Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IAF3_LEIIN

TriTrypDb:

LINF_340046100

Length:

259

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IAF3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAF3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	65	69	PF00082	0.521
CLV_PCSK_SKI1_1	93	97	PF00082	0.561
DEG_APCC_DBOX_1	28	36	PF00400	0.369
DOC_MAPK_gen_1	26	34	PF00069	0.379
DOC_PP2B_LxvP_1	185	188	PF13499	0.474
DOC_PP4_FxxP_1	152	155	PF00568	0.475
DOC_USP7_MATH_1	122	126	PF00917	0.660
DOC_USP7_MATH_1	142	146	PF00917	0.626
DOC_USP7_MATH_1	188	192	PF00917	0.480
DOC_WW_Pin1_4	144	149	PF00397	0.698
DOC_WW_Pin1_4	4	9	PF00397	0.626
LIG_14-3-3_CanoR_1	135	141	PF00244	0.550
LIG_14-3-3_CanoR_1	179	185	PF00244	0.368
LIG_BIR_II_1	1	5	PF00653	0.590
LIG_BRCT_BRCA1_1	155	159	PF00533	0.540
LIG_BRCT_BRCA1_1	190	194	PF00533	0.353
LIG_FHA_1	246	252	PF00498	0.466
LIG_FHA_1	41	47	PF00498	0.423
LIG_FHA_2	211	217	PF00498	0.501
LIG_FHA_2	230	236	PF00498	0.510
LIG_FHA_2	58	64	PF00498	0.477
LIG_LIR_Gen_1	156	167	PF02991	0.416
LIG_LIR_Gen_1	183	190	PF02991	0.411
LIG_LIR_Gen_1	59	68	PF02991	0.518
LIG_LIR_Nem_3	156	162	PF02991	0.418
LIG_LIR_Nem_3	17	22	PF02991	0.453
LIG_LIR_Nem_3	183	187	PF02991	0.491
LIG_LIR_Nem_3	191	196	PF02991	0.347
LIG_LIR_Nem_3	220	226	PF02991	0.354
LIG_LIR_Nem_3	59	64	PF02991	0.520
LIG_LIR_Nem_3	66	71	PF02991	0.505
LIG_MLH1_MIPbox_1	190	194	PF16413	0.466
LIG_NRBOX	108	114	PF00104	0.429
LIG_PCNA_yPIPBox_3	89	103	PF02747	0.354
LIG_SH2_STAP1	219	223	PF00017	0.315
LIG_SH2_STAT5	22	25	PF00017	0.327
LIG_SH2_STAT5	80	83	PF00017	0.621
LIG_SH3_3	10	16	PF00018	0.568
LIG_SH3_3	118	124	PF00018	0.650
LIG_SUMO_SIM_anti_2	30	36	PF11976	0.436
LIG_TRAF2_1	166	169	PF00917	0.435
LIG_TRAF2_1	8	11	PF00917	0.607
MOD_CDK_SPK_2	4	9	PF00069	0.554
MOD_CK1_1	125	131	PF00069	0.757
MOD_CK1_1	134	140	PF00069	0.638
MOD_CK1_1	2	8	PF00069	0.581
MOD_CK2_1	229	235	PF00069	0.477
MOD_CK2_1	4	10	PF00069	0.762
MOD_CK2_1	57	63	PF00069	0.445
MOD_CMANNOS	181	184	PF00535	0.334
MOD_GlcNHglycan	4	7	PF01048	0.711
MOD_GlcNHglycan	74	77	PF01048	0.535
MOD_GSK3_1	122	129	PF00069	0.621
MOD_GSK3_1	153	160	PF00069	0.539
MOD_GSK3_1	218	225	PF00069	0.420
MOD_GSK3_1	74	81	PF00069	0.584
MOD_N-GLC_1	57	62	PF02516	0.497
MOD_N-GLC_2	176	178	PF02516	0.420
MOD_NEK2_1	105	110	PF00069	0.457
MOD_NEK2_1	157	162	PF00069	0.501
MOD_NEK2_1	78	83	PF00069	0.596
MOD_PIKK_1	142	148	PF00454	0.505
MOD_PIKK_1	150	156	PF00454	0.362
MOD_PKA_2	134	140	PF00069	0.628
MOD_Plk_1	188	194	PF00069	0.513
MOD_Plk_1	57	63	PF00069	0.500
MOD_Plk_4	153	159	PF00069	0.380
MOD_Plk_4	180	186	PF00069	0.302
MOD_Plk_4	57	63	PF00069	0.516
MOD_ProDKin_1	144	150	PF00069	0.684
MOD_ProDKin_1	4	10	PF00069	0.623
MOD_SUMO_rev_2	59	67	PF00179	0.531
MOD_SUMO_rev_2	90	95	PF00179	0.563

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE51	Leptomonas seymouri	54%	98%
A0A0S4KKN8	Bodo saltans	28%	92%
A0A1X0ND66	Trypanosomatidae	35%	100%
A0A3Q8IEP6	Leishmania donovani	99%	100%
A0A422NSY2	Trypanosoma rangeli	36%	100%
A4HBA5	Leishmania braziliensis	69%	100%
C9ZLU1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9B5H7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q2F8	Leishmania major	86%	100%