Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IAE8_LEIIN

TriTrypDb:

LINF_340045600

Length:

355

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4IAE8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAE8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	145	149	PF00656	0.399
CLV_C14_Caspase3-7	223	227	PF00656	0.641
CLV_C14_Caspase3-7	31	35	PF00656	0.412
CLV_MEL_PAP_1	66	72	PF00089	0.388
CLV_NRD_NRD_1	146	148	PF00675	0.544
CLV_NRD_NRD_1	315	317	PF00675	0.390
CLV_NRD_NRD_1	4	6	PF00675	0.620
CLV_PCSK_FUR_1	2	6	PF00082	0.630
CLV_PCSK_KEX2_1	146	148	PF00082	0.404
CLV_PCSK_KEX2_1	302	304	PF00082	0.491
CLV_PCSK_KEX2_1	32	34	PF00082	0.428
CLV_PCSK_KEX2_1	4	6	PF00082	0.545
CLV_PCSK_KEX2_1	59	61	PF00082	0.312
CLV_PCSK_PC1ET2_1	302	304	PF00082	0.419
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.428
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.321
CLV_PCSK_SKI1_1	118	122	PF00082	0.447
CLV_PCSK_SKI1_1	205	209	PF00082	0.412
CLV_PCSK_SKI1_1	278	282	PF00082	0.376
CLV_PCSK_SKI1_1	302	306	PF00082	0.523
CLV_PCSK_SKI1_1	349	353	PF00082	0.440
DEG_Nend_UBRbox_1	1	4	PF02207	0.504
DOC_CYCLIN_RxL_1	202	211	PF00134	0.368
DOC_CYCLIN_yCln2_LP_2	315	321	PF00134	0.479
DOC_MAPK_gen_1	316	327	PF00069	0.521
DOC_MAPK_gen_1	32	39	PF00069	0.519
DOC_MAPK_HePTP_8	29	41	PF00069	0.420
DOC_MAPK_MEF2A_6	194	203	PF00069	0.332
DOC_MAPK_MEF2A_6	32	41	PF00069	0.423
DOC_MAPK_RevD_3	17	33	PF00069	0.336
DOC_PP2B_LxvP_1	207	210	PF13499	0.465
DOC_PP2B_LxvP_1	54	57	PF13499	0.322
DOC_PP4_FxxP_1	76	79	PF00568	0.491
DOC_USP7_MATH_1	3	7	PF00917	0.613
DOC_USP7_MATH_1	345	349	PF00917	0.372
DOC_USP7_MATH_1	55	59	PF00917	0.404
DOC_WW_Pin1_4	125	130	PF00397	0.383
DOC_WW_Pin1_4	75	80	PF00397	0.449
LIG_14-3-3_CanoR_1	155	165	PF00244	0.410
LIG_14-3-3_CanoR_1	2	12	PF00244	0.479
LIG_14-3-3_CanoR_1	320	327	PF00244	0.472
LIG_14-3-3_CanoR_1	60	70	PF00244	0.348
LIG_APCC_ABBA_1	246	251	PF00400	0.294
LIG_BRCT_BRCA1_1	5	9	PF00533	0.437
LIG_BRCT_BRCA1_1	57	61	PF00533	0.440
LIG_FHA_1	13	19	PF00498	0.342
LIG_FHA_1	157	163	PF00498	0.410
LIG_FHA_1	25	31	PF00498	0.405
LIG_FHA_1	279	285	PF00498	0.377
LIG_FHA_1	333	339	PF00498	0.376
LIG_FHA_1	49	55	PF00498	0.320
LIG_FHA_1	61	67	PF00498	0.355
LIG_FHA_2	223	229	PF00498	0.651
LIG_FHA_2	26	32	PF00498	0.410
LIG_FHA_2	269	275	PF00498	0.448
LIG_FHA_2	338	344	PF00498	0.413
LIG_LIR_Apic_2	328	332	PF02991	0.497
LIG_LIR_Apic_2	74	79	PF02991	0.418
LIG_LIR_Gen_1	14	24	PF02991	0.332
LIG_LIR_Gen_1	307	318	PF02991	0.342
LIG_LIR_Nem_3	109	115	PF02991	0.328
LIG_LIR_Nem_3	128	134	PF02991	0.371
LIG_LIR_Nem_3	14	19	PF02991	0.338
LIG_LIR_Nem_3	307	313	PF02991	0.336
LIG_LIR_Nem_3	348	353	PF02991	0.413
LIG_LIR_Nem_3	6	12	PF02991	0.400
LIG_PCNA_PIPBox_1	99	108	PF02747	0.461
LIG_PDZ_Class_2	350	355	PF00595	0.304
LIG_Pex14_2	76	80	PF04695	0.494
LIG_SH2_CRK	180	184	PF00017	0.538
LIG_SH2_STAT5	12	15	PF00017	0.360
LIG_SH2_STAT5	165	168	PF00017	0.378
LIG_SH2_STAT5	310	313	PF00017	0.431
LIG_SH2_STAT5	42	45	PF00017	0.384
LIG_SH3_3	250	256	PF00018	0.375
LIG_SUMO_SIM_par_1	51	58	PF11976	0.308
LIG_TRAF2_1	139	142	PF00917	0.446
LIG_TRAF2_1	321	324	PF00917	0.354
LIG_WRC_WIRS_1	102	107	PF05994	0.454
MOD_CDC14_SPxK_1	78	81	PF00782	0.392
MOD_CDK_SPxK_1	75	81	PF00069	0.386
MOD_CK1_1	104	110	PF00069	0.458
MOD_CK1_1	136	142	PF00069	0.434
MOD_CK1_1	272	278	PF00069	0.369
MOD_CK1_1	65	71	PF00069	0.344
MOD_CK1_1	75	81	PF00069	0.402
MOD_CK1_1	88	94	PF00069	0.587
MOD_CK2_1	136	142	PF00069	0.432
MOD_CK2_1	222	228	PF00069	0.699
MOD_CK2_1	25	31	PF00069	0.415
MOD_CK2_1	268	274	PF00069	0.427
MOD_CK2_1	337	343	PF00069	0.421
MOD_DYRK1A_RPxSP_1	125	129	PF00069	0.374
MOD_GlcNHglycan	88	91	PF01048	0.613
MOD_GSK3_1	218	225	PF00069	0.743
MOD_GSK3_1	268	275	PF00069	0.528
MOD_GSK3_1	333	340	PF00069	0.371
MOD_GSK3_1	61	68	PF00069	0.481
MOD_GSK3_1	71	78	PF00069	0.501
MOD_GSK3_1	81	88	PF00069	0.421
MOD_N-GLC_1	221	226	PF02516	0.599
MOD_NEK2_1	106	111	PF00069	0.384
MOD_NEK2_1	220	225	PF00069	0.684
MOD_NEK2_1	304	309	PF00069	0.467
MOD_NEK2_1	311	316	PF00069	0.360
MOD_NEK2_1	61	66	PF00069	0.382
MOD_NEK2_1	72	77	PF00069	0.392
MOD_NEK2_2	3	8	PF00069	0.480
MOD_PIKK_1	107	113	PF00454	0.449
MOD_PIKK_1	178	184	PF00454	0.358
MOD_PKA_2	3	9	PF00069	0.589
MOD_PKA_2	319	325	PF00069	0.474
MOD_PKB_1	171	179	PF00069	0.401
MOD_Plk_1	173	179	PF00069	0.469
MOD_Plk_4	101	107	PF00069	0.424
MOD_Plk_4	157	163	PF00069	0.479
MOD_Plk_4	25	31	PF00069	0.405
MOD_Plk_4	62	68	PF00069	0.479
MOD_ProDKin_1	125	131	PF00069	0.384
MOD_ProDKin_1	75	81	PF00069	0.458
MOD_SUMO_rev_2	296	304	PF00179	0.428
TRG_DiLeu_BaEn_1	300	305	PF01217	0.378
TRG_DiLeu_LyEn_5	300	305	PF01217	0.470
TRG_ENDOCYTIC_2	16	19	PF00928	0.351
TRG_ENDOCYTIC_2	180	183	PF00928	0.416
TRG_ENDOCYTIC_2	310	313	PF00928	0.428
TRG_ER_diArg_1	1	4	PF00400	0.654
TRG_ER_diArg_1	169	172	PF00400	0.450
TRG_Pf-PMV_PEXEL_1	278	282	PF00026	0.300
TRG_Pf-PMV_PEXEL_1	302	306	PF00026	0.385

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P771	Leptomonas seymouri	58%	95%
A0A0S4KPS3	Bodo saltans	30%	100%
A0A1X0PA34	Trypanosomatidae	40%	100%
A0A3S7X8E4	Leishmania donovani	100%	100%
A0A422NT02	Trypanosoma rangeli	39%	100%
A4HBA0	Leishmania braziliensis	80%	100%
C9ZLU6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9B5H2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q2G3	Leishmania major	96%	100%
V5DMU4	Trypanosoma cruzi	41%	100%