PCI domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IAL1_LEIIN

TriTrypDb:

LINF_340052100

Length:

358

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IAL1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAL1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	115	117	PF00675	0.511
CLV_NRD_NRD_1	215	217	PF00675	0.503
CLV_NRD_NRD_1	24	26	PF00675	0.621
CLV_NRD_NRD_1	50	52	PF00675	0.749
CLV_PCSK_KEX2_1	105	107	PF00082	0.458
CLV_PCSK_KEX2_1	115	117	PF00082	0.553
CLV_PCSK_KEX2_1	215	217	PF00082	0.503
CLV_PCSK_KEX2_1	24	26	PF00082	0.621
CLV_PCSK_KEX2_1	242	244	PF00082	0.678
CLV_PCSK_KEX2_1	52	54	PF00082	0.780
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.418
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.678
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.802
CLV_PCSK_SKI1_1	189	193	PF00082	0.527
CLV_PCSK_SKI1_1	24	28	PF00082	0.540
CLV_PCSK_SKI1_1	334	338	PF00082	0.496
CLV_PCSK_SKI1_1	40	44	PF00082	0.622
DEG_APCC_DBOX_1	39	47	PF00400	0.600
DOC_CKS1_1	174	179	PF01111	0.410
DOC_CYCLIN_RxL_1	331	339	PF00134	0.519
DOC_MAPK_DCC_7	232	241	PF00069	0.684
DOC_MAPK_DCC_7	40	48	PF00069	0.455
DOC_MAPK_gen_1	21	29	PF00069	0.614
DOC_MAPK_gen_1	215	223	PF00069	0.599
DOC_MAPK_gen_1	242	250	PF00069	0.636
DOC_MAPK_MEF2A_6	40	48	PF00069	0.455
DOC_PP2B_LxvP_1	46	49	PF13499	0.564
DOC_USP7_UBL2_3	352	356	PF12436	0.589
DOC_WW_Pin1_4	120	125	PF00397	0.533
DOC_WW_Pin1_4	139	144	PF00397	0.513
DOC_WW_Pin1_4	173	178	PF00397	0.585
DOC_WW_Pin1_4	209	214	PF00397	0.712
DOC_WW_Pin1_4	234	239	PF00397	0.647
LIG_14-3-3_CanoR_1	196	206	PF00244	0.621
LIG_14-3-3_CanoR_1	227	236	PF00244	0.614
LIG_14-3-3_CanoR_1	53	59	PF00244	0.677
LIG_14-3-3_CanoR_1	77	86	PF00244	0.646
LIG_Actin_WH2_2	306	321	PF00022	0.616
LIG_BIR_II_1	1	5	PF00653	0.704
LIG_eIF4E_1	31	37	PF01652	0.572
LIG_FHA_1	231	237	PF00498	0.681
LIG_FHA_1	3	9	PF00498	0.466
LIG_FHA_1	31	37	PF00498	0.611
LIG_FHA_1	55	61	PF00498	0.667
LIG_FHA_1	94	100	PF00498	0.468
LIG_FHA_2	121	127	PF00498	0.531
LIG_LIR_Gen_1	123	131	PF02991	0.605
LIG_LIR_Gen_1	217	225	PF02991	0.569
LIG_LIR_Nem_3	121	125	PF02991	0.590
LIG_LIR_Nem_3	159	163	PF02991	0.506
LIG_LIR_Nem_3	217	221	PF02991	0.570
LIG_NRBOX	201	207	PF00104	0.571
LIG_NRBOX	263	269	PF00104	0.626
LIG_NRBOX	7	13	PF00104	0.481
LIG_RPA_C_Fungi	191	203	PF08784	0.584
LIG_SH2_CRK	290	294	PF00017	0.538
LIG_SH2_NCK_1	108	112	PF00017	0.583
LIG_SH2_NCK_1	125	129	PF00017	0.331
LIG_SH2_SRC	347	350	PF00017	0.606
LIG_SH2_STAT5	152	155	PF00017	0.619
LIG_SH2_STAT5	240	243	PF00017	0.576
LIG_SH2_STAT5	7	10	PF00017	0.472
LIG_SH3_2	210	215	PF14604	0.532
LIG_SH3_3	137	143	PF00018	0.464
LIG_SH3_3	171	177	PF00018	0.537
LIG_SH3_3	207	213	PF00018	0.633
LIG_SUMO_SIM_par_1	25	30	PF11976	0.605
LIG_TYR_ITSM	121	128	PF00017	0.414
LIG_UBA3_1	345	352	PF00899	0.532
MOD_CDC14_SPxK_1	212	215	PF00782	0.527
MOD_CDK_SPxK_1	209	215	PF00069	0.540
MOD_CDK_SPxxK_3	209	216	PF00069	0.706
MOD_CK1_1	2	8	PF00069	0.606
MOD_CK1_1	230	236	PF00069	0.619
MOD_CK2_1	120	126	PF00069	0.536
MOD_CK2_1	139	145	PF00069	0.494
MOD_DYRK1A_RPxSP_1	139	143	PF00069	0.459
MOD_GlcNHglycan	8	11	PF01048	0.539
MOD_GSK3_1	197	204	PF00069	0.660
MOD_GSK3_1	2	9	PF00069	0.564
MOD_GSK3_1	226	233	PF00069	0.698
MOD_GSK3_1	76	83	PF00069	0.441
MOD_N-GLC_1	269	274	PF02516	0.690
MOD_N-GLC_1	93	98	PF02516	0.426
MOD_N-GLC_2	15	17	PF02516	0.505
MOD_NEK2_1	197	202	PF00069	0.529
MOD_NEK2_1	271	276	PF00069	0.671
MOD_NEK2_1	298	303	PF00069	0.639
MOD_NEK2_1	318	323	PF00069	0.327
MOD_NEK2_1	336	341	PF00069	0.380
MOD_PIKK_1	197	203	PF00454	0.506
MOD_PKA_1	54	60	PF00069	0.754
MOD_PKA_2	195	201	PF00069	0.624
MOD_PKA_2	226	232	PF00069	0.620
MOD_PKA_2	318	324	PF00069	0.651
MOD_PKA_2	54	60	PF00069	0.708
MOD_PKA_2	76	82	PF00069	0.671
MOD_PKB_1	75	83	PF00069	0.626
MOD_Plk_1	269	275	PF00069	0.693
MOD_Plk_2-3	244	250	PF00069	0.446
MOD_Plk_4	201	207	PF00069	0.672
MOD_Plk_4	32	38	PF00069	0.680
MOD_ProDKin_1	120	126	PF00069	0.536
MOD_ProDKin_1	139	145	PF00069	0.503
MOD_ProDKin_1	173	179	PF00069	0.583
MOD_ProDKin_1	209	215	PF00069	0.703
MOD_ProDKin_1	234	240	PF00069	0.649
MOD_SUMO_for_1	241	244	PF00179	0.671
TRG_DiLeu_BaEn_1	32	37	PF01217	0.669
TRG_DiLeu_BaLyEn_6	341	346	PF01217	0.503
TRG_ENDOCYTIC_2	125	128	PF00928	0.522
TRG_ENDOCYTIC_2	131	134	PF00928	0.511
TRG_ENDOCYTIC_2	261	264	PF00928	0.585
TRG_ENDOCYTIC_2	290	293	PF00928	0.543
TRG_ER_diArg_1	114	116	PF00400	0.487
TRG_ER_diArg_1	184	187	PF00400	0.558
TRG_ER_diArg_1	23	25	PF00400	0.614
TRG_ER_diArg_1	75	78	PF00400	0.659
TRG_NLS_MonoCore_2	50	55	PF00514	0.755
TRG_NLS_MonoExtC_3	50	55	PF00514	0.692
TRG_NLS_MonoExtN_4	101	108	PF00514	0.411
TRG_NLS_MonoExtN_4	49	56	PF00514	0.790
TRG_Pf-PMV_PEXEL_1	25	30	PF00026	0.638
TRG_Pf-PMV_PEXEL_1	300	305	PF00026	0.538
TRG_Pf-PMV_PEXEL_1	344	348	PF00026	0.480

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRX1	Leptomonas seymouri	44%	100%
A0A3Q8ILM5	Leishmania donovani	99%	100%
A4HBG5	Leishmania braziliensis	77%	100%
E9B5N6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q282	Leishmania major	90%	100%