Cell differentiation protein-like protein

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cell differentiation protein-like protein

Species:

Leishmania infantum

UniProt:

A4IAK7_LEIIN

TriTrypDb:

LINF_340051700

Length:

358

Annotations

LeishMANIAdb annotations

A conserved Eukaryotic protein. Certainly not TM.

Annotations by Jardim et al.

RNA Processing, Cell differentiation -like

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0030014	CCR4-NOT complex	3	10
GO:0032991	protein-containing complex	1	11
GO:0140535	intracellular protein-containing complex	2	11
GO:0000932	P-body	5	1
GO:0005737	cytoplasm	2	1
GO:0030015	CCR4-NOT core complex	3	1
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	2

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4IAK7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAK7

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006401	RNA catabolic process	5	11
GO:0006402	mRNA catabolic process	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009056	catabolic process	2	11
GO:0009057	macromolecule catabolic process	4	11
GO:0009892	negative regulation of metabolic process	4	11
GO:0009987	cellular process	1	11
GO:0010468	regulation of gene expression	5	11
GO:0010605	negative regulation of macromolecule metabolic process	5	11
GO:0010629	negative regulation of gene expression	6	11
GO:0016070	RNA metabolic process	5	11
GO:0016071	mRNA metabolic process	6	11
GO:0019222	regulation of metabolic process	3	11
GO:0019439	aromatic compound catabolic process	4	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034655	nucleobase-containing compound catabolic process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044248	cellular catabolic process	3	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0044265	obsolete cellular macromolecule catabolic process	4	11
GO:0044270	cellular nitrogen compound catabolic process	4	11
GO:0046483	heterocycle metabolic process	3	11
GO:0046700	heterocycle catabolic process	4	11
GO:0048519	negative regulation of biological process	3	11
GO:0050789	regulation of biological process	2	11
GO:0060255	regulation of macromolecule metabolic process	4	11
GO:0065007	biological regulation	1	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:1901361	organic cyclic compound catabolic process	4	11
GO:1901575	organic substance catabolic process	3	11
GO:0006417	regulation of translation	6	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009890	negative regulation of biosynthetic process	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010558	negative regulation of macromolecule biosynthetic process	6	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0017148	negative regulation of translation	7	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031327	negative regulation of cellular biosynthetic process	6	1
GO:0034248	regulation of amide metabolic process	5	1
GO:0034249	negative regulation of amide metabolic process	6	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051246	regulation of protein metabolic process	5	1
GO:0051248	negative regulation of protein metabolic process	6	1
GO:0080090	regulation of primary metabolic process	4	1
GO:2000112	obsolete regulation of cellular macromolecule biosynthetic process	6	1
GO:2000113	obsolete negative regulation of cellular macromolecule biosynthetic process	7	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	142	148	PF00089	0.438
CLV_NRD_NRD_1	163	165	PF00675	0.373
CLV_NRD_NRD_1	331	333	PF00675	0.458
CLV_NRD_NRD_1	348	350	PF00675	0.439
CLV_PCSK_KEX2_1	163	165	PF00082	0.438
CLV_PCSK_KEX2_1	348	350	PF00082	0.583
CLV_PCSK_KEX2_1	99	101	PF00082	0.274
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.274
CLV_PCSK_SKI1_1	286	290	PF00082	0.447
CLV_PCSK_SKI1_1	305	309	PF00082	0.333
CLV_PCSK_SKI1_1	333	337	PF00082	0.419
CLV_PCSK_SKI1_1	74	78	PF00082	0.251
CLV_PCSK_SKI1_1	91	95	PF00082	0.141
CLV_Separin_Metazoa	188	192	PF03568	0.274
DEG_APCC_DBOX_1	304	312	PF00400	0.274
DEG_APCC_DBOX_1	331	339	PF00400	0.239
DEG_APCC_DBOX_1	73	81	PF00400	0.469
DEG_Nend_UBRbox_2	1	3	PF02207	0.643
DOC_CDC14_PxL_1	173	181	PF14671	0.182
DOC_CKS1_1	131	136	PF01111	0.213
DOC_MAPK_FxFP_2	174	177	PF00069	0.182
DOC_MAPK_gen_1	332	340	PF00069	0.182
DOC_MAPK_gen_1	89	96	PF00069	0.405
DOC_MAPK_MEF2A_6	332	340	PF00069	0.172
DOC_MAPK_NFAT4_5	333	341	PF00069	0.182
DOC_PP4_FxxP_1	174	177	PF00568	0.182
DOC_USP7_MATH_1	184	188	PF00917	0.278
DOC_USP7_UBL2_3	98	102	PF12436	0.438
DOC_WW_Pin1_4	130	135	PF00397	0.195
DOC_WW_Pin1_4	179	184	PF00397	0.274
LIG_14-3-3_CanoR_1	145	150	PF00244	0.213
LIG_14-3-3_CanoR_1	191	196	PF00244	0.178
LIG_14-3-3_CanoR_1	260	268	PF00244	0.205
LIG_14-3-3_CanoR_1	317	322	PF00244	0.238
LIG_14-3-3_CanoR_1	91	97	PF00244	0.422
LIG_Actin_WH2_2	284	299	PF00022	0.171
LIG_CtBP_PxDLS_1	313	317	PF00389	0.238
LIG_EH1_1	238	246	PF00400	0.171
LIG_FHA_1	236	242	PF00498	0.171
LIG_FHA_2	180	186	PF00498	0.274
LIG_FHA_2	318	324	PF00498	0.222
LIG_LIR_Gen_1	101	110	PF02991	0.395
LIG_LIR_Gen_1	259	268	PF02991	0.213
LIG_LIR_Nem_3	101	106	PF02991	0.371
LIG_LIR_Nem_3	109	114	PF02991	0.207
LIG_LIR_Nem_3	126	131	PF02991	0.103
LIG_LIR_Nem_3	259	264	PF02991	0.191
LIG_LIR_Nem_3	320	324	PF02991	0.239
LIG_LIR_Nem_3	67	72	PF02991	0.555
LIG_LYPXL_S_1	127	131	PF13949	0.371
LIG_LYPXL_S_1	175	179	PF13949	0.371
LIG_LYPXL_yS_3	128	131	PF13949	0.171
LIG_LYPXL_yS_3	176	179	PF13949	0.171
LIG_LYPXL_yS_3	69	72	PF13949	0.541
LIG_NRBOX	334	340	PF00104	0.171
LIG_Pex14_2	174	178	PF04695	0.182
LIG_PTB_Apo_2	315	322	PF02174	0.182
LIG_SH2_STAT3	22	25	PF00017	0.624
LIG_SH2_STAT3	253	256	PF00017	0.213
LIG_SH2_STAT5	212	215	PF00017	0.171
LIG_SH2_STAT5	295	298	PF00017	0.192
LIG_SH2_STAT5	324	327	PF00017	0.274
LIG_SH3_3	135	141	PF00018	0.274
LIG_SH3_3	279	285	PF00018	0.222
LIG_SH3_3	34	40	PF00018	0.676
LIG_SH3_3	42	48	PF00018	0.711
LIG_SUMO_SIM_anti_2	147	154	PF11976	0.183
LIG_SUMO_SIM_par_1	92	97	PF11976	0.467
LIG_TRAF2_1	320	323	PF00917	0.222
LIG_TRAF2_1	9	12	PF00917	0.631
LIG_TRAF2_2	66	71	PF00917	0.577
LIG_UBA3_1	218	224	PF00899	0.213
LIG_UBA3_1	93	99	PF00899	0.451
LIG_WRC_WIRS_1	236	241	PF05994	0.171
MOD_CDK_SPxxK_3	179	186	PF00069	0.274
MOD_CK1_1	148	154	PF00069	0.199
MOD_CK1_1	259	265	PF00069	0.222
MOD_CK2_1	179	185	PF00069	0.274
MOD_CK2_1	296	302	PF00069	0.286
MOD_CK2_1	317	323	PF00069	0.250
MOD_GlcNHglycan	135	138	PF01048	0.474
MOD_GSK3_1	106	113	PF00069	0.351
MOD_GSK3_1	144	151	PF00069	0.185
MOD_GSK3_1	230	237	PF00069	0.278
MOD_N-GLC_1	317	322	PF02516	0.395
MOD_N-GLC_2	170	172	PF02516	0.474
MOD_NEK2_1	110	115	PF00069	0.152
MOD_NEK2_1	166	171	PF00069	0.216
MOD_NEK2_1	190	195	PF00069	0.197
MOD_NEK2_1	94	99	PF00069	0.431
MOD_PIKK_1	64	70	PF00454	0.558
MOD_PK_1	145	151	PF00069	0.195
MOD_PKA_1	348	354	PF00069	0.301
MOD_PKA_2	144	150	PF00069	0.195
MOD_PKA_2	190	196	PF00069	0.187
MOD_PKA_2	259	265	PF00069	0.210
MOD_PKA_2	296	302	PF00069	0.171
MOD_PKA_2	348	354	PF00069	0.301
MOD_Plk_1	317	323	PF00069	0.213
MOD_Plk_4	106	112	PF00069	0.342
MOD_Plk_4	123	129	PF00069	0.222
MOD_Plk_4	145	151	PF00069	0.182
MOD_Plk_4	235	241	PF00069	0.187
MOD_ProDKin_1	130	136	PF00069	0.195
MOD_ProDKin_1	179	185	PF00069	0.274
TRG_DiLeu_BaEn_1	101	106	PF01217	0.474
TRG_DiLeu_BaLyEn_6	126	131	PF01217	0.171
TRG_DiLeu_BaLyEn_6	283	288	PF01217	0.171
TRG_ENDOCYTIC_2	128	131	PF00928	0.171
TRG_ENDOCYTIC_2	176	179	PF00928	0.171
TRG_ENDOCYTIC_2	295	298	PF00928	0.213
TRG_ENDOCYTIC_2	32	35	PF00928	0.723
TRG_ENDOCYTIC_2	69	72	PF00928	0.545
TRG_ER_diArg_1	163	165	PF00400	0.238
TRG_ER_diArg_1	348	350	PF00400	0.383
TRG_NES_CRM1_1	231	242	PF08389	0.195
TRG_Pf-PMV_PEXEL_1	310	314	PF00026	0.395
TRG_Pf-PMV_PEXEL_1	348	352	PF00026	0.515

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1Y3	Leptomonas seymouri	91%	100%
A0A0S4ITM9	Bodo saltans	57%	100%
A0A1X0PA96	Trypanosomatidae	54%	100%
A0A3R7N5E2	Trypanosoma rangeli	53%	100%
A0A3S7X8L0	Leishmania donovani	100%	100%
A4HBG1	Leishmania braziliensis	94%	100%
A7MB47	Bos taurus	48%	100%
C9ZLN4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9B5N2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
P53829	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	47%	96%
Q4Q286	Leishmania major	98%	100%
Q4R347	Macaca fascicularis	48%	100%
Q5PQL2	Rattus norvegicus	48%	100%
Q5R6Z6	Pongo abelii	48%	100%
Q6IP65	Xenopus laevis	48%	100%
Q6NWL4	Danio rerio	50%	100%
Q6P819	Xenopus tropicalis	48%	100%
Q92368	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	50%	100%
Q92600	Homo sapiens	48%	100%
Q9JKY0	Mus musculus	48%	100%
V5BLQ5	Trypanosoma cruzi	54%	100%