Putative expression site-associated protein 5 (ESAG5)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

expression site-associated protein 5 (ESAG5) - putative

Species:

Leishmania infantum

UniProt:

A4IAG2_LEIIN

TriTrypDb:

LINF_340047000

Length:

548

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 5
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4IAG2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAG2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	9
GO:0008289	lipid binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	172	176	PF00656	0.386
CLV_NRD_NRD_1	244	246	PF00675	0.543
CLV_NRD_NRD_1	423	425	PF00675	0.538
CLV_NRD_NRD_1	433	435	PF00675	0.642
CLV_PCSK_FUR_1	424	428	PF00082	0.488
CLV_PCSK_KEX2_1	13	15	PF00082	0.610
CLV_PCSK_KEX2_1	23	25	PF00082	0.414
CLV_PCSK_KEX2_1	236	238	PF00082	0.451
CLV_PCSK_KEX2_1	426	428	PF00082	0.561
CLV_PCSK_PC1ET2_1	13	15	PF00082	0.610
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.414
CLV_PCSK_PC1ET2_1	236	238	PF00082	0.385
CLV_PCSK_PC1ET2_1	426	428	PF00082	0.492
CLV_PCSK_SKI1_1	113	117	PF00082	0.384
CLV_PCSK_SKI1_1	151	155	PF00082	0.559
CLV_PCSK_SKI1_1	194	198	PF00082	0.438
CLV_PCSK_SKI1_1	236	240	PF00082	0.538
CLV_PCSK_SKI1_1	261	265	PF00082	0.428
CLV_PCSK_SKI1_1	434	438	PF00082	0.399
CLV_PCSK_SKI1_1	490	494	PF00082	0.567
CLV_Separin_Metazoa	242	246	PF03568	0.432
DEG_COP1_1	125	133	PF00400	0.378
DEG_COP1_1	288	298	PF00400	0.437
DEG_SPOP_SBC_1	74	78	PF00917	0.492
DOC_CYCLIN_yClb1_LxF_4	509	514	PF00134	0.468
DOC_CYCLIN_yCln2_LP_2	510	516	PF00134	0.417
DOC_MAPK_gen_1	23	31	PF00069	0.510
DOC_MAPK_gen_1	434	442	PF00069	0.410
DOC_MAPK_MEF2A_6	139	147	PF00069	0.562
DOC_MAPK_MEF2A_6	24	33	PF00069	0.601
DOC_MAPK_MEF2A_6	372	380	PF00069	0.462
DOC_MAPK_MEF2A_6	434	442	PF00069	0.415
DOC_MAPK_MEF2A_6	67	75	PF00069	0.385
DOC_PP2B_LxvP_1	510	513	PF13499	0.455
DOC_PP2B_LxvP_1	99	102	PF13499	0.508
DOC_PP2B_PxIxI_1	365	371	PF00149	0.352
DOC_PP4_FxxP_1	499	502	PF00568	0.428
DOC_SPAK_OSR1_1	257	261	PF12202	0.423
DOC_USP7_MATH_1	290	294	PF00917	0.552
DOC_USP7_MATH_1	391	395	PF00917	0.403
DOC_USP7_MATH_1	399	403	PF00917	0.477
DOC_USP7_MATH_1	69	73	PF00917	0.542
DOC_USP7_MATH_1	7	11	PF00917	0.546
DOC_USP7_MATH_1	74	78	PF00917	0.405
DOC_USP7_UBL2_3	486	490	PF12436	0.463
DOC_USP7_UBL2_3	9	13	PF12436	0.569
DOC_WW_Pin1_4	261	266	PF00397	0.387
DOC_WW_Pin1_4	286	291	PF00397	0.470
DOC_WW_Pin1_4	505	510	PF00397	0.494
LIG_14-3-3_CanoR_1	179	183	PF00244	0.447
LIG_14-3-3_CanoR_1	187	193	PF00244	0.415
LIG_14-3-3_CanoR_1	306	316	PF00244	0.440
LIG_14-3-3_CanoR_1	355	360	PF00244	0.471
LIG_14-3-3_CanoR_1	412	422	PF00244	0.509
LIG_14-3-3_CanoR_1	42	52	PF00244	0.624
LIG_14-3-3_CanoR_1	56	64	PF00244	0.601
LIG_APCC_ABBA_1	202	207	PF00400	0.395
LIG_BIR_II_1	1	5	PF00653	0.617
LIG_BRCT_BRCA1_1	1	5	PF00533	0.639
LIG_BRCT_BRCA1_1	161	165	PF00533	0.360
LIG_deltaCOP1_diTrp_1	185	192	PF00928	0.517
LIG_FHA_1	210	216	PF00498	0.503
LIG_FHA_1	222	228	PF00498	0.441
LIG_FHA_1	262	268	PF00498	0.404
LIG_FHA_1	274	280	PF00498	0.390
LIG_FHA_1	335	341	PF00498	0.443
LIG_FHA_1	483	489	PF00498	0.492
LIG_FHA_1	96	102	PF00498	0.599
LIG_FHA_2	170	176	PF00498	0.439
LIG_FHA_2	292	298	PF00498	0.533
LIG_LIR_Apic_2	498	502	PF02991	0.522
LIG_LIR_Gen_1	164	174	PF02991	0.418
LIG_LIR_Gen_1	2	11	PF02991	0.545
LIG_LIR_Gen_1	253	263	PF02991	0.435
LIG_LIR_Gen_1	460	471	PF02991	0.572
LIG_LIR_Gen_1	493	504	PF02991	0.408
LIG_LIR_Nem_3	164	169	PF02991	0.426
LIG_LIR_Nem_3	191	195	PF02991	0.490
LIG_LIR_Nem_3	198	202	PF02991	0.449
LIG_LIR_Nem_3	253	258	PF02991	0.456
LIG_LIR_Nem_3	342	347	PF02991	0.498
LIG_LIR_Nem_3	35	41	PF02991	0.502
LIG_LIR_Nem_3	416	422	PF02991	0.516
LIG_LIR_Nem_3	460	466	PF02991	0.569
LIG_LIR_Nem_3	493	499	PF02991	0.414
LIG_PCNA_yPIPBox_3	103	113	PF02747	0.322
LIG_PDZ_Class_1	543	548	PF00595	0.628
LIG_Pex14_1	188	192	PF04695	0.503
LIG_Pex14_2	79	83	PF04695	0.361
LIG_PTB_Apo_2	311	318	PF02174	0.408
LIG_PTB_Phospho_1	311	317	PF10480	0.456
LIG_REV1ctd_RIR_1	419	430	PF16727	0.396
LIG_SH2_CRK	156	160	PF00017	0.504
LIG_SH2_CRK	317	321	PF00017	0.396
LIG_SH2_NCK_1	317	321	PF00017	0.444
LIG_SH2_NCK_1	357	361	PF00017	0.435
LIG_SH2_PTP2	388	391	PF00017	0.441
LIG_SH2_STAT5	357	360	PF00017	0.444
LIG_SH2_STAT5	388	391	PF00017	0.475
LIG_SH3_3	187	193	PF00018	0.434
LIG_SUMO_SIM_par_1	218	224	PF11976	0.433
LIG_TRAF2_1	102	105	PF00917	0.479
LIG_TRFH_1	463	467	PF08558	0.433
LIG_TYR_ITIM	315	320	PF00017	0.364
LIG_TYR_ITIM	461	466	PF00017	0.452
LIG_WRC_WIRS_1	80	85	PF05994	0.367
MOD_CDC14_SPxK_1	508	511	PF00782	0.490
MOD_CDK_SPxK_1	505	511	PF00069	0.488
MOD_CK1_1	288	294	PF00069	0.471
MOD_CK1_1	394	400	PF00069	0.409
MOD_CK1_1	402	408	PF00069	0.396
MOD_CK1_1	445	451	PF00069	0.453
MOD_CK1_1	454	460	PF00069	0.531
MOD_CK2_1	165	171	PF00069	0.400
MOD_CK2_1	291	297	PF00069	0.441
MOD_CK2_1	532	538	PF00069	0.493
MOD_Cter_Amidation	11	14	PF01082	0.622
MOD_DYRK1A_RPxSP_1	261	265	PF00069	0.428
MOD_GlcNHglycan	1	4	PF01048	0.575
MOD_GlcNHglycan	161	164	PF01048	0.470
MOD_GlcNHglycan	331	334	PF01048	0.525
MOD_GlcNHglycan	34	37	PF01048	0.447
MOD_GlcNHglycan	397	400	PF01048	0.446
MOD_GlcNHglycan	415	418	PF01048	0.379
MOD_GlcNHglycan	444	447	PF01048	0.431
MOD_GlcNHglycan	453	456	PF01048	0.419
MOD_GlcNHglycan	505	508	PF01048	0.415
MOD_GlcNHglycan	67	70	PF01048	0.393
MOD_GSK3_1	120	127	PF00069	0.535
MOD_GSK3_1	161	168	PF00069	0.383
MOD_GSK3_1	207	214	PF00069	0.503
MOD_GSK3_1	286	293	PF00069	0.463
MOD_GSK3_1	304	311	PF00069	0.451
MOD_GSK3_1	390	397	PF00069	0.580
MOD_GSK3_1	398	405	PF00069	0.412
MOD_GSK3_1	453	460	PF00069	0.531
MOD_GSK3_1	65	72	PF00069	0.425
MOD_GSK3_1	75	82	PF00069	0.420
MOD_LATS_1	118	124	PF00433	0.445
MOD_N-GLC_1	147	152	PF02516	0.366
MOD_N-GLC_1	188	193	PF02516	0.508
MOD_N-GLC_1	335	340	PF02516	0.445
MOD_N-GLC_1	391	396	PF02516	0.412
MOD_N-GLC_1	451	456	PF02516	0.437
MOD_N-GLC_1	532	537	PF02516	0.539
MOD_N-GLC_1	69	74	PF02516	0.367
MOD_N-GLC_1	93	98	PF02516	0.506
MOD_NEK2_1	124	129	PF00069	0.419
MOD_NEK2_1	165	170	PF00069	0.387
MOD_NEK2_1	178	183	PF00069	0.403
MOD_NEK2_1	230	235	PF00069	0.514
MOD_NEK2_1	334	339	PF00069	0.446
MOD_NEK2_1	34	39	PF00069	0.448
MOD_NEK2_1	41	46	PF00069	0.500
MOD_NEK2_1	503	508	PF00069	0.413
MOD_NEK2_1	79	84	PF00069	0.419
MOD_PIKK_1	41	47	PF00454	0.498
MOD_PIKK_1	427	433	PF00454	0.498
MOD_PKA_1	426	432	PF00069	0.539
MOD_PKA_2	138	144	PF00069	0.517
MOD_PKA_2	159	165	PF00069	0.351
MOD_PKA_2	178	184	PF00069	0.422
MOD_PKA_2	305	311	PF00069	0.444
MOD_PKA_2	41	47	PF00069	0.512
MOD_PKA_2	426	432	PF00069	0.552
MOD_PKA_2	55	61	PF00069	0.586
MOD_Plk_1	147	153	PF00069	0.339
MOD_Plk_1	188	194	PF00069	0.385
MOD_Plk_1	335	341	PF00069	0.444
MOD_Plk_1	374	380	PF00069	0.373
MOD_Plk_1	532	538	PF00069	0.518
MOD_Plk_1	69	75	PF00069	0.368
MOD_Plk_4	132	138	PF00069	0.527
MOD_Plk_4	161	167	PF00069	0.400
MOD_Plk_4	178	184	PF00069	0.302
MOD_Plk_4	335	341	PF00069	0.398
MOD_Plk_4	34	40	PF00069	0.490
MOD_Plk_4	399	405	PF00069	0.526
MOD_Plk_4	75	81	PF00069	0.369
MOD_Plk_4	95	101	PF00069	0.564
MOD_ProDKin_1	261	267	PF00069	0.393
MOD_ProDKin_1	286	292	PF00069	0.469
MOD_ProDKin_1	505	511	PF00069	0.499
MOD_SUMO_for_1	536	539	PF00179	0.389
TRG_DiLeu_BaEn_2	225	231	PF01217	0.396
TRG_ENDOCYTIC_2	156	159	PF00928	0.513
TRG_ENDOCYTIC_2	317	320	PF00928	0.385
TRG_ENDOCYTIC_2	419	422	PF00928	0.437
TRG_ENDOCYTIC_2	463	466	PF00928	0.388
TRG_ER_diArg_1	409	412	PF00400	0.602
TRG_NLS_MonoExtN_4	424	429	PF00514	0.484
TRG_Pf-PMV_PEXEL_1	237	241	PF00026	0.486

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I082	Leptomonas seymouri	40%	98%
A0A3S5H7X9	Leishmania donovani	99%	100%
A4HBB4	Leishmania braziliensis	59%	100%
C9ZLT1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	21%	100%
E9B5I6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4Q2E9	Leishmania major	88%	100%
V5DMU0	Trypanosoma cruzi	21%	100%