Proteasome subunit beta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

20s proteasome beta 7 subunit - (putative)

Species:

Leishmania infantum

UniProt:

A4IAL6_LEIIN

TriTrypDb:

LINF_340051100

Length:

169

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 28

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	13
GO:0005737	cytoplasm	2	13
GO:0005839	proteasome core complex	3	13
GO:0032991	protein-containing complex	1	13
GO:0043226	organelle	2	13
GO:0043227	membrane-bounded organelle	3	13
GO:0043229	intracellular organelle	3	13
GO:0043231	intracellular membrane-bounded organelle	4	13
GO:0110165	cellular anatomical entity	1	13
GO:0140535	intracellular protein-containing complex	2	13
GO:1902494	catalytic complex	2	13
GO:0019774	proteasome core complex, beta-subunit complex	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A4IAL6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAL6

PDB structure(s): 6qm7_b , 6qm7_N , 6qm8_b , 6qm8_N , 6tcz_n , 6td5_n

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0019538	protein metabolic process	3	13
GO:0043170	macromolecule metabolic process	3	13
GO:0044238	primary metabolic process	2	13
GO:0051603	proteolysis involved in protein catabolic process	5	13
GO:0071704	organic substance metabolic process	2	13
GO:1901564	organonitrogen compound metabolic process	3	13
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0030163	protein catabolic process	4	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004175	endopeptidase activity	4	10
GO:0004298	threonine-type endopeptidase activity	5	10
GO:0008233	peptidase activity	3	10
GO:0016787	hydrolase activity	2	10
GO:0070003	threonine-type peptidase activity	4	10
GO:0140096	catalytic activity, acting on a protein	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	161	163	PF00082	0.412
CLV_PCSK_KEX2_1	95	97	PF00082	0.300
CLV_PCSK_PC1ET2_1	161	163	PF00082	0.412
CLV_PCSK_PC1ET2_1	95	97	PF00082	0.300
CLV_PCSK_SKI1_1	147	151	PF00082	0.318
DOC_CDC14_PxL_1	140	148	PF14671	0.563
DOC_MAPK_DCC_7	31	40	PF00069	0.500
DOC_MAPK_MEF2A_6	31	40	PF00069	0.500
DOC_USP7_MATH_1	49	53	PF00917	0.583
DOC_USP7_MATH_2	81	87	PF00917	0.597
DOC_WW_Pin1_4	77	82	PF00397	0.451
LIG_14-3-3_CanoR_1	162	168	PF00244	0.440
LIG_14-3-3_CterR_2	164	169	PF00244	0.402
LIG_BIR_II_1	1	5	PF00653	0.518
LIG_BRCT_BRCA1_1	113	117	PF00533	0.552
LIG_BRCT_BRCA1_1	81	85	PF00533	0.552
LIG_eIF4E_1	12	18	PF01652	0.500
LIG_eIF4E_1	140	146	PF01652	0.560
LIG_FHA_1	58	64	PF00498	0.430
LIG_FHA_2	124	130	PF00498	0.541
LIG_LIR_Gen_1	50	59	PF02991	0.499
LIG_LIR_Gen_1	82	93	PF02991	0.520
LIG_LIR_Nem_3	135	140	PF02991	0.551
LIG_LIR_Nem_3	25	29	PF02991	0.489
LIG_LIR_Nem_3	50	56	PF02991	0.499
LIG_LIR_Nem_3	82	88	PF02991	0.520
LIG_PDZ_Class_2	164	169	PF00595	0.402
LIG_SH2_CRK	26	30	PF00017	0.500
LIG_SH2_GRB2like	73	76	PF00017	0.572
LIG_SH2_PTP2	140	143	PF00017	0.560
LIG_SH2_STAT5	140	143	PF00017	0.560
LIG_SH2_STAT5	87	90	PF00017	0.533
LIG_SH3_3	30	36	PF00018	0.494
LIG_TYR_ITIM	24	29	PF00017	0.500
MOD_CK1_1	25	31	PF00069	0.500
MOD_CK1_1	3	9	PF00069	0.503
MOD_CK2_1	123	129	PF00069	0.565
MOD_CK2_1	77	83	PF00069	0.448
MOD_GlcNHglycan	2	5	PF01048	0.300
MOD_GlcNHglycan	44	47	PF01048	0.333
MOD_GSK3_1	79	86	PF00069	0.552
MOD_NEK2_1	150	155	PF00069	0.327
MOD_NEK2_1	40	45	PF00069	0.525
MOD_NEK2_1	88	93	PF00069	0.553
MOD_PKA_2	111	117	PF00069	0.592
MOD_PKA_2	163	169	PF00069	0.454
MOD_Plk_1	150	156	PF00069	0.299
MOD_Plk_4	113	119	PF00069	0.558
MOD_Plk_4	19	25	PF00069	0.500
MOD_Plk_4	3	9	PF00069	0.500
MOD_ProDKin_1	77	83	PF00069	0.451
TRG_DiLeu_BaLyEn_6	141	146	PF01217	0.500
TRG_ENDOCYTIC_2	140	143	PF00928	0.563
TRG_ENDOCYTIC_2	26	29	PF00928	0.500
TRG_ENDOCYTIC_2	53	56	PF00928	0.499
TRG_ENDOCYTIC_2	73	76	PF00928	0.366
TRG_ER_diArg_1	69	72	PF00400	0.525
TRG_NLS_MonoExtN_4	158	165	PF00514	0.406
TRG_Pf-PMV_PEXEL_1	90	94	PF00026	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IKM4	Bodo saltans	64%	69%
A0A1X0PA78	Trypanosomatidae	66%	79%
A0A381MU64	Leishmania infantum	99%	100%
A0A3Q8IIL6	Leishmania donovani	99%	77%
A0A3Q8INX1	Leishmania donovani	99%	77%
A0A3R7K5Z0	Trypanosoma rangeli	69%	78%
A0RU86	Cenarchaeum symbiosum (strain A)	27%	88%
A1RX71	Thermofilum pendens (strain DSM 2475 / Hrk 5)	25%	83%
A4HBF5	Leishmania braziliensis	88%	100%
A4HBF8	Leishmania braziliensis	88%	100%
A8AA46	Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)	27%	85%
C9ZLN7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	78%
E9B5M9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O57983	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	28%	86%
P28024	Xenopus laevis	38%	70%
Q4JAY3	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	27%	87%
Q4Q289	Leishmania major	95%	100%
Q5JHL8	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	26%	85%
Q7DLR9	Arabidopsis thaliana	38%	69%
Q8SS01	Encephalitozoon cuniculi (strain GB-M1)	28%	75%
Q8TW10	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	25%	80%
Q8U4C9	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	29%	86%
Q975U8	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	25%	86%
Q9V247	Pyrococcus abyssi (strain GE5 / Orsay)	28%	86%