LeishMANIAdb
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Phosphomannomutase-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Phosphomannomutase-like protein
Gene product:
phosphomannomutase-like protein
Species:
Leishmania infantum
UniProt:
A4IAE6_LEIIN
TriTrypDb:
LINF_340045400
Length:
593

Annotations

Annotations by Jardim et al.

Carbohydrate metabolism, Phosphomannomutase-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IAE6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAE6

Function

Biological processes
Term Name Level Count
GO:0005975 carbohydrate metabolic process 3 11
GO:0008152 metabolic process 1 11
GO:0044238 primary metabolic process 2 11
GO:0071704 organic substance metabolic process 2 11
GO:0006139 nucleobase-containing compound metabolic process 3 1
GO:0006166 purine ribonucleoside salvage 5 1
GO:0006725 cellular aromatic compound metabolic process 3 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0009058 biosynthetic process 2 1
GO:0009116 nucleoside metabolic process 4 1
GO:0009119 ribonucleoside metabolic process 5 1
GO:0009163 nucleoside biosynthetic process 5 1
GO:0009987 cellular process 1 1
GO:0018130 heterocycle biosynthetic process 4 1
GO:0019438 aromatic compound biosynthetic process 4 1
GO:0034404 nucleobase-containing small molecule biosynthetic process 4 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0034654 nucleobase-containing compound biosynthetic process 4 1
GO:0042278 purine nucleoside metabolic process 5 1
GO:0042451 purine nucleoside biosynthetic process 6 1
GO:0042455 ribonucleoside biosynthetic process 6 1
GO:0043094 cellular metabolic compound salvage 3 1
GO:0043101 purine-containing compound salvage 4 1
GO:0043174 nucleoside salvage 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044249 cellular biosynthetic process 3 1
GO:0044271 cellular nitrogen compound biosynthetic process 4 1
GO:0044281 small molecule metabolic process 2 1
GO:0044283 small molecule biosynthetic process 3 1
GO:0046128 purine ribonucleoside metabolic process 6 1
GO:0046129 purine ribonucleoside biosynthetic process 7 1
GO:0046483 heterocycle metabolic process 3 1
GO:0055086 nucleobase-containing small molecule metabolic process 3 1
GO:0072521 purine-containing compound metabolic process 4 1
GO:0072522 purine-containing compound biosynthetic process 5 1
GO:1901135 carbohydrate derivative metabolic process 3 1
GO:1901137 carbohydrate derivative biosynthetic process 4 1
GO:1901360 organic cyclic compound metabolic process 3 1
GO:1901362 organic cyclic compound biosynthetic process 4 1
GO:1901564 organonitrogen compound metabolic process 3 1
GO:1901566 organonitrogen compound biosynthetic process 4 1
GO:1901576 organic substance biosynthetic process 3 1
GO:1901657 glycosyl compound metabolic process 4 1
GO:1901659 glycosyl compound biosynthetic process 5 1
Molecular functions
Term Name Level Count
GO:0000287 magnesium ion binding 5 11
GO:0003824 catalytic activity 1 11
GO:0005488 binding 1 11
GO:0016853 isomerase activity 2 11
GO:0016866 intramolecular transferase activity 3 11
GO:0016868 intramolecular transferase activity, phosphotransferases 4 11
GO:0043167 ion binding 2 11
GO:0043169 cation binding 3 11
GO:0046872 metal ion binding 4 11
GO:0008973 phosphopentomutase activity 5 2
GO:0004614 phosphoglucomutase activity 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 343 345 PF00675 0.370
CLV_NRD_NRD_1 38 40 PF00675 0.553
CLV_NRD_NRD_1 391 393 PF00675 0.456
CLV_NRD_NRD_1 435 437 PF00675 0.414
CLV_NRD_NRD_1 440 442 PF00675 0.392
CLV_NRD_NRD_1 513 515 PF00675 0.559
CLV_PCSK_FUR_1 341 345 PF00082 0.368
CLV_PCSK_KEX2_1 343 345 PF00082 0.368
CLV_PCSK_KEX2_1 37 39 PF00082 0.574
CLV_PCSK_KEX2_1 439 441 PF00082 0.318
CLV_PCSK_KEX2_1 513 515 PF00082 0.500
CLV_PCSK_PC7_1 436 442 PF00082 0.246
CLV_PCSK_SKI1_1 247 251 PF00082 0.382
CLV_PCSK_SKI1_1 351 355 PF00082 0.417
CLV_PCSK_SKI1_1 473 477 PF00082 0.426
CLV_PCSK_SKI1_1 494 498 PF00082 0.556
DEG_Nend_Nbox_1 1 3 PF02207 0.497
DEG_SCF_FBW7_1 184 189 PF00400 0.432
DEG_SCF_FBW7_1 517 524 PF00400 0.480
DOC_ANK_TNKS_1 88 95 PF00023 0.389
DOC_CKS1_1 126 131 PF01111 0.334
DOC_CYCLIN_RxL_1 348 357 PF00134 0.416
DOC_CYCLIN_RxL_1 470 478 PF00134 0.385
DOC_CYCLIN_yCln2_LP_2 250 256 PF00134 0.427
DOC_MAPK_gen_1 341 349 PF00069 0.459
DOC_MAPK_gen_1 37 46 PF00069 0.566
DOC_PP1_RVXF_1 157 163 PF00149 0.334
DOC_PP1_RVXF_1 541 547 PF00149 0.397
DOC_PP2B_LxvP_1 250 253 PF13499 0.388
DOC_PP4_FxxP_1 275 278 PF00568 0.315
DOC_USP7_MATH_1 186 190 PF00917 0.391
DOC_USP7_MATH_1 509 513 PF00917 0.556
DOC_USP7_MATH_2 278 284 PF00917 0.427
DOC_WW_Pin1_4 125 130 PF00397 0.317
DOC_WW_Pin1_4 182 187 PF00397 0.466
DOC_WW_Pin1_4 517 522 PF00397 0.409
LIG_14-3-3_CanoR_1 215 219 PF00244 0.438
LIG_14-3-3_CanoR_1 228 237 PF00244 0.276
LIG_14-3-3_CanoR_1 240 249 PF00244 0.299
LIG_14-3-3_CanoR_1 392 401 PF00244 0.382
LIG_14-3-3_CanoR_1 43 51 PF00244 0.439
LIG_14-3-3_CanoR_1 439 444 PF00244 0.379
LIG_14-3-3_CanoR_1 52 56 PF00244 0.415
LIG_14-3-3_CanoR_1 64 68 PF00244 0.401
LIG_AP2alpha_1 207 211 PF02296 0.501
LIG_BIR_III_4 554 558 PF00653 0.539
LIG_BRCT_BRCA1_1 100 104 PF00533 0.315
LIG_DCNL_PONY_1 1 4 PF03556 0.354
LIG_deltaCOP1_diTrp_1 188 194 PF00928 0.538
LIG_deltaCOP1_diTrp_1 9 14 PF00928 0.419
LIG_FHA_1 106 112 PF00498 0.427
LIG_FHA_1 126 132 PF00498 0.129
LIG_FHA_1 18 24 PF00498 0.459
LIG_FHA_1 195 201 PF00498 0.491
LIG_FHA_1 241 247 PF00498 0.305
LIG_FHA_1 31 37 PF00498 0.377
LIG_FHA_1 421 427 PF00498 0.406
LIG_FHA_1 46 52 PF00498 0.248
LIG_FHA_1 470 476 PF00498 0.514
LIG_FHA_1 495 501 PF00498 0.504
LIG_FHA_1 518 524 PF00498 0.463
LIG_FHA_2 183 189 PF00498 0.487
LIG_FHA_2 193 199 PF00498 0.452
LIG_FHA_2 324 330 PF00498 0.388
LIG_GBD_Chelix_1 176 184 PF00786 0.368
LIG_GBD_Chelix_1 427 435 PF00786 0.459
LIG_LIR_Apic_2 272 278 PF02991 0.315
LIG_LIR_Gen_1 201 211 PF02991 0.373
LIG_LIR_Gen_1 230 237 PF02991 0.334
LIG_LIR_Gen_1 319 330 PF02991 0.523
LIG_LIR_Gen_1 461 469 PF02991 0.509
LIG_LIR_Gen_1 588 593 PF02991 0.605
LIG_LIR_Nem_3 101 107 PF02991 0.334
LIG_LIR_Nem_3 128 133 PF02991 0.353
LIG_LIR_Nem_3 154 158 PF02991 0.324
LIG_LIR_Nem_3 188 194 PF02991 0.441
LIG_LIR_Nem_3 201 206 PF02991 0.297
LIG_LIR_Nem_3 208 214 PF02991 0.129
LIG_LIR_Nem_3 269 273 PF02991 0.320
LIG_LIR_Nem_3 319 325 PF02991 0.439
LIG_LIR_Nem_3 449 454 PF02991 0.314
LIG_LIR_Nem_3 461 466 PF02991 0.410
LIG_LIR_Nem_3 588 593 PF02991 0.549
LIG_PCNA_PIPBox_1 114 123 PF02747 0.427
LIG_PCNA_yPIPBox_3 114 123 PF02747 0.368
LIG_PCNA_yPIPBox_3 553 565 PF02747 0.529
LIG_PDZ_Class_1 588 593 PF00595 0.549
LIG_Pex14_2 207 211 PF04695 0.381
LIG_PTB_Apo_2 264 271 PF02174 0.388
LIG_SH2_CRK 155 159 PF00017 0.459
LIG_SH2_CRK 203 207 PF00017 0.484
LIG_SH2_NCK_1 203 207 PF00017 0.469
LIG_SH2_NCK_1 218 222 PF00017 0.427
LIG_SH2_SRC 218 221 PF00017 0.469
LIG_SH2_SRC 404 407 PF00017 0.459
LIG_SH2_STAP1 203 207 PF00017 0.469
LIG_SH2_STAP1 375 379 PF00017 0.388
LIG_SH2_STAP1 404 408 PF00017 0.459
LIG_SH2_STAP1 547 551 PF00017 0.375
LIG_SH2_STAT3 487 490 PF00017 0.486
LIG_SH2_STAT3 77 80 PF00017 0.459
LIG_SH2_STAT5 120 123 PF00017 0.382
LIG_SH2_STAT5 210 213 PF00017 0.306
LIG_SH2_STAT5 434 437 PF00017 0.358
LIG_SH2_STAT5 77 80 PF00017 0.311
LIG_SH3_3 126 132 PF00018 0.319
LIG_SH3_3 265 271 PF00018 0.315
LIG_SH3_3 578 584 PF00018 0.505
LIG_SUMO_SIM_anti_2 255 262 PF11976 0.389
LIG_TRAF2_1 317 320 PF00917 0.551
LIG_TRAF2_1 403 406 PF00917 0.315
LIG_UBA3_1 1 7 PF00899 0.337
LIG_WRC_WIRS_1 522 527 PF05994 0.300
MOD_CK1_1 222 228 PF00069 0.459
MOD_CK1_1 255 261 PF00069 0.433
MOD_CK1_1 288 294 PF00069 0.388
MOD_CK1_1 478 484 PF00069 0.481
MOD_CK2_1 182 188 PF00069 0.443
MOD_CK2_1 323 329 PF00069 0.391
MOD_CK2_1 439 445 PF00069 0.404
MOD_CK2_1 535 541 PF00069 0.433
MOD_CMANNOS 11 14 PF00535 0.388
MOD_GlcNHglycan 223 227 PF01048 0.421
MOD_GlcNHglycan 282 285 PF01048 0.406
MOD_GlcNHglycan 483 486 PF01048 0.555
MOD_GlcNHglycan 537 540 PF01048 0.457
MOD_GlcNHglycan 58 61 PF01048 0.444
MOD_GSK3_1 172 179 PF00069 0.396
MOD_GSK3_1 182 189 PF00069 0.388
MOD_GSK3_1 210 217 PF00069 0.388
MOD_GSK3_1 236 243 PF00069 0.414
MOD_GSK3_1 291 298 PF00069 0.327
MOD_GSK3_1 353 360 PF00069 0.301
MOD_GSK3_1 373 380 PF00069 0.362
MOD_GSK3_1 505 512 PF00069 0.448
MOD_GSK3_1 513 520 PF00069 0.478
MOD_GSK3_1 531 538 PF00069 0.397
MOD_GSK3_1 63 70 PF00069 0.334
MOD_N-GLC_1 182 187 PF02516 0.439
MOD_NEK2_1 172 177 PF00069 0.459
MOD_NEK2_1 187 192 PF00069 0.292
MOD_NEK2_1 214 219 PF00069 0.394
MOD_NEK2_1 229 234 PF00069 0.210
MOD_NEK2_1 285 290 PF00069 0.427
MOD_NEK2_1 353 358 PF00069 0.326
MOD_NEK2_1 44 49 PF00069 0.368
MOD_NEK2_1 458 463 PF00069 0.367
MOD_NEK2_1 475 480 PF00069 0.475
MOD_NEK2_1 51 56 PF00069 0.382
MOD_NEK2_1 531 536 PF00069 0.429
MOD_NEK2_2 210 215 PF00069 0.345
MOD_NEK2_2 397 402 PF00069 0.467
MOD_NEK2_2 521 526 PF00069 0.359
MOD_PIKK_1 486 492 PF00454 0.568
MOD_PIKK_1 570 576 PF00454 0.333
MOD_PKA_1 392 398 PF00069 0.382
MOD_PKA_1 439 445 PF00069 0.318
MOD_PKA_1 513 519 PF00069 0.507
MOD_PKA_2 214 220 PF00069 0.438
MOD_PKA_2 227 233 PF00069 0.276
MOD_PKA_2 239 245 PF00069 0.257
MOD_PKA_2 439 445 PF00069 0.318
MOD_PKA_2 51 57 PF00069 0.427
MOD_PKA_2 513 519 PF00069 0.496
MOD_PKA_2 535 541 PF00069 0.436
MOD_PKA_2 63 69 PF00069 0.401
MOD_PKB_1 37 45 PF00069 0.492
MOD_Plk_1 172 178 PF00069 0.438
MOD_Plk_1 187 193 PF00069 0.329
MOD_Plk_1 222 228 PF00069 0.429
MOD_Plk_4 107 113 PF00069 0.382
MOD_Plk_4 116 122 PF00069 0.355
MOD_Plk_4 255 261 PF00069 0.388
MOD_Plk_4 295 301 PF00069 0.450
MOD_Plk_4 354 360 PF00069 0.311
MOD_Plk_4 397 403 PF00069 0.429
MOD_Plk_4 446 452 PF00069 0.401
MOD_Plk_4 459 465 PF00069 0.322
MOD_Plk_4 63 69 PF00069 0.315
MOD_ProDKin_1 125 131 PF00069 0.317
MOD_ProDKin_1 182 188 PF00069 0.471
MOD_ProDKin_1 517 523 PF00069 0.400
MOD_SUMO_for_1 6 9 PF00179 0.445
MOD_SUMO_rev_2 3 8 PF00179 0.489
MOD_SUMO_rev_2 538 544 PF00179 0.441
TRG_DiLeu_BaEn_1 329 334 PF01217 0.334
TRG_DiLeu_BaEn_1 350 355 PF01217 0.382
TRG_DiLeu_BaEn_3 319 325 PF01217 0.480
TRG_DiLeu_BaEn_3 405 411 PF01217 0.388
TRG_ENDOCYTIC_2 155 158 PF00928 0.427
TRG_ENDOCYTIC_2 203 206 PF00928 0.455
TRG_ENDOCYTIC_2 463 466 PF00928 0.455
TRG_ENDOCYTIC_2 547 550 PF00928 0.370
TRG_ER_diArg_1 341 344 PF00400 0.429
TRG_ER_diArg_1 36 39 PF00400 0.560
TRG_ER_diArg_1 439 441 PF00400 0.246
TRG_ER_diArg_1 513 515 PF00400 0.562
TRG_Pf-PMV_PEXEL_1 441 445 PF00026 0.246
TRG_PTS1 590 593 PF00515 0.533

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6T5 Leptomonas seymouri 70% 100%
A0A0S4JIH0 Bodo saltans 50% 100%
A0A1X0PBG2 Trypanosomatidae 50% 100%
A0A3R7KJ42 Trypanosoma rangeli 51% 100%
A0A3S7X8H1 Leishmania donovani 100% 100%
A0K6C4 Burkholderia cenocepacia (strain HI2424) 24% 100%
A3PAW2 Prochlorococcus marinus (strain MIT 9301) 22% 100%
A4HB98 Leishmania braziliensis 86% 100%
A7H514 Campylobacter jejuni subsp. doylei (strain ATCC BAA-1458 / RM4099 / 269.97) 20% 100%
A7HCU0 Anaeromyxobacter sp. (strain Fw109-5) 24% 100%
A7IIG5 Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2) 24% 100%
A8G2Q0 Prochlorococcus marinus (strain MIT 9215) 22% 100%
A9G862 Sorangium cellulosum (strain So ce56) 23% 100%
A9HYU0 Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448) 24% 100%
A9IYI0 Bartonella tribocorum (strain CIP 105476 / IBS 506) 22% 100%
B0C132 Acaryochloris marina (strain MBIC 11017) 22% 100%
B0TQA7 Shewanella halifaxensis (strain HAW-EB4) 21% 100%
B1JZF2 Burkholderia cenocepacia (strain MC0-3) 24% 100%
B2IGB3 Beijerinckia indica subsp. indica (strain ATCC 9039 / DSM 1715 / NCIMB 8712) 23% 100%
B3E692 Trichlorobacter lovleyi (strain ATCC BAA-1151 / DSM 17278 / SZ) 23% 100%
B4E5F6 Burkholderia cenocepacia (strain ATCC BAA-245 / DSM 16553 / LMG 16656 / NCTC 13227 / J2315 / CF5610) 25% 100%
B5YS65 Escherichia coli O157:H7 (strain EC4115 / EHEC) 22% 100%
B7JYN0 Rippkaea orientalis (strain PCC 8801) 22% 100%
B8CKG8 Shewanella piezotolerans (strain WP3 / JCM 13877) 23% 100%
C3K264 Pseudomonas fluorescens (strain SBW25) 23% 100%
C4XU39 Solidesulfovibrio magneticus (strain ATCC 700980 / DSM 13731 / RS-1) 25% 100%
E9B5H0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
O74478 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 40% 100%
P00949 Oryctolagus cuniculus 25% 100%
P18159 Bacillus subtilis (strain 168) 34% 100%
P36871 Homo sapiens 25% 100%
P38652 Rattus norvegicus 24% 100%
P47299 Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37) 25% 100%
P47723 Mycoplasma pirum 25% 100%
P75050 Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1) 26% 100%
Q03262 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 34% 95%
Q08DP0 Bos taurus 25% 100%
Q116W4 Trichodesmium erythraeum (strain IMS101) 22% 100%
Q1BXC7 Burkholderia cenocepacia (strain AU 1054) 24% 100%
Q1QSY5 Chromohalobacter salexigens (strain ATCC BAA-138 / DSM 3043 / CIP 106854 / NCIMB 13768 / 1H11) 24% 100%
Q2FE11 Staphylococcus aureus (strain USA300) 33% 100%
Q2FVC1 Staphylococcus aureus (strain NCTC 8325 / PS 47) 33% 100%
Q2GB44 Novosphingobium aromaticivorans (strain ATCC 700278 / DSM 12444 / CCUG 56034 / CIP 105152 / NBRC 16084 / F199) 24% 100%
Q2RVE4 Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIMB 8255 / S1) 25% 100%
Q2YW66 Staphylococcus aureus (strain bovine RF122 / ET3-1) 33% 100%
Q3M6L2 Trichormus variabilis (strain ATCC 29413 / PCC 7937) 22% 100%
Q49WH7 Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41) 28% 100%
Q4L9R5 Staphylococcus haemolyticus (strain JCSC1435) 29% 100%
Q4Q2G5 Leishmania major 95% 100%
Q4R5E4 Macaca fascicularis 25% 100%
Q4WY53 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 24% 100%
Q54UQ2 Dictyostelium discoideum 40% 98%
Q57290 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) 37% 100%
Q5HD61 Staphylococcus aureus (strain COL) 33% 100%
Q5HLD2 Staphylococcus epidermidis (strain ATCC 35984 / RP62A) 31% 100%
Q5R979 Pongo abelii 40% 95%
Q5RFI8 Pongo abelii 41% 97%
Q68BJ6 Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) 24% 100%
Q6AMQ5 Desulfotalea psychrophila (strain LSv54 / DSM 12343) 23% 100%
Q6G6I3 Staphylococcus aureus (strain MSSA476) 33% 100%
Q6GDU9 Staphylococcus aureus (strain MRSA252) 32% 100%
Q6PCE3 Homo sapiens 40% 95%
Q7A3K7 Staphylococcus aureus (strain N315) 33% 100%
Q7TSV4 Mus musculus 41% 96%
Q8CAA7 Mus musculus 40% 95%
Q8CN38 Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200) 31% 100%
Q8NUV4 Staphylococcus aureus (strain MW2) 33% 100%
Q8X9L2 Escherichia coli O157:H7 22% 100%
Q8YVS4 Nostoc sp. (strain PCC 7120 / SAG 25.82 / UTEX 2576) 22% 100%
Q96G03 Homo sapiens 41% 97%
Q98F91 Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) 24% 100%
Q99RE2 Staphylococcus aureus (strain Mu50 / ATCC 700699) 33% 100%
Q9D0F9 Mus musculus 25% 100%
V5B6A2 Trypanosoma cruzi 51% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS