Sjogren syndrome nuclear autoantigen 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

sjogren s syndrome nuclear autoantigen 1 - putative

Species:

Leishmania infantum

UniProt:

A4IAK6_LEIIN

TriTrypDb:

LINF_340051600

Length:

108

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005813	centrosome	3	1
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	3
GO:0005929	cilium	4	2
GO:0031514	motile cilium	5	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0120025	plasma membrane bounded cell projection	3	2

Expansion

Sequence features

A4IAK6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAK6

Function

Biological processes
Term	Name	Level	Count
GO:0010468	regulation of gene expression	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	84	88	PF00656	0.299
CLV_NRD_NRD_1	24	26	PF00675	0.308
CLV_PCSK_SKI1_1	26	30	PF00082	0.325
CLV_PCSK_SKI1_1	83	87	PF00082	0.320
CLV_PCSK_SKI1_1	90	94	PF00082	0.298
DOC_CYCLIN_RxL_1	87	95	PF00134	0.330
DOC_USP7_MATH_1	3	7	PF00917	0.444
DOC_USP7_MATH_1	81	85	PF00917	0.507
LIG_14-3-3_CanoR_1	25	29	PF00244	0.383
LIG_14-3-3_CanoR_1	53	61	PF00244	0.359
LIG_14-3-3_CanoR_1	73	82	PF00244	0.385
LIG_Actin_WH2_2	43	60	PF00022	0.316
LIG_BIR_II_1	1	5	PF00653	0.361
LIG_FHA_2	25	31	PF00498	0.294
LIG_FHA_2	72	78	PF00498	0.409
LIG_FHA_2	9	15	PF00498	0.297
LIG_FHA_2	93	99	PF00498	0.426
LIG_LIR_Gen_1	76	86	PF02991	0.359
LIG_LIR_Nem_3	37	43	PF02991	0.318
LIG_LIR_Nem_3	76	82	PF02991	0.297
LIG_SUMO_SIM_anti_2	11	17	PF11976	0.314
LIG_SUMO_SIM_par_1	14	20	PF11976	0.309
LIG_TRAF2_1	34	37	PF00917	0.411
LIG_TRAF2_1	49	52	PF00917	0.542
LIG_TRAF2_1	96	99	PF00917	0.431
MOD_CK2_1	24	30	PF00069	0.291
MOD_CK2_1	71	77	PF00069	0.351
MOD_CK2_1	8	14	PF00069	0.296
MOD_CK2_1	92	98	PF00069	0.425
MOD_GlcNHglycan	54	57	PF01048	0.259
MOD_GlcNHglycan	79	82	PF01048	0.355
MOD_GSK3_1	71	78	PF00069	0.351
MOD_NEK2_1	57	62	PF00069	0.351
MOD_NEK2_1	71	76	PF00069	0.282
MOD_NEK2_1	86	91	PF00069	0.254
MOD_NEK2_1	92	97	PF00069	0.312
MOD_PKA_2	24	30	PF00069	0.411
MOD_PKA_2	52	58	PF00069	0.374
MOD_Plk_1	71	77	PF00069	0.383
MOD_Plk_1	97	103	PF00069	0.356
MOD_Plk_2-3	14	20	PF00069	0.328
MOD_Plk_2-3	24	30	PF00069	0.339
MOD_Plk_4	14	20	PF00069	0.328
MOD_Plk_4	24	30	PF00069	0.339
MOD_Plk_4	81	87	PF00069	0.409
MOD_Plk_4	98	104	PF00069	0.261
MOD_SUMO_for_1	96	99	PF00179	0.431
MOD_SUMO_rev_2	20	28	PF00179	0.426
TRG_DiLeu_BaEn_1	24	29	PF01217	0.368
TRG_DiLeu_BaEn_4	98	104	PF01217	0.373
TRG_ENDOCYTIC_2	40	43	PF00928	0.315
TRG_ENDOCYTIC_2	79	82	PF00928	0.308
TRG_Pf-PMV_PEXEL_1	26	30	PF00026	0.485
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.324
TRG_PTS2	1	33	PF00400	0.432

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAT9	Leptomonas seymouri	70%	100%
A0A0S4IPN0	Bodo saltans	51%	100%
A0A1X0P6Z2	Trypanosomatidae	52%	99%
A0A3S7X8K8	Leishmania donovani	100%	100%
A0A422NPR2	Trypanosoma rangeli	48%	99%
A4HBG0	Leishmania braziliensis	91%	100%
C9ZZY9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	83%
E9B5N1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O43805	Homo sapiens	38%	91%
Q4Q287	Leishmania major	94%	100%
Q5E9C3	Bos taurus	38%	91%
Q9JJ94	Mus musculus	38%	91%
Q9XF62	Chlamydomonas reinhardtii	31%	97%