Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NLI interacting factor-like phosphatase - putative

Species:

Leishmania infantum

UniProt:

A4IAG1_LEIIN

TriTrypDb:

LINF_340046900

Length:

531

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4IAG1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAG1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004721	phosphoprotein phosphatase activity	3	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	110	114	PF00656	0.602
CLV_C14_Caspase3-7	233	237	PF00656	0.576
CLV_C14_Caspase3-7	421	425	PF00656	0.620
CLV_C14_Caspase3-7	53	57	PF00656	0.551
CLV_C14_Caspase3-7	85	89	PF00656	0.627
CLV_NRD_NRD_1	147	149	PF00675	0.612
CLV_NRD_NRD_1	155	157	PF00675	0.613
CLV_NRD_NRD_1	201	203	PF00675	0.549
CLV_NRD_NRD_1	204	206	PF00675	0.530
CLV_NRD_NRD_1	208	210	PF00675	0.524
CLV_NRD_NRD_1	216	218	PF00675	0.426
CLV_NRD_NRD_1	238	240	PF00675	0.512
CLV_NRD_NRD_1	306	308	PF00675	0.299
CLV_NRD_NRD_1	38	40	PF00675	0.611
CLV_PCSK_FUR_1	316	320	PF00082	0.299
CLV_PCSK_KEX2_1	147	149	PF00082	0.616
CLV_PCSK_KEX2_1	154	156	PF00082	0.618
CLV_PCSK_KEX2_1	201	203	PF00082	0.583
CLV_PCSK_KEX2_1	208	210	PF00082	0.508
CLV_PCSK_KEX2_1	216	218	PF00082	0.389
CLV_PCSK_KEX2_1	238	240	PF00082	0.512
CLV_PCSK_KEX2_1	306	308	PF00082	0.299
CLV_PCSK_KEX2_1	318	320	PF00082	0.299
CLV_PCSK_KEX2_1	38	40	PF00082	0.611
CLV_PCSK_PC1ET2_1	318	320	PF00082	0.289
CLV_PCSK_PC7_1	234	240	PF00082	0.452
CLV_PCSK_SKI1_1	156	160	PF00082	0.605
CLV_PCSK_SKI1_1	378	382	PF00082	0.374
CLV_PCSK_SKI1_1	423	427	PF00082	0.619
CLV_Separin_Metazoa	270	274	PF03568	0.358
DEG_SPOP_SBC_1	175	179	PF00917	0.593
DEG_SPOP_SBC_1	63	67	PF00917	0.581
DEG_SPOP_SBC_1	72	76	PF00917	0.462
DOC_CYCLIN_RxL_1	375	385	PF00134	0.334
DOC_CYCLIN_RxL_1	483	493	PF00134	0.393
DOC_CYCLIN_yCln2_LP_2	219	222	PF00134	0.377
DOC_MAPK_MEF2A_6	273	282	PF00069	0.299
DOC_PP2B_LxvP_1	219	222	PF13499	0.412
DOC_PP4_FxxP_1	3	6	PF00568	0.594
DOC_USP7_MATH_1	158	162	PF00917	0.602
DOC_USP7_MATH_1	173	177	PF00917	0.595
DOC_USP7_MATH_1	210	214	PF00917	0.522
DOC_USP7_MATH_1	29	33	PF00917	0.668
DOC_USP7_MATH_1	353	357	PF00917	0.452
DOC_USP7_MATH_1	370	374	PF00917	0.207
DOC_USP7_MATH_1	392	396	PF00917	0.523
DOC_USP7_MATH_1	425	429	PF00917	0.616
DOC_USP7_MATH_1	432	436	PF00917	0.646
DOC_USP7_MATH_1	437	441	PF00917	0.400
DOC_USP7_MATH_1	510	514	PF00917	0.567
DOC_USP7_MATH_1	518	522	PF00917	0.397
DOC_WW_Pin1_4	414	419	PF00397	0.628
DOC_WW_Pin1_4	490	495	PF00397	0.366
DOC_WW_Pin1_4	6	11	PF00397	0.611
LIG_14-3-3_CanoR_1	172	182	PF00244	0.628
LIG_14-3-3_CanoR_1	322	331	PF00244	0.276
LIG_14-3-3_CanoR_1	383	387	PF00244	0.273
LIG_14-3-3_CanoR_1	393	397	PF00244	0.424
LIG_14-3-3_CanoR_1	42	50	PF00244	0.580
LIG_ActinCP_TwfCPI_2	3	12	PF01115	0.617
LIG_BIR_II_1	1	5	PF00653	0.593
LIG_Clathr_ClatBox_1	341	345	PF01394	0.358
LIG_EH1_1	455	463	PF00400	0.391
LIG_eIF4E_1	91	97	PF01652	0.518
LIG_FHA_1	177	183	PF00498	0.585
LIG_FHA_1	428	434	PF00498	0.618
LIG_FHA_1	491	497	PF00498	0.441
LIG_FHA_1	74	80	PF00498	0.500
LIG_FHA_2	419	425	PF00498	0.628
LIG_GBD_Chelix_1	246	254	PF00786	0.299
LIG_LIR_Apic_2	2	6	PF02991	0.595
LIG_LIR_Apic_2	215	221	PF02991	0.420
LIG_LIR_Apic_2	289	295	PF02991	0.358
LIG_LIR_Apic_2	362	367	PF02991	0.358
LIG_LIR_Gen_1	92	101	PF02991	0.484
LIG_LIR_Nem_3	521	525	PF02991	0.382
LIG_LIR_Nem_3	88	94	PF02991	0.593
LIG_MYND_1	494	498	PF01753	0.431
LIG_MYND_3	438	442	PF01753	0.417
LIG_NRBOX	356	362	PF00104	0.358
LIG_NRBOX	376	382	PF00104	0.183
LIG_Pex14_2	124	128	PF04695	0.622
LIG_Pex14_2	244	248	PF04695	0.299
LIG_SH2_CRK	259	263	PF00017	0.289
LIG_SH2_CRK	492	496	PF00017	0.434
LIG_SH2_CRK	522	526	PF00017	0.390
LIG_SH2_CRK	94	98	PF00017	0.551
LIG_SH2_GRB2like	292	295	PF00017	0.299
LIG_SH2_GRB2like	78	81	PF00017	0.560
LIG_SH2_NCK_1	94	98	PF00017	0.703
LIG_SH2_PTP2	292	295	PF00017	0.358
LIG_SH2_SRC	292	295	PF00017	0.299
LIG_SH2_STAP1	388	392	PF00017	0.406
LIG_SH2_STAP1	68	72	PF00017	0.522
LIG_SH2_STAP1	73	77	PF00017	0.446
LIG_SH2_STAT5	292	295	PF00017	0.299
LIG_SH2_STAT5	364	367	PF00017	0.299
LIG_SH2_STAT5	492	495	PF00017	0.423
LIG_SH2_STAT5	73	76	PF00017	0.517
LIG_SH2_STAT5	78	81	PF00017	0.502
LIG_SH3_1	492	498	PF00018	0.460
LIG_SH3_2	37	42	PF14604	0.596
LIG_SH3_3	131	137	PF00018	0.528
LIG_SH3_3	34	40	PF00018	0.591
LIG_SH3_3	49	55	PF00018	0.512
LIG_SH3_3	492	498	PF00018	0.426
LIG_SH3_3	524	530	PF00018	0.483
LIG_SUMO_SIM_anti_2	371	379	PF11976	0.355
LIG_SUMO_SIM_anti_2	440	445	PF11976	0.417
LIG_SUMO_SIM_par_1	339	345	PF11976	0.299
LIG_SUMO_SIM_par_1	371	379	PF11976	0.297
LIG_TRAF2_1	404	407	PF00917	0.562
LIG_UBA3_1	374	378	PF00899	0.358
MOD_CDC14_SPxK_1	9	12	PF00782	0.617
MOD_CDK_SPK_2	414	419	PF00069	0.628
MOD_CDK_SPxK_1	6	12	PF00069	0.614
MOD_CK1_1	108	114	PF00069	0.565
MOD_CK1_1	163	169	PF00069	0.607
MOD_CK1_1	176	182	PF00069	0.618
MOD_CK1_1	224	230	PF00069	0.461
MOD_CK1_1	428	434	PF00069	0.536
MOD_CK1_1	521	527	PF00069	0.384
MOD_CK1_1	89	95	PF00069	0.650
MOD_CK2_1	396	402	PF00069	0.479
MOD_CK2_1	84	90	PF00069	0.566
MOD_Cter_Amidation	236	239	PF01082	0.528
MOD_Cter_Amidation	304	307	PF01082	0.299
MOD_GlcNHglycan	212	215	PF01048	0.559
MOD_GlcNHglycan	223	226	PF01048	0.414
MOD_GlcNHglycan	349	352	PF01048	0.358
MOD_GlcNHglycan	402	406	PF01048	0.523
MOD_GlcNHglycan	435	438	PF01048	0.585
MOD_GlcNHglycan	84	87	PF01048	0.614
MOD_GSK3_1	105	112	PF00069	0.700
MOD_GSK3_1	158	165	PF00069	0.598
MOD_GSK3_1	171	178	PF00069	0.588
MOD_GSK3_1	180	187	PF00069	0.744
MOD_GSK3_1	224	231	PF00069	0.469
MOD_GSK3_1	392	399	PF00069	0.509
MOD_GSK3_1	414	421	PF00069	0.692
MOD_GSK3_1	423	430	PF00069	0.595
MOD_GSK3_1	433	440	PF00069	0.399
MOD_GSK3_1	6	13	PF00069	0.619
MOD_GSK3_1	62	69	PF00069	0.601
MOD_GSK3_1	82	89	PF00069	0.477
MOD_N-GLC_2	325	327	PF02516	0.299
MOD_NEK2_1	1	6	PF00069	0.597
MOD_NEK2_1	14	19	PF00069	0.593
MOD_NEK2_1	250	255	PF00069	0.299
MOD_NEK2_1	271	276	PF00069	0.358
MOD_NEK2_1	396	401	PF00069	0.467
MOD_NEK2_1	41	46	PF00069	0.621
MOD_NEK2_2	10	15	PF00069	0.634
MOD_NEK2_2	418	423	PF00069	0.622
MOD_NEK2_2	481	486	PF00069	0.412
MOD_PKA_1	147	153	PF00069	0.602
MOD_PKA_1	201	207	PF00069	0.567
MOD_PKA_2	14	20	PF00069	0.641
MOD_PKA_2	146	152	PF00069	0.612
MOD_PKA_2	171	177	PF00069	0.633
MOD_PKA_2	201	207	PF00069	0.589
MOD_PKA_2	21	27	PF00069	0.679
MOD_PKA_2	29	35	PF00069	0.578
MOD_PKA_2	382	388	PF00069	0.312
MOD_PKA_2	392	398	PF00069	0.525
MOD_PKA_2	41	47	PF00069	0.509
MOD_PKA_2	412	418	PF00069	0.505
MOD_PKA_2	428	434	PF00069	0.496
MOD_PKA_2	505	511	PF00069	0.526
MOD_Plk_1	250	256	PF00069	0.299
MOD_Plk_1	370	376	PF00069	0.299
MOD_Plk_2-3	109	115	PF00069	0.679
MOD_Plk_4	177	183	PF00069	0.585
MOD_Plk_4	250	256	PF00069	0.299
MOD_Plk_4	370	376	PF00069	0.358
MOD_Plk_4	465	471	PF00069	0.529
MOD_ProDKin_1	414	420	PF00069	0.631
MOD_ProDKin_1	490	496	PF00069	0.375
MOD_ProDKin_1	6	12	PF00069	0.614
TRG_DiLeu_BaEn_1	215	220	PF01217	0.487
TRG_DiLeu_BaEn_1	474	479	PF01217	0.418
TRG_DiLeu_BaLyEn_6	337	342	PF01217	0.253
TRG_DiLeu_BaLyEn_6	492	497	PF01217	0.426
TRG_ENDOCYTIC_2	259	262	PF00928	0.289
TRG_ENDOCYTIC_2	522	525	PF00928	0.382
TRG_ENDOCYTIC_2	94	97	PF00928	0.638
TRG_ER_diArg_1	146	148	PF00400	0.623
TRG_ER_diArg_1	154	156	PF00400	0.627
TRG_ER_diArg_1	216	218	PF00400	0.438
TRG_ER_diArg_1	37	39	PF00400	0.623
TRG_NES_CRM1_1	240	252	PF08389	0.358
TRG_NES_CRM1_1	270	281	PF08389	0.299
TRG_NES_CRM1_1	333	345	PF08389	0.358
TRG_NLS_MonoExtC_3	204	209	PF00514	0.569
TRG_NLS_MonoExtN_4	202	209	PF00514	0.568
TRG_Pf-PMV_PEXEL_1	340	345	PF00026	0.241
TRG_Pf-PMV_PEXEL_1	378	382	PF00026	0.334

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCT0	Leptomonas seymouri	54%	100%
A0A3S7X8G2	Leishmania donovani	100%	100%
A4HBB3	Leishmania braziliensis	73%	100%
E9B5I5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q2F0	Leishmania major	90%	99%