LeishMANIAdb
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AP-1 complex subunit gamma

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
AP-1 complex subunit gamma
Gene product:
AP-1 adapter complex gamma subunit - putative
Species:
Leishmania infantum
UniProt:
A4IAG8_LEIIN
TriTrypDb:
LINF_340047500
Length:
831

Annotations

Annotations by Jardim et al.

Intracellular protein trafficking, adaptor gamma-1 chain

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 5
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0030119 AP-type membrane coat adaptor complex 3 12
GO:0030121 AP-1 adaptor complex 5 12
GO:0030131 clathrin adaptor complex 4 12
GO:0032991 protein-containing complex 1 12
GO:0098796 membrane protein complex 2 12

Expansion

Sequence features

A4IAG8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAG8

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 12
GO:0006886 intracellular protein transport 4 12
GO:0008104 protein localization 4 12
GO:0009987 cellular process 1 12
GO:0015031 protein transport 4 12
GO:0016192 vesicle-mediated transport 4 12
GO:0033036 macromolecule localization 2 12
GO:0045184 establishment of protein localization 3 12
GO:0046907 intracellular transport 3 12
GO:0051179 localization 1 12
GO:0051234 establishment of localization 2 12
GO:0051641 cellular localization 2 12
GO:0051649 establishment of localization in cell 3 12
GO:0070727 cellular macromolecule localization 3 12
GO:0071702 organic substance transport 4 12
GO:0071705 nitrogen compound transport 4 12
GO:0006892 post-Golgi vesicle-mediated transport 6 1
GO:0006896 Golgi to vacuole transport 5 1
GO:0006897 endocytosis 5 1
GO:0006898 receptor-mediated endocytosis 6 1
GO:0007034 vacuolar transport 4 1
GO:0048193 Golgi vesicle transport 5 1
Molecular functions
Term Name Level Count
GO:0005488 binding 1 1
GO:0005515 protein binding 2 1
GO:0030276 clathrin binding 3 1
GO:0030674 protein-macromolecule adaptor activity 2 1
GO:0035615 clathrin adaptor activity 4 1
GO:0060090 molecular adaptor activity 1 1
GO:0140312 cargo adaptor activity 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 148 152 PF00656 0.426
CLV_C14_Caspase3-7 2 6 PF00656 0.588
CLV_C14_Caspase3-7 288 292 PF00656 0.253
CLV_C14_Caspase3-7 331 335 PF00656 0.271
CLV_C14_Caspase3-7 687 691 PF00656 0.481
CLV_NRD_NRD_1 119 121 PF00675 0.281
CLV_NRD_NRD_1 176 178 PF00675 0.396
CLV_NRD_NRD_1 224 226 PF00675 0.399
CLV_NRD_NRD_1 36 38 PF00675 0.396
CLV_NRD_NRD_1 376 378 PF00675 0.253
CLV_NRD_NRD_1 487 489 PF00675 0.268
CLV_PCSK_KEX2_1 119 121 PF00082 0.414
CLV_PCSK_KEX2_1 375 377 PF00082 0.253
CLV_PCSK_SKI1_1 147 151 PF00082 0.253
CLV_PCSK_SKI1_1 167 171 PF00082 0.299
CLV_PCSK_SKI1_1 233 237 PF00082 0.235
CLV_PCSK_SKI1_1 376 380 PF00082 0.287
CLV_PCSK_SKI1_1 437 441 PF00082 0.335
CLV_PCSK_SKI1_1 488 492 PF00082 0.269
CLV_PCSK_SKI1_1 50 54 PF00082 0.312
CLV_PCSK_SKI1_1 511 515 PF00082 0.294
CLV_PCSK_SKI1_1 544 548 PF00082 0.334
DEG_APCC_DBOX_1 146 154 PF00400 0.268
DEG_APCC_DBOX_1 49 57 PF00400 0.268
DEG_ODPH_VHL_1 782 794 PF01847 0.281
DEG_SPOP_SBC_1 674 678 PF00917 0.511
DOC_CYCLIN_RxL_1 233 242 PF00134 0.253
DOC_CYCLIN_RxL_1 374 384 PF00134 0.287
DOC_CYCLIN_yClb1_LxF_4 334 340 PF00134 0.313
DOC_MAPK_gen_1 375 383 PF00069 0.253
DOC_MAPK_gen_1 440 450 PF00069 0.268
DOC_MAPK_gen_1 48 56 PF00069 0.308
DOC_MAPK_gen_1 488 496 PF00069 0.396
DOC_MAPK_MEF2A_6 375 383 PF00069 0.253
DOC_MAPK_MEF2A_6 488 496 PF00069 0.396
DOC_MAPK_MEF2A_6 50 58 PF00069 0.419
DOC_MAPK_MEF2A_6 85 93 PF00069 0.257
DOC_MAPK_NFAT4_5 376 384 PF00069 0.268
DOC_MAPK_RevD_3 362 376 PF00069 0.313
DOC_PP1_RVXF_1 258 265 PF00149 0.253
DOC_PP2B_LxvP_1 393 396 PF13499 0.268
DOC_PP2B_PxIxI_1 44 50 PF00149 0.329
DOC_USP7_MATH_1 310 314 PF00917 0.306
DOC_USP7_MATH_1 400 404 PF00917 0.329
DOC_USP7_MATH_1 668 672 PF00917 0.741
DOC_USP7_MATH_1 694 698 PF00917 0.690
DOC_USP7_MATH_1 703 707 PF00917 0.635
DOC_USP7_MATH_1 724 728 PF00917 0.425
DOC_USP7_MATH_1 749 753 PF00917 0.415
DOC_USP7_MATH_1 777 781 PF00917 0.307
DOC_USP7_MATH_2 608 614 PF00917 0.530
DOC_USP7_UBL2_3 544 548 PF12436 0.347
DOC_WW_Pin1_4 157 162 PF00397 0.404
DOC_WW_Pin1_4 638 643 PF00397 0.638
DOC_WW_Pin1_4 659 664 PF00397 0.654
DOC_WW_Pin1_4 710 715 PF00397 0.629
LIG_14-3-3_CanoR_1 119 125 PF00244 0.379
LIG_14-3-3_CanoR_1 243 249 PF00244 0.268
LIG_14-3-3_CanoR_1 327 333 PF00244 0.313
LIG_14-3-3_CanoR_1 415 421 PF00244 0.317
LIG_14-3-3_CanoR_1 673 681 PF00244 0.516
LIG_14-3-3_CanoR_1 769 774 PF00244 0.390
LIG_14-3-3_CanoR_1 809 815 PF00244 0.323
LIG_Actin_WH2_2 322 340 PF00022 0.313
LIG_Actin_WH2_2 425 442 PF00022 0.365
LIG_AP2alpha_2 254 256 PF02296 0.268
LIG_BIR_II_1 1 5 PF00653 0.526
LIG_BIR_III_2 42 46 PF00653 0.305
LIG_BIR_III_2 551 555 PF00653 0.305
LIG_BRCT_BRCA1_1 349 353 PF00533 0.269
LIG_BRCT_BRCA1_1 434 438 PF00533 0.455
LIG_BRCT_BRCA1_1 477 481 PF00533 0.287
LIG_BRCT_BRCA1_1 741 745 PF00533 0.416
LIG_BRCT_BRCA1_2 434 440 PF00533 0.329
LIG_Clathr_ClatBox_1 630 634 PF01394 0.632
LIG_deltaCOP1_diTrp_1 471 481 PF00928 0.329
LIG_DLG_GKlike_1 120 127 PF00625 0.281
LIG_eIF4E_1 124 130 PF01652 0.396
LIG_eIF4E_1 537 543 PF01652 0.253
LIG_eIF4E_1 88 94 PF01652 0.396
LIG_FHA_1 10 16 PF00498 0.374
LIG_FHA_1 196 202 PF00498 0.364
LIG_FHA_1 204 210 PF00498 0.370
LIG_FHA_1 291 297 PF00498 0.325
LIG_FHA_1 317 323 PF00498 0.327
LIG_FHA_1 380 386 PF00498 0.275
LIG_FHA_1 460 466 PF00498 0.347
LIG_FHA_1 577 583 PF00498 0.268
LIG_FHA_1 622 628 PF00498 0.642
LIG_FHA_1 644 650 PF00498 0.693
LIG_FHA_1 770 776 PF00498 0.267
LIG_FHA_2 101 107 PF00498 0.253
LIG_FHA_2 19 25 PF00498 0.368
LIG_FHA_2 243 249 PF00498 0.253
LIG_FHA_2 286 292 PF00498 0.298
LIG_FHA_2 512 518 PF00498 0.329
LIG_FHA_2 563 569 PF00498 0.287
LIG_FHA_2 624 630 PF00498 0.630
LIG_FXI_DFP_1 582 586 PF00024 0.477
LIG_LIR_Gen_1 123 132 PF02991 0.395
LIG_LIR_Gen_1 253 264 PF02991 0.233
LIG_LIR_Gen_1 350 361 PF02991 0.367
LIG_LIR_Gen_1 435 446 PF02991 0.451
LIG_LIR_Gen_1 501 510 PF02991 0.278
LIG_LIR_Gen_1 529 539 PF02991 0.287
LIG_LIR_Gen_1 577 586 PF02991 0.254
LIG_LIR_Gen_1 592 601 PF02991 0.398
LIG_LIR_Gen_1 65 75 PF02991 0.329
LIG_LIR_Gen_1 730 739 PF02991 0.379
LIG_LIR_Gen_1 742 750 PF02991 0.419
LIG_LIR_Nem_3 123 127 PF02991 0.395
LIG_LIR_Nem_3 253 259 PF02991 0.233
LIG_LIR_Nem_3 350 356 PF02991 0.367
LIG_LIR_Nem_3 435 441 PF02991 0.451
LIG_LIR_Nem_3 501 505 PF02991 0.278
LIG_LIR_Nem_3 529 534 PF02991 0.268
LIG_LIR_Nem_3 577 581 PF02991 0.287
LIG_LIR_Nem_3 664 670 PF02991 0.556
LIG_LIR_Nem_3 678 684 PF02991 0.555
LIG_LIR_Nem_3 730 734 PF02991 0.388
LIG_LIR_Nem_3 742 748 PF02991 0.394
LIG_LIR_Nem_3 79 84 PF02991 0.338
LIG_LYPXL_SIV_4 45 53 PF13949 0.396
LIG_LYPXL_SIV_4 784 792 PF13949 0.305
LIG_NRBOX 341 347 PF00104 0.293
LIG_PCNA_yPIPBox_3 258 266 PF02747 0.253
LIG_PCNA_yPIPBox_3 280 294 PF02747 0.265
LIG_PCNA_yPIPBox_3 535 543 PF02747 0.350
LIG_Pex14_1 430 434 PF04695 0.313
LIG_Pex14_2 681 685 PF04695 0.560
LIG_PTB_Apo_2 525 532 PF02174 0.318
LIG_SH2_CRK 401 405 PF00017 0.396
LIG_SH2_CRK 578 582 PF00017 0.287
LIG_SH2_PTP2 46 49 PF00017 0.329
LIG_SH2_PTP2 502 505 PF00017 0.313
LIG_SH2_STAP1 434 438 PF00017 0.347
LIG_SH2_STAP1 578 582 PF00017 0.308
LIG_SH2_STAT5 185 188 PF00017 0.396
LIG_SH2_STAT5 46 49 PF00017 0.306
LIG_SH2_STAT5 502 505 PF00017 0.313
LIG_SH2_STAT5 57 60 PF00017 0.203
LIG_SH2_STAT5 578 581 PF00017 0.268
LIG_SH2_STAT5 814 817 PF00017 0.274
LIG_SH2_STAT5 88 91 PF00017 0.253
LIG_SH3_3 580 586 PF00018 0.409
LIG_SH3_3 595 601 PF00018 0.564
LIG_SH3_3 636 642 PF00018 0.702
LIG_SUMO_SIM_anti_2 382 387 PF11976 0.253
LIG_SUMO_SIM_anti_2 501 507 PF11976 0.313
LIG_SUMO_SIM_anti_2 764 769 PF11976 0.439
LIG_SUMO_SIM_anti_2 96 106 PF11976 0.434
LIG_SUMO_SIM_par_1 205 210 PF11976 0.329
LIG_SUMO_SIM_par_1 318 324 PF11976 0.329
LIG_SUMO_SIM_par_1 380 387 PF11976 0.287
LIG_SUMO_SIM_par_1 453 460 PF11976 0.338
LIG_SUMO_SIM_par_1 579 584 PF11976 0.461
LIG_SUMO_SIM_par_1 607 613 PF11976 0.638
LIG_SUMO_SIM_par_1 96 106 PF11976 0.263
LIG_TRAF2_1 21 24 PF00917 0.377
LIG_TYR_ITIM 122 127 PF00017 0.379
LIG_TYR_ITIM 300 305 PF00017 0.253
LIG_TYR_ITIM 399 404 PF00017 0.268
LIG_TYR_ITIM 86 91 PF00017 0.268
LIG_UBA3_1 149 158 PF00899 0.379
LIG_UBA3_1 454 463 PF00899 0.385
LIG_UBA3_1 744 753 PF00899 0.281
LIG_WRC_WIRS_1 557 562 PF05994 0.389
LIG_WRC_WIRS_1 590 595 PF05994 0.437
MOD_CK1_1 242 248 PF00069 0.253
MOD_CK1_1 272 278 PF00069 0.287
MOD_CK1_1 3 9 PF00069 0.537
MOD_CK1_1 403 409 PF00069 0.327
MOD_CK1_1 459 465 PF00069 0.289
MOD_CK1_1 524 530 PF00069 0.355
MOD_CK1_1 562 568 PF00069 0.303
MOD_CK1_1 640 646 PF00069 0.668
MOD_CK1_1 659 665 PF00069 0.554
MOD_CK1_1 697 703 PF00069 0.578
MOD_CK1_1 706 712 PF00069 0.642
MOD_CK1_1 752 758 PF00069 0.343
MOD_CK2_1 100 106 PF00069 0.253
MOD_CK2_1 18 24 PF00069 0.376
MOD_CK2_1 416 422 PF00069 0.410
MOD_GlcNHglycan 215 218 PF01048 0.334
MOD_GlcNHglycan 229 232 PF01048 0.379
MOD_GlcNHglycan 32 35 PF01048 0.336
MOD_GlcNHglycan 664 667 PF01048 0.643
MOD_GlcNHglycan 687 690 PF01048 0.683
MOD_GlcNHglycan 696 699 PF01048 0.658
MOD_GlcNHglycan 710 713 PF01048 0.640
MOD_GlcNHglycan 735 738 PF01048 0.282
MOD_GlcNHglycan 80 84 PF01048 0.396
MOD_GSK3_1 111 118 PF00069 0.396
MOD_GSK3_1 238 245 PF00069 0.253
MOD_GSK3_1 269 276 PF00069 0.256
MOD_GSK3_1 323 330 PF00069 0.337
MOD_GSK3_1 416 423 PF00069 0.392
MOD_GSK3_1 517 524 PF00069 0.362
MOD_GSK3_1 559 566 PF00069 0.366
MOD_GSK3_1 634 641 PF00069 0.643
MOD_GSK3_1 652 659 PF00069 0.634
MOD_GSK3_1 662 669 PF00069 0.558
MOD_GSK3_1 706 713 PF00069 0.720
MOD_N-GLC_1 527 532 PF02516 0.318
MOD_N-GLC_1 562 567 PF02516 0.317
MOD_NEK2_1 149 154 PF00069 0.358
MOD_NEK2_1 238 243 PF00069 0.280
MOD_NEK2_1 328 333 PF00069 0.331
MOD_NEK2_1 346 351 PF00069 0.403
MOD_NEK2_1 379 384 PF00069 0.268
MOD_NEK2_1 591 596 PF00069 0.497
MOD_NEK2_1 739 744 PF00069 0.302
MOD_NEK2_1 761 766 PF00069 0.369
MOD_NEK2_1 825 830 PF00069 0.329
MOD_NEK2_1 9 14 PF00069 0.441
MOD_NEK2_2 370 375 PF00069 0.248
MOD_NEK2_2 703 708 PF00069 0.773
MOD_PIKK_1 457 463 PF00454 0.360
MOD_PIKK_1 591 597 PF00454 0.498
MOD_PIKK_1 612 618 PF00454 0.611
MOD_PIKK_1 652 658 PF00454 0.757
MOD_PIKK_1 668 674 PF00454 0.726
MOD_PIKK_1 74 80 PF00454 0.396
MOD_PIKK_1 794 800 PF00454 0.433
MOD_PIKK_1 825 831 PF00454 0.396
MOD_PKA_2 242 248 PF00069 0.308
MOD_PKA_2 810 816 PF00069 0.329
MOD_Plk_1 370 376 PF00069 0.253
MOD_Plk_1 379 385 PF00069 0.253
MOD_Plk_1 432 438 PF00069 0.253
MOD_Plk_1 475 481 PF00069 0.243
MOD_Plk_1 527 533 PF00069 0.352
MOD_Plk_1 562 568 PF00069 0.329
MOD_Plk_1 576 582 PF00069 0.268
MOD_Plk_1 703 709 PF00069 0.729
MOD_Plk_2-3 100 106 PF00069 0.253
MOD_Plk_4 100 106 PF00069 0.430
MOD_Plk_4 149 155 PF00069 0.388
MOD_Plk_4 197 203 PF00069 0.305
MOD_Plk_4 341 347 PF00069 0.298
MOD_Plk_4 381 387 PF00069 0.398
MOD_Plk_4 416 422 PF00069 0.369
MOD_Plk_4 521 527 PF00069 0.353
MOD_Plk_4 577 583 PF00069 0.253
MOD_Plk_4 645 651 PF00069 0.731
MOD_Plk_4 656 662 PF00069 0.716
MOD_Plk_4 697 703 PF00069 0.578
MOD_Plk_4 739 745 PF00069 0.381
MOD_ProDKin_1 157 163 PF00069 0.404
MOD_ProDKin_1 638 644 PF00069 0.639
MOD_ProDKin_1 659 665 PF00069 0.652
MOD_ProDKin_1 710 716 PF00069 0.627
MOD_SUMO_for_1 707 710 PF00179 0.585
TRG_DiLeu_BaEn_1 100 105 PF01217 0.442
TRG_DiLeu_BaEn_1 125 130 PF01217 0.396
TRG_DiLeu_BaEn_1 501 506 PF01217 0.268
TRG_DiLeu_BaEn_1 577 582 PF01217 0.313
TRG_DiLeu_BaEn_1 71 76 PF01217 0.253
TRG_DiLeu_BaLyEn_6 11 16 PF01217 0.418
TRG_DiLeu_BaLyEn_6 389 394 PF01217 0.268
TRG_ENDOCYTIC_2 124 127 PF00928 0.396
TRG_ENDOCYTIC_2 302 305 PF00928 0.253
TRG_ENDOCYTIC_2 401 404 PF00928 0.268
TRG_ENDOCYTIC_2 46 49 PF00928 0.306
TRG_ENDOCYTIC_2 502 505 PF00928 0.268
TRG_ENDOCYTIC_2 51 54 PF00928 0.258
TRG_ENDOCYTIC_2 57 60 PF00928 0.203
TRG_ENDOCYTIC_2 578 581 PF00928 0.253
TRG_ENDOCYTIC_2 88 91 PF00928 0.253
TRG_ER_diArg_1 374 377 PF00400 0.253
TRG_ER_diArg_1 47 50 PF00400 0.268
TRG_ER_diArg_1 808 811 PF00400 0.329
TRG_NES_CRM1_1 199 210 PF08389 0.389
TRG_NES_CRM1_1 759 774 PF08389 0.396
TRG_Pf-PMV_PEXEL_1 14 18 PF00026 0.556
TRG_Pf-PMV_PEXEL_1 147 151 PF00026 0.396
TRG_Pf-PMV_PEXEL_1 392 397 PF00026 0.253

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P707 Leptomonas seymouri 72% 100%
A0A0N1I3J7 Leptomonas seymouri 20% 76%
A0A0N1PA13 Leptomonas seymouri 26% 86%
A0A0S4JAH1 Bodo saltans 25% 79%
A0A0S4JIE7 Bodo saltans 40% 95%
A0A1X0NLY4 Trypanosomatidae 26% 86%
A0A1X0P1U8 Trypanosomatidae 26% 81%
A0A1X0PA59 Trypanosomatidae 51% 100%
A0A3Q8IHK1 Leishmania donovani 100% 100%
A0A3S7WPR4 Leishmania donovani 26% 86%
A0A422NSY3 Trypanosoma rangeli 48% 100%
A0A422NT90 Trypanosoma rangeli 25% 86%
A0A422P3I9 Trypanosoma rangeli 25% 83%
A4H4U8 Leishmania braziliensis 26% 100%
A4HBC0 Leishmania braziliensis 83% 100%
A4HT27 Leishmania infantum 26% 100%
C9ZLS4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 47% 100%
E9AL15 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9B5J2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
O43747 Homo sapiens 30% 100%
O75843 Homo sapiens 35% 100%
O88512 Mus musculus 35% 100%
O94973 Homo sapiens 23% 88%
O95782 Homo sapiens 23% 85%
P17426 Mus musculus 23% 85%
P17427 Mus musculus 23% 89%
P18484 Rattus norvegicus 23% 89%
P22892 Mus musculus 30% 100%
P38065 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 21% 81%
P91926 Drosophila melanogaster 24% 88%
Q0VCK5 Bos taurus 24% 89%
Q12028 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 25% 100%
Q29N38 Drosophila pseudoobscura pseudoobscura 24% 88%
Q4Q2E4 Leishmania major 93% 98%
Q4QIT9 Leishmania major 26% 100%
Q5R5M2 Pongo abelii 30% 100%
Q7QG73 Anopheles gambiae 24% 89%
Q84K16 Arabidopsis thaliana 35% 95%
Q86KI1 Dictyostelium discoideum 28% 84%
Q8I8U2 Dictyostelium discoideum 38% 93%
Q8L7A9 Arabidopsis thaliana 27% 89%
Q8LPK4 Arabidopsis thaliana 26% 82%
Q8LPL6 Arabidopsis thaliana 26% 82%
Q99128 Ustilago maydis (strain 521 / FGSC 9021) 36% 95%
Q9C0W7 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 25% 95%
Q9UTL8 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 21% 100%
Q9UU81 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 28% 96%
Q9ZUI6 Arabidopsis thaliana 30% 96%
V5B8U2 Trypanosoma cruzi 26% 100%
V5BPJ4 Trypanosoma cruzi 26% 82%
V5BW37 Trypanosoma cruzi 49% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS