Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IAE5_LEIIN

TriTrypDb:

LINF_340045300

Length:

285

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 8
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IAE5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAE5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	113	115	PF00675	0.586
CLV_NRD_NRD_1	120	122	PF00675	0.562
CLV_NRD_NRD_1	210	212	PF00675	0.447
CLV_NRD_NRD_1	3	5	PF00675	0.538
CLV_NRD_NRD_1	40	42	PF00675	0.607
CLV_PCSK_KEX2_1	112	114	PF00082	0.595
CLV_PCSK_KEX2_1	120	122	PF00082	0.562
CLV_PCSK_KEX2_1	20	22	PF00082	0.625
CLV_PCSK_KEX2_1	210	212	PF00082	0.391
CLV_PCSK_KEX2_1	3	5	PF00082	0.547
CLV_PCSK_KEX2_1	40	42	PF00082	0.354
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.643
CLV_PCSK_SKI1_1	141	145	PF00082	0.531
CLV_PCSK_SKI1_1	222	226	PF00082	0.491
CLV_PCSK_SKI1_1	69	73	PF00082	0.507
DEG_APCC_DBOX_1	210	218	PF00400	0.466
DEG_Nend_UBRbox_2	1	3	PF02207	0.602
DOC_MAPK_gen_1	120	127	PF00069	0.539
DOC_MAPK_MEF2A_6	120	129	PF00069	0.436
DOC_PP2B_LxvP_1	56	59	PF13499	0.425
DOC_PP4_FxxP_1	224	227	PF00568	0.404
DOC_USP7_MATH_1	154	158	PF00917	0.617
DOC_USP7_MATH_1	170	174	PF00917	0.725
DOC_USP7_MATH_1	240	244	PF00917	0.522
DOC_USP7_MATH_1	46	50	PF00917	0.657
DOC_WW_Pin1_4	225	230	PF00397	0.566
LIG_14-3-3_CanoR_1	12	16	PF00244	0.618
LIG_14-3-3_CanoR_1	120	124	PF00244	0.542
LIG_14-3-3_CanoR_1	159	165	PF00244	0.689
LIG_14-3-3_CanoR_1	3	11	PF00244	0.598
LIG_14-3-3_CanoR_1	40	44	PF00244	0.651
LIG_14-3-3_CanoR_1	69	75	PF00244	0.462
LIG_BRCT_BRCA1_1	201	205	PF00533	0.545
LIG_CaM_NSCaTE_8	7	14	PF13499	0.658
LIG_CtBP_PxDLS_1	126	130	PF00389	0.433
LIG_eIF4E_1	88	94	PF01652	0.517
LIG_FHA_1	142	148	PF00498	0.555
LIG_FHA_1	201	207	PF00498	0.598
LIG_FHA_1	51	57	PF00498	0.499
LIG_FHA_1	65	71	PF00498	0.359
LIG_FHA_2	228	234	PF00498	0.659
LIG_FHA_2	278	284	PF00498	0.526
LIG_FHA_2	40	46	PF00498	0.595
LIG_LIR_Apic_2	221	227	PF02991	0.393
LIG_LIR_Gen_1	258	267	PF02991	0.554
LIG_LIR_Gen_1	97	104	PF02991	0.467
LIG_LIR_Nem_3	184	188	PF02991	0.685
LIG_LIR_Nem_3	191	197	PF02991	0.634
LIG_LIR_Nem_3	258	263	PF02991	0.554
LIG_LIR_Nem_3	97	101	PF02991	0.456
LIG_Pex14_2	205	209	PF04695	0.475
LIG_SH2_PTP2	98	101	PF00017	0.463
LIG_SH2_STAP1	220	224	PF00017	0.464
LIG_SH2_STAT3	146	149	PF00017	0.641
LIG_SH2_STAT5	146	149	PF00017	0.615
LIG_SH2_STAT5	88	91	PF00017	0.410
LIG_SH2_STAT5	98	101	PF00017	0.341
LIG_SH3_3	120	126	PF00018	0.436
LIG_SH3_3	162	168	PF00018	0.636
LIG_SUMO_SIM_anti_2	253	258	PF11976	0.493
LIG_SUMO_SIM_par_1	125	130	PF11976	0.431
LIG_TRAF2_1	42	45	PF00917	0.417
MOD_CK1_1	10	16	PF00069	0.619
MOD_CK1_1	184	190	PF00069	0.729
MOD_CK1_1	19	25	PF00069	0.560
MOD_CK1_1	228	234	PF00069	0.676
MOD_CK1_1	258	264	PF00069	0.457
MOD_CK1_1	49	55	PF00069	0.665
MOD_CK2_1	190	196	PF00069	0.712
MOD_CK2_1	39	45	PF00069	0.662
MOD_GlcNHglycan	156	159	PF01048	0.618
MOD_GlcNHglycan	21	24	PF01048	0.709
MOD_GlcNHglycan	238	241	PF01048	0.579
MOD_GlcNHglycan	257	260	PF01048	0.343
MOD_GlcNHglycan	36	39	PF01048	0.473
MOD_GSK3_1	127	134	PF00069	0.428
MOD_GSK3_1	225	232	PF00069	0.639
MOD_GSK3_1	236	243	PF00069	0.584
MOD_GSK3_1	255	262	PF00069	0.409
MOD_GSK3_1	45	52	PF00069	0.643
MOD_GSK3_1	7	14	PF00069	0.599
MOD_N-GLC_1	234	239	PF02516	0.562
MOD_N-GLC_1	50	55	PF02516	0.593
MOD_NEK2_1	11	16	PF00069	0.609
MOD_NEK2_1	119	124	PF00069	0.473
MOD_NEK2_1	127	132	PF00069	0.391
MOD_NEK2_1	190	195	PF00069	0.674
MOD_NEK2_1	70	75	PF00069	0.486
MOD_NEK2_1	89	94	PF00069	0.235
MOD_NEK2_2	133	138	PF00069	0.447
MOD_NEK2_2	220	225	PF00069	0.495
MOD_NEK2_2	7	12	PF00069	0.594
MOD_PIKK_1	57	63	PF00454	0.523
MOD_PIKK_1	64	70	PF00454	0.527
MOD_PKA_2	11	17	PF00069	0.530
MOD_PKA_2	119	125	PF00069	0.509
MOD_PKA_2	160	166	PF00069	0.619
MOD_PKA_2	2	8	PF00069	0.545
MOD_PKA_2	278	284	PF00069	0.662
MOD_PKA_2	39	45	PF00069	0.665
MOD_Plk_1	127	133	PF00069	0.428
MOD_Plk_1	141	147	PF00069	0.498
MOD_Plk_1	190	196	PF00069	0.695
MOD_Plk_1	200	206	PF00069	0.523
MOD_Plk_1	220	226	PF00069	0.494
MOD_Plk_1	240	246	PF00069	0.545
MOD_Plk_2-3	278	284	PF00069	0.526
MOD_Plk_4	213	219	PF00069	0.406
MOD_Plk_4	220	226	PF00069	0.418
MOD_Plk_4	259	265	PF00069	0.520
MOD_Plk_4	52	58	PF00069	0.517
MOD_Plk_4	89	95	PF00069	0.402
MOD_ProDKin_1	225	231	PF00069	0.571
TRG_DiLeu_BaLyEn_6	135	140	PF01217	0.458
TRG_DiLeu_BaLyEn_6	66	71	PF01217	0.439
TRG_ENDOCYTIC_2	98	101	PF00928	0.463
TRG_ER_diArg_1	111	114	PF00400	0.557
TRG_ER_diArg_1	119	121	PF00400	0.553
TRG_ER_diArg_1	209	211	PF00400	0.388
TRG_ER_diArg_1	39	41	PF00400	0.665
TRG_Pf-PMV_PEXEL_1	138	142	PF00026	0.486
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.577

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I090	Leptomonas seymouri	48%	100%
A0A3Q8ILI1	Leishmania donovani	100%	100%
A0A422NT07	Trypanosoma rangeli	31%	100%
A4HB97	Leishmania braziliensis	78%	100%
C9ZLU8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	89%
E9B5G9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q2G6	Leishmania major	89%	100%
V5DMU7	Trypanosoma cruzi	32%	100%