LeishMANIAdb
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Small nuclear ribonucleoprotein Sm D3

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Small nuclear ribonucleoprotein Sm D3
Gene product:
small nuclear ribonucleoprotein - putative
Species:
Leishmania infantum
UniProt:
A4IAF5_LEIIN
TriTrypDb:
LINF_340046300
Length:
113

Annotations

Annotations by Jardim et al.

Nucleic acid binding, small nuclear ribonucleo

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005681 spliceosomal complex 3 10
GO:0005829 cytosol 2 10
GO:0032991 protein-containing complex 1 11
GO:0110165 cellular anatomical entity 1 11
GO:0140513 nuclear protein-containing complex 2 10
GO:1990904 ribonucleoprotein complex 2 11
GO:0000243 commitment complex 5 1
GO:0005682 U5 snRNP 5 1
GO:0005684 U2-type spliceosomal complex 4 1
GO:0005685 U1 snRNP 5 1
GO:0005686 U2 snRNP 5 1
GO:0005687 U4 snRNP 5 1
GO:0005689 U12-type spliceosomal complex 4 1
GO:0005730 nucleolus 5 1
GO:0030532 small nuclear ribonucleoprotein complex 3 1
GO:0034715 pICln-Sm protein complex 3 1
GO:0034719 SMN-Sm protein complex 3 1
GO:0043226 organelle 2 2
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 2
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0071011 precatalytic spliceosome 4 1
GO:0071013 catalytic step 2 spliceosome 3 1
GO:0071024 SL snRNP 5 1
GO:0097525 spliceosomal snRNP complex 4 1
GO:0097526 spliceosomal tri-snRNP complex 5 1
GO:0120114 Sm-like protein family complex 2 1
GO:1902494 catalytic complex 2 1
GO:0005634 nucleus 5 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4IAF5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAF5

Function

Biological processes
Term Name Level Count
GO:0000387 spliceosomal snRNP assembly 7 10
GO:0009987 cellular process 1 11
GO:0016043 cellular component organization 3 10
GO:0022607 cellular component assembly 4 10
GO:0022618 ribonucleoprotein complex assembly 6 10
GO:0043933 protein-containing complex organization 4 10
GO:0065003 protein-containing complex assembly 5 10
GO:0071826 ribonucleoprotein complex subunit organization 5 10
GO:0071840 cellular component organization or biogenesis 2 10
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006396 RNA processing 6 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008152 metabolic process 1 1
GO:0016070 RNA metabolic process 5 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0043170 macromolecule metabolic process 3 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0046483 heterocycle metabolic process 3 1
GO:0071704 organic substance metabolic process 2 1
GO:0090304 nucleic acid metabolic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 1
GO:0003723 RNA binding 4 1
GO:0005488 binding 1 1
GO:0097159 organic cyclic compound binding 2 1
GO:1901363 heterocyclic compound binding 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 56 60 PF00656 0.427
CLV_C14_Caspase3-7 96 100 PF00656 0.509
CLV_NRD_NRD_1 106 108 PF00675 0.481
CLV_PCSK_KEX2_1 108 110 PF00082 0.488
CLV_PCSK_PC1ET2_1 108 110 PF00082 0.491
CLV_PCSK_SKI1_1 44 48 PF00082 0.267
CLV_PCSK_SKI1_1 8 12 PF00082 0.273
DOC_CYCLIN_RxL_1 5 12 PF00134 0.280
DOC_MAPK_gen_1 54 63 PF00069 0.467
DOC_PP1_RVXF_1 6 12 PF00149 0.302
DOC_PP4_FxxP_1 71 74 PF00568 0.426
DOC_USP7_UBL2_3 44 48 PF12436 0.411
DOC_WW_Pin1_4 77 82 PF00397 0.327
LIG_14-3-3_CterR_2 109 113 PF00244 0.584
LIG_Actin_WH2_2 2 19 PF00022 0.428
LIG_Actin_WH2_2 28 46 PF00022 0.467
LIG_Actin_WH2_2 70 87 PF00022 0.505
LIG_BIR_II_1 1 5 PF00653 0.387
LIG_FHA_1 22 28 PF00498 0.423
LIG_FHA_2 29 35 PF00498 0.372
LIG_FHA_2 54 60 PF00498 0.427
LIG_FHA_2 94 100 PF00498 0.541
LIG_Integrin_RGD_1 97 99 PF01839 0.499
LIG_Rb_pABgroove_1 5 13 PF01858 0.311
LIG_TRAF2_1 31 34 PF00917 0.393
LIG_UBA3_1 10 17 PF00899 0.262
MOD_CK2_1 28 34 PF00069 0.409
MOD_GSK3_1 53 60 PF00069 0.437
MOD_NEK2_1 1 6 PF00069 0.489
MOD_NEK2_1 103 108 PF00069 0.554
MOD_PK_1 57 63 PF00069 0.441
MOD_PKA_2 63 69 PF00069 0.404
MOD_Plk_4 57 63 PF00069 0.408
MOD_ProDKin_1 77 83 PF00069 0.331
MOD_SUMO_rev_2 95 103 PF00179 0.468
TRG_NLS_MonoExtC_3 106 111 PF00514 0.499
TRG_NLS_MonoExtN_4 107 112 PF00514 0.493

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HYK5 Leptomonas seymouri 86% 100%
A0A0S4KRF8 Bodo saltans 50% 90%
A0A1X0PAE8 Trypanosomatidae 65% 98%
A0A3Q8IKS2 Leishmania donovani 33% 97%
A0A3S7X8L1 Leishmania donovani 99% 100%
A0A3S7XAB5 Leishmania donovani 32% 80%
A0A422NSZ6 Trypanosoma rangeli 60% 98%
A4HBA7 Leishmania braziliensis 95% 100%
A4HK52 Leishmania braziliensis 32% 100%
A4HNR2 Leishmania braziliensis 34% 80%
A4ICT3 Leishmania infantum 32% 80%
C9ZLT9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 51% 98%
E9B5H9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 97% 100%
O44437 Drosophila melanogaster 34% 75%
P43321 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 44% 100%
P62318 Homo sapiens 36% 90%
P62320 Mus musculus 36% 90%
P62323 Xenopus laevis 36% 90%
Q17348 Caenorhabditis elegans 36% 83%
Q4Q2F6 Leishmania major 99% 100%
Q969L4 Homo sapiens 25% 92%
Q9LM92 Arabidopsis thaliana 37% 86%
Q9S7E6 Arabidopsis thaliana 35% 88%
Q9SY09 Arabidopsis thaliana 33% 97%
Q9UUC6 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 36% 100%
Q9VU02 Drosophila melanogaster 31% 91%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS