Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF1193) - putative

Species:

Leishmania infantum

UniProt:

A4IAI9_LEIIN

TriTrypDb:

LINF_340049600

Length:

580

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4IAI9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAI9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	48	52	PF00656	0.450
CLV_NRD_NRD_1	273	275	PF00675	0.590
CLV_NRD_NRD_1	383	385	PF00675	0.581
CLV_NRD_NRD_1	490	492	PF00675	0.521
CLV_NRD_NRD_1	531	533	PF00675	0.601
CLV_NRD_NRD_1	66	68	PF00675	0.711
CLV_NRD_NRD_1	7	9	PF00675	0.441
CLV_PCSK_FUR_1	488	492	PF00082	0.535
CLV_PCSK_KEX2_1	132	134	PF00082	0.787
CLV_PCSK_KEX2_1	398	400	PF00082	0.611
CLV_PCSK_KEX2_1	490	492	PF00082	0.525
CLV_PCSK_KEX2_1	7	9	PF00082	0.448
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.650
CLV_PCSK_PC1ET2_1	398	400	PF00082	0.611
CLV_PCSK_SKI1_1	171	175	PF00082	0.701
CLV_PCSK_SKI1_1	239	243	PF00082	0.549
CLV_PCSK_SKI1_1	252	256	PF00082	0.476
CLV_PCSK_SKI1_1	411	415	PF00082	0.496
DEG_APCC_DBOX_1	398	406	PF00400	0.411
DEG_Nend_Nbox_1	1	3	PF02207	0.679
DEG_SPOP_SBC_1	96	100	PF00917	0.591
DOC_CYCLIN_yCln2_LP_2	372	378	PF00134	0.314
DOC_MAPK_gen_1	132	139	PF00069	0.568
DOC_MAPK_gen_1	532	538	PF00069	0.374
DOC_MAPK_gen_1	7	17	PF00069	0.469
DOC_MAPK_JIP1_4	11	17	PF00069	0.518
DOC_MAPK_MEF2A_6	297	306	PF00069	0.332
DOC_MAPK_MEF2A_6	8	17	PF00069	0.480
DOC_PP1_RVXF_1	289	296	PF00149	0.326
DOC_PP2B_LxvP_1	372	375	PF13499	0.308
DOC_PP4_FxxP_1	558	561	PF00568	0.329
DOC_PP4_FxxP_1	75	78	PF00568	0.532
DOC_SPAK_OSR1_1	327	331	PF12202	0.401
DOC_USP7_MATH_1	106	110	PF00917	0.571
DOC_USP7_MATH_1	243	247	PF00917	0.355
DOC_USP7_MATH_1	53	57	PF00917	0.553
DOC_USP7_UBL2_3	266	270	PF12436	0.254
DOC_USP7_UBL2_3	452	456	PF12436	0.350
DOC_WW_Pin1_4	126	131	PF00397	0.529
DOC_WW_Pin1_4	142	147	PF00397	0.506
DOC_WW_Pin1_4	315	320	PF00397	0.330
DOC_WW_Pin1_4	67	72	PF00397	0.521
DOC_WW_Pin1_4	98	103	PF00397	0.439
LIG_14-3-3_CanoR_1	107	116	PF00244	0.584
LIG_14-3-3_CanoR_1	11	16	PF00244	0.542
LIG_14-3-3_CanoR_1	209	215	PF00244	0.417
LIG_14-3-3_CanoR_1	216	221	PF00244	0.424
LIG_14-3-3_CanoR_1	297	303	PF00244	0.303
LIG_14-3-3_CanoR_1	347	354	PF00244	0.381
LIG_14-3-3_CanoR_1	37	47	PF00244	0.547
LIG_14-3-3_CanoR_1	488	497	PF00244	0.326
LIG_14-3-3_CanoR_1	549	558	PF00244	0.421
LIG_Actin_WH2_2	251	268	PF00022	0.419
LIG_BRCT_BRCA1_1	317	321	PF00533	0.320
LIG_CtBP_PxDLS_1	12	16	PF00389	0.391
LIG_deltaCOP1_diTrp_1	283	289	PF00928	0.383
LIG_DLG_GKlike_1	11	18	PF00625	0.518
LIG_EH_1	474	478	PF12763	0.392
LIG_EVH1_2	71	75	PF00568	0.380
LIG_FHA_1	139	145	PF00498	0.530
LIG_FHA_1	30	36	PF00498	0.627
LIG_FHA_1	344	350	PF00498	0.378
LIG_FHA_1	354	360	PF00498	0.233
LIG_FHA_1	99	105	PF00498	0.505
LIG_FHA_2	115	121	PF00498	0.577
LIG_FHA_2	209	215	PF00498	0.368
LIG_FHA_2	551	557	PF00498	0.389
LIG_FHA_2	572	578	PF00498	0.487
LIG_IRF3_LxIS_1	134	140	PF10401	0.439
LIG_KLC1_Yacidic_2	200	205	PF13176	0.374
LIG_LIR_Apic_2	556	561	PF02991	0.346
LIG_LIR_Gen_1	181	189	PF02991	0.399
LIG_LIR_Gen_1	294	303	PF02991	0.339
LIG_LIR_Gen_1	309	317	PF02991	0.297
LIG_LIR_Gen_1	322	332	PF02991	0.372
LIG_LIR_Gen_1	369	378	PF02991	0.332
LIG_LIR_Gen_1	412	418	PF02991	0.340
LIG_LIR_Gen_1	492	501	PF02991	0.316
LIG_LIR_Gen_1	562	569	PF02991	0.437
LIG_LIR_Gen_1	60	71	PF02991	0.397
LIG_LIR_Nem_3	181	187	PF02991	0.397
LIG_LIR_Nem_3	26	31	PF02991	0.376
LIG_LIR_Nem_3	282	287	PF02991	0.303
LIG_LIR_Nem_3	294	298	PF02991	0.304
LIG_LIR_Nem_3	300	306	PF02991	0.246
LIG_LIR_Nem_3	309	313	PF02991	0.255
LIG_LIR_Nem_3	322	328	PF02991	0.339
LIG_LIR_Nem_3	369	374	PF02991	0.300
LIG_LIR_Nem_3	412	417	PF02991	0.333
LIG_LIR_Nem_3	492	497	PF02991	0.318
LIG_LIR_Nem_3	562	566	PF02991	0.403
LIG_LIR_Nem_3	60	66	PF02991	0.507
LIG_LYPXL_yS_3	508	511	PF13949	0.375
LIG_MYND_1	146	150	PF01753	0.479
LIG_MYND_1	87	91	PF01753	0.578
LIG_Pex14_1	285	289	PF04695	0.383
LIG_Pex14_1	324	328	PF04695	0.313
LIG_Pex14_2	321	325	PF04695	0.331
LIG_PTB_Apo_2	333	340	PF02174	0.388
LIG_PTB_Apo_2	472	479	PF02174	0.425
LIG_REV1ctd_RIR_1	72	77	PF16727	0.379
LIG_SH2_CRK	158	162	PF00017	0.402
LIG_SH2_CRK	317	321	PF00017	0.345
LIG_SH2_CRK	563	567	PF00017	0.439
LIG_SH2_GRB2like	334	337	PF00017	0.391
LIG_SH2_NCK_1	278	282	PF00017	0.375
LIG_SH2_SRC	387	390	PF00017	0.363
LIG_SH2_SRC	457	460	PF00017	0.367
LIG_SH2_STAP1	158	162	PF00017	0.424
LIG_SH2_STAP1	345	349	PF00017	0.431
LIG_SH2_STAT3	345	348	PF00017	0.407
LIG_SH2_STAT5	203	206	PF00017	0.427
LIG_SH2_STAT5	231	234	PF00017	0.315
LIG_SH2_STAT5	310	313	PF00017	0.362
LIG_SH2_STAT5	334	337	PF00017	0.340
LIG_SH2_STAT5	34	37	PF00017	0.477
LIG_SH2_STAT5	345	348	PF00017	0.355
LIG_SH2_STAT5	387	390	PF00017	0.323
LIG_SH2_STAT5	459	462	PF00017	0.363
LIG_SH2_STAT5	552	555	PF00017	0.431
LIG_SH3_1	174	180	PF00018	0.465
LIG_SH3_2	102	107	PF14604	0.583
LIG_SH3_2	127	132	PF14604	0.446
LIG_SH3_2	177	182	PF14604	0.478
LIG_SH3_3	124	130	PF00018	0.551
LIG_SH3_3	174	180	PF00018	0.393
LIG_SH3_3	192	198	PF00018	0.250
LIG_SH3_3	299	305	PF00018	0.288
LIG_SH3_3	41	47	PF00018	0.530
LIG_SH3_3	563	569	PF00018	0.391
LIG_SH3_3	75	81	PF00018	0.583
LIG_SH3_3	84	90	PF00018	0.586
LIG_SH3_3	99	105	PF00018	0.577
LIG_SUMO_SIM_anti_2	92	101	PF11976	0.467
LIG_SUMO_SIM_par_1	21	26	PF11976	0.363
LIG_TYR_ITIM	308	313	PF00017	0.329
LIG_TYR_ITIM	315	320	PF00017	0.344
LIG_WRC_WIRS_1	368	373	PF05994	0.320
LIG_WW_3	104	108	PF00397	0.585
MOD_CDC14_SPxK_1	129	132	PF00782	0.446
MOD_CDK_SPxK_1	126	132	PF00069	0.557
MOD_CDK_SPxxK_3	126	133	PF00069	0.449
MOD_CK1_1	109	115	PF00069	0.514
MOD_CK1_1	140	146	PF00069	0.546
MOD_CK1_1	350	356	PF00069	0.353
MOD_CK1_1	38	44	PF00069	0.569
MOD_CK1_1	437	443	PF00069	0.384
MOD_CK1_1	465	471	PF00069	0.362
MOD_CK1_1	526	532	PF00069	0.383
MOD_CK1_1	58	64	PF00069	0.504
MOD_CK1_1	98	104	PF00069	0.563
MOD_CK2_1	114	120	PF00069	0.572
MOD_CK2_1	465	471	PF00069	0.362
MOD_CK2_1	489	495	PF00069	0.349
MOD_CK2_1	550	556	PF00069	0.386
MOD_GlcNHglycan	134	137	PF01048	0.773
MOD_GlcNHglycan	436	439	PF01048	0.636
MOD_GSK3_1	106	113	PF00069	0.473
MOD_GSK3_1	138	145	PF00069	0.532
MOD_GSK3_1	146	153	PF00069	0.405
MOD_GSK3_1	315	322	PF00069	0.298
MOD_GSK3_1	343	350	PF00069	0.376
MOD_GSK3_1	35	42	PF00069	0.494
MOD_GSK3_1	418	425	PF00069	0.418
MOD_GSK3_1	461	468	PF00069	0.333
MOD_GSK3_1	96	103	PF00069	0.547
MOD_LATS_1	9	15	PF00433	0.518
MOD_N-GLC_1	216	221	PF02516	0.637
MOD_N-GLC_1	332	337	PF02516	0.556
MOD_N-GLC_1	38	43	PF02516	0.694
MOD_N-GLC_2	546	548	PF02516	0.556
MOD_NEK2_1	137	142	PF00069	0.563
MOD_NEK2_1	23	28	PF00069	0.378
MOD_NEK2_1	256	261	PF00069	0.388
MOD_NEK2_1	394	399	PF00069	0.413
MOD_NEK2_1	409	414	PF00069	0.330
MOD_NEK2_1	489	494	PF00069	0.332
MOD_NEK2_2	29	34	PF00069	0.526
MOD_PIKK_1	269	275	PF00454	0.313
MOD_PIKK_1	319	325	PF00454	0.297
MOD_PIKK_1	55	61	PF00454	0.509
MOD_PKA_1	132	138	PF00069	0.444
MOD_PKA_1	490	496	PF00069	0.331
MOD_PKA_2	106	112	PF00069	0.556
MOD_PKA_2	132	138	PF00069	0.591
MOD_PKA_2	208	214	PF00069	0.408
MOD_PKA_2	422	428	PF00069	0.457
MOD_PKA_2	482	488	PF00069	0.346
MOD_PKA_2	489	495	PF00069	0.298
MOD_PKB_1	488	496	PF00069	0.316
MOD_Plk_1	150	156	PF00069	0.390
MOD_Plk_1	216	222	PF00069	0.408
MOD_Plk_1	350	356	PF00069	0.329
MOD_Plk_1	378	384	PF00069	0.409
MOD_Plk_1	38	44	PF00069	0.534
MOD_Plk_1	409	415	PF00069	0.352
MOD_Plk_1	514	520	PF00069	0.413
MOD_Plk_1	571	577	PF00069	0.457
MOD_Plk_2-3	556	562	PF00069	0.386
MOD_Plk_2-3	571	577	PF00069	0.450
MOD_Plk_4	264	270	PF00069	0.303
MOD_Plk_4	29	35	PF00069	0.549
MOD_Plk_4	298	304	PF00069	0.332
MOD_Plk_4	367	373	PF00069	0.308
MOD_Plk_4	378	384	PF00069	0.304
MOD_Plk_4	462	468	PF00069	0.337
MOD_Plk_4	526	532	PF00069	0.358
MOD_Plk_4	58	64	PF00069	0.464
MOD_ProDKin_1	126	132	PF00069	0.529
MOD_ProDKin_1	142	148	PF00069	0.495
MOD_ProDKin_1	315	321	PF00069	0.328
MOD_ProDKin_1	67	73	PF00069	0.524
MOD_ProDKin_1	98	104	PF00069	0.440
TRG_DiLeu_BaEn_4	570	576	PF01217	0.457
TRG_DiLeu_BaLyEn_6	41	46	PF01217	0.495
TRG_DiLeu_BaLyEn_6	506	511	PF01217	0.394
TRG_ENDOCYTIC_2	158	161	PF00928	0.420
TRG_ENDOCYTIC_2	278	281	PF00928	0.338
TRG_ENDOCYTIC_2	310	313	PF00928	0.316
TRG_ENDOCYTIC_2	317	320	PF00928	0.331
TRG_ENDOCYTIC_2	457	460	PF00928	0.299
TRG_ENDOCYTIC_2	508	511	PF00928	0.354
TRG_ENDOCYTIC_2	563	566	PF00928	0.385
TRG_ER_diArg_1	399	402	PF00400	0.408
TRG_ER_diArg_1	489	491	PF00400	0.312
TRG_ER_diArg_1	547	550	PF00400	0.421
TRG_ER_diArg_1	6	8	PF00400	0.647
TRG_NES_CRM1_1	152	165	PF08389	0.399
TRG_NES_CRM1_1	407	422	PF08389	0.333
TRG_NLS_Bipartite_1	384	402	PF00514	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5V7	Leptomonas seymouri	65%	100%
A0A0S4IP10	Bodo saltans	25%	100%
A0A0S4KMJ1	Bodo saltans	49%	100%
A0A1X0PB74	Trypanosomatidae	56%	100%
A0A3S5IRZ3	Trypanosoma rangeli	56%	100%
A0A3S7X8K5	Leishmania donovani	99%	99%
A4HBE1	Leishmania braziliensis	82%	100%
C9ZLP9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
C9ZS63	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	89%
E9B5L3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q2C3	Leishmania major	93%	100%
V5BRE4	Trypanosoma cruzi	54%	100%