Serine/threonine-protein phosphatase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein serine/threonine phosphatase - putative

Species:

Leishmania infantum

UniProt:

A4IAJ0_LEIIN

TriTrypDb:

LINF_340049700

Length:

309

Annotations

LeishMANIAdb annotations

A large collection of various protein phosphatases. Very highly expanded in kinetoplastids.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A4IAJ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAJ0

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004721	phosphoprotein phosphatase activity	3	11
GO:0004722	protein serine/threonine phosphatase activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0016791	phosphatase activity	5	11
GO:0017018	myosin phosphatase activity	5	11
GO:0042578	phosphoric ester hydrolase activity	4	11
GO:0140096	catalytic activity, acting on a protein	2	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	201	205	PF00656	0.417
CLV_NRD_NRD_1	182	184	PF00675	0.325
CLV_NRD_NRD_1	69	71	PF00675	0.447
CLV_PCSK_KEX2_1	182	184	PF00082	0.349
CLV_PCSK_KEX2_1	69	71	PF00082	0.417
CLV_PCSK_PC7_1	178	184	PF00082	0.377
CLV_PCSK_SKI1_1	118	122	PF00082	0.363
DEG_APCC_DBOX_1	227	235	PF00400	0.324
DEG_Nend_UBRbox_3	1	3	PF02207	0.492
DOC_CYCLIN_yClb5_NLxxxL_5	266	274	PF00134	0.386

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7S7	Leptomonas seymouri	37%	100%
A0A0N1HSR2	Leptomonas seymouri	38%	83%
A0A0N1I0V3	Leptomonas seymouri	39%	79%
A0A0N1IBK9	Leptomonas seymouri	49%	100%
A0A0N1ILH2	Leptomonas seymouri	31%	73%
A0A0N1P9X9	Leptomonas seymouri	56%	100%
A0A0N1PAV9	Leptomonas seymouri	43%	85%
A0A0N1PCC5	Leptomonas seymouri	92%	100%
A0A0N1PDK9	Leptomonas seymouri	48%	97%
A0A0S4IIW0	Bodo saltans	36%	78%

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