Putative ribosomal protein L14

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ribosomal protein L14 - putative

Species:

Leishmania infantum

UniProt:

A4IAF0_LEIIN

TriTrypDb:

LINF_340045800

Length:

190

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	10
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	10
GO:0043228	non-membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043232	intracellular non-membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10
GO:1990904	ribonucleoprotein complex	2	11
GO:0000315	organellar large ribosomal subunit	5	1
GO:0005762	mitochondrial large ribosomal subunit	3	1
GO:0015934	large ribosomal subunit	4	1
GO:0044391	ribosomal subunit	3	1
GO:0098798	mitochondrial protein-containing complex	2	1

Expansion

Sequence features

A4IAF0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAF0

PDB structure(s): 7aih_BO , 7am2_BO , 7ane_BO

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	11
GO:0006518	peptide metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009059	macromolecule biosynthetic process	4	11
GO:0009987	cellular process	1	11
GO:0019538	protein metabolic process	3	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	11
GO:0043043	peptide biosynthetic process	5	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043603	amide metabolic process	3	11
GO:0043604	amide biosynthetic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901566	organonitrogen compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	11
GO:0005198	structural molecule activity	1	11
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0019843	rRNA binding	5	1
GO:0070180	large ribosomal subunit rRNA binding	6	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.550
CLV_MEL_PAP_1	97	103	PF00089	0.289
CLV_NRD_NRD_1	133	135	PF00675	0.271
CLV_NRD_NRD_1	38	40	PF00675	0.389
CLV_PCSK_KEX2_1	133	135	PF00082	0.271
CLV_PCSK_KEX2_1	38	40	PF00082	0.400
DEG_Nend_Nbox_1	1	3	PF02207	0.487
DEG_SPOP_SBC_1	10	14	PF00917	0.536
DOC_USP7_UBL2_3	177	181	PF12436	0.271
LIG_14-3-3_CanoR_1	100	104	PF00244	0.271
LIG_14-3-3_CanoR_1	149	155	PF00244	0.273
LIG_FHA_1	149	155	PF00498	0.271
LIG_FHA_2	10	16	PF00498	0.541
LIG_FHA_2	143	149	PF00498	0.271
LIG_PDZ_Class_2	185	190	PF00595	0.271
LIG_Pex14_1	127	131	PF04695	0.404
LIG_REV1ctd_RIR_1	2	10	PF16727	0.599
LIG_SH2_STAT5	168	171	PF00017	0.271
MOD_CK1_1	42	48	PF00069	0.381
MOD_GlcNHglycan	140	143	PF01048	0.271
MOD_GSK3_1	129	136	PF00069	0.271
MOD_GSK3_1	138	145	PF00069	0.271
MOD_N-GLC_1	26	31	PF02516	0.433
MOD_N-GLC_1	48	53	PF02516	0.477
MOD_N-GLC_2	150	152	PF02516	0.271
MOD_PKA_1	133	139	PF00069	0.271
MOD_PKA_1	39	45	PF00069	0.409
MOD_PKA_2	133	139	PF00069	0.286
MOD_PKA_2	148	154	PF00069	0.281
MOD_PKA_2	99	105	PF00069	0.271
MOD_Plk_1	26	32	PF00069	0.432
MOD_Plk_4	26	32	PF00069	0.389
TRG_DiLeu_BaLyEn_6	75	80	PF01217	0.271
TRG_ER_diArg_1	117	120	PF00400	0.300
TRG_ER_diArg_1	37	39	PF00400	0.373
TRG_ER_diArg_1	43	46	PF00400	0.410
TRG_ER_diArg_1	5	8	PF00400	0.627

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8K5	Leptomonas seymouri	94%	100%
A0A0S4KLR4	Bodo saltans	71%	98%
A0A1X0NDF6	Trypanosomatidae	91%	100%
A0A3S7X8G7	Leishmania donovani	100%	100%
A0A422NT00	Trypanosoma rangeli	88%	100%
A4HBA2	Leishmania braziliensis	99%	100%
C9ZLU4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	87%	100%
E9B5H4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q4Q2G1	Leishmania major	99%	100%