Inner membrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IAH3_LEIIN

TriTrypDb:

LINF_340048000

Length:

329

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

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Expansion

Sequence features

A4IAH3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAH3

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	298	302	PF00656	0.363
CLV_NRD_NRD_1	142	144	PF00675	0.393
CLV_NRD_NRD_1	278	280	PF00675	0.612
CLV_NRD_NRD_1	39	41	PF00675	0.436
CLV_NRD_NRD_1	5	7	PF00675	0.434
CLV_PCSK_KEX2_1	142	144	PF00082	0.393
CLV_PCSK_KEX2_1	39	41	PF00082	0.436
CLV_PCSK_KEX2_1	5	7	PF00082	0.434
CLV_PCSK_SKI1_1	142	146	PF00082	0.388
CLV_PCSK_SKI1_1	255	259	PF00082	0.591

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5V1	Leptomonas seymouri	62%	100%
A0A3S7X8H0	Leishmania donovani	100%	100%
A4HBC5	Leishmania braziliensis	79%	100%
E9B5J7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	95%
Q4Q2D9	Leishmania major	96%	100%

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