AB hydrolase-1 domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Alpha/beta hydrolase family - putative

Species:

Leishmania infantum

UniProt:

A4IAI3_LEIIN

TriTrypDb:

LINF_340049000

Length:

274

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4IAI3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAI3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	139	141	PF00675	0.467
CLV_NRD_NRD_1	175	177	PF00675	0.533
CLV_PCSK_KEX2_1	139	141	PF00082	0.467
CLV_PCSK_KEX2_1	175	177	PF00082	0.536
CLV_PCSK_SKI1_1	165	169	PF00082	0.510
CLV_PCSK_SKI1_1	235	239	PF00082	0.467
CLV_Separin_Metazoa	136	140	PF03568	0.456
DEG_Nend_UBRbox_2	1	3	PF02207	0.575
DOC_MAPK_gen_1	228	236	PF00069	0.509
DOC_MAPK_MEF2A_6	228	236	PF00069	0.512
DOC_PP2B_LxvP_1	105	108	PF13499	0.435
DOC_PP4_FxxP_1	204	207	PF00568	0.465
DOC_USP7_MATH_1	110	114	PF00917	0.487
DOC_USP7_MATH_1	199	203	PF00917	0.546
DOC_USP7_MATH_1	61	65	PF00917	0.541
DOC_WW_Pin1_4	195	200	PF00397	0.469
DOC_WW_Pin1_4	217	222	PF00397	0.577
DOC_WW_Pin1_4	245	250	PF00397	0.546
DOC_WW_Pin1_4	36	41	PF00397	0.392
LIG_EH1_1	131	139	PF00400	0.448
LIG_eIF4E_1	132	138	PF01652	0.508
LIG_EVH1_2	5	9	PF00568	0.384
LIG_FHA_1	113	119	PF00498	0.370
LIG_FHA_1	39	45	PF00498	0.424
LIG_FHA_2	239	245	PF00498	0.549
LIG_FHA_2	37	43	PF00498	0.409
LIG_LIR_Apic_2	202	207	PF02991	0.468
LIG_LIR_Gen_1	109	118	PF02991	0.376
LIG_LIR_Nem_3	109	114	PF02991	0.383
LIG_NRBOX	21	27	PF00104	0.349
LIG_SH2_NCK_1	190	194	PF00017	0.440
LIG_SH2_STAT5	15	18	PF00017	0.482
LIG_SH2_STAT5	154	157	PF00017	0.462
LIG_SH2_STAT5	190	193	PF00017	0.517
LIG_SH2_STAT5	211	214	PF00017	0.460
LIG_SH2_STAT5	47	50	PF00017	0.504
LIG_SH2_STAT5	68	71	PF00017	0.397
LIG_SH3_1	37	43	PF00018	0.520
LIG_SH3_3	37	43	PF00018	0.402
LIG_TRAF2_1	220	223	PF00917	0.548
MOD_CDK_SPxxK_3	245	252	PF00069	0.443
MOD_CK1_1	112	118	PF00069	0.347
MOD_CK1_1	18	24	PF00069	0.436
MOD_CK1_1	202	208	PF00069	0.459
MOD_CK1_1	36	42	PF00069	0.427
MOD_CK2_1	217	223	PF00069	0.566
MOD_CK2_1	238	244	PF00069	0.549
MOD_CK2_1	36	42	PF00069	0.475
MOD_GlcNHglycan	65	68	PF01048	0.426
MOD_GSK3_1	195	202	PF00069	0.562
MOD_GSK3_1	238	245	PF00069	0.473
MOD_GSK3_1	94	101	PF00069	0.430
MOD_N-GLC_1	143	148	PF02516	0.336
MOD_N-GLC_1	26	31	PF02516	0.533
MOD_N-GLC_1	54	59	PF02516	0.440
MOD_NEK2_1	257	262	PF00069	0.459
MOD_NEK2_1	26	31	PF00069	0.457
MOD_NEK2_1	98	103	PF00069	0.436
MOD_PIKK_1	238	244	PF00454	0.540
MOD_PKA_2	181	187	PF00069	0.421
MOD_Plk_1	26	32	PF00069	0.499
MOD_Plk_4	112	118	PF00069	0.324
MOD_Plk_4	150	156	PF00069	0.502
MOD_Plk_4	205	211	PF00069	0.399
MOD_Plk_4	94	100	PF00069	0.442
MOD_ProDKin_1	195	201	PF00069	0.475
MOD_ProDKin_1	217	223	PF00069	0.572
MOD_ProDKin_1	245	251	PF00069	0.539
MOD_ProDKin_1	36	42	PF00069	0.393
TRG_DiLeu_BaEn_1	164	169	PF01217	0.474
TRG_ER_diArg_1	138	140	PF00400	0.462
TRG_ER_diArg_1	174	176	PF00400	0.535
TRG_ER_diArg_1	227	230	PF00400	0.490
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.420
TRG_Pf-PMV_PEXEL_1	156	161	PF00026	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7A3	Leptomonas seymouri	62%	88%
A0A0S4KLY1	Bodo saltans	29%	79%
A0A1X0PB14	Trypanosomatidae	44%	87%
A0A3Q8INV4	Leishmania donovani	99%	100%
A0A422NVB8	Trypanosoma rangeli	43%	85%
A4HBD5	Leishmania braziliensis	82%	100%
C9ZLQ5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	86%
E9B5K7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q2C9	Leishmania major	91%	100%
V5BLS2	Trypanosoma cruzi	42%	86%