LeishMANIAdb
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Transmembrane protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Transmembrane protein
Gene product:
hypothetical protein - conserved
Species:
Leishmania infantum
UniProt:
A4IAF8_LEIIN
TriTrypDb:
LINF_340046600
Length:
304

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0020022 acidocalcisome 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

A4IAF8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAF8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 122 124 PF00675 0.579
CLV_NRD_NRD_1 21 23 PF00675 0.361
CLV_NRD_NRD_1 84 86 PF00675 0.582
CLV_PCSK_KEX2_1 122 124 PF00082 0.579
CLV_PCSK_KEX2_1 21 23 PF00082 0.362
CLV_PCSK_KEX2_1 83 85 PF00082 0.572
CLV_PCSK_PC1ET2_1 83 85 PF00082 0.587
CLV_PCSK_SKI1_1 134 138 PF00082 0.575
CLV_PCSK_SKI1_1 14 18 PF00082 0.321
CLV_PCSK_SKI1_1 22 26 PF00082 0.302
CLV_PCSK_SKI1_1 256 260 PF00082 0.493
DEG_APCC_DBOX_1 277 285 PF00400 0.316
DEG_SPOP_SBC_1 290 294 PF00917 0.319
DOC_MAPK_gen_1 21 29 PF00069 0.485
DOC_MAPK_gen_1 83 90 PF00069 0.415
DOC_USP7_MATH_1 290 294 PF00917 0.444
DOC_WW_Pin1_4 231 236 PF00397 0.365
DOC_WW_Pin1_4 248 253 PF00397 0.463
LIG_14-3-3_CanoR_1 122 129 PF00244 0.398
LIG_14-3-3_CanoR_1 159 163 PF00244 0.362
LIG_14-3-3_CanoR_1 189 194 PF00244 0.301
LIG_14-3-3_CanoR_1 21 27 PF00244 0.478
LIG_14-3-3_CanoR_1 256 265 PF00244 0.325
LIG_CaM_IQ_9 270 285 PF13499 0.314
LIG_FHA_1 107 113 PF00498 0.413
LIG_FHA_1 159 165 PF00498 0.389
LIG_FHA_1 208 214 PF00498 0.389
LIG_FHA_1 23 29 PF00498 0.337
LIG_FHA_1 259 265 PF00498 0.318
LIG_FHA_2 77 83 PF00498 0.260
LIG_GBD_Chelix_1 73 81 PF00786 0.514
LIG_LIR_Gen_1 156 164 PF02991 0.364
LIG_LIR_Gen_1 25 34 PF02991 0.286
LIG_LIR_Gen_1 40 49 PF02991 0.580
LIG_LIR_Gen_1 57 66 PF02991 0.405
LIG_LIR_Nem_3 143 147 PF02991 0.379
LIG_LIR_Nem_3 156 160 PF02991 0.297
LIG_LIR_Nem_3 198 203 PF02991 0.319
LIG_LIR_Nem_3 25 29 PF02991 0.286
LIG_LIR_Nem_3 251 257 PF02991 0.344
LIG_LIR_Nem_3 40 44 PF02991 0.524
LIG_LYPXL_yS_3 144 147 PF13949 0.407
LIG_PCNA_yPIPBox_3 14 27 PF02747 0.540
LIG_Pex14_2 26 30 PF04695 0.284
LIG_PTB_Apo_2 151 158 PF02174 0.326
LIG_PTB_Phospho_1 151 157 PF10480 0.332
LIG_SH2_GRB2like 230 233 PF00017 0.401
LIG_SH2_NCK_1 157 161 PF00017 0.318
LIG_SH2_STAP1 131 135 PF00017 0.280
LIG_SH2_STAT5 10 13 PF00017 0.589
LIG_SH2_STAT5 176 179 PF00017 0.387
LIG_SH2_STAT5 221 224 PF00017 0.390
LIG_SH2_STAT5 230 233 PF00017 0.406
LIG_SUMO_SIM_anti_2 31 36 PF11976 0.353
LIG_SUMO_SIM_par_1 269 276 PF11976 0.394
LIG_TYR_ITIM 155 160 PF00017 0.371
LIG_WRC_WIRS_1 23 28 PF05994 0.303
LIG_WRC_WIRS_1 38 43 PF05994 0.405
MOD_CK1_1 124 130 PF00069 0.432
MOD_CK1_1 181 187 PF00069 0.356
MOD_CK1_1 272 278 PF00069 0.396
MOD_CK2_1 273 279 PF00069 0.386
MOD_CK2_1 65 71 PF00069 0.350
MOD_CK2_1 76 82 PF00069 0.252
MOD_GlcNHglycan 217 220 PF01048 0.608
MOD_GSK3_1 165 172 PF00069 0.362
MOD_GSK3_1 177 184 PF00069 0.280
MOD_GSK3_1 191 198 PF00069 0.335
MOD_GSK3_1 207 214 PF00069 0.339
MOD_GSK3_1 215 222 PF00069 0.341
MOD_GSK3_1 244 251 PF00069 0.464
MOD_GSK3_1 269 276 PF00069 0.382
MOD_GSK3_1 72 79 PF00069 0.430
MOD_N-GLC_1 170 175 PF02516 0.624
MOD_N-GLC_1 231 236 PF02516 0.578
MOD_N-GLC_1 288 293 PF02516 0.634
MOD_NEK2_1 106 111 PF00069 0.282
MOD_NEK2_1 140 145 PF00069 0.338
MOD_NEK2_1 169 174 PF00069 0.373
MOD_NEK2_1 177 182 PF00069 0.305
MOD_NEK2_1 273 278 PF00069 0.359
MOD_NEK2_1 28 33 PF00069 0.307
MOD_NEK2_1 37 42 PF00069 0.239
MOD_OFUCOSY 288 295 PF10250 0.543
MOD_PIKK_1 191 197 PF00454 0.363
MOD_PIKK_1 224 230 PF00454 0.316
MOD_PIKK_1 258 264 PF00454 0.376
MOD_PKA_2 121 127 PF00069 0.336
MOD_PKA_2 158 164 PF00069 0.340
MOD_PKA_2 188 194 PF00069 0.303
MOD_PKA_2 211 217 PF00069 0.409
MOD_Plk_1 14 20 PF00069 0.564
MOD_Plk_1 170 176 PF00069 0.399
MOD_Plk_4 14 20 PF00069 0.630
MOD_Plk_4 165 171 PF00069 0.405
MOD_Plk_4 178 184 PF00069 0.312
MOD_Plk_4 195 201 PF00069 0.282
MOD_Plk_4 22 28 PF00069 0.375
MOD_Plk_4 76 82 PF00069 0.412
MOD_Plk_4 96 102 PF00069 0.398
MOD_ProDKin_1 231 237 PF00069 0.365
MOD_ProDKin_1 248 254 PF00069 0.454
TRG_ENDOCYTIC_2 144 147 PF00928 0.380
TRG_ENDOCYTIC_2 157 160 PF00928 0.286
TRG_ER_diArg_1 121 123 PF00400 0.352
TRG_ER_diArg_1 21 23 PF00400 0.604
TRG_ER_diArg_1 238 241 PF00400 0.233

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I5I4 Leptomonas seymouri 61% 100%
A0A0S4JKH0 Bodo saltans 24% 100%
A0A1X0PA82 Trypanosomatidae 35% 100%
A0A3S7X8F5 Leishmania donovani 100% 100%
A0A422NSU6 Trypanosoma rangeli 30% 100%
A4HBB0 Leishmania braziliensis 76% 100%
C9ZLT6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 30% 100%
E9B5I2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 89% 100%
Q4Q2F3 Leishmania major 93% 100%
V5B695 Trypanosoma cruzi 31% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS