Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IAF2_LEIIN

TriTrypDb:

LINF_340046000

Length:

233

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IAF2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAF2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	211	215	PF00656	0.614
CLV_NRD_NRD_1	117	119	PF00675	0.397
CLV_NRD_NRD_1	181	183	PF00675	0.586
CLV_NRD_NRD_1	40	42	PF00675	0.671
CLV_NRD_NRD_1	46	48	PF00675	0.567
CLV_NRD_NRD_1	75	77	PF00675	0.599
CLV_NRD_NRD_1	97	99	PF00675	0.654
CLV_PCSK_KEX2_1	117	119	PF00082	0.591
CLV_PCSK_KEX2_1	181	183	PF00082	0.617
CLV_PCSK_KEX2_1	40	42	PF00082	0.671
CLV_PCSK_KEX2_1	61	63	PF00082	0.521
CLV_PCSK_KEX2_1	75	77	PF00082	0.528
CLV_PCSK_KEX2_1	96	98	PF00082	0.679
CLV_PCSK_PC1ET2_1	61	63	PF00082	0.492
CLV_PCSK_PC7_1	71	77	PF00082	0.594
CLV_PCSK_PC7_1	93	99	PF00082	0.665
CLV_PCSK_SKI1_1	182	186	PF00082	0.573
CLV_PCSK_SKI1_1	26	30	PF00082	0.615
CLV_PCSK_SKI1_1	40	44	PF00082	0.491
CLV_PCSK_SKI1_1	56	60	PF00082	0.392
DEG_APCC_DBOX_1	25	33	PF00400	0.589
DEG_SCF_FBW7_2	158	165	PF00400	0.647
DOC_CKS1_1	159	164	PF01111	0.646
DOC_MAPK_DCC_7	148	158	PF00069	0.614
DOC_MAPK_gen_1	201	209	PF00069	0.630
DOC_MAPK_gen_1	47	55	PF00069	0.582
DOC_MAPK_MEF2A_6	48	57	PF00069	0.659
DOC_PP2B_PxIxI_1	130	136	PF00149	0.691
DOC_USP7_MATH_1	154	158	PF00917	0.774
DOC_USP7_MATH_1	163	167	PF00917	0.608
DOC_USP7_MATH_1	86	90	PF00917	0.687
DOC_WW_Pin1_4	123	128	PF00397	0.795
DOC_WW_Pin1_4	158	163	PF00397	0.578
LIG_14-3-3_CanoR_1	181	185	PF00244	0.664
LIG_14-3-3_CanoR_1	201	210	PF00244	0.537
LIG_14-3-3_CanoR_1	40	50	PF00244	0.628
LIG_Actin_WH2_2	103	119	PF00022	0.588
LIG_Actin_WH2_2	17	32	PF00022	0.491
LIG_Actin_WH2_2	189	206	PF00022	0.610
LIG_APCC_ABBA_1	218	223	PF00400	0.524
LIG_FHA_1	86	92	PF00498	0.678
LIG_Integrin_RGD_1	212	214	PF01839	0.687
LIG_LIR_Gen_1	49	58	PF02991	0.540
LIG_LIR_Nem_3	49	53	PF02991	0.541
LIG_SH2_SRC	102	105	PF00017	0.645
LIG_SH2_STAP1	102	106	PF00017	0.640
LIG_SH3_2	159	164	PF14604	0.646
LIG_SH3_3	153	159	PF00018	0.786
LIG_SUMO_SIM_anti_2	205	211	PF11976	0.648
LIG_TRAF2_1	176	179	PF00917	0.602
MOD_CDK_SPxK_1	158	164	PF00069	0.568
MOD_CK1_1	126	132	PF00069	0.690
MOD_CK1_1	141	147	PF00069	0.597
MOD_DYRK1A_RPxSP_1	123	127	PF00069	0.592
MOD_GlcNHglycan	65	68	PF01048	0.565
MOD_GSK3_1	138	145	PF00069	0.637
MOD_GSK3_1	154	161	PF00069	0.643
MOD_GSK3_1	223	230	PF00069	0.645
MOD_N-GLC_1	142	147	PF02516	0.685
MOD_NEK2_1	202	207	PF00069	0.506
MOD_PIKK_1	41	47	PF00454	0.551
MOD_PKA_1	117	123	PF00069	0.525
MOD_PKA_2	117	123	PF00069	0.629
MOD_PKA_2	163	169	PF00069	0.735
MOD_PKA_2	180	186	PF00069	0.379
MOD_PKA_2	203	209	PF00069	0.536
MOD_PKA_2	86	92	PF00069	0.678
MOD_Plk_1	154	160	PF00069	0.712
MOD_Plk_1	213	219	PF00069	0.623
MOD_ProDKin_1	123	129	PF00069	0.797
MOD_ProDKin_1	158	164	PF00069	0.574
MOD_SUMO_rev_2	44	50	PF00179	0.554
TRG_DiLeu_BaLyEn_6	87	92	PF01217	0.676
TRG_ENDOCYTIC_2	221	224	PF00928	0.533
TRG_ER_diArg_1	116	118	PF00400	0.369
TRG_ER_diArg_1	96	98	PF00400	0.679
TRG_Pf-PMV_PEXEL_1	108	112	PF00026	0.652

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IUX1	Leishmania donovani	100%	100%
A4HBA4	Leishmania braziliensis	70%	100%
E9B5H6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q2F9	Leishmania major	90%	100%