GRIP domain-containing protein

Quick info Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GRIP domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4IAI0_LEIIN

TriTrypDb:

LINF_340048700

Length:

488

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Phosphorylation

Promastigote/Amastigote: 294

Expansion

Sequence features

A4IAI0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAI0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	14	18	PF00656	0.688
CLV_C14_Caspase3-7	277	281	PF00656	0.637
CLV_C14_Caspase3-7	373	377	PF00656	0.684
CLV_NRD_NRD_1	202	204	PF00675	0.549
CLV_NRD_NRD_1	398	400	PF00675	0.547
CLV_NRD_NRD_1	418	420	PF00675	0.498
CLV_NRD_NRD_1	425	427	PF00675	0.679
CLV_PCSK_KEX2_1	177	179	PF00082	0.600
CLV_PCSK_KEX2_1	201	203	PF00082	0.543
CLV_PCSK_KEX2_1	398	400	PF00082	0.608
CLV_PCSK_KEX2_1	418	420	PF00082	0.387
CLV_PCSK_KEX2_1	425	427	PF00082	0.567
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.587
CLV_PCSK_SKI1_1	160	164	PF00082	0.626
CLV_PCSK_SKI1_1	462	466	PF00082	0.378
CLV_PCSK_SKI1_1	484	488	PF00082	0.597
CLV_PCSK_SKI1_1	84	88	PF00082	0.603
DEG_APCC_DBOX_1	200	208	PF00400	0.403
DEG_APCC_DBOX_1	461	469	PF00400	0.410
DOC_CYCLIN_RxL_1	459	469	PF00134	0.408
DOC_CYCLIN_RxL_1	81	90	PF00134	0.559
DOC_MAPK_DCC_7	462	470	PF00069	0.434
DOC_MAPK_DCC_7	93	102	PF00069	0.631
DOC_MAPK_gen_1	418	424	PF00069	0.601
DOC_MAPK_gen_1	459	467	PF00069	0.442
DOC_MAPK_MEF2A_6	462	470	PF00069	0.434
DOC_MAPK_MEF2A_6	93	102	PF00069	0.631
DOC_MIT_MIM_1	199	207	PF04212	0.573
DOC_PP1_RVXF_1	402	408	PF00149	0.541
DOC_USP7_MATH_1	11	15	PF00917	0.764
DOC_USP7_UBL2_3	56	60	PF12436	0.520
DOC_WW_Pin1_4	140	145	PF00397	0.759
DOC_WW_Pin1_4	25	30	PF00397	0.495
DOC_WW_Pin1_4	291	296	PF00397	0.673
LIG_14-3-3_CanoR_1	404	408	PF00244	0.541
LIG_Actin_WH2_2	155	172	PF00022	0.612
LIG_Actin_WH2_2	457	475	PF00022	0.420
LIG_BIR_II_1	1	5	PF00653	0.661
LIG_BRCT_BRCA1_1	104	108	PF00533	0.634
LIG_CaM_IQ_9	155	170	PF13499	0.647
LIG_CaM_IQ_9	271	286	PF13499	0.525
LIG_FHA_1	121	127	PF00498	0.527
LIG_FHA_1	153	159	PF00498	0.555
LIG_FHA_1	185	191	PF00498	0.556
LIG_FHA_1	20	26	PF00498	0.512
LIG_FHA_1	33	39	PF00498	0.353
LIG_FHA_1	367	373	PF00498	0.689
LIG_FHA_1	388	394	PF00498	0.661
LIG_FHA_1	72	78	PF00498	0.542
LIG_FHA_2	151	157	PF00498	0.691
LIG_FHA_2	159	165	PF00498	0.513
LIG_FHA_2	239	245	PF00498	0.604
LIG_FHA_2	305	311	PF00498	0.566
LIG_FHA_2	371	377	PF00498	0.721
LIG_FHA_2	473	479	PF00498	0.451
LIG_FHA_2	59	65	PF00498	0.577
LIG_GBD_Chelix_1	447	455	PF00786	0.480
LIG_LIR_Gen_1	310	320	PF02991	0.544
LIG_LIR_Gen_1	381	391	PF02991	0.566
LIG_LIR_Gen_1	406	415	PF02991	0.547
LIG_LIR_Nem_3	310	316	PF02991	0.518
LIG_LIR_Nem_3	381	387	PF02991	0.589
LIG_LIR_Nem_3	406	410	PF02991	0.618
LIG_NRBOX	347	353	PF00104	0.569
LIG_NRBOX	467	473	PF00104	0.335
LIG_RPA_C_Fungi	413	425	PF08784	0.563
LIG_SH2_STAT3	101	104	PF00017	0.649
LIG_SH2_STAT5	101	104	PF00017	0.628
LIG_SH2_STAT5	313	316	PF00017	0.619
LIG_SH2_STAT5	443	446	PF00017	0.335
LIG_SUMO_SIM_par_1	122	127	PF11976	0.430
LIG_SUMO_SIM_par_1	69	74	PF11976	0.538
LIG_TRAF2_1	230	233	PF00917	0.582
LIG_TRAF2_1	330	333	PF00917	0.630
LIG_TRAF2_2	133	138	PF00917	0.636
LIG_UBA3_1	464	473	PF00899	0.447
MOD_CDC14_SPxK_1	143	146	PF00782	0.624
MOD_CDK_SPxK_1	140	146	PF00069	0.626
MOD_CK1_1	152	158	PF00069	0.664
MOD_CK1_1	247	253	PF00069	0.575
MOD_CK2_1	150	156	PF00069	0.703
MOD_CK2_1	238	244	PF00069	0.549
MOD_CK2_1	414	420	PF00069	0.627
MOD_CK2_1	58	64	PF00069	0.578
MOD_GlcNHglycan	128	131	PF01048	0.641
MOD_GlcNHglycan	13	16	PF01048	0.636
MOD_GlcNHglycan	353	356	PF01048	0.658
MOD_GlcNHglycan	361	364	PF01048	0.743
MOD_GlcNHglycan	436	439	PF01048	0.658
MOD_GSK3_1	1	8	PF00069	0.671
MOD_GSK3_1	120	127	PF00069	0.538
MOD_GSK3_1	136	143	PF00069	0.743
MOD_GSK3_1	146	153	PF00069	0.619
MOD_GSK3_1	154	161	PF00069	0.463
MOD_GSK3_1	25	32	PF00069	0.564
MOD_GSK3_1	366	373	PF00069	0.678
MOD_GSK3_1	383	390	PF00069	0.434
MOD_N-GLC_1	210	215	PF02516	0.585
MOD_N-GLC_1	291	296	PF02516	0.523
MOD_N-GLC_1	364	369	PF02516	0.636
MOD_N-GLC_1	5	10	PF02516	0.541
MOD_NEK2_1	1	6	PF00069	0.502
MOD_NEK2_1	120	125	PF00069	0.468
MOD_NEK2_1	126	131	PF00069	0.550
MOD_NEK2_1	150	155	PF00069	0.684
MOD_NEK2_1	158	163	PF00069	0.558
MOD_NEK2_1	238	243	PF00069	0.588
MOD_NEK2_1	351	356	PF00069	0.603
MOD_NEK2_1	387	392	PF00069	0.586
MOD_NEK2_1	414	419	PF00069	0.498
MOD_NEK2_1	451	456	PF00069	0.420
MOD_NEK2_1	77	82	PF00069	0.496
MOD_NEK2_1	87	92	PF00069	0.536
MOD_NEK2_2	210	215	PF00069	0.571
MOD_PIKK_1	102	108	PF00454	0.553
MOD_PIKK_1	247	253	PF00454	0.621
MOD_PIKK_1	328	334	PF00454	0.523
MOD_PKA_1	177	183	PF00069	0.622
MOD_PKA_2	177	183	PF00069	0.591
MOD_PKA_2	247	253	PF00069	0.504
MOD_PKA_2	333	339	PF00069	0.472
MOD_PKA_2	403	409	PF00069	0.473
MOD_Plk_1	210	216	PF00069	0.512
MOD_Plk_1	87	93	PF00069	0.624
MOD_Plk_4	120	126	PF00069	0.508
MOD_Plk_4	293	299	PF00069	0.694
MOD_Plk_4	466	472	PF00069	0.358
MOD_ProDKin_1	140	146	PF00069	0.760
MOD_ProDKin_1	25	31	PF00069	0.492
MOD_ProDKin_1	291	297	PF00069	0.680
MOD_SUMO_rev_2	220	230	PF00179	0.619
MOD_SUMO_rev_2	315	323	PF00179	0.505
TRG_DiLeu_BaEn_1	340	345	PF01217	0.593
TRG_DiLeu_BaEn_1	347	352	PF01217	0.598
TRG_ENDOCYTIC_2	313	316	PF00928	0.507
TRG_ENDOCYTIC_2	320	323	PF00928	0.470
TRG_ER_diArg_1	200	203	PF00400	0.533
TRG_ER_diArg_1	240	243	PF00400	0.574
TRG_ER_diArg_1	397	399	PF00400	0.596
TRG_ER_diArg_1	424	426	PF00400	0.678
TRG_Pf-PMV_PEXEL_1	202	206	PF00026	0.535
TRG_Pf-PMV_PEXEL_1	346	350	PF00026	0.566
TRG_Pf-PMV_PEXEL_1	398	402	PF00026	0.584
TRG_Pf-PMV_PEXEL_1	84	88	PF00026	0.632

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF68	Leptomonas seymouri	41%	100%
A0A0S4KIU3	Bodo saltans	27%	100%
A0A1X0PB65	Trypanosomatidae	25%	100%
A0A3S7X8J7	Leishmania donovani	99%	100%
A4HBD2	Leishmania braziliensis	66%	100%
C9ZLQ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9B5K4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4Q2D2	Leishmania major	85%	100%
V5BW28	Trypanosoma cruzi	27%	100%