Palmitoyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DHHC palmitoyltransferase - putative

Species:

Leishmania infantum

UniProt:

A4IAK1_LEIIN

TriTrypDb:

LINF_340050800

Length:

189

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005783	endoplasmic reticulum	5	1
GO:0005794	Golgi apparatus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4IAK1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAK1

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	1
GO:0006605	protein targeting	5	1
GO:0006612	protein targeting to membrane	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018198	peptidyl-cysteine modification	6	1
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	1
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	1
GO:0018345	protein palmitoylation	6	1
GO:0019538	protein metabolic process	3	1
GO:0033036	macromolecule localization	2	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043543	protein acylation	5	1
GO:0044238	primary metabolic process	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0071705	nitrogen compound transport	4	1
GO:0072657	protein localization to membrane	4	1
GO:0090150	establishment of protein localization to membrane	4	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016409	palmitoyltransferase activity	5	11
GO:0016417	S-acyltransferase activity	5	11
GO:0016740	transferase activity	2	11
GO:0016746	acyltransferase activity	3	11
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	11
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	11
GO:0019707	protein-cysteine S-acyltransferase activity	3	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	152	154	PF00675	0.559
CLV_PCSK_FUR_1	149	153	PF00082	0.573
CLV_PCSK_KEX2_1	149	151	PF00082	0.527
CLV_PCSK_KEX2_1	152	154	PF00082	0.556
CLV_PCSK_SKI1_1	169	173	PF00082	0.637
DOC_CYCLIN_RxL_1	109	120	PF00134	0.460
DOC_MAPK_gen_1	109	119	PF00069	0.552
DOC_MAPK_MEF2A_6	109	118	PF00069	0.586
DOC_PP2B_LxvP_1	108	111	PF13499	0.460
DOC_PP4_FxxP_1	176	179	PF00568	0.509
DOC_SPAK_OSR1_1	153	157	PF12202	0.333
DOC_USP7_MATH_1	185	189	PF00917	0.432
LIG_14-3-3_CanoR_1	136	140	PF00244	0.335
LIG_14-3-3_CanoR_1	169	179	PF00244	0.462
LIG_14-3-3_CanoR_1	27	35	PF00244	0.353
LIG_Actin_WH2_2	121	138	PF00022	0.441
LIG_BRCT_BRCA1_1	160	164	PF00533	0.409
LIG_BRCT_BRCA1_1	172	176	PF00533	0.450
LIG_eIF4E_1	56	62	PF01652	0.447
LIG_FHA_2	31	37	PF00498	0.330
LIG_GBD_Chelix_1	97	105	PF00786	0.233
LIG_LIR_Apic_2	173	179	PF02991	0.495
LIG_LIR_Gen_1	131	140	PF02991	0.464
LIG_LIR_Gen_1	14	24	PF02991	0.465
LIG_LIR_Gen_1	93	101	PF02991	0.548
LIG_LIR_Nem_3	131	135	PF02991	0.449
LIG_LIR_Nem_3	138	142	PF02991	0.370
LIG_LIR_Nem_3	14	20	PF02991	0.510
LIG_LIR_Nem_3	93	97	PF02991	0.533
LIG_NRBOX	5	11	PF00104	0.507
LIG_Pex14_2	164	168	PF04695	0.364
LIG_Pex14_2	172	176	PF04695	0.410
LIG_PTB_Apo_2	72	79	PF02174	0.447
LIG_SH2_CRK	137	141	PF00017	0.350
LIG_SH2_CRK	142	146	PF00017	0.366
LIG_SH2_CRK	181	185	PF00017	0.479
LIG_SH2_STAP1	137	141	PF00017	0.376
LIG_SH2_STAT5	137	140	PF00017	0.316
LIG_SH2_STAT5	56	59	PF00017	0.447
LIG_SH3_3	9	15	PF00018	0.434
LIG_SUMO_SIM_par_1	115	120	PF11976	0.487
LIG_SUMO_SIM_par_1	8	14	PF11976	0.498
LIG_TYR_ITIM	135	140	PF00017	0.430
LIG_WRC_WIRS_1	129	134	PF05994	0.484
MOD_CK1_1	93	99	PF00069	0.556
MOD_GlcNHglycan	155	159	PF01048	0.655
MOD_GSK3_1	154	161	PF00069	0.383
MOD_GSK3_1	22	29	PF00069	0.402
MOD_N-GLC_2	53	55	PF02516	0.562
MOD_NEK2_1	100	105	PF00069	0.591
MOD_NEK2_1	117	122	PF00069	0.451
MOD_NEK2_1	135	140	PF00069	0.312
MOD_NEK2_1	154	159	PF00069	0.249
MOD_NEK2_1	164	169	PF00069	0.375
MOD_NEK2_2	144	149	PF00069	0.362
MOD_PKA_2	135	141	PF00069	0.447
MOD_PKA_2	26	32	PF00069	0.353
MOD_PKA_2	87	93	PF00069	0.565
MOD_Plk_4	100	106	PF00069	0.502
MOD_Plk_4	128	134	PF00069	0.443
MOD_Plk_4	135	141	PF00069	0.387
TRG_ENDOCYTIC_2	137	140	PF00928	0.325
TRG_ENDOCYTIC_2	142	145	PF00928	0.337
TRG_ENDOCYTIC_2	181	184	PF00928	0.482
TRG_ENDOCYTIC_2	56	59	PF00928	0.442
TRG_ER_diArg_1	148	151	PF00400	0.341
TRG_ER_diArg_1	152	154	PF00400	0.364

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0L0	Leptomonas seymouri	53%	84%
A0A0S4KJ92	Bodo saltans	33%	68%
A0A1X0PBJ7	Trypanosomatidae	30%	74%
A0A3R7M6T4	Trypanosoma rangeli	25%	72%
A0A3S7X8K2	Leishmania donovani	100%	71%
A4HBF2	Leishmania braziliensis	74%	71%
E9B5M5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	71%
Q4Q2B1	Leishmania major	90%	100%
V5BW09	Trypanosoma cruzi	27%	74%