Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IAI1_LEIIN

TriTrypDb:

LINF_340048800

Length:

308

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4IAI1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAI1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	226	228	PF00675	0.468
CLV_PCSK_FUR_1	224	228	PF00082	0.558
CLV_PCSK_KEX2_1	226	228	PF00082	0.468
CLV_PCSK_SKI1_1	142	146	PF00082	0.570
CLV_PCSK_SKI1_1	210	214	PF00082	0.599
CLV_PCSK_SKI1_1	274	278	PF00082	0.474
CLV_PCSK_SKI1_1	47	51	PF00082	0.573
CLV_Separin_Metazoa	161	165	PF03568	0.543
DOC_CYCLIN_RxL_1	239	250	PF00134	0.385
DOC_CYCLIN_RxL_1	47	57	PF00134	0.570
DOC_MAPK_gen_1	118	125	PF00069	0.408
DOC_MAPK_gen_1	271	280	PF00069	0.413
DOC_MAPK_gen_1	47	56	PF00069	0.580
DOC_MAPK_gen_1	5	14	PF00069	0.600
DOC_MAPK_MEF2A_6	118	127	PF00069	0.402
DOC_PP4_FxxP_1	14	17	PF00568	0.539
DOC_USP7_MATH_1	290	294	PF00917	0.372
DOC_WW_Pin1_4	211	216	PF00397	0.498
LIG_14-3-3_CanoR_1	224	232	PF00244	0.464
LIG_14-3-3_CanoR_1	274	279	PF00244	0.424
LIG_BRCT_BRCA1_1	123	127	PF00533	0.423
LIG_eIF4E_1	115	121	PF01652	0.424
LIG_FHA_1	231	237	PF00498	0.514
LIG_FHA_1	275	281	PF00498	0.461
LIG_FHA_1	33	39	PF00498	0.657
LIG_FHA_2	145	151	PF00498	0.385
LIG_FHA_2	253	259	PF00498	0.583
LIG_FHA_2	98	104	PF00498	0.573
LIG_LIR_Gen_1	124	134	PF02991	0.478
LIG_LIR_Gen_1	77	83	PF02991	0.452
LIG_LIR_Nem_3	110	116	PF02991	0.529
LIG_LIR_Nem_3	124	130	PF02991	0.472
LIG_LIR_Nem_3	269	273	PF02991	0.370
LIG_LIR_Nem_3	284	289	PF02991	0.334
LIG_LIR_Nem_3	77	81	PF02991	0.455
LIG_PCNA_yPIPBox_3	193	204	PF02747	0.544
LIG_Pex14_2	209	213	PF04695	0.545
LIG_PTB_Apo_2	264	271	PF02174	0.502
LIG_PTB_Phospho_1	264	270	PF10480	0.500
LIG_REV1ctd_RIR_1	11	16	PF16727	0.533
LIG_SH2_GRB2like	265	268	PF00017	0.507
LIG_SH2_NCK_1	289	293	PF00017	0.379
LIG_SH2_SRC	88	91	PF00017	0.462
LIG_SH2_STAP1	241	245	PF00017	0.480
LIG_SH2_STAP1	67	71	PF00017	0.540
LIG_SH2_STAT3	235	238	PF00017	0.463
LIG_SH2_STAT3	67	70	PF00017	0.546
LIG_SH2_STAT5	115	118	PF00017	0.491
LIG_SH2_STAT5	235	238	PF00017	0.457
LIG_SH2_STAT5	265	268	PF00017	0.566
LIG_SH3_3	193	199	PF00018	0.579
LIG_SUMO_SIM_par_1	119	124	PF11976	0.515
LIG_TRAF2_1	187	190	PF00917	0.422
LIG_TRAF2_1	96	99	PF00917	0.540
LIG_UBA3_1	53	61	PF00899	0.497
LIG_WRC_WIRS_1	270	275	PF05994	0.489
MOD_CK1_1	214	220	PF00069	0.593
MOD_CK1_1	269	275	PF00069	0.498
MOD_CK2_1	184	190	PF00069	0.466
MOD_CK2_1	252	258	PF00069	0.535
MOD_GlcNHglycan	135	138	PF01048	0.477
MOD_GSK3_1	184	191	PF00069	0.508
MOD_GSK3_1	290	297	PF00069	0.385
MOD_N-GLC_1	266	271	PF02516	0.489
MOD_N-GLC_1	294	299	PF02516	0.532
MOD_NEK2_1	266	271	PF00069	0.439
MOD_NEK2_1	294	299	PF00069	0.411
MOD_PIKK_1	81	87	PF00454	0.549
MOD_PK_1	119	125	PF00069	0.400
MOD_PKA_2	107	113	PF00069	0.606
MOD_PKA_2	225	231	PF00069	0.519
MOD_Plk_1	172	178	PF00069	0.568
MOD_Plk_1	266	272	PF00069	0.522
MOD_Plk_1	294	300	PF00069	0.449
MOD_Plk_2-3	150	156	PF00069	0.526
MOD_Plk_4	172	178	PF00069	0.523
MOD_Plk_4	97	103	PF00069	0.517
MOD_ProDKin_1	211	217	PF00069	0.494
TRG_ENDOCYTIC_2	270	273	PF00928	0.491
TRG_ENDOCYTIC_2	88	91	PF00928	0.453
TRG_ER_diArg_1	223	226	PF00400	0.565
TRG_Pf-PMV_PEXEL_1	186	190	PF00026	0.430
TRG_Pf-PMV_PEXEL_1	234	238	PF00026	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILS3	Leptomonas seymouri	76%	100%
A0A0S4KKA1	Bodo saltans	36%	93%
A0A1X0PBI9	Trypanosomatidae	41%	100%
A0A3R7M5H3	Trypanosoma rangeli	46%	100%
A0A3S7X8I2	Leishmania donovani	100%	100%
A4HBD3	Leishmania braziliensis	83%	100%
C9ZLQ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9B5K5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q2D1	Leishmania major	93%	100%
V5BRF3	Trypanosoma cruzi	46%	100%