Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IAG4_LEIIN

TriTrypDb:

LINF_340047200

Length:

270

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0020016	ciliary pocket	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4IAG4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAG4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.490
CLV_C14_Caspase3-7	20	24	PF00656	0.606
CLV_NRD_NRD_1	161	163	PF00675	0.567
CLV_NRD_NRD_1	206	208	PF00675	0.467
CLV_NRD_NRD_1	66	68	PF00675	0.472
CLV_NRD_NRD_1	7	9	PF00675	0.515
CLV_NRD_NRD_1	73	75	PF00675	0.333
CLV_NRD_NRD_1	81	83	PF00675	0.573
CLV_PCSK_FUR_1	204	208	PF00082	0.478
CLV_PCSK_KEX2_1	160	162	PF00082	0.555
CLV_PCSK_KEX2_1	206	208	PF00082	0.467
CLV_PCSK_KEX2_1	66	68	PF00082	0.471
CLV_PCSK_KEX2_1	7	9	PF00082	0.515
CLV_PCSK_KEX2_1	81	83	PF00082	0.664
CLV_PCSK_SKI1_1	161	165	PF00082	0.542
CLV_PCSK_SKI1_1	173	177	PF00082	0.447
CLV_PCSK_SKI1_1	209	213	PF00082	0.585
CLV_PCSK_SKI1_1	217	221	PF00082	0.520
CLV_PCSK_SKI1_1	75	79	PF00082	0.507
DOC_ANK_TNKS_1	81	88	PF00023	0.583
DOC_CYCLIN_RxL_1	69	79	PF00134	0.537
DOC_MAPK_gen_1	160	172	PF00069	0.548
DOC_MAPK_MEF2A_6	165	172	PF00069	0.595
DOC_MAPK_RevD_3	51	67	PF00069	0.525
DOC_PP4_FxxP_1	114	117	PF00568	0.624
DOC_USP7_MATH_1	153	157	PF00917	0.601
DOC_USP7_MATH_1	18	22	PF00917	0.694
DOC_USP7_MATH_1	237	241	PF00917	0.623
DOC_USP7_MATH_1	243	247	PF00917	0.713
DOC_WW_Pin1_4	14	19	PF00397	0.644
DOC_WW_Pin1_4	164	169	PF00397	0.602
DOC_WW_Pin1_4	247	252	PF00397	0.582
DOC_WW_Pin1_4	254	259	PF00397	0.554
LIG_14-3-3_CanoR_1	105	114	PF00244	0.681
LIG_14-3-3_CanoR_1	136	142	PF00244	0.549
LIG_14-3-3_CanoR_1	39	49	PF00244	0.672
LIG_14-3-3_CanoR_1	7	15	PF00244	0.588
LIG_14-3-3_CterR_2	265	270	PF00244	0.589
LIG_APCC_ABBA_1	49	54	PF00400	0.603
LIG_BIR_II_1	1	5	PF00653	0.698
LIG_FHA_1	107	113	PF00498	0.691
LIG_FHA_1	165	171	PF00498	0.588
LIG_FHA_1	236	242	PF00498	0.646
LIG_FHA_1	88	94	PF00498	0.685
LIG_FHA_2	18	24	PF00498	0.606
LIG_LIR_Apic_2	10	16	PF02991	0.644
LIG_LIR_Apic_2	113	117	PF02991	0.622
LIG_LIR_Gen_1	257	267	PF02991	0.628
LIG_LIR_Nem_3	205	211	PF02991	0.473
LIG_LIR_Nem_3	257	263	PF02991	0.634
LIG_SH2_CRK	260	264	PF00017	0.593
LIG_SH2_SRC	142	145	PF00017	0.556
LIG_SH2_STAT5	218	221	PF00017	0.447
LIG_SH2_STAT5	256	259	PF00017	0.571
LIG_SH3_3	12	18	PF00018	0.611
LIG_WRC_WIRS_1	188	193	PF05994	0.533
LIG_WW_3	265	269	PF00397	0.655
MOD_CDK_SPK_2	254	259	PF00069	0.586
MOD_CK1_1	106	112	PF00069	0.629
MOD_CK1_1	17	23	PF00069	0.704
MOD_CK1_1	261	267	PF00069	0.591
MOD_CK1_1	96	102	PF00069	0.668
MOD_CK2_1	153	159	PF00069	0.495
MOD_Cter_Amidation	79	82	PF01082	0.556
MOD_GlcNHglycan	1	4	PF01048	0.652
MOD_GlcNHglycan	109	112	PF01048	0.664
MOD_GlcNHglycan	127	130	PF01048	0.692
MOD_GlcNHglycan	220	223	PF01048	0.554
MOD_GlcNHglycan	241	244	PF01048	0.677
MOD_GlcNHglycan	245	248	PF01048	0.527
MOD_GlcNHglycan	93	96	PF01048	0.644
MOD_GSK3_1	103	110	PF00069	0.593
MOD_GSK3_1	116	123	PF00069	0.608
MOD_GSK3_1	14	21	PF00069	0.704
MOD_GSK3_1	235	242	PF00069	0.583
MOD_GSK3_1	243	250	PF00069	0.685
MOD_GSK3_1	254	261	PF00069	0.595
MOD_GSK3_1	35	42	PF00069	0.617
MOD_GSK3_1	87	94	PF00069	0.624
MOD_N-GLC_1	230	235	PF02516	0.620
MOD_NEK2_1	187	192	PF00069	0.581
MOD_NEK2_1	230	235	PF00069	0.692
MOD_PIKK_1	21	27	PF00454	0.638
MOD_PIKK_1	245	251	PF00454	0.674
MOD_PKA_2	135	141	PF00069	0.588
MOD_PKA_2	21	27	PF00069	0.693
MOD_PKA_2	258	264	PF00069	0.704
MOD_PKA_2	38	44	PF00069	0.676
MOD_PKA_2	6	12	PF00069	0.649
MOD_Plk_1	182	188	PF00069	0.545
MOD_Plk_4	137	143	PF00069	0.659
MOD_Plk_4	182	188	PF00069	0.497
MOD_ProDKin_1	14	20	PF00069	0.642
MOD_ProDKin_1	164	170	PF00069	0.593
MOD_ProDKin_1	247	253	PF00069	0.587
MOD_ProDKin_1	254	260	PF00069	0.559
MOD_SUMO_for_1	45	48	PF00179	0.592
TRG_DiLeu_BaEn_1	159	164	PF01217	0.583
TRG_DiLeu_BaLyEn_6	207	212	PF01217	0.579
TRG_DiLeu_LyEn_5	159	164	PF01217	0.545
TRG_ENDOCYTIC_2	260	263	PF00928	0.597
TRG_ER_diArg_1	160	162	PF00400	0.536
TRG_ER_diArg_1	206	208	PF00400	0.467
TRG_ER_diArg_1	6	8	PF00400	0.513
TRG_Pf-PMV_PEXEL_1	209	214	PF00026	0.466
TRG_Pf-PMV_PEXEL_1	58	62	PF00026	0.549
TRG_Pf-PMV_PEXEL_1	75	79	PF00026	0.599

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P700	Leptomonas seymouri	48%	100%
A0A0S4JIE0	Bodo saltans	33%	100%
A0A1X0PA42	Trypanosomatidae	35%	100%
A0A3R7M3X3	Trypanosoma rangeli	38%	100%
A0A3S7X8G3	Leishmania donovani	100%	100%
A4HBB6	Leishmania braziliensis	69%	100%
E9B5I8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4Q2E7	Leishmania major	90%	100%