TPR_REGION domain-containing protein

Quick info Annotations Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR repeat - putative

Species:

Leishmania infantum

UniProt:

A4IAF1_LEIIN

TriTrypDb:

LINF_340045900

Length:

289

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Phosphorylation

Amastigote: 268, 269, 284

Expansion

Sequence features

A4IAF1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAF1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	200	202	PF00675	0.320
CLV_NRD_NRD_1	234	236	PF00675	0.398
CLV_NRD_NRD_1	98	100	PF00675	0.386
CLV_PCSK_KEX2_1	200	202	PF00082	0.320
CLV_PCSK_SKI1_1	99	103	PF00082	0.417
DOC_USP7_MATH_1	132	136	PF00917	0.590
DOC_USP7_MATH_1	36	40	PF00917	0.718
DOC_USP7_MATH_1	63	67	PF00917	0.670
DOC_USP7_UBL2_3	173	177	PF12436	0.536
DOC_USP7_UBL2_3	236	240	PF12436	0.384
DOC_WW_Pin1_4	120	125	PF00397	0.585
DOC_WW_Pin1_4	31	36	PF00397	0.689
LIG_Actin_WH2_2	65	81	PF00022	0.519
LIG_BIR_III_4	229	233	PF00653	0.415
LIG_BIR_III_4	62	66	PF00653	0.529
LIG_BRCT_BRCA1_1	283	287	PF00533	0.383
LIG_Clathr_ClatBox_1	171	175	PF01394	0.437
LIG_FHA_1	158	164	PF00498	0.290
LIG_FHA_2	123	129	PF00498	0.697
LIG_FHA_2	136	142	PF00498	0.718
LIG_FHA_2	143	149	PF00498	0.749
LIG_LIR_Gen_1	219	228	PF02991	0.409
LIG_LIR_Nem_3	212	218	PF02991	0.341
LIG_LIR_Nem_3	219	224	PF02991	0.421
LIG_NRP_CendR_1	286	289	PF00754	0.454
LIG_Pex14_1	211	215	PF04695	0.317
LIG_SH2_CRK	26	30	PF00017	0.574
LIG_SH2_STAP1	157	161	PF00017	0.369
LIG_SH2_STAP1	283	287	PF00017	0.383
LIG_SH2_STAT3	206	209	PF00017	0.426
LIG_SH2_STAT5	157	160	PF00017	0.313
LIG_SH2_STAT5	164	167	PF00017	0.262
LIG_SH2_STAT5	194	197	PF00017	0.330
LIG_SH2_STAT5	198	201	PF00017	0.279
LIG_SH3_3	106	112	PF00018	0.396
LIG_SH3_3	55	61	PF00018	0.497
LIG_SUMO_SIM_par_1	66	74	PF11976	0.538
LIG_UBA3_1	171	177	PF00899	0.383
LIG_UBA3_1	250	255	PF00899	0.332
MOD_CK1_1	120	126	PF00069	0.577
MOD_CK1_1	135	141	PF00069	0.625
MOD_CK2_1	135	141	PF00069	0.663
MOD_CK2_1	142	148	PF00069	0.644
MOD_CK2_1	36	42	PF00069	0.703
MOD_CK2_1	8	14	PF00069	0.582
MOD_GlcNHglycan	120	123	PF01048	0.604
MOD_GlcNHglycan	128	132	PF01048	0.555
MOD_GlcNHglycan	212	215	PF01048	0.436
MOD_GSK3_1	114	121	PF00069	0.592
MOD_GSK3_1	133	140	PF00069	0.573
MOD_GSK3_1	151	158	PF00069	0.429
MOD_GSK3_1	277	284	PF00069	0.401
MOD_GSK3_1	89	96	PF00069	0.386
MOD_NEK2_1	127	132	PF00069	0.473
MOD_NEK2_2	103	108	PF00069	0.270
MOD_NEK2_2	281	286	PF00069	0.379
MOD_Plk_1	155	161	PF00069	0.347
MOD_Plk_2-3	217	223	PF00069	0.330
MOD_Plk_4	190	196	PF00069	0.518
MOD_Plk_4	93	99	PF00069	0.436
MOD_ProDKin_1	120	126	PF00069	0.585
MOD_ProDKin_1	31	37	PF00069	0.690
MOD_SUMO_for_1	176	179	PF00179	0.454
TRG_DiLeu_BaEn_3	178	184	PF01217	0.437
TRG_DiLeu_BaEn_3	245	251	PF01217	0.340
TRG_DiLeu_BaEn_4	73	79	PF01217	0.562
TRG_ENDOCYTIC_2	205	208	PF00928	0.289
TRG_ENDOCYTIC_2	221	224	PF00928	0.337
TRG_ENDOCYTIC_2	26	29	PF00928	0.578
TRG_ER_diArg_1	199	201	PF00400	0.331
TRG_Pf-PMV_PEXEL_1	249	253	PF00026	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILM5	Leptomonas seymouri	57%	100%
A0A0S4KMF2	Bodo saltans	49%	100%
A0A1X0PA31	Trypanosomatidae	55%	100%
A0A3Q8IHU2	Leishmania donovani	100%	100%
A0A422NSX9	Trypanosoma rangeli	54%	100%
A4HBA3	Leishmania braziliensis	78%	100%
C9ZLU3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9B5H5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q3ZBR5	Bos taurus	32%	99%
Q4Q2G0	Leishmania major	91%	100%