LeishMANIAdb
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FHA domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
FHA domain-containing protein
Gene product:
FHA domain/BRCA1 C Terminus (BRCT) domain/twin BRCT domain containing protein - putative
Species:
Leishmania infantum
UniProt:
A4IAJ5_LEIIN
TriTrypDb:
LINF_340050200
Length:
410

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IAJ5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAJ5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 248 252 PF00656 0.498
CLV_NRD_NRD_1 131 133 PF00675 0.660
CLV_NRD_NRD_1 195 197 PF00675 0.694
CLV_NRD_NRD_1 198 200 PF00675 0.647
CLV_NRD_NRD_1 310 312 PF00675 0.585
CLV_NRD_NRD_1 341 343 PF00675 0.418
CLV_PCSK_FUR_1 196 200 PF00082 0.572
CLV_PCSK_KEX2_1 195 197 PF00082 0.731
CLV_PCSK_KEX2_1 198 200 PF00082 0.680
CLV_PCSK_KEX2_1 209 211 PF00082 0.522
CLV_PCSK_KEX2_1 260 262 PF00082 0.319
CLV_PCSK_KEX2_1 310 312 PF00082 0.580
CLV_PCSK_PC1ET2_1 209 211 PF00082 0.609
CLV_PCSK_PC1ET2_1 260 262 PF00082 0.319
CLV_PCSK_SKI1_1 263 267 PF00082 0.286
CLV_PCSK_SKI1_1 311 315 PF00082 0.344
CLV_PCSK_SKI1_1 97 101 PF00082 0.323
DEG_SPOP_SBC_1 217 221 PF00917 0.553
DOC_CKS1_1 286 291 PF01111 0.487
DOC_CYCLIN_yClb5_NLxxxL_5 34 43 PF00134 0.410
DOC_CYCLIN_yCln2_LP_2 39 45 PF00134 0.410
DOC_MAPK_gen_1 132 139 PF00069 0.644
DOC_MAPK_gen_1 287 295 PF00069 0.439
DOC_MAPK_MEF2A_6 297 304 PF00069 0.559
DOC_MAPK_MEF2A_6 77 84 PF00069 0.294
DOC_PP1_RVXF_1 95 101 PF00149 0.373
DOC_PP1_SILK_1 399 404 PF00149 0.455
DOC_PP2B_LxvP_1 114 117 PF13499 0.724
DOC_PP2B_LxvP_1 127 130 PF13499 0.420
DOC_USP7_MATH_1 123 127 PF00917 0.545
DOC_USP7_MATH_1 162 166 PF00917 0.741
DOC_USP7_MATH_1 216 220 PF00917 0.657
DOC_USP7_MATH_1 300 304 PF00917 0.496
DOC_USP7_MATH_2 30 36 PF00917 0.355
DOC_WW_Pin1_4 148 153 PF00397 0.668
DOC_WW_Pin1_4 202 207 PF00397 0.574
DOC_WW_Pin1_4 285 290 PF00397 0.441
DOC_WW_Pin1_4 343 348 PF00397 0.474
DOC_WW_Pin1_4 38 43 PF00397 0.317
DOC_WW_Pin1_4 90 95 PF00397 0.391
LIG_14-3-3_CanoR_1 132 140 PF00244 0.584
LIG_14-3-3_CanoR_1 26 30 PF00244 0.357
LIG_BIR_II_1 1 5 PF00653 0.565
LIG_BIR_III_2 344 348 PF00653 0.427
LIG_FHA_1 132 138 PF00498 0.653
LIG_FHA_1 148 154 PF00498 0.431
LIG_FHA_1 257 263 PF00498 0.458
LIG_FHA_1 361 367 PF00498 0.476
LIG_FHA_2 107 113 PF00498 0.503
LIG_FHA_2 209 215 PF00498 0.631
LIG_FHA_2 246 252 PF00498 0.496
LIG_FHA_2 330 336 PF00498 0.360
LIG_LIR_Gen_1 106 114 PF02991 0.503
LIG_LIR_Gen_1 3 10 PF02991 0.452
LIG_LIR_Gen_1 35 44 PF02991 0.300
LIG_LIR_Gen_1 395 406 PF02991 0.351
LIG_LIR_Gen_1 72 80 PF02991 0.311
LIG_LIR_Nem_3 106 110 PF02991 0.443
LIG_LIR_Nem_3 3 9 PF02991 0.412
LIG_LIR_Nem_3 35 39 PF02991 0.300
LIG_LIR_Nem_3 395 401 PF02991 0.353
LIG_LIR_Nem_3 72 76 PF02991 0.318
LIG_PDZ_Class_3 405 410 PF00595 0.495
LIG_PTAP_UEV_1 200 205 PF05743 0.619
LIG_Rb_pABgroove_1 392 400 PF01858 0.475
LIG_SH2_CRK 398 402 PF00017 0.368
LIG_SH2_CRK 6 10 PF00017 0.398
LIG_SH2_NCK_1 331 335 PF00017 0.403
LIG_SH2_NCK_1 6 10 PF00017 0.391
LIG_SH2_STAP1 398 402 PF00017 0.328
LIG_SH2_STAP1 6 10 PF00017 0.446
LIG_SH2_STAT3 15 18 PF00017 0.489
LIG_SH2_STAT5 169 172 PF00017 0.605
LIG_SH2_STAT5 306 309 PF00017 0.501
LIG_SH2_STAT5 331 334 PF00017 0.421
LIG_SH3_1 198 204 PF00018 0.644
LIG_SH3_2 204 209 PF14604 0.632
LIG_SH3_3 114 120 PF00018 0.712
LIG_SH3_3 198 204 PF00018 0.673
LIG_SH3_3 278 284 PF00018 0.445
LIG_Sin3_3 276 283 PF02671 0.401
LIG_SUMO_SIM_par_1 300 305 PF11976 0.496
LIG_TRFH_1 90 94 PF08558 0.322
LIG_TYR_ITSM 2 9 PF00017 0.434
LIG_WRC_WIRS_1 104 109 PF05994 0.368
MOD_CDK_SPK_2 285 290 PF00069 0.442
MOD_CDK_SPxK_1 148 154 PF00069 0.636
MOD_CDK_SPxxK_3 202 209 PF00069 0.671
MOD_CDK_SPxxK_3 90 97 PF00069 0.410
MOD_CK1_1 128 134 PF00069 0.574
MOD_CK1_1 360 366 PF00069 0.501
MOD_CK2_1 106 112 PF00069 0.515
MOD_CK2_1 208 214 PF00069 0.567
MOD_CK2_1 329 335 PF00069 0.390
MOD_CK2_1 371 377 PF00069 0.461
MOD_GlcNHglycan 145 148 PF01048 0.657
MOD_GlcNHglycan 171 175 PF01048 0.753
MOD_GlcNHglycan 214 217 PF01048 0.614
MOD_GlcNHglycan 373 376 PF01048 0.545
MOD_GSK3_1 143 150 PF00069 0.587
MOD_GSK3_1 170 177 PF00069 0.622
MOD_GSK3_1 183 190 PF00069 0.573
MOD_GSK3_1 208 215 PF00069 0.626
MOD_GSK3_1 226 233 PF00069 0.463
MOD_GSK3_1 245 252 PF00069 0.381
MOD_GSK3_1 323 330 PF00069 0.431
MOD_GSK3_1 358 365 PF00069 0.449
MOD_GSK3_1 61 68 PF00069 0.282
MOD_N-GLC_1 66 71 PF02516 0.284
MOD_NEK2_1 1 6 PF00069 0.474
MOD_NEK2_1 143 148 PF00069 0.668
MOD_NEK2_1 170 175 PF00069 0.618
MOD_NEK2_1 183 188 PF00069 0.640
MOD_NEK2_1 208 213 PF00069 0.690
MOD_NEK2_1 397 402 PF00069 0.441
MOD_NEK2_2 218 223 PF00069 0.736
MOD_PK_1 362 368 PF00069 0.422
MOD_PKA_2 131 137 PF00069 0.652
MOD_PKA_2 183 189 PF00069 0.755
MOD_PKA_2 25 31 PF00069 0.410
MOD_Plk_4 32 38 PF00069 0.306
MOD_Plk_4 397 403 PF00069 0.414
MOD_Plk_4 69 75 PF00069 0.297
MOD_ProDKin_1 148 154 PF00069 0.673
MOD_ProDKin_1 202 208 PF00069 0.576
MOD_ProDKin_1 285 291 PF00069 0.441
MOD_ProDKin_1 343 349 PF00069 0.465
MOD_ProDKin_1 38 44 PF00069 0.317
MOD_ProDKin_1 90 96 PF00069 0.391
MOD_SUMO_for_1 222 225 PF00179 0.585
TRG_DiLeu_BaEn_2 31 37 PF01217 0.410
TRG_DiLeu_BaLyEn_6 344 349 PF01217 0.473
TRG_ENDOCYTIC_2 398 401 PF00928 0.352
TRG_ENDOCYTIC_2 6 9 PF00928 0.341
TRG_ENDOCYTIC_2 89 92 PF00928 0.394
TRG_ER_diArg_1 194 196 PF00400 0.763
TRG_NLS_Bipartite_1 191 213 PF00514 0.630
TRG_NLS_MonoExtC_3 208 214 PF00514 0.595
TRG_NLS_MonoExtN_4 206 213 PF00514 0.602

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1ILS6 Leptomonas seymouri 59% 96%
A0A0S4IL96 Bodo saltans 30% 86%
A0A3R7KTI0 Trypanosoma rangeli 36% 100%
A0A3S7X8R1 Leishmania donovani 100% 100%
A4HBE7 Leishmania braziliensis 80% 100%
C9ZLP5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 95%
E9B5L9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
Q4Q2B7 Leishmania major 92% 100%
V5BW13 Trypanosoma cruzi 39% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS