LeishMANIAdb
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Putative 1,2-Dihydroxy-3-keto-5-methylthiopentene dioxygenase

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative 1,2-Dihydroxy-3-keto-5-methylthiopentene dioxygenase
Gene product:
1 -2-Dihydroxy-3-keto-5-methylthiopentene dioxygenase - putative
Species:
Leishmania infantum
UniProt:
A4IAL2_LEIIN
TriTrypDb:
LINF_340052200
Length:
279

Annotations

Annotations by Jardim et al.

Amino acid metabolism, 1,2-Dihydroxy-3-keto-5-methylthiopentene dioxygenase

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) yes yes: 3
Silverman et al. no yes: 3
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005930 axoneme 2 1
GO:0110165 cellular anatomical entity 1 2
GO:0005634 nucleus 5 1
GO:0005737 cytoplasm 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4IAL2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAL2

Function

Biological processes
Term Name Level Count
GO:0000096 sulfur amino acid metabolic process 4 12
GO:0000097 sulfur amino acid biosynthetic process 5 12
GO:0006082 organic acid metabolic process 3 12
GO:0006520 amino acid metabolic process 3 12
GO:0006555 methionine metabolic process 5 12
GO:0006790 sulfur compound metabolic process 3 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0008652 amino acid biosynthetic process 4 12
GO:0009058 biosynthetic process 2 12
GO:0009066 aspartate family amino acid metabolic process 5 12
GO:0009067 aspartate family amino acid biosynthetic process 6 12
GO:0009086 methionine biosynthetic process 6 12
GO:0009987 cellular process 1 12
GO:0016053 organic acid biosynthetic process 4 12
GO:0019752 carboxylic acid metabolic process 5 12
GO:0043436 oxoacid metabolic process 4 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0044249 cellular biosynthetic process 3 12
GO:0044272 sulfur compound biosynthetic process 4 12
GO:0044281 small molecule metabolic process 2 12
GO:0044283 small molecule biosynthetic process 3 12
GO:0046394 carboxylic acid biosynthetic process 5 12
GO:0071704 organic substance metabolic process 2 12
GO:1901564 organonitrogen compound metabolic process 3 12
GO:1901566 organonitrogen compound biosynthetic process 4 12
GO:1901576 organic substance biosynthetic process 3 12
GO:1901605 alpha-amino acid metabolic process 4 12
GO:1901607 alpha-amino acid biosynthetic process 5 12
GO:0019509 L-methionine salvage from methylthioadenosine 6 1
GO:0043094 cellular metabolic compound salvage 3 1
GO:0043102 amino acid salvage 4 1
GO:0071265 L-methionine biosynthetic process 7 1
GO:0071267 L-methionine salvage 5 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0010309 acireductone dioxygenase [iron(II)-requiring] activity 5 12
GO:0016491 oxidoreductase activity 2 12
GO:0016701 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 3 12
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen 4 12
GO:0051213 dioxygenase activity 3 12
GO:0010308 acireductone dioxygenase (Ni2+-requiring) activity 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 252 256 PF00656 0.416
CLV_MEL_PAP_1 131 137 PF00089 0.218
CLV_NRD_NRD_1 112 114 PF00675 0.444
CLV_NRD_NRD_1 20 22 PF00675 0.461
CLV_NRD_NRD_1 32 34 PF00675 0.419
CLV_NRD_NRD_1 42 44 PF00675 0.408
CLV_NRD_NRD_1 45 47 PF00675 0.411
CLV_NRD_NRD_1 57 59 PF00675 0.380
CLV_PCSK_FUR_1 43 47 PF00082 0.508
CLV_PCSK_FUR_1 58 62 PF00082 0.418
CLV_PCSK_KEX2_1 22 24 PF00082 0.447
CLV_PCSK_KEX2_1 248 250 PF00082 0.569
CLV_PCSK_KEX2_1 32 34 PF00082 0.444
CLV_PCSK_KEX2_1 44 46 PF00082 0.408
CLV_PCSK_KEX2_1 57 59 PF00082 0.381
CLV_PCSK_KEX2_1 60 62 PF00082 0.369
CLV_PCSK_KEX2_1 67 69 PF00082 0.493
CLV_PCSK_PC1ET2_1 22 24 PF00082 0.447
CLV_PCSK_PC1ET2_1 248 250 PF00082 0.569
CLV_PCSK_PC1ET2_1 44 46 PF00082 0.489
CLV_PCSK_PC1ET2_1 57 59 PF00082 0.372
CLV_PCSK_PC1ET2_1 60 62 PF00082 0.356
CLV_PCSK_PC1ET2_1 67 69 PF00082 0.498
DEG_Nend_UBRbox_2 1 3 PF02207 0.571
DOC_MAPK_gen_1 123 133 PF00069 0.452
DOC_MAPK_gen_1 150 160 PF00069 0.401
DOC_MAPK_gen_1 197 206 PF00069 0.411
DOC_MAPK_gen_1 43 53 PF00069 0.481
DOC_MAPK_HePTP_8 120 132 PF00069 0.311
DOC_MAPK_HePTP_8 196 208 PF00069 0.500
DOC_MAPK_MEF2A_6 113 122 PF00069 0.412
DOC_MAPK_MEF2A_6 123 132 PF00069 0.409
DOC_MAPK_MEF2A_6 199 208 PF00069 0.500
DOC_USP7_UBL2_3 110 114 PF12436 0.387
LIG_14-3-3_CanoR_1 134 143 PF00244 0.452
LIG_14-3-3_CanoR_1 223 227 PF00244 0.506
LIG_EVH1_1 77 81 PF00568 0.407
LIG_FHA_1 104 110 PF00498 0.409
LIG_FHA_1 153 159 PF00498 0.398
LIG_FHA_2 161 167 PF00498 0.407
LIG_FHA_2 177 183 PF00498 0.398
LIG_FHA_2 223 229 PF00498 0.398
LIG_LIR_Gen_1 138 147 PF02991 0.405
LIG_LIR_Gen_1 201 210 PF02991 0.431
LIG_LIR_Gen_1 228 238 PF02991 0.398
LIG_LIR_LC3C_4 212 215 PF02991 0.452
LIG_LIR_Nem_3 138 143 PF02991 0.440
LIG_LIR_Nem_3 181 187 PF02991 0.454
LIG_LIR_Nem_3 191 196 PF02991 0.391
LIG_LIR_Nem_3 201 206 PF02991 0.435
LIG_LIR_Nem_3 228 234 PF02991 0.411
LIG_LIR_Nem_3 63 69 PF02991 0.454
LIG_Pex14_2 169 173 PF04695 0.398
LIG_SH2_PTP2 231 234 PF00017 0.441
LIG_SH2_SRC 174 177 PF00017 0.500
LIG_SH2_STAT5 178 181 PF00017 0.478
LIG_SH2_STAT5 231 234 PF00017 0.439
LIG_SH2_STAT5 263 266 PF00017 0.311
LIG_SH2_STAT5 94 97 PF00017 0.343
LIG_SH3_3 211 217 PF00018 0.468
LIG_SH3_3 75 81 PF00018 0.424
LIG_SH3_4 110 117 PF00018 0.523
LIG_SUMO_SIM_anti_2 212 217 PF11976 0.452
LIG_TRAF2_1 39 42 PF00917 0.480
LIG_UBA3_1 264 269 PF00899 0.377
MOD_CK1_1 105 111 PF00069 0.434
MOD_CK2_1 165 171 PF00069 0.483
MOD_CK2_1 176 182 PF00069 0.436
MOD_CK2_1 222 228 PF00069 0.398
MOD_Cter_Amidation 111 114 PF01082 0.366
MOD_GSK3_1 249 256 PF00069 0.487
MOD_NEK2_1 133 138 PF00069 0.465
MOD_NEK2_1 188 193 PF00069 0.511
MOD_NEK2_2 118 123 PF00069 0.512
MOD_NEK2_2 263 268 PF00069 0.373
MOD_PIKK_1 158 164 PF00454 0.398
MOD_PIKK_1 271 277 PF00454 0.460
MOD_PIKK_1 97 103 PF00454 0.447
MOD_PKA_2 133 139 PF00069 0.452
MOD_PKA_2 222 228 PF00069 0.406
MOD_Plk_1 165 171 PF00069 0.500
MOD_Plk_2-3 176 182 PF00069 0.500
MOD_Plk_2-3 2 8 PF00069 0.606
MOD_Plk_4 165 171 PF00069 0.503
MOD_Plk_4 188 194 PF00069 0.487
MOD_SUMO_rev_2 149 155 PF00179 0.476
MOD_SUMO_rev_2 156 161 PF00179 0.451
MOD_SUMO_rev_2 31 39 PF00179 0.506
MOD_SUMO_rev_2 63 69 PF00179 0.544
TRG_DiLeu_BaEn_4 64 70 PF01217 0.436
TRG_ENDOCYTIC_2 231 234 PF00928 0.416
TRG_ENDOCYTIC_2 235 238 PF00928 0.417
TRG_ER_diArg_1 32 34 PF00400 0.445
TRG_ER_diArg_1 43 46 PF00400 0.382
TRG_NES_CRM1_1 127 139 PF08389 0.406
TRG_NLS_Bipartite_1 43 62 PF00514 0.553
TRG_NLS_MonoCore_2 57 62 PF00514 0.559
TRG_NLS_MonoExtC_3 57 63 PF00514 0.560
TRG_NLS_MonoExtN_4 57 62 PF00514 0.559
TRG_Pf-PMV_PEXEL_1 123 127 PF00026 0.300
TRG_Pf-PMV_PEXEL_1 32 36 PF00026 0.474

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PA36 Leptomonas seymouri 78% 100%
A0A0S4IQB1 Bodo saltans 59% 98%
A0A1X0PAJ9 Trypanosomatidae 66% 99%
A0A3S7X8L3 Leishmania donovani 100% 100%
A0A422NJ26 Trypanosoma rangeli 60% 99%
A1L4T4 Oryza sativa subsp. japonica 30% 100%
A2Z7C4 Oryza sativa subsp. indica 30% 100%
A4HBG6 Leishmania braziliensis 92% 100%
A9SCJ6 Physcomitrium patens 32% 100%
A9SS00 Physcomitrium patens 34% 100%
C9ZLM6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 66% 100%
E9B5N7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
F6HDT7 Vitis vinifera 30% 100%
O48707 Arabidopsis thaliana 30% 100%
Q4Q281 Leishmania major 95% 100%
Q8W108 Arabidopsis thaliana 28% 100%
V5B654 Trypanosoma cruzi 62% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS