LeishMANIAdb
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ER membrane protein complex subunit 1

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
ER membrane protein complex subunit 1
Gene product:
Protein of unknown function (DUF1620) - putative
Species:
Leishmania infantum
UniProt:
A4IAI4_LEIIN
TriTrypDb:
LINF_340049100
Length:
815

Annotations

Annotations by Jardim et al.

ER/Golgi Proteins, ER membrane protein complex subunit 1

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 10, no: 1
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0032991 protein-containing complex 1 12
GO:0072546 EMC complex 3 12
GO:0098796 membrane protein complex 2 12
GO:0140534 endoplasmic reticulum protein-containing complex 2 12

Expansion

Sequence features

A4IAI4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAI4

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005488 binding 1 1
GO:0043167 ion binding 2 1
GO:0043169 cation binding 3 1
GO:0046872 metal ion binding 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 224 228 PF00656 0.386
CLV_MEL_PAP_1 361 367 PF00089 0.545
CLV_NRD_NRD_1 330 332 PF00675 0.569
CLV_NRD_NRD_1 516 518 PF00675 0.597
CLV_NRD_NRD_1 540 542 PF00675 0.498
CLV_NRD_NRD_1 684 686 PF00675 0.442
CLV_NRD_NRD_1 741 743 PF00675 0.478
CLV_NRD_NRD_1 806 808 PF00675 0.232
CLV_PCSK_KEX2_1 152 154 PF00082 0.574
CLV_PCSK_KEX2_1 330 332 PF00082 0.569
CLV_PCSK_KEX2_1 516 518 PF00082 0.597
CLV_PCSK_KEX2_1 540 542 PF00082 0.498
CLV_PCSK_KEX2_1 646 648 PF00082 0.455
CLV_PCSK_PC1ET2_1 152 154 PF00082 0.574
CLV_PCSK_PC1ET2_1 646 648 PF00082 0.456
CLV_PCSK_SKI1_1 357 361 PF00082 0.457
CLV_PCSK_SKI1_1 436 440 PF00082 0.549
CLV_PCSK_SKI1_1 703 707 PF00082 0.482
CLV_PCSK_SKI1_1 737 741 PF00082 0.478
CLV_PCSK_SKI1_1 742 746 PF00082 0.452
CLV_PCSK_SKI1_1 784 788 PF00082 0.442
CLV_PCSK_SKI1_1 807 811 PF00082 0.274
DEG_Nend_Nbox_1 1 3 PF02207 0.527
DEG_SCF_FBW7_2 448 455 PF00400 0.405
DEG_SPOP_SBC_1 767 771 PF00917 0.274
DOC_CDC14_PxL_1 292 300 PF14671 0.279
DOC_CKS1_1 449 454 PF01111 0.360
DOC_CYCLIN_RxL_1 683 694 PF00134 0.291
DOC_CYCLIN_RxL_1 781 789 PF00134 0.242
DOC_MAPK_DCC_7 652 661 PF00069 0.256
DOC_MAPK_gen_1 652 661 PF00069 0.256
DOC_MAPK_gen_1 717 726 PF00069 0.335
DOC_MAPK_MEF2A_6 3 10 PF00069 0.391
DOC_MAPK_MEF2A_6 302 311 PF00069 0.392
DOC_MAPK_MEF2A_6 652 661 PF00069 0.242
DOC_MAPK_RevD_3 632 647 PF00069 0.335
DOC_PP1_RVXF_1 735 741 PF00149 0.278
DOC_PP2B_LxvP_1 724 727 PF13499 0.365
DOC_PP4_FxxP_1 667 670 PF00568 0.329
DOC_PP4_FxxP_1 782 785 PF00568 0.335
DOC_USP7_MATH_1 132 136 PF00917 0.377
DOC_USP7_MATH_1 169 173 PF00917 0.376
DOC_USP7_MATH_1 510 514 PF00917 0.373
DOC_USP7_MATH_1 684 688 PF00917 0.256
DOC_USP7_MATH_1 809 813 PF00917 0.431
DOC_WW_Pin1_4 107 112 PF00397 0.395
DOC_WW_Pin1_4 448 453 PF00397 0.315
DOC_WW_Pin1_4 620 625 PF00397 0.298
DOC_WW_Pin1_4 83 88 PF00397 0.425
LIG_14-3-3_CanoR_1 275 279 PF00244 0.328
LIG_14-3-3_CanoR_1 436 442 PF00244 0.384
LIG_14-3-3_CanoR_1 463 472 PF00244 0.301
LIG_14-3-3_CanoR_1 516 524 PF00244 0.332
LIG_14-3-3_CanoR_1 540 544 PF00244 0.387
LIG_14-3-3_CanoR_1 685 689 PF00244 0.265
LIG_14-3-3_CanoR_1 719 727 PF00244 0.335
LIG_14-3-3_CanoR_1 742 748 PF00244 0.275
LIG_14-3-3_CanoR_1 768 775 PF00244 0.231
LIG_14-3-3_CanoR_1 80 90 PF00244 0.285
LIG_Actin_WH2_2 260 277 PF00022 0.342
LIG_BRCT_BRCA1_1 727 731 PF00533 0.335
LIG_Clathr_ClatBox_1 297 301 PF01394 0.291
LIG_CtBP_PxDLS_1 74 80 PF00389 0.308
LIG_FHA_1 111 117 PF00498 0.326
LIG_FHA_1 124 130 PF00498 0.371
LIG_FHA_1 260 266 PF00498 0.370
LIG_FHA_1 413 419 PF00498 0.281
LIG_FHA_1 449 455 PF00498 0.424
LIG_FHA_1 495 501 PF00498 0.368
LIG_FHA_1 516 522 PF00498 0.346
LIG_FHA_1 571 577 PF00498 0.321
LIG_FHA_1 692 698 PF00498 0.266
LIG_FHA_2 156 162 PF00498 0.311
LIG_FHA_2 222 228 PF00498 0.386
LIG_FHA_2 267 273 PF00498 0.335
LIG_FHA_2 440 446 PF00498 0.406
LIG_FHA_2 565 571 PF00498 0.269
LIG_FHA_2 643 649 PF00498 0.335
LIG_FHA_2 747 753 PF00498 0.232
LIG_GBD_Chelix_1 10 18 PF00786 0.555
LIG_GBD_Chelix_1 698 706 PF00786 0.407
LIG_LIR_Apic_2 367 372 PF02991 0.297
LIG_LIR_Apic_2 666 670 PF02991 0.231
LIG_LIR_Apic_2 780 785 PF02991 0.335
LIG_LIR_Gen_1 677 688 PF02991 0.322
LIG_LIR_Nem_3 293 298 PF02991 0.392
LIG_LIR_Nem_3 363 368 PF02991 0.243
LIG_LIR_Nem_3 677 683 PF02991 0.217
LIG_LIR_Nem_3 78 82 PF02991 0.295
LIG_LYPXL_S_1 526 530 PF13949 0.553
LIG_LYPXL_yS_3 295 298 PF13949 0.275
LIG_LYPXL_yS_3 527 530 PF13949 0.349
LIG_NRBOX 701 707 PF00104 0.256
LIG_PTB_Apo_2 776 783 PF02174 0.231
LIG_SH2_CRK 369 373 PF00017 0.254
LIG_SH2_CRK 680 684 PF00017 0.282
LIG_SH2_CRK 72 76 PF00017 0.315
LIG_SH2_NCK_1 170 174 PF00017 0.363
LIG_SH2_NCK_1 680 684 PF00017 0.322
LIG_SH2_SRC 554 557 PF00017 0.311
LIG_SH2_SRC 602 605 PF00017 0.278
LIG_SH2_STAP1 474 478 PF00017 0.345
LIG_SH2_STAP1 486 490 PF00017 0.354
LIG_SH2_STAT3 120 123 PF00017 0.395
LIG_SH2_STAT5 181 184 PF00017 0.373
LIG_SH2_STAT5 382 385 PF00017 0.394
LIG_SH2_STAT5 472 475 PF00017 0.309
LIG_SH2_STAT5 56 59 PF00017 0.288
LIG_SH2_STAT5 602 605 PF00017 0.301
LIG_SH2_STAT5 610 613 PF00017 0.303
LIG_SH2_STAT5 766 769 PF00017 0.231
LIG_SH2_STAT5 803 806 PF00017 0.431
LIG_SH3_3 280 286 PF00018 0.322
LIG_SH3_3 497 503 PF00018 0.293
LIG_SH3_3 735 741 PF00018 0.300
LIG_SUMO_SIM_anti_2 185 190 PF11976 0.383
LIG_SUMO_SIM_anti_2 306 314 PF11976 0.336
LIG_SUMO_SIM_anti_2 567 573 PF11976 0.323
LIG_SUMO_SIM_par_1 306 314 PF11976 0.289
LIG_SUMO_SIM_par_1 317 322 PF11976 0.232
LIG_SUMO_SIM_par_1 358 363 PF11976 0.290
LIG_SUMO_SIM_par_1 429 435 PF11976 0.343
LIG_SUMO_SIM_par_1 590 595 PF11976 0.264
LIG_SUMO_SIM_par_1 656 663 PF11976 0.292
LIG_SUMO_SIM_par_1 696 701 PF11976 0.232
LIG_SUMO_SIM_par_1 784 789 PF11976 0.240
LIG_TRAF2_1 159 162 PF00917 0.427
LIG_TRAF2_1 556 559 PF00917 0.375
LIG_TYR_ITIM 598 603 PF00017 0.274
LIG_TYR_ITSM 676 683 PF00017 0.257
LIG_WRC_WIRS_1 638 643 PF05994 0.242
LIG_WRC_WIRS_1 664 669 PF05994 0.231
LIG_WRC_WIRS_1 726 731 PF05994 0.278
MOD_CK1_1 110 116 PF00069 0.350
MOD_CK1_1 135 141 PF00069 0.354
MOD_CK1_1 157 163 PF00069 0.427
MOD_CK1_1 233 239 PF00069 0.367
MOD_CK1_1 281 287 PF00069 0.361
MOD_CK1_1 290 296 PF00069 0.329
MOD_CK1_1 422 428 PF00069 0.391
MOD_CK1_1 440 446 PF00069 0.317
MOD_CK1_1 651 657 PF00069 0.263
MOD_CK1_1 83 89 PF00069 0.376
MOD_CK2_1 155 161 PF00069 0.308
MOD_CK2_1 319 325 PF00069 0.363
MOD_CK2_1 439 445 PF00069 0.342
MOD_CK2_1 447 453 PF00069 0.354
MOD_CK2_1 473 479 PF00069 0.329
MOD_CK2_1 528 534 PF00069 0.411
MOD_CK2_1 554 560 PF00069 0.360
MOD_CK2_1 642 648 PF00069 0.335
MOD_CK2_1 746 752 PF00069 0.232
MOD_GlcNHglycan 137 140 PF01048 0.591
MOD_GlcNHglycan 171 174 PF01048 0.584
MOD_GlcNHglycan 194 197 PF01048 0.516
MOD_GlcNHglycan 313 316 PF01048 0.537
MOD_GlcNHglycan 321 324 PF01048 0.492
MOD_GlcNHglycan 421 424 PF01048 0.613
MOD_GlcNHglycan 425 428 PF01048 0.580
MOD_GlcNHglycan 43 46 PF01048 0.609
MOD_GlcNHglycan 479 482 PF01048 0.541
MOD_GlcNHglycan 488 491 PF01048 0.555
MOD_GlcNHglycan 503 506 PF01048 0.518
MOD_GlcNHglycan 530 533 PF01048 0.628
MOD_GlcNHglycan 759 762 PF01048 0.441
MOD_GlcNHglycan 770 773 PF01048 0.427
MOD_GlcNHglycan 811 814 PF01048 0.262
MOD_GlcNHglycan 83 86 PF01048 0.589
MOD_GSK3_1 112 119 PF00069 0.352
MOD_GSK3_1 121 128 PF00069 0.320
MOD_GSK3_1 157 164 PF00069 0.446
MOD_GSK3_1 171 178 PF00069 0.242
MOD_GSK3_1 255 262 PF00069 0.351
MOD_GSK3_1 274 281 PF00069 0.300
MOD_GSK3_1 360 367 PF00069 0.303
MOD_GSK3_1 419 426 PF00069 0.353
MOD_GSK3_1 436 443 PF00069 0.284
MOD_GSK3_1 458 465 PF00069 0.379
MOD_GSK3_1 473 480 PF00069 0.247
MOD_GSK3_1 560 567 PF00069 0.285
MOD_GSK3_1 572 579 PF00069 0.293
MOD_GSK3_1 626 633 PF00069 0.281
MOD_GSK3_1 647 654 PF00069 0.265
MOD_GSK3_1 659 666 PF00069 0.256
MOD_GSK3_1 742 749 PF00069 0.282
MOD_N-GLC_1 528 533 PF02516 0.538
MOD_N-GLC_1 75 80 PF02516 0.596
MOD_N-GLC_2 287 289 PF02516 0.501
MOD_NEK2_1 154 159 PF00069 0.326
MOD_NEK2_1 213 218 PF00069 0.313
MOD_NEK2_1 274 279 PF00069 0.318
MOD_NEK2_1 310 315 PF00069 0.330
MOD_NEK2_1 319 324 PF00069 0.289
MOD_NEK2_1 360 365 PF00069 0.309
MOD_NEK2_1 437 442 PF00069 0.390
MOD_NEK2_1 564 569 PF00069 0.264
MOD_NEK2_1 577 582 PF00069 0.297
MOD_NEK2_1 642 647 PF00069 0.258
MOD_NEK2_1 674 679 PF00069 0.256
MOD_NEK2_1 730 735 PF00069 0.270
MOD_NEK2_1 75 80 PF00069 0.347
MOD_NEK2_1 750 755 PF00069 0.145
MOD_NEK2_1 786 791 PF00069 0.275
MOD_NEK2_2 458 463 PF00069 0.404
MOD_PIKK_1 266 272 PF00454 0.390
MOD_PIKK_1 384 390 PF00454 0.420
MOD_PK_1 206 212 PF00069 0.315
MOD_PKA_1 742 748 PF00069 0.278
MOD_PKA_2 274 280 PF00069 0.358
MOD_PKA_2 462 468 PF00069 0.336
MOD_PKA_2 494 500 PF00069 0.397
MOD_PKA_2 515 521 PF00069 0.350
MOD_PKA_2 539 545 PF00069 0.387
MOD_PKA_2 651 657 PF00069 0.256
MOD_PKA_2 684 690 PF00069 0.274
MOD_PKA_2 767 773 PF00069 0.231
MOD_Plk_1 116 122 PF00069 0.333
MOD_Plk_1 161 167 PF00069 0.477
MOD_Plk_1 206 212 PF00069 0.281
MOD_Plk_1 458 464 PF00069 0.394
MOD_Plk_1 75 81 PF00069 0.394
MOD_Plk_2-3 479 485 PF00069 0.402
MOD_Plk_4 104 110 PF00069 0.312
MOD_Plk_4 132 138 PF00069 0.363
MOD_Plk_4 182 188 PF00069 0.417
MOD_Plk_4 278 284 PF00069 0.426
MOD_Plk_4 364 370 PF00069 0.314
MOD_Plk_4 494 500 PF00069 0.356
MOD_Plk_4 560 566 PF00069 0.278
MOD_Plk_4 572 578 PF00069 0.280
MOD_Plk_4 637 643 PF00069 0.231
MOD_Plk_4 684 690 PF00069 0.247
MOD_Plk_4 725 731 PF00069 0.284
MOD_Plk_4 746 752 PF00069 0.322
MOD_Plk_4 795 801 PF00069 0.334
MOD_ProDKin_1 107 113 PF00069 0.400
MOD_ProDKin_1 448 454 PF00069 0.311
MOD_ProDKin_1 620 626 PF00069 0.298
MOD_ProDKin_1 83 89 PF00069 0.421
MOD_SUMO_rev_2 586 592 PF00179 0.384
TRG_DiLeu_BaEn_1 560 565 PF01217 0.292
TRG_DiLeu_BaEn_1 701 706 PF01217 0.256
TRG_DiLeu_BaLyEn_6 293 298 PF01217 0.271
TRG_DiLeu_BaLyEn_6 782 787 PF01217 0.335
TRG_ENDOCYTIC_2 295 298 PF00928 0.275
TRG_ENDOCYTIC_2 527 530 PF00928 0.416
TRG_ENDOCYTIC_2 600 603 PF00928 0.231
TRG_ENDOCYTIC_2 680 683 PF00928 0.257
TRG_ENDOCYTIC_2 72 75 PF00928 0.312
TRG_ER_diArg_1 329 331 PF00400 0.382
TRG_ER_diArg_1 515 517 PF00400 0.418
TRG_ER_diArg_1 539 541 PF00400 0.310

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I0K5 Leptomonas seymouri 68% 93%
A0A0S4KM87 Bodo saltans 33% 95%
A0A1X0PA62 Trypanosomatidae 39% 99%
A0A3S7X8I3 Leishmania donovani 100% 100%
A0A422NVA5 Trypanosoma rangeli 44% 100%
A4HBD6 Leishmania braziliensis 83% 100%
C9ZLQ4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 100%
E9B5K8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
Q4Q2C8 Leishmania major 93% 100%
V5BW22 Trypanosoma cruzi 44% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS