Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IAH5_LEIIN

TriTrypDb:

LINF_340048200

Length:

339

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IAH5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAH5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	4	8	PF00656	0.620
CLV_C14_Caspase3-7	50	54	PF00656	0.736
CLV_NRD_NRD_1	21	23	PF00675	0.570
CLV_NRD_NRD_1	210	212	PF00675	0.425
CLV_NRD_NRD_1	275	277	PF00675	0.558
CLV_NRD_NRD_1	40	42	PF00675	0.365
CLV_NRD_NRD_1	63	65	PF00675	0.748
CLV_PCSK_KEX2_1	160	162	PF00082	0.396
CLV_PCSK_KEX2_1	21	23	PF00082	0.592
CLV_PCSK_KEX2_1	210	212	PF00082	0.404
CLV_PCSK_KEX2_1	275	277	PF00082	0.545
CLV_PCSK_KEX2_1	63	65	PF00082	0.715
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.396
CLV_PCSK_SKI1_1	110	114	PF00082	0.506
CLV_PCSK_SKI1_1	211	215	PF00082	0.472
CLV_PCSK_SKI1_1	289	293	PF00082	0.396
CLV_PCSK_SKI1_1	312	316	PF00082	0.414
DEG_APCC_DBOX_1	183	191	PF00400	0.335
DEG_APCC_DBOX_1	25	33	PF00400	0.516
DEG_APCC_DBOX_1	288	296	PF00400	0.395
DEG_Nend_UBRbox_2	1	3	PF02207	0.662
DEG_SCF_FBW7_2	332	337	PF00400	0.520
DEG_SPOP_SBC_1	133	137	PF00917	0.408
DOC_MAPK_DCC_7	286	296	PF00069	0.505
DOC_MAPK_gen_1	160	166	PF00069	0.413
DOC_MAPK_gen_1	286	296	PF00069	0.469
DOC_MAPK_gen_1	319	329	PF00069	0.497
DOC_MAPK_MEF2A_6	289	296	PF00069	0.457
DOC_MAPK_NFAT4_5	289	297	PF00069	0.498
DOC_PP2B_LxvP_1	16	19	PF13499	0.463
DOC_PP2B_LxvP_1	164	167	PF13499	0.467
DOC_PP4_FxxP_1	82	85	PF00568	0.536
DOC_USP7_MATH_1	12	16	PF00917	0.545
DOC_USP7_MATH_1	206	210	PF00917	0.528
DOC_USP7_MATH_1	59	63	PF00917	0.721
DOC_WW_Pin1_4	254	259	PF00397	0.511
DOC_WW_Pin1_4	330	335	PF00397	0.426
DOC_WW_Pin1_4	55	60	PF00397	0.751
DOC_WW_Pin1_4	76	81	PF00397	0.474
LIG_14-3-3_CanoR_1	141	151	PF00244	0.501
LIG_14-3-3_CanoR_1	210	219	PF00244	0.477
LIG_14-3-3_CanoR_1	275	281	PF00244	0.607
LIG_14-3-3_CanoR_1	324	328	PF00244	0.500
LIG_Actin_WH2_2	114	130	PF00022	0.517
LIG_BRCT_BRCA1_1	325	329	PF00533	0.422
LIG_BRCT_BRCA1_1	78	82	PF00533	0.416
LIG_CaM_NSCaTE_8	28	35	PF13499	0.470
LIG_deltaCOP1_diTrp_1	73	82	PF00928	0.508
LIG_EVH1_1	164	168	PF00568	0.515
LIG_FHA_1	11	17	PF00498	0.521
LIG_FHA_1	297	303	PF00498	0.453
LIG_FHA_1	84	90	PF00498	0.547
LIG_FHA_2	102	108	PF00498	0.550
LIG_FHA_2	142	148	PF00498	0.499
LIG_LIR_Apic_2	79	85	PF02991	0.446
LIG_LIR_Gen_1	326	336	PF02991	0.434
LIG_LIR_LC3C_4	185	189	PF02991	0.460
LIG_LIR_Nem_3	326	332	PF02991	0.441
LIG_LIR_Nem_3	79	84	PF02991	0.470
LIG_MLH1_MIPbox_1	78	82	PF16413	0.416
LIG_NRBOX	108	114	PF00104	0.496
LIG_PCNA_yPIPBox_3	141	155	PF02747	0.369
LIG_SH2_PTP2	267	270	PF00017	0.448
LIG_SH2_STAT5	267	270	PF00017	0.363
LIG_SH2_STAT5	38	41	PF00017	0.523
LIG_SH2_STAT5	81	84	PF00017	0.440
LIG_SH3_3	162	168	PF00018	0.452
LIG_SUMO_SIM_anti_2	123	128	PF11976	0.486
LIG_SUMO_SIM_anti_2	144	153	PF11976	0.522
LIG_SUMO_SIM_anti_2	185	191	PF11976	0.384
LIG_SUMO_SIM_par_1	12	17	PF11976	0.571
LIG_SUMO_SIM_par_1	185	191	PF11976	0.468
LIG_SUMO_SIM_par_1	292	297	PF11976	0.493
LIG_WRC_WIRS_1	6	11	PF05994	0.589
MOD_CDK_SPK_2	254	259	PF00069	0.511
MOD_CDK_SPK_2	55	60	PF00069	0.751
MOD_CK1_1	330	336	PF00069	0.424
MOD_CK1_1	58	64	PF00069	0.724
MOD_CK1_1	76	82	PF00069	0.301
MOD_CK1_1	83	89	PF00069	0.429
MOD_CK2_1	141	147	PF00069	0.507
MOD_CK2_1	179	185	PF00069	0.522
MOD_CK2_1	254	260	PF00069	0.496
MOD_CK2_1	44	50	PF00069	0.599
MOD_GlcNHglycan	181	184	PF01048	0.458
MOD_GlcNHglycan	46	49	PF01048	0.672
MOD_GlcNHglycan	75	78	PF01048	0.552
MOD_GSK3_1	1	8	PF00069	0.540
MOD_GSK3_1	10	17	PF00069	0.484
MOD_GSK3_1	276	283	PF00069	0.596
MOD_GSK3_1	323	330	PF00069	0.419
MOD_GSK3_1	42	49	PF00069	0.657
MOD_GSK3_1	55	62	PF00069	0.664
MOD_GSK3_1	76	83	PF00069	0.478
MOD_N-GLC_2	138	140	PF02516	0.388
MOD_NEK2_1	1	6	PF00069	0.617
MOD_NEK2_1	134	139	PF00069	0.502
MOD_NEK2_1	280	285	PF00069	0.464
MOD_NEK2_1	327	332	PF00069	0.538
MOD_PIKK_1	211	217	PF00454	0.468
MOD_PKA_1	41	47	PF00069	0.679
MOD_PKA_2	142	148	PF00069	0.488
MOD_PKA_2	323	329	PF00069	0.516
MOD_PKA_2	59	65	PF00069	0.732
MOD_PKB_1	141	149	PF00069	0.487
MOD_Plk_1	1	7	PF00069	0.620
MOD_Plk_1	42	48	PF00069	0.651
MOD_Plk_4	1	7	PF00069	0.640
MOD_Plk_4	323	329	PF00069	0.426
MOD_ProDKin_1	254	260	PF00069	0.508
MOD_ProDKin_1	330	336	PF00069	0.424
MOD_ProDKin_1	55	61	PF00069	0.750
MOD_ProDKin_1	76	82	PF00069	0.464
MOD_SUMO_for_1	117	120	PF00179	0.506
TRG_DiLeu_BaEn_1	147	152	PF01217	0.500
TRG_DiLeu_BaEn_1	229	234	PF01217	0.398
TRG_DiLeu_BaEn_1	287	292	PF01217	0.379
TRG_DiLeu_BaLyEn_6	290	295	PF01217	0.454
TRG_DiLeu_BaLyEn_6	298	303	PF01217	0.449
TRG_ENDOCYTIC_2	267	270	PF00928	0.378
TRG_ENDOCYTIC_2	81	84	PF00928	0.549
TRG_ER_diArg_1	63	66	PF00400	0.702
TRG_NES_CRM1_1	107	123	PF08389	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P703	Leptomonas seymouri	60%	80%
A0A0S4KKR7	Bodo saltans	32%	66%
A0A1X0PA52	Trypanosomatidae	46%	84%
A0A3S7X8N4	Leishmania donovani	100%	100%
A0A422NVD0	Trypanosoma rangeli	44%	90%
A4HBC7	Leishmania braziliensis	82%	100%
C9ZLR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	89%
E9B5J9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q2D7	Leishmania major	91%	100%
V5BW32	Trypanosoma cruzi	41%	89%