Zinc knuckle-domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc knuckle - putative

Species:

Leishmania infantum

UniProt:

A4IAI8_LEIIN

TriTrypDb:

LINF_340049500

Length:

149

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 7
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4IAI8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAI8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	68	70	PF00675	0.567
CLV_PCSK_KEX2_1	22	24	PF00082	0.477
CLV_PCSK_KEX2_1	68	70	PF00082	0.503
CLV_PCSK_PC1ET2_1	22	24	PF00082	0.477
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.503
CLV_PCSK_PC7_1	64	70	PF00082	0.431
CLV_PCSK_SKI1_1	41	45	PF00082	0.363
CLV_PCSK_SKI1_1	81	85	PF00082	0.550
CLV_PCSK_SKI1_1	92	96	PF00082	0.499
DEG_Nend_Nbox_1	1	3	PF02207	0.591
DOC_PP4_FxxP_1	35	38	PF00568	0.438
DOC_USP7_MATH_1	110	114	PF00917	0.648
DOC_USP7_MATH_1	123	127	PF00917	0.705
DOC_USP7_MATH_1	43	47	PF00917	0.389
DOC_USP7_UBL2_3	5	9	PF12436	0.634
DOC_WW_Pin1_4	130	135	PF00397	0.616
DOC_WW_Pin1_4	55	60	PF00397	0.428
LIG_14-3-3_CanoR_1	69	76	PF00244	0.544
LIG_BRCT_BRCA1_1	70	74	PF00533	0.670
LIG_deltaCOP1_diTrp_1	31	35	PF00928	0.363
LIG_FHA_1	52	58	PF00498	0.340
LIG_FHA_1	94	100	PF00498	0.544
LIG_FHA_2	77	83	PF00498	0.500
LIG_LIR_Apic_2	34	38	PF02991	0.438
LIG_SH2_CRK	11	15	PF00017	0.557
LIG_SH3_1	131	137	PF00018	0.522
LIG_SH3_2	134	139	PF14604	0.518
LIG_SH3_3	131	137	PF00018	0.522
LIG_SH3_3	72	78	PF00018	0.508
MOD_CK1_1	42	48	PF00069	0.429
MOD_CK2_1	25	31	PF00069	0.368
MOD_CK2_1	76	82	PF00069	0.505
MOD_GlcNHglycan	112	115	PF01048	0.631
MOD_GlcNHglycan	125	128	PF01048	0.672
MOD_GlcNHglycan	41	44	PF01048	0.434
MOD_GlcNHglycan	45	48	PF01048	0.412
MOD_GlcNHglycan	49	52	PF01048	0.420
MOD_GlcNHglycan	70	73	PF01048	0.589
MOD_GSK3_1	23	30	PF00069	0.433
MOD_GSK3_1	39	46	PF00069	0.415
MOD_GSK3_1	47	54	PF00069	0.311
MOD_N-GLC_1	18	23	PF02516	0.477
MOD_N-GLC_2	115	117	PF02516	0.620
MOD_NEK2_1	39	44	PF00069	0.489
MOD_NEK2_2	51	56	PF00069	0.477
MOD_PIKK_1	57	63	PF00454	0.338
MOD_PK_1	9	15	PF00069	0.660
MOD_PKA_1	68	74	PF00069	0.456
MOD_PKA_2	68	74	PF00069	0.584
MOD_Plk_2-3	31	37	PF00069	0.334
MOD_ProDKin_1	130	136	PF00069	0.614
MOD_ProDKin_1	55	61	PF00069	0.428
MOD_SUMO_for_1	129	132	PF00179	0.607
MOD_SUMO_for_1	140	143	PF00179	0.560
MOD_SUMO_rev_2	113	119	PF00179	0.545
MOD_SUMO_rev_2	98	105	PF00179	0.588

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P713	Leptomonas seymouri	60%	97%
A0A1X0PAA9	Trypanosomatidae	47%	100%
A0A3Q8IHW3	Leishmania donovani	99%	100%
A0A3S5IRZ4	Trypanosoma rangeli	50%	81%
A4HBE0	Leishmania braziliensis	78%	100%
C9ZLQ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
Q4Q2C4	Leishmania major	89%	100%