J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein - putative

Species:

Leishmania infantum

UniProt:

A4IAF6_LEIIN

TriTrypDb:

LINF_340046400

Length:

780

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4IAF6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAF6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	628	634	PF00089	0.620
CLV_NRD_NRD_1	130	132	PF00675	0.621
CLV_NRD_NRD_1	173	175	PF00675	0.746
CLV_NRD_NRD_1	399	401	PF00675	0.628
CLV_NRD_NRD_1	686	688	PF00675	0.758
CLV_NRD_NRD_1	692	694	PF00675	0.706
CLV_NRD_NRD_1	724	726	PF00675	0.601
CLV_NRD_NRD_1	727	729	PF00675	0.611
CLV_NRD_NRD_1	746	748	PF00675	0.448
CLV_PCSK_FUR_1	725	729	PF00082	0.524
CLV_PCSK_KEX2_1	130	132	PF00082	0.621
CLV_PCSK_KEX2_1	399	401	PF00082	0.600
CLV_PCSK_KEX2_1	656	658	PF00082	0.686
CLV_PCSK_KEX2_1	686	688	PF00082	0.795
CLV_PCSK_KEX2_1	723	725	PF00082	0.604
CLV_PCSK_KEX2_1	727	729	PF00082	0.610
CLV_PCSK_KEX2_1	746	748	PF00082	0.448
CLV_PCSK_PC1ET2_1	656	658	PF00082	0.708
CLV_PCSK_PC7_1	723	729	PF00082	0.524
CLV_PCSK_SKI1_1	40	44	PF00082	0.543
CLV_PCSK_SKI1_1	441	445	PF00082	0.605
CLV_PCSK_SKI1_1	693	697	PF00082	0.687
CLV_PCSK_SKI1_1	727	731	PF00082	0.552
CLV_PCSK_SKI1_1	747	751	PF00082	0.588
CLV_Separin_Metazoa	552	556	PF03568	0.462
DEG_Nend_Nbox_1	1	3	PF02207	0.497
DEG_SPOP_SBC_1	204	208	PF00917	0.479
DEG_SPOP_SBC_1	479	483	PF00917	0.420
DOC_CDC14_PxL_1	370	378	PF14671	0.354
DOC_CKS1_1	419	424	PF01111	0.383
DOC_CYCLIN_RxL_1	503	513	PF00134	0.453
DOC_CYCLIN_yClb3_PxF_3	374	382	PF00134	0.358
DOC_CYCLIN_yCln2_LP_2	141	147	PF00134	0.526
DOC_CYCLIN_yCln2_LP_2	191	197	PF00134	0.555
DOC_CYCLIN_yCln2_LP_2	443	449	PF00134	0.462
DOC_MAPK_DCC_7	368	378	PF00069	0.366
DOC_MAPK_gen_1	130	138	PF00069	0.373
DOC_MAPK_gen_1	174	182	PF00069	0.528
DOC_MAPK_gen_1	723	733	PF00069	0.356
DOC_MAPK_MEF2A_6	130	138	PF00069	0.498
DOC_MAPK_MEF2A_6	246	254	PF00069	0.381
DOC_MAPK_MEF2A_6	724	733	PF00069	0.351
DOC_MAPK_MEF2A_6	74	81	PF00069	0.299
DOC_MAPK_NFAT4_5	74	82	PF00069	0.287
DOC_PP1_RVXF_1	176	183	PF00149	0.529
DOC_PP2B_LxvP_1	141	144	PF13499	0.512
DOC_PP2B_LxvP_1	443	446	PF13499	0.469
DOC_PP2B_LxvP_1	554	557	PF13499	0.415
DOC_PP2B_LxvP_1	61	64	PF13499	0.618
DOC_PP2B_LxvP_1	79	82	PF13499	0.182
DOC_USP7_MATH_1	160	164	PF00917	0.490
DOC_USP7_MATH_1	197	201	PF00917	0.601
DOC_USP7_MATH_1	486	490	PF00917	0.332
DOC_USP7_MATH_1	536	540	PF00917	0.425
DOC_USP7_MATH_1	610	614	PF00917	0.420
DOC_USP7_MATH_1	64	68	PF00917	0.475
DOC_USP7_MATH_1	667	671	PF00917	0.520
DOC_USP7_MATH_1	672	676	PF00917	0.525
DOC_USP7_MATH_1	677	681	PF00917	0.505
DOC_USP7_MATH_1	741	745	PF00917	0.351
DOC_USP7_MATH_1	9	13	PF00917	0.410
DOC_USP7_MATH_2	456	462	PF00917	0.355
DOC_WW_Pin1_4	130	135	PF00397	0.564
DOC_WW_Pin1_4	173	178	PF00397	0.576
DOC_WW_Pin1_4	199	204	PF00397	0.525
DOC_WW_Pin1_4	362	367	PF00397	0.474
DOC_WW_Pin1_4	418	423	PF00397	0.441
DOC_WW_Pin1_4	508	513	PF00397	0.411
DOC_WW_Pin1_4	673	678	PF00397	0.480
LIG_14-3-3_CanoR_1	105	113	PF00244	0.438
LIG_14-3-3_CanoR_1	122	129	PF00244	0.540
LIG_14-3-3_CanoR_1	284	290	PF00244	0.354
LIG_14-3-3_CanoR_1	657	661	PF00244	0.465
LIG_14-3-3_CanoR_1	693	702	PF00244	0.514
LIG_14-3-3_CanoR_1	727	732	PF00244	0.390
LIG_14-3-3_CanoR_1	769	773	PF00244	0.391
LIG_Actin_WH2_2	496	511	PF00022	0.393
LIG_APCC_ABBA_1	731	736	PF00400	0.351
LIG_BRCT_BRCA1_1	201	205	PF00533	0.517
LIG_BRCT_BRCA1_1	366	370	PF00533	0.566
LIG_BRCT_BRCA1_1	61	65	PF00533	0.454
LIG_CtBP_PxDLS_1	701	705	PF00389	0.409
LIG_eIF4E_1	514	520	PF01652	0.397
LIG_EVH1_1	451	455	PF00568	0.409
LIG_FHA_1	205	211	PF00498	0.506
LIG_FHA_1	21	27	PF00498	0.295
LIG_FHA_1	216	222	PF00498	0.481
LIG_FHA_1	235	241	PF00498	0.449
LIG_FHA_1	300	306	PF00498	0.455
LIG_FHA_1	460	466	PF00498	0.462
LIG_FHA_1	480	486	PF00498	0.419
LIG_FHA_1	558	564	PF00498	0.450
LIG_FHA_1	728	734	PF00498	0.351
LIG_FHA_1	99	105	PF00498	0.455
LIG_FHA_2	135	141	PF00498	0.496
LIG_FHA_2	174	180	PF00498	0.548
LIG_FHA_2	379	385	PF00498	0.417
LIG_FHA_2	694	700	PF00498	0.570
LIG_FHA_2	704	710	PF00498	0.372
LIG_GBD_Chelix_1	331	339	PF00786	0.633
LIG_LIR_Gen_1	23	32	PF02991	0.249
LIG_LIR_Gen_1	288	294	PF02991	0.435
LIG_LIR_Gen_1	494	504	PF02991	0.395
LIG_LIR_Gen_1	607	616	PF02991	0.467
LIG_LIR_Gen_1	706	713	PF02991	0.338
LIG_LIR_Gen_1	751	760	PF02991	0.371
LIG_LIR_Nem_3	23	27	PF02991	0.249
LIG_LIR_Nem_3	288	292	PF02991	0.415
LIG_LIR_Nem_3	367	373	PF02991	0.535
LIG_LIR_Nem_3	494	499	PF02991	0.407
LIG_LIR_Nem_3	706	711	PF02991	0.338
LIG_LIR_Nem_3	751	756	PF02991	0.327
LIG_MYND_1	139	143	PF01753	0.456
LIG_NRBOX	29	35	PF00104	0.249
LIG_PCNA_yPIPBox_3	330	340	PF02747	0.424
LIG_PCNA_yPIPBox_3	626	636	PF02747	0.419
LIG_Pex14_2	523	527	PF04695	0.384
LIG_Rb_pABgroove_1	630	638	PF01858	0.418
LIG_SH2_CRK	10	14	PF00017	0.440
LIG_SH2_CRK	289	293	PF00017	0.400
LIG_SH2_CRK	708	712	PF00017	0.303
LIG_SH2_CRK	726	730	PF00017	0.375
LIG_SH2_CRK	760	764	PF00017	0.317
LIG_SH2_GRB2like	496	499	PF00017	0.408
LIG_SH2_NCK_1	345	349	PF00017	0.375
LIG_SH2_NCK_1	646	650	PF00017	0.396
LIG_SH2_PTP2	249	252	PF00017	0.444
LIG_SH2_SRC	249	252	PF00017	0.444
LIG_SH2_SRC	496	499	PF00017	0.408
LIG_SH2_SRC	514	517	PF00017	0.396
LIG_SH2_STAP1	345	349	PF00017	0.429
LIG_SH2_STAP1	69	73	PF00017	0.249
LIG_SH2_STAT5	10	13	PF00017	0.433
LIG_SH2_STAT5	24	27	PF00017	0.192
LIG_SH2_STAT5	249	252	PF00017	0.393
LIG_SH2_STAT5	253	256	PF00017	0.363
LIG_SH2_STAT5	447	450	PF00017	0.371
LIG_SH2_STAT5	478	481	PF00017	0.337
LIG_SH2_STAT5	496	499	PF00017	0.369
LIG_SH2_STAT5	568	571	PF00017	0.438
LIG_SH3_2	194	199	PF14604	0.533
LIG_SH3_3	133	139	PF00018	0.469
LIG_SH3_3	140	146	PF00018	0.446
LIG_SH3_3	177	183	PF00018	0.589
LIG_SH3_3	186	192	PF00018	0.541
LIG_SH3_3	222	228	PF00018	0.472
LIG_SH3_3	371	377	PF00018	0.437
LIG_SH3_3	449	455	PF00018	0.413
LIG_SUMO_SIM_anti_2	83	88	PF11976	0.307
LIG_SUMO_SIM_par_1	83	88	PF11976	0.307
LIG_TRFH_1	193	197	PF08558	0.561
LIG_TYR_ITIM	8	13	PF00017	0.409
LIG_WRC_WIRS_1	389	394	PF05994	0.448
LIG_WRC_WIRS_1	524	529	PF05994	0.391
MOD_CDK_SPK_2	173	178	PF00069	0.576
MOD_CDK_SPK_2	673	678	PF00069	0.454
MOD_CDK_SPxK_1	362	368	PF00069	0.445
MOD_CK1_1	150	156	PF00069	0.521
MOD_CK1_1	242	248	PF00069	0.421
MOD_CK1_1	258	264	PF00069	0.491
MOD_CK1_1	315	321	PF00069	0.547
MOD_CK1_1	354	360	PF00069	0.454
MOD_CK1_1	388	394	PF00069	0.397
MOD_CK1_1	410	416	PF00069	0.321
MOD_CK1_1	489	495	PF00069	0.433
MOD_CK1_1	665	671	PF00069	0.568
MOD_CK1_1	680	686	PF00069	0.439
MOD_CK1_1	703	709	PF00069	0.380
MOD_CK1_1	715	721	PF00069	0.243
MOD_CK1_1	761	767	PF00069	0.322
MOD_CK1_1	98	104	PF00069	0.545
MOD_CK2_1	134	140	PF00069	0.507
MOD_CK2_1	173	179	PF00069	0.544
MOD_CK2_1	447	453	PF00069	0.461
MOD_CK2_1	673	679	PF00069	0.525
MOD_CK2_1	693	699	PF00069	0.549
MOD_CK2_1	715	721	PF00069	0.310
MOD_GlcNHglycan	106	109	PF01048	0.747
MOD_GlcNHglycan	149	152	PF01048	0.793
MOD_GlcNHglycan	359	362	PF01048	0.639
MOD_GlcNHglycan	491	494	PF01048	0.619
MOD_GlcNHglycan	499	502	PF01048	0.552
MOD_GlcNHglycan	538	541	PF01048	0.640
MOD_GlcNHglycan	658	661	PF01048	0.700
MOD_GlcNHglycan	667	670	PF01048	0.724
MOD_GlcNHglycan	687	690	PF01048	0.810
MOD_GlcNHglycan	717	720	PF01048	0.454
MOD_GSK3_1	130	137	PF00069	0.577
MOD_GSK3_1	199	206	PF00069	0.608
MOD_GSK3_1	254	261	PF00069	0.423
MOD_GSK3_1	312	319	PF00069	0.468
MOD_GSK3_1	378	385	PF00069	0.357
MOD_GSK3_1	409	416	PF00069	0.453
MOD_GSK3_1	673	680	PF00069	0.502
MOD_GSK3_1	711	718	PF00069	0.382
MOD_GSK3_1	92	99	PF00069	0.558
MOD_N-GLC_1	497	502	PF02516	0.649
MOD_N-GLC_1	715	720	PF02516	0.551
MOD_NEK2_1	205	210	PF00069	0.582
MOD_NEK2_1	234	239	PF00069	0.528
MOD_NEK2_1	254	259	PF00069	0.349
MOD_NEK2_1	351	356	PF00069	0.437
MOD_NEK2_1	378	383	PF00069	0.420
MOD_NEK2_1	480	485	PF00069	0.396
MOD_NEK2_1	491	496	PF00069	0.354
MOD_NEK2_1	497	502	PF00069	0.308
MOD_NEK2_1	56	61	PF00069	0.697
MOD_NEK2_1	569	574	PF00069	0.347
MOD_NEK2_1	622	627	PF00069	0.324
MOD_NEK2_1	65	70	PF00069	0.308
MOD_NEK2_1	711	716	PF00069	0.351
MOD_NEK2_1	763	768	PF00069	0.351
MOD_NEK2_1	85	90	PF00069	0.494
MOD_NEK2_2	22	27	PF00069	0.179
MOD_NEK2_2	9	14	PF00069	0.397
MOD_PIKK_1	569	575	PF00454	0.381
MOD_PIKK_1	763	769	PF00454	0.351
MOD_PK_1	545	551	PF00069	0.452
MOD_PKA_1	656	662	PF00069	0.522
MOD_PKA_1	693	699	PF00069	0.483
MOD_PKA_1	727	733	PF00069	0.324
MOD_PKA_2	656	662	PF00069	0.464
MOD_PKA_2	677	683	PF00069	0.562
MOD_PKA_2	685	691	PF00069	0.589
MOD_PKA_2	727	733	PF00069	0.386
MOD_PKA_2	768	774	PF00069	0.386
MOD_PKA_2	92	98	PF00069	0.553
MOD_PKA_2	99	105	PF00069	0.533
MOD_PKB_1	691	699	PF00069	0.457
MOD_PKB_1	725	733	PF00069	0.379
MOD_Plk_1	160	166	PF00069	0.562
MOD_Plk_1	313	319	PF00069	0.483
MOD_Plk_1	557	563	PF00069	0.412
MOD_Plk_4	215	221	PF00069	0.622
MOD_Plk_4	22	28	PF00069	0.202
MOD_Plk_4	239	245	PF00069	0.500
MOD_Plk_4	255	261	PF00069	0.410
MOD_Plk_4	354	360	PF00069	0.378
MOD_Plk_4	413	419	PF00069	0.388
MOD_Plk_4	480	486	PF00069	0.350
MOD_Plk_4	758	764	PF00069	0.356
MOD_Plk_4	80	86	PF00069	0.416
MOD_Plk_4	9	15	PF00069	0.396
MOD_ProDKin_1	130	136	PF00069	0.555
MOD_ProDKin_1	173	179	PF00069	0.578
MOD_ProDKin_1	199	205	PF00069	0.525
MOD_ProDKin_1	362	368	PF00069	0.473
MOD_ProDKin_1	418	424	PF00069	0.438
MOD_ProDKin_1	508	514	PF00069	0.408
MOD_ProDKin_1	673	679	PF00069	0.481
MOD_SUMO_rev_2	433	440	PF00179	0.453
MOD_SUMO_rev_2	688	696	PF00179	0.497
TRG_DiLeu_BaEn_1	558	563	PF01217	0.453
TRG_DiLeu_BaEn_1	751	756	PF01217	0.407
TRG_DiLeu_BaLyEn_6	51	56	PF01217	0.611
TRG_ENDOCYTIC_2	10	13	PF00928	0.411
TRG_ENDOCYTIC_2	24	27	PF00928	0.180
TRG_ENDOCYTIC_2	249	252	PF00928	0.393
TRG_ENDOCYTIC_2	289	292	PF00928	0.395
TRG_ENDOCYTIC_2	308	311	PF00928	0.476
TRG_ENDOCYTIC_2	496	499	PF00928	0.403
TRG_ENDOCYTIC_2	708	711	PF00928	0.338
TRG_ENDOCYTIC_2	726	729	PF00928	0.317
TRG_ENDOCYTIC_2	760	763	PF00928	0.317
TRG_ER_diArg_1	129	131	PF00400	0.418
TRG_ER_diArg_1	399	401	PF00400	0.430
TRG_ER_diArg_1	602	605	PF00400	0.378
TRG_ER_diArg_1	643	646	PF00400	0.476
TRG_ER_diArg_1	722	725	PF00400	0.356
TRG_ER_diArg_1	726	728	PF00400	0.356
TRG_Pf-PMV_PEXEL_1	122	126	PF00026	0.693
TRG_Pf-PMV_PEXEL_1	309	314	PF00026	0.651
TRG_Pf-PMV_PEXEL_1	342	347	PF00026	0.609
TRG_Pf-PMV_PEXEL_1	727	732	PF00026	0.579

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD42	Leptomonas seymouri	44%	100%
A0A0S4KK52	Bodo saltans	22%	78%
A0A3S7X8I0	Leishmania donovani	99%	100%
A4HBA8	Leishmania braziliensis	68%	100%
E9B5I0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q2F5	Leishmania major	86%	100%