LeishMANIAdb
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Inner membrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Inner membrane protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IAH3_LEIIN
TriTrypDb:
LINF_340048000
Length:
329

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 5
GO:0110165 cellular anatomical entity 1 5

Expansion

Sequence features

A4IAH3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAH3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 298 302 PF00656 0.363
CLV_NRD_NRD_1 142 144 PF00675 0.393
CLV_NRD_NRD_1 278 280 PF00675 0.612
CLV_NRD_NRD_1 39 41 PF00675 0.436
CLV_NRD_NRD_1 5 7 PF00675 0.434
CLV_PCSK_KEX2_1 142 144 PF00082 0.393
CLV_PCSK_KEX2_1 39 41 PF00082 0.436
CLV_PCSK_KEX2_1 5 7 PF00082 0.434
CLV_PCSK_SKI1_1 142 146 PF00082 0.388
CLV_PCSK_SKI1_1 255 259 PF00082 0.591
CLV_PCSK_SKI1_1 279 283 PF00082 0.599
CLV_PCSK_SKI1_1 293 297 PF00082 0.566
CLV_PCSK_SKI1_1 79 83 PF00082 0.450
CLV_Separin_Metazoa 208 212 PF03568 0.400
DEG_Nend_UBRbox_1 1 4 PF02207 0.645
DEG_SCF_FBW7_2 169 175 PF00400 0.462
DEG_SPOP_SBC_1 117 121 PF00917 0.673
DEG_SPOP_SBC_1 18 22 PF00917 0.624
DOC_CKS1_1 169 174 PF01111 0.457
DOC_CYCLIN_RxL_1 139 147 PF00134 0.628
DOC_CYCLIN_RxL_1 288 298 PF00134 0.403
DOC_MAPK_DCC_7 2 12 PF00069 0.613
DOC_MAPK_gen_1 193 201 PF00069 0.408
DOC_MAPK_gen_1 2 12 PF00069 0.630
DOC_MAPK_gen_1 254 260 PF00069 0.389
DOC_MAPK_MEF2A_6 5 12 PF00069 0.611
DOC_PP2B_LxvP_1 27 30 PF13499 0.625
DOC_SPAK_OSR1_1 40 44 PF12202 0.600
DOC_USP7_MATH_1 103 107 PF00917 0.759
DOC_USP7_MATH_1 112 116 PF00917 0.671
DOC_USP7_MATH_1 17 21 PF00917 0.623
DOC_USP7_MATH_1 235 239 PF00917 0.370
DOC_USP7_MATH_1 299 303 PF00917 0.364
DOC_USP7_UBL2_3 293 297 PF12436 0.381
DOC_WW_Pin1_4 168 173 PF00397 0.448
DOC_WW_Pin1_4 57 62 PF00397 0.673
DOC_WW_Pin1_4 81 86 PF00397 0.658
LIG_14-3-3_CanoR_1 143 149 PF00244 0.684
LIG_14-3-3_CanoR_1 211 217 PF00244 0.428
LIG_14-3-3_CanoR_1 317 321 PF00244 0.359
LIG_Actin_WH2_2 284 299 PF00022 0.368
LIG_AP2alpha_2 263 265 PF02296 0.387
LIG_APCC_ABBAyCdc20_2 305 311 PF00400 0.445
LIG_BRCT_BRCA1_1 37 41 PF00533 0.635
LIG_EH1_1 317 325 PF00400 0.403
LIG_FHA_1 139 145 PF00498 0.643
LIG_FHA_1 179 185 PF00498 0.425
LIG_FHA_1 217 223 PF00498 0.400
LIG_FHA_1 247 253 PF00498 0.389
LIG_FHA_2 69 75 PF00498 0.640
LIG_GBD_Chelix_1 152 160 PF00786 0.304
LIG_LIR_Nem_3 46 52 PF02991 0.602
LIG_PCNA_APIM_2 291 297 PF02747 0.412
LIG_Pex14_2 164 168 PF04695 0.304
LIG_SH2_CRK 170 174 PF00017 0.382
LIG_SH2_CRK 50 54 PF00017 0.628
LIG_SH2_STAP1 248 252 PF00017 0.392
LIG_SH2_STAT5 170 173 PF00017 0.386
LIG_SH2_STAT5 248 251 PF00017 0.393
LIG_SH3_1 50 56 PF00018 0.616
LIG_SH3_3 20 26 PF00018 0.638
LIG_SH3_3 258 264 PF00018 0.416
LIG_SH3_3 50 56 PF00018 0.616
LIG_SUMO_SIM_anti_2 219 225 PF11976 0.431
LIG_TRAF2_1 228 231 PF00917 0.390
LIG_UBA3_1 165 174 PF00899 0.441
MOD_CDK_SPxK_1 168 174 PF00069 0.452
MOD_CK1_1 106 112 PF00069 0.635
MOD_CK1_1 123 129 PF00069 0.655
MOD_CK1_1 21 27 PF00069 0.650
MOD_CK1_1 319 325 PF00069 0.352
MOD_CK1_1 60 66 PF00069 0.663
MOD_CK2_1 112 118 PF00069 0.654
MOD_CK2_1 239 245 PF00069 0.383
MOD_CK2_1 68 74 PF00069 0.639
MOD_GlcNHglycan 120 123 PF01048 0.485
MOD_GlcNHglycan 125 128 PF01048 0.467
MOD_GlcNHglycan 297 300 PF01048 0.551
MOD_GlcNHglycan 31 34 PF01048 0.448
MOD_GlcNHglycan 62 65 PF01048 0.507
MOD_GlcNHglycan 87 90 PF01048 0.495
MOD_GlcNHglycan 94 97 PF01048 0.453
MOD_GSK3_1 108 115 PF00069 0.665
MOD_GSK3_1 116 123 PF00069 0.687
MOD_GSK3_1 13 20 PF00069 0.619
MOD_GSK3_1 174 181 PF00069 0.415
MOD_GSK3_1 212 219 PF00069 0.423
MOD_GSK3_1 235 242 PF00069 0.373
MOD_GSK3_1 246 253 PF00069 0.389
MOD_GSK3_1 29 36 PF00069 0.631
MOD_GSK3_1 295 302 PF00069 0.362
MOD_GSK3_1 81 88 PF00069 0.637
MOD_NEK2_1 1 6 PF00069 0.639
MOD_NEK2_1 144 149 PF00069 0.557
MOD_NEK2_1 239 244 PF00069 0.414
MOD_NEK2_1 295 300 PF00069 0.350
MOD_NEK2_1 316 321 PF00069 0.407
MOD_PIKK_1 246 252 PF00454 0.393
MOD_PKA_2 1 7 PF00069 0.621
MOD_PKA_2 316 322 PF00069 0.359
MOD_Plk_1 13 19 PF00069 0.615
MOD_Plk_1 174 180 PF00069 0.415
MOD_Plk_1 216 222 PF00069 0.434
MOD_Plk_4 235 241 PF00069 0.372
MOD_Plk_4 319 325 PF00069 0.352
MOD_ProDKin_1 168 174 PF00069 0.452
MOD_ProDKin_1 57 63 PF00069 0.675
MOD_ProDKin_1 81 87 PF00069 0.658
MOD_SUMO_for_1 287 290 PF00179 0.413
MOD_SUMO_rev_2 225 235 PF00179 0.397
TRG_DiLeu_BaEn_2 289 295 PF01217 0.408
TRG_ENDOCYTIC_2 170 173 PF00928 0.379
TRG_ER_diArg_1 142 144 PF00400 0.595
TRG_ER_diArg_1 39 41 PF00400 0.632
TRG_ER_diArg_1 5 7 PF00400 0.630

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I5V1 Leptomonas seymouri 62% 100%
A0A3S7X8H0 Leishmania donovani 100% 100%
A4HBC5 Leishmania braziliensis 79% 100%
E9B5J7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 81% 95%
Q4Q2D9 Leishmania major 96% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS