	43%	100%
Q4QI93	Leishmania major	43%	100%
Q4QI95	Leishmania major	43%	100%
Q4QI97	Leishmania major	43%	100%
Q4QIA0	Leishmania major	42%	100%
Q4QIA1	Leishmania major	42%	100%