LeishMANIAdb
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Putative aquaporin 9

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative aquaporin 9
Gene product:
aquaporin 2 - putative
Species:
Leishmania infantum
UniProt:
A4IAF4_LEIIN
TriTrypDb:
LINF_340046200
Length:
230

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: antonio.jimenez@uah.es
Publication title: A functional BH3 domain in an aquaporin from Leishmania infantum
Publication 1st author(s): Genes
Publication Identifier(s): 27551533
Host organism: taxid:4932
Interaction detection method(s): two hybrid
Interaction type: physical association
Identification method participant A: predetermined participant
Identification method participant B: predetermined participant
ID(s) interactor A: Q07817
ID(s) interactor B: A4I001
Taxid interactor A: Homo sapiens
Taxid interactor B: Leishmania infantum
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: bait

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 29
NetGPI no yes: 0, no: 29
Cellular components
Term Name Level Count
GO:0016020 membrane 2 30
GO:0110165 cellular anatomical entity 1 30
GO:0005886 plasma membrane 3 1

Expansion

Sequence features

A4IAF4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAF4

Function

Biological processes
Term Name Level Count
GO:0006810 transport 3 2
GO:0006833 water transport 5 2
GO:0042044 fluid transport 4 2
GO:0051179 localization 1 2
GO:0051234 establishment of localization 2 2
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 30
GO:0015267 channel activity 4 30
GO:0022803 passive transmembrane transporter activity 3 30
GO:0022857 transmembrane transporter activity 2 30
GO:0005372 water transmembrane transporter activity 4 2
GO:0015250 water channel activity 5 2
GO:0015318 inorganic molecular entity transmembrane transporter activity 3 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 68 70 PF00675 0.329
CLV_NRD_NRD_1 74 76 PF00675 0.283
CLV_PCSK_KEX2_1 74 76 PF00082 0.329
CLV_PCSK_SKI1_1 69 73 PF00082 0.305
DEG_Nend_Nbox_1 1 3 PF02207 0.605
DEG_ODPH_VHL_1 198 211 PF01847 0.168
DOC_CYCLIN_yCln2_LP_2 100 106 PF00134 0.203
DOC_MAPK_gen_1 74 82 PF00069 0.498
DOC_MAPK_MEF2A_6 74 82 PF00069 0.535
DOC_PP2B_LxvP_1 100 103 PF13499 0.247
DOC_USP7_MATH_1 127 131 PF00917 0.336
LIG_14-3-3_CanoR_1 69 74 PF00244 0.558
LIG_Actin_WH2_2 58 76 PF00022 0.415
LIG_BRCT_BRCA1_1 141 145 PF00533 0.494
LIG_BRCT_BRCA1_1 207 211 PF00533 0.232
LIG_FHA_1 112 118 PF00498 0.252
LIG_FHA_1 123 129 PF00498 0.310
LIG_FHA_1 14 20 PF00498 0.310
LIG_FHA_1 175 181 PF00498 0.318
LIG_GBD_Chelix_1 206 214 PF00786 0.207
LIG_LIR_Gen_1 114 123 PF02991 0.293
LIG_LIR_Gen_1 16 25 PF02991 0.266
LIG_LIR_Gen_1 208 218 PF02991 0.403
LIG_LIR_Gen_1 62 71 PF02991 0.292
LIG_LIR_Gen_1 76 85 PF02991 0.426
LIG_LIR_Nem_3 114 118 PF02991 0.273
LIG_LIR_Nem_3 142 148 PF02991 0.482
LIG_LIR_Nem_3 16 20 PF02991 0.272
LIG_LIR_Nem_3 208 214 PF02991 0.318
LIG_LIR_Nem_3 48 52 PF02991 0.307
LIG_LIR_Nem_3 62 66 PF02991 0.303
LIG_LIR_Nem_3 76 82 PF02991 0.422
LIG_NBox_RRM_1 57 67 PF00076 0.264
LIG_Pex14_2 13 17 PF04695 0.310
LIG_Pex14_2 193 197 PF04695 0.265
LIG_SH2_PTP2 79 82 PF00017 0.398
LIG_SH2_STAP1 124 128 PF00017 0.294
LIG_SH2_STAP1 93 97 PF00017 0.339
LIG_SH2_STAT5 124 127 PF00017 0.281
LIG_SH2_STAT5 192 195 PF00017 0.294
LIG_SH2_STAT5 51 54 PF00017 0.469
LIG_SH2_STAT5 79 82 PF00017 0.320
LIG_SUMO_SIM_anti_2 16 22 PF11976 0.346
LIG_SUMO_SIM_par_1 16 22 PF11976 0.311
LIG_TYR_ITIM 190 195 PF00017 0.346
LIG_TYR_ITIM 77 82 PF00017 0.348
LIG_WRC_WIRS_1 123 128 PF05994 0.306
LIG_WRC_WIRS_1 14 19 PF05994 0.304
MOD_CMANNOS 194 197 PF00535 0.303
MOD_GlcNHglycan 52 55 PF01048 0.249
MOD_GlcNHglycan 94 97 PF01048 0.467
MOD_GSK3_1 122 129 PF00069 0.300
MOD_GSK3_1 135 142 PF00069 0.401
MOD_GSK3_1 69 76 PF00069 0.533
MOD_GSK3_1 84 91 PF00069 0.350
MOD_NEK2_1 111 116 PF00069 0.286
MOD_NEK2_1 122 127 PF00069 0.258
MOD_NEK2_1 13 18 PF00069 0.308
MOD_NEK2_1 19 24 PF00069 0.318
MOD_NEK2_1 205 210 PF00069 0.300
MOD_NEK2_1 45 50 PF00069 0.280
MOD_NEK2_1 73 78 PF00069 0.503
MOD_NEK2_1 84 89 PF00069 0.253
MOD_NEK2_1 92 97 PF00069 0.216
MOD_PIKK_1 174 180 PF00454 0.332
MOD_PIKK_1 4 10 PF00454 0.533
MOD_PKA_1 69 75 PF00069 0.403
MOD_PKA_2 73 79 PF00069 0.533
MOD_Plk_4 127 133 PF00069 0.309
MOD_Plk_4 13 19 PF00069 0.304
MOD_Plk_4 150 156 PF00069 0.314
MOD_Plk_4 205 211 PF00069 0.271
MOD_Plk_4 88 94 PF00069 0.361
TRG_ENDOCYTIC_2 192 195 PF00928 0.345
TRG_ENDOCYTIC_2 79 82 PF00928 0.348
TRG_ER_diArg_1 73 75 PF00400 0.529

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I1D2 Leptomonas seymouri 39% 81%
A0A0N1ILB4 Leptomonas seymouri 78% 100%
A0A0N1PB10 Leptomonas seymouri 43% 82%
A0A0S4IS78 Bodo saltans 43% 83%
A0A0S4JRP5 Bodo saltans 27% 68%
A0A0S4KLV5 Bodo saltans 64% 99%
A0A1X0ND19 Trypanosomatidae 68% 100%
A0A1X0NT73 Trypanosomatidae 42% 83%
A0A1X0NTY8 Trypanosomatidae 40% 87%
A0A3R7RFH0 Trypanosoma rangeli 43% 83%
A0A3S5H7B2 Leishmania donovani 41% 78%
A0A3S5H7S4 Leishmania donovani 41% 83%
A0A3S7X8F2 Leishmania donovani 100% 100%
A0A422N493 Trypanosoma rangeli 42% 87%
A0A422NSX8 Trypanosoma rangeli 64% 100%
A0A6M3QG69 Musa acuminata 28% 82%
A0A804KTT0 Musa acuminata subsp. malaccensis 27% 80%
A2IBY8 Canis lupus familiaris 28% 87%
A4HBA6 Leishmania braziliensis 86% 100%
A4HCI0 Leishmania braziliensis 38% 100%
A4HKM8 Leishmania braziliensis 40% 100%
A4I001 Leishmania infantum 41% 100%
A4I859 Leishmania infantum 41% 100%
A4L9J0 Oryctolagus cuniculus 29% 87%
A6ZX66 Saccharomyces cerevisiae (strain YJM789) 26% 75%
A8W649 Sus scrofa 32% 87%
A9Y006 Sus scrofa 25% 79%
B1VB61 Citrobacter freundii 26% 86%
C8ZJM1 Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse) 27% 70%
E9AVX4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 41% 100%
E9B316 Leishmania mexicana (strain MHOM/GT/2001/U1103) 41% 100%
E9B5H8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
F9UTW9 Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) 27% 96%
F9UUB3 Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) 28% 92%
F9UUD2 Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) 31% 100%
G5CTF8 Milnesium tardigradum 25% 69%
G5CTG2 Milnesium tardigradum 26% 83%
G5CTG6 Milnesium tardigradum 24% 82%
O14520 Homo sapiens 25% 67%
O22588 Arabidopsis thaliana 34% 86%
O26206 Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) 31% 93%
O28846 Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) 32% 93%
O62735 Ovis aries 28% 85%
O64964 Zea mays 35% 92%
O68874 Shigella flexneri 27% 100%
O77750 Bos taurus 28% 71%
O82316 Arabidopsis thaliana 26% 92%
O82598 Arabidopsis thaliana 30% 91%
O86231 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 25% 100%
O94778 Homo sapiens 25% 88%
P06624 Bos taurus 28% 87%
P08995 Glycine max 30% 85%
P09011 Rattus norvegicus 29% 88%
P0A3Q7 Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) 25% 98%
P0A3Q8 Streptococcus pneumoniae (strain ATCC BAA-255 / R6) 26% 98%
P0AER0 Escherichia coli (strain K12) 27% 82%
P0AER1 Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) 27% 82%
P0AER2 Escherichia coli O157:H7 27% 82%
P0C112 Brucella abortus biovar 1 (strain 9-941) 28% 100%
P0CD89 Saccharomyces cerevisiae 27% 80%
P0CD91 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 26% 75%
P0CD92 Saccharomyces cerevisiae 27% 70%
P0DO53 Musa acuminata 28% 89%
P0DO54 Musa acuminata 30% 91%
P21653 Nicotiana tabacum 28% 92%
P23958 Phaseolus vulgaris 30% 90%
P24422 Nicotiana tabacum 28% 92%
P25794 Pisum sativum 27% 80%
P25818 Arabidopsis thaliana 30% 92%
P26587 Arabidopsis thaliana 28% 86%
P29972 Homo sapiens 28% 86%
P29975 Rattus norvegicus 29% 86%
P30301 Homo sapiens 28% 87%
P30302 Arabidopsis thaliana 27% 81%
P31140 Shigella flexneri 27% 82%
P33560 Antirrhinum majus 27% 92%
P34080 Rattus norvegicus 25% 85%
P37451 Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) 25% 87%
P41181 Homo sapiens 26% 85%
P42067 Medicago sativa 28% 92%
P42767 Atriplex canescens 28% 82%
P43286 Arabidopsis thaliana 27% 80%
P43287 Arabidopsis thaliana 27% 81%
P47862 Rattus norvegicus 25% 79%
P47863 Rattus norvegicus 28% 71%
P47864 Rattus norvegicus 29% 87%
P47865 Bos taurus 26% 85%
P49173 Nicotiana alata 28% 85%
P50156 Oryza sativa subsp. japonica 31% 92%
P50501 Pelophylax lessonae 29% 85%
P51180 Mus musculus 28% 87%
P55064 Homo sapiens 28% 87%
P55087 Homo sapiens 29% 71%
P55088 Mus musculus 28% 71%
P56401 Ovis aries 25% 85%
P56402 Mus musculus 26% 85%
P56404 Mus musculus 23% 88%
P56405 Rattus norvegicus 24% 87%
P60844 Escherichia coli (strain K12) 27% 100%
P60845 Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) 27% 100%
P60925 Rhodopseudomonas palustris (strain ATCC BAA-98 / CGA009) 24% 96%
P61837 Arabidopsis thaliana 30% 80%
P61838 Vicia faba 30% 80%
P73809 Synechocystis sp. (strain PCC 6803 / Kazusa) 29% 93%
P79099 Bos taurus 28% 85%
P93004 Arabidopsis thaliana 28% 82%
Q02013 Mus musculus 29% 86%
Q06019 Lithobates pipiens 30% 87%
Q06611 Arabidopsis thaliana 30% 80%
Q08451 Solanum lycopersicum 26% 80%
Q08733 Arabidopsis thaliana 30% 80%
Q08DE6 Bos taurus 25% 79%
Q0DK16 Oryza sativa subsp. japonica 29% 80%
Q0IWF3 Oryza sativa subsp. japonica 28% 74%
Q0JPT5 Oryza sativa subsp. japonica 26% 76%
Q13520 Homo sapiens 30% 82%
Q19KC1 Zea mays 28% 78%
Q23808 Cicadella viridis 29% 90%
Q25074 Haematobia irritans exigua 30% 92%
Q2YR68 Brucella abortus (strain 2308) 28% 100%
Q39196 Arabidopsis thaliana 29% 80%
Q40746 Oryza sativa subsp. japonica 27% 81%
Q41870 Zea mays 28% 80%
Q41951 Arabidopsis thaliana 28% 92%
Q41963 Arabidopsis thaliana 30% 91%
Q41975 Arabidopsis thaliana 28% 92%
Q4Q2F7 Leishmania major 97% 100%
Q4Q538 Leishmania major 41% 100%
Q4QBK5 Leishmania major 41% 100%
Q51389 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 27% 82%
Q54V53 Dictyostelium discoideum 25% 84%
Q54WT8 Dictyostelium discoideum 32% 78%
Q5I4F8 Notomys alexis 23% 88%
Q5I4F9 Notomys alexis 28% 71%
Q5R819 Pongo abelii 28% 86%
Q5Z6F0 Oryza sativa subsp. japonica 26% 93%
Q5Z9E2 Oryza sativa subsp. japonica 31% 84%
Q651D5 Oryza sativa subsp. japonica 27% 79%
Q67WJ8 Oryza sativa subsp. japonica 25% 77%
Q6EU94 Oryza sativa subsp. japonica 28% 80%
Q6J8I9 Ovis aries 28% 87%
Q6K215 Oryza sativa subsp. japonica 29% 80%
Q6PQZ1 Sus scrofa 29% 85%
Q6RZ07 Cavia porcellus 30% 87%
Q6Z2T3 Oryza sativa subsp. japonica 28% 77%
Q75GA5 Oryza sativa subsp. japonica 29% 92%
Q7EYH7 Oryza sativa subsp. japonica 28% 75%
Q7MIV9 Vibrio vulnificus (strain YJ016) 28% 100%
Q7N5C1 Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01) 27% 100%
Q7NNP3 Gloeobacter violaceus (strain ATCC 29082 / PCC 7421) 28% 93%
Q7NU39 Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757) 28% 100%
Q7PWV1 Anopheles gambiae 31% 92%
Q7W917 Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253) 30% 97%
Q7WKG2 Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) 30% 97%
Q7XA61 Oryza sativa subsp. japonica 28% 93%
Q7XKI5 Oryza sativa subsp. japonica 31% 87%
Q7XLR1 Oryza sativa subsp. japonica 31% 82%
Q7XSQ9 Oryza sativa subsp. japonica 28% 80%
Q7XU31 Oryza sativa subsp. japonica 28% 86%
Q7XUA6 Oryza sativa subsp. japonica 29% 79%
Q7Y1E6 Oryza sativa subsp. japonica 28% 82%
Q84RL6 Zea mays 27% 93%
Q84RL7 Zea mays 28% 79%
Q84S07 Oryza sativa subsp. japonica 27% 83%
Q866S3 Ovis aries 28% 87%
Q87MQ5 Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) 27% 99%
Q88F17 Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) 28% 100%
Q89EG9 Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110) 25% 96%
Q8C4A0 Mus musculus 28% 78%
Q8DB17 Vibrio vulnificus (strain CMCP6) 29% 100%
Q8EHC1 Shewanella oneidensis (strain MR-1) 28% 100%
Q8FY85 Brucella suis biovar 1 (strain 1330) 28% 100%
Q8GRI8 Oryza sativa subsp. japonica 29% 81%
Q8GRT8 Oryza sativa subsp. japonica 29% 80%
Q8H5N9 Oryza sativa subsp. japonica 29% 79%
Q8LAA6 Arabidopsis thaliana 28% 80%
Q8LAI1 Arabidopsis thaliana 27% 84%
Q8LFP7 Arabidopsis thaliana 27% 78%
Q8R2N1 Mus musculus 25% 79%
Q8UI24 Agrobacterium fabrum (strain C58 / ATCC 33970) 29% 95%
Q8UJW4 Agrobacterium fabrum (strain C58 / ATCC 33970) 28% 100%
Q8VZW1 Arabidopsis thaliana 27% 78%
Q8W036 Arabidopsis thaliana 28% 81%
Q8W037 Arabidopsis thaliana 28% 80%
Q8X6K6 Escherichia coli O157:H7 27% 100%
Q923J4 Dipodomys merriami 28% 71%
Q92482 Homo sapiens 24% 79%
Q92NM3 Rhizobium meliloti (strain 1021) 30% 100%
Q92ZW9 Rhizobium meliloti (strain 1021) 31% 99%
Q94CS9 Oryza sativa subsp. japonica 29% 91%
Q96PS8 Homo sapiens 28% 76%
Q9AQU5 Zea mays 28% 79%
Q9AR14 Zea mays 28% 80%
Q9ASI1 Oryza sativa subsp. japonica 28% 80%
Q9AT74 Zea mays 25% 76%
Q9AT75 Zea mays 28% 86%
Q9ATL2 Zea mays 29% 88%
Q9ATL3 Zea mays 29% 91%
Q9ATL4 Zea mays 26% 92%
Q9ATL5 Zea mays 28% 89%
Q9ATL6 Zea mays 28% 90%
Q9ATL7 Zea mays 31% 88%
Q9ATL8 Zea mays 27% 92%
Q9ATL9 Zea mays 29% 92%
Q9ATM0 Zea mays 28% 91%
Q9ATM4 Zea mays 28% 80%
Q9ATM5 Zea mays 29% 80%
Q9ATM6 Zea mays 29% 80%
Q9ATM7 Zea mays 29% 80%
Q9ATM8 Zea mays 28% 79%
Q9ATN0 Zea mays 29% 78%
Q9ATN1 Zea mays 26% 76%
Q9ATN2 Zea mays 25% 78%
Q9ATN4 Zea mays 28% 82%
Q9C4Z5 Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg) 30% 93%
Q9C6T0 Arabidopsis thaliana 28% 71%
Q9FF53 Arabidopsis thaliana 28% 79%
Q9FGL2 Arabidopsis thaliana 28% 92%
Q9FIZ9 Arabidopsis thaliana 29% 81%
Q9FWV6 Oryza sativa subsp. japonica 30% 87%
Q9FY14 Medicago truncatula 29% 92%
Q9HWZ3 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 29% 100%
Q9L772 Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) 28% 100%
Q9LWR0 Oryza sativa subsp. japonica 29% 90%
Q9LWR2 Oryza sativa subsp. japonica 28% 92%
Q9N2J4 Canis lupus familiaris 28% 85%
Q9NHW7 Aedes aegypti 31% 92%
Q9SAI4 Arabidopsis thaliana 27% 75%
Q9STX9 Arabidopsis thaliana 27% 90%
Q9SV31 Arabidopsis thaliana 26% 80%
Q9SV84 Arabidopsis thaliana 30% 76%
Q9SXF8 Oryza sativa subsp. japonica 28% 80%
Q9U8P7 Dictyostelium discoideum 30% 82%
Q9V5Z7 Drosophila melanogaster 30% 94%
Q9WTY0 Rattus norvegicus 31% 83%
Q9WTY4 Mus musculus 29% 87%
Q9XF58 Zea mays 29% 81%
Q9XF59 Zea mays 28% 80%
Q9ZV07 Arabidopsis thaliana 24% 80%
Q9ZVX8 Arabidopsis thaliana 29% 83%
S5ZH89 Musa acuminata 27% 80%
V5ANF5 Trypanosoma cruzi 42% 83%
V5B469 Trypanosoma cruzi 41% 87%
V5BW46 Trypanosoma cruzi 65% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS