DUF418 domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IAK9_LEIIN

TriTrypDb:

LINF_340051900

Length:

119

Annotations

LeishMANIAdb annotations

A very conserved Kinetoplastid protein with no relatives in other life forms

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4IAK9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAK9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	111	113	PF00675	0.421
CLV_NRD_NRD_1	43	45	PF00675	0.410
CLV_PCSK_KEX2_1	43	45	PF00082	0.399
CLV_PCSK_SKI1_1	113	117	PF00082	0.441
CLV_PCSK_SKI1_1	21	25	PF00082	0.378
CLV_PCSK_SKI1_1	44	48	PF00082	0.455
CLV_PCSK_SKI1_1	51	55	PF00082	0.395
DEG_APCC_DBOX_1	43	51	PF00400	0.616
DOC_CYCLIN_RxL_1	40	49	PF00134	0.529
DOC_MAPK_gen_1	48	57	PF00069	0.625
DOC_PP1_RVXF_1	19	25	PF00149	0.378
DOC_PP1_RVXF_1	46	53	PF00149	0.660
DOC_PP4_FxxP_1	85	88	PF00568	0.473
DOC_USP7_MATH_1	88	92	PF00917	0.451
LIG_Actin_WH2_2	32	50	PF00022	0.383
LIG_eIF4E_1	34	40	PF01652	0.355
LIG_FHA_1	68	74	PF00498	0.447
LIG_LIR_Apic_2	84	88	PF02991	0.470
LIG_LIR_Gen_1	32	41	PF02991	0.257
LIG_LIR_Gen_1	49	60	PF02991	0.535
LIG_LIR_Nem_3	17	22	PF02991	0.389
LIG_LIR_Nem_3	3	8	PF02991	0.477
LIG_LIR_Nem_3	30	36	PF02991	0.271
LIG_PDZ_Class_2	114	119	PF00595	0.630
LIG_Pex14_2	33	37	PF04695	0.405
LIG_SH2_CRK	97	101	PF00017	0.355
LIG_SH2_STAT5	107	110	PF00017	0.408
LIG_SH2_STAT5	34	37	PF00017	0.378
LIG_SH2_STAT5	59	62	PF00017	0.378
LIG_SUMO_SIM_anti_2	70	75	PF11976	0.355
LIG_TYR_ITIM	95	100	PF00017	0.318
LIG_WRC_WIRS_1	82	87	PF05994	0.509
MOD_CK1_1	26	32	PF00069	0.482
MOD_Cter_Amidation	110	113	PF01082	0.500
MOD_GlcNHglycan	90	93	PF01048	0.588
MOD_GlcNHglycan	97	100	PF01048	0.381
MOD_GSK3_1	111	118	PF00069	0.581
MOD_GSK3_1	23	30	PF00069	0.377
MOD_GSK3_1	95	102	PF00069	0.375
MOD_NEK2_1	1	6	PF00069	0.595
MOD_NEK2_1	58	63	PF00069	0.466
MOD_NEK2_1	69	74	PF00069	0.357
MOD_PKA_2	111	117	PF00069	0.522
MOD_Plk_4	1	7	PF00069	0.595
MOD_Plk_4	111	117	PF00069	0.502
MOD_Plk_4	14	20	PF00069	0.422
MOD_Plk_4	29	35	PF00069	0.288
MOD_Plk_4	69	75	PF00069	0.399
MOD_Plk_4	99	105	PF00069	0.341
TRG_DiLeu_BaLyEn_6	18	23	PF01217	0.408
TRG_DiLeu_BaLyEn_6	41	46	PF01217	0.498
TRG_ENDOCYTIC_2	34	37	PF00928	0.335
TRG_ENDOCYTIC_2	59	62	PF00928	0.342
TRG_ENDOCYTIC_2	97	100	PF00928	0.335
TRG_ER_diArg_1	43	45	PF00400	0.500

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC58	Leptomonas seymouri	71%	100%
A0A0S4IQ54	Bodo saltans	30%	99%
A0A1X0PAC4	Trypanosomatidae	43%	100%
A0A3R7KFI4	Trypanosoma rangeli	46%	100%
A0A3S7X8T4	Leishmania donovani	99%	100%
A4HBG3	Leishmania braziliensis	87%	100%
C9ZLN1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9B5N4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q284	Leishmania major	92%	100%