Protein-serine/threonine kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Histidine kinase- - DNA gyrase B- - and HSP90-like ATPase - putative

Species:

Leishmania infantum

UniProt:

A4IAF9_LEIIN

TriTrypDb:

LINF_340046700

Length:

501

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005759	mitochondrial matrix	5	8
GO:0031974	membrane-enclosed lumen	2	8
GO:0043233	organelle lumen	3	8
GO:0070013	intracellular organelle lumen	4	8
GO:0110165	cellular anatomical entity	1	8
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4IAF9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAF9

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	8
GO:0006796	phosphate-containing compound metabolic process	4	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0016310	phosphorylation	5	8
GO:0044237	cellular metabolic process	2	8
GO:0006109	regulation of carbohydrate metabolic process	5	1
GO:0006468	protein phosphorylation	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0010675	obsolete regulation of cellular carbohydrate metabolic process	5	1
GO:0010906	regulation of glucose metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0019538	protein metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0062012	regulation of small molecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003824	catalytic activity	1	8
GO:0004672	protein kinase activity	3	8
GO:0005488	binding	1	8
GO:0005524	ATP binding	5	8
GO:0016301	kinase activity	4	8
GO:0016740	transferase activity	2	8
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	8
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	8
GO:0017076	purine nucleotide binding	4	8
GO:0030554	adenyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032559	adenyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:0140096	catalytic activity, acting on a protein	2	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8
GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	143	147	PF00656	0.580
CLV_C14_Caspase3-7	157	161	PF00656	0.779
CLV_C14_Caspase3-7	308	312	PF00656	0.409
CLV_NRD_NRD_1	14	16	PF00675	0.604
CLV_NRD_NRD_1	261	263	PF00675	0.377
CLV_NRD_NRD_1	79	81	PF00675	0.544
CLV_PCSK_KEX2_1	14	16	PF00082	0.604
CLV_PCSK_KEX2_1	260	262	PF00082	0.378
CLV_PCSK_KEX2_1	326	328	PF00082	0.475
CLV_PCSK_PC1ET2_1	326	328	PF00082	0.475
CLV_PCSK_PC7_1	257	263	PF00082	0.437
CLV_PCSK_SKI1_1	326	330	PF00082	0.514
CLV_PCSK_SKI1_1	376	380	PF00082	0.430
DEG_SCF_FBW7_1	356	361	PF00400	0.560
DEG_SPOP_SBC_1	179	183	PF00917	0.739
DEG_SPOP_SBC_1	338	342	PF00917	0.611
DEG_SPOP_SBC_1	487	491	PF00917	0.587
DOC_CKS1_1	30	35	PF01111	0.459
DOC_CYCLIN_RxL_1	189	198	PF00134	0.689
DOC_CYCLIN_yCln2_LP_2	345	351	PF00134	0.719
DOC_MAPK_gen_1	216	225	PF00069	0.614
DOC_MAPK_gen_1	388	397	PF00069	0.380
DOC_MAPK_gen_1	476	486	PF00069	0.488
DOC_MAPK_MEF2A_6	216	225	PF00069	0.614
DOC_MAPK_MEF2A_6	388	397	PF00069	0.380
DOC_MAPK_MEF2A_6	479	486	PF00069	0.464
DOC_MAPK_NFAT4_5	218	226	PF00069	0.595
DOC_PP1_RVXF_1	259	266	PF00149	0.403
DOC_PP1_RVXF_1	472	478	PF00149	0.376
DOC_PP1_RVXF_1	84	90	PF00149	0.473
DOC_PP2B_LxvP_1	27	30	PF13499	0.517
DOC_PP2B_LxvP_1	34	37	PF13499	0.484
DOC_PP2B_PxIxI_1	390	396	PF00149	0.430
DOC_PP4_FxxP_1	70	73	PF00568	0.510
DOC_USP7_MATH_1	232	236	PF00917	0.533
DOC_USP7_MATH_1	245	249	PF00917	0.527
DOC_USP7_MATH_1	358	362	PF00917	0.492
DOC_USP7_MATH_1	4	8	PF00917	0.547
DOC_USP7_MATH_1	494	498	PF00917	0.563
DOC_USP7_UBL2_3	423	427	PF12436	0.430
DOC_USP7_UBL2_3	77	81	PF12436	0.542
DOC_WW_Pin1_4	130	135	PF00397	0.571
DOC_WW_Pin1_4	29	34	PF00397	0.453
DOC_WW_Pin1_4	340	345	PF00397	0.649
DOC_WW_Pin1_4	354	359	PF00397	0.537
LIG_14-3-3_CanoR_1	139	149	PF00244	0.522
LIG_14-3-3_CanoR_1	216	222	PF00244	0.553
LIG_14-3-3_CanoR_1	231	237	PF00244	0.334
LIG_14-3-3_CanoR_1	362	368	PF00244	0.392
LIG_14-3-3_CanoR_1	398	407	PF00244	0.478
LIG_14-3-3_CanoR_1	65	71	PF00244	0.501
LIG_Actin_WH2_2	364	382	PF00022	0.487
LIG_APCC_ABBA_1	318	323	PF00400	0.568
LIG_BIR_II_1	1	5	PF00653	0.682
LIG_deltaCOP1_diTrp_1	402	410	PF00928	0.430
LIG_FHA_1	218	224	PF00498	0.529
LIG_FHA_1	279	285	PF00498	0.528
LIG_FHA_1	287	293	PF00498	0.450
LIG_FHA_1	340	346	PF00498	0.593
LIG_FHA_1	384	390	PF00498	0.355
LIG_FHA_1	402	408	PF00498	0.316
LIG_FHA_1	447	453	PF00498	0.430
LIG_FHA_1	464	470	PF00498	0.287
LIG_FHA_2	141	147	PF00498	0.696
LIG_FHA_2	201	207	PF00498	0.610
LIG_FHA_2	30	36	PF00498	0.501
LIG_FHA_2	429	435	PF00498	0.430
LIG_GBD_Chelix_1	51	59	PF00786	0.489
LIG_LIR_Apic_2	69	73	PF02991	0.548
LIG_LIR_Gen_1	304	310	PF02991	0.459
LIG_LIR_Gen_1	402	411	PF02991	0.430
LIG_LIR_Gen_1	462	469	PF02991	0.444
LIG_LIR_Gen_1	64	75	PF02991	0.499
LIG_LIR_Nem_3	135	140	PF02991	0.656
LIG_LIR_Nem_3	147	153	PF02991	0.774
LIG_LIR_Nem_3	189	194	PF02991	0.777
LIG_LIR_Nem_3	304	309	PF02991	0.485
LIG_LIR_Nem_3	372	378	PF02991	0.399
LIG_LIR_Nem_3	402	408	PF02991	0.430
LIG_LIR_Nem_3	462	467	PF02991	0.478
LIG_LIR_Nem_3	64	70	PF02991	0.430
LIG_MYND_1	134	138	PF01753	0.634
LIG_Pex14_1	254	258	PF04695	0.415
LIG_Pex14_1	89	93	PF04695	0.480
LIG_Pex14_2	422	426	PF04695	0.430
LIG_Pex14_2	8	12	PF04695	0.660
LIG_SH2_CRK	464	468	PF00017	0.353
LIG_SH2_NCK_1	150	154	PF00017	0.708
LIG_SH2_SRC	150	153	PF00017	0.717
LIG_SH2_STAP1	436	440	PF00017	0.430
LIG_SH2_STAT5	100	103	PF00017	0.383
LIG_SH2_STAT5	26	29	PF00017	0.498
LIG_SH2_STAT5	274	277	PF00017	0.483
LIG_SH2_STAT5	373	376	PF00017	0.376
LIG_SH2_STAT5	93	96	PF00017	0.475
LIG_SH3_3	226	232	PF00018	0.390
LIG_SH3_3	27	33	PF00018	0.457
LIG_SH3_3	40	46	PF00018	0.494
LIG_SH3_3	442	448	PF00018	0.396
LIG_SH3_3	472	478	PF00018	0.376
LIG_SH3_3	481	487	PF00018	0.447
LIG_SUMO_SIM_anti_2	235	241	PF11976	0.531
LIG_SUMO_SIM_anti_2	286	296	PF11976	0.523
LIG_SUMO_SIM_anti_2	392	397	PF11976	0.404
LIG_SUMO_SIM_par_1	301	308	PF11976	0.442
LIG_SUMO_SIM_par_1	314	319	PF11976	0.464
LIG_TYR_ITIM	148	153	PF00017	0.560
LIG_WRC_WIRS_1	5	10	PF05994	0.636
LIG_WRC_WIRS_1	67	72	PF05994	0.572
MOD_CK1_1	132	138	PF00069	0.639
MOD_CK1_1	158	164	PF00069	0.789
MOD_CK1_1	181	187	PF00069	0.725
MOD_CK1_1	286	292	PF00069	0.430
MOD_CK1_1	314	320	PF00069	0.500
MOD_CK1_1	339	345	PF00069	0.587
MOD_CK1_1	401	407	PF00069	0.507
MOD_CK2_1	116	122	PF00069	0.430
MOD_CK2_1	200	206	PF00069	0.625
MOD_CK2_1	428	434	PF00069	0.410
MOD_GlcNHglycan	118	122	PF01048	0.528
MOD_GlcNHglycan	175	178	PF01048	0.742
MOD_GlcNHglycan	185	188	PF01048	0.725
MOD_GlcNHglycan	496	499	PF01048	0.568
MOD_GSK3_1	140	147	PF00069	0.625
MOD_GSK3_1	152	159	PF00069	0.512
MOD_GSK3_1	178	185	PF00069	0.684
MOD_GSK3_1	217	224	PF00069	0.515
MOD_GSK3_1	333	340	PF00069	0.486
MOD_GSK3_1	354	361	PF00069	0.481
MOD_GSK3_1	4	11	PF00069	0.634
MOD_N-GLC_1	144	149	PF02516	0.514
MOD_N-GLC_1	311	316	PF02516	0.495
MOD_N-GLC_2	381	383	PF02516	0.430
MOD_N-GLC_2	99	101	PF02516	0.466
MOD_NEK2_1	273	278	PF00069	0.556
MOD_NEK2_1	337	342	PF00069	0.468
MOD_NEK2_1	428	433	PF00069	0.376
MOD_NEK2_1	8	13	PF00069	0.728
MOD_NEK2_2	383	388	PF00069	0.501
MOD_PIKK_1	278	284	PF00454	0.606
MOD_PKA_2	140	146	PF00069	0.586
MOD_PKA_2	61	67	PF00069	0.465
MOD_Plk_1	144	150	PF00069	0.683
MOD_Plk_1	171	177	PF00069	0.603
MOD_Plk_1	401	407	PF00069	0.453
MOD_Plk_1	469	475	PF00069	0.509
MOD_Plk_4	132	138	PF00069	0.692
MOD_Plk_4	144	150	PF00069	0.562
MOD_Plk_4	232	238	PF00069	0.572
MOD_Plk_4	305	311	PF00069	0.548
MOD_Plk_4	333	339	PF00069	0.399
MOD_Plk_4	369	375	PF00069	0.452
MOD_Plk_4	401	407	PF00069	0.462
MOD_Plk_4	89	95	PF00069	0.465
MOD_ProDKin_1	130	136	PF00069	0.568
MOD_ProDKin_1	29	35	PF00069	0.455
MOD_ProDKin_1	340	346	PF00069	0.651
MOD_ProDKin_1	354	360	PF00069	0.535
MOD_SUMO_rev_2	319	328	PF00179	0.556
TRG_DiLeu_BaEn_3	323	329	PF01217	0.497
TRG_ENDOCYTIC_2	150	153	PF00928	0.574
TRG_ENDOCYTIC_2	26	29	PF00928	0.498
TRG_ENDOCYTIC_2	453	456	PF00928	0.376
TRG_ENDOCYTIC_2	464	467	PF00928	0.376
TRG_ENDOCYTIC_2	67	70	PF00928	0.437
TRG_ER_diArg_1	138	141	PF00400	0.474
TRG_ER_diArg_1	14	16	PF00400	0.673
TRG_ER_diArg_1	260	262	PF00400	0.408
TRG_ER_diArg_1	473	476	PF00400	0.430
TRG_Pf-PMV_PEXEL_1	106	110	PF00026	0.585
TRG_Pf-PMV_PEXEL_1	266	270	PF00026	0.404

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P768	Leptomonas seymouri	57%	100%
A0A1X0PBH1	Trypanosomatidae	37%	100%
A0A3Q8III9	Leishmania donovani	100%	100%
A4HBB1	Leishmania braziliensis	82%	100%
E9B5I3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q2F2	Leishmania major	91%	100%