Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IAH2_LEIIN

TriTrypDb:

LINF_340047900

Length:

104

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4IAH2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAH2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	35	37	PF00675	0.549
CLV_NRD_NRD_1	4	6	PF00675	0.571
CLV_PCSK_KEX2_1	35	37	PF00082	0.550
CLV_PCSK_KEX2_1	4	6	PF00082	0.592
DOC_PP4_FxxP_1	30	33	PF00568	0.540
DOC_WW_Pin1_4	37	42	PF00397	0.653
DOC_WW_Pin1_4	67	72	PF00397	0.499
LIG_APCC_ABBA_1	27	32	PF00400	0.569
LIG_deltaCOP1_diTrp_1	53	58	PF00928	0.523
LIG_LIR_Gen_1	22	33	PF02991	0.548
LIG_LIR_Gen_1	78	87	PF02991	0.465
LIG_LIR_Nem_3	22	28	PF02991	0.540
LIG_LIR_Nem_3	56	61	PF02991	0.499
LIG_LIR_Nem_3	78	83	PF02991	0.459
LIG_MYND_1	37	41	PF01753	0.654
LIG_Pex14_1	54	58	PF04695	0.495
LIG_Pex14_2	91	95	PF04695	0.495
LIG_SH2_NCK_1	96	100	PF00017	0.539
LIG_SH2_STAP1	96	100	PF00017	0.539
LIG_SH3_2	63	68	PF14604	0.537
LIG_SH3_3	31	37	PF00018	0.689
LIG_SH3_3	60	66	PF00018	0.529
LIG_SH3_3	95	101	PF00018	0.656
LIG_TRAF2_1	40	43	PF00917	0.498
MOD_CDK_SPxxK_3	37	44	PF00069	0.651
MOD_CK2_1	37	43	PF00069	0.509
MOD_NEK2_1	18	23	PF00069	0.539
MOD_ProDKin_1	37	43	PF00069	0.650
MOD_ProDKin_1	67	73	PF00069	0.500
TRG_DiLeu_BaLyEn_6	14	19	PF01217	0.552
TRG_ENDOCYTIC_2	25	28	PF00928	0.548
TRG_ENDOCYTIC_2	96	99	PF00928	0.538
TRG_ER_diArg_1	3	5	PF00400	0.595
TRG_ER_diArg_1	34	36	PF00400	0.559

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF74	Leptomonas seymouri	87%	100%
A0A0S4KIS5	Bodo saltans	63%	100%
A0A1X0PBI1	Trypanosomatidae	77%	99%
A0A3Q8IUX8	Leishmania donovani	100%	100%
A0A422NVD7	Trypanosoma rangeli	76%	99%
A4HBC4	Leishmania braziliensis	89%	100%
E9B5J6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
Q4Q2E0	Leishmania major	99%	100%