Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IAE3_LEIIN

TriTrypDb:

LINF_340045100

Length:

517

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4IAE3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAE3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	424	428	PF00656	0.729
CLV_C14_Caspase3-7	49	53	PF00656	0.608
CLV_NRD_NRD_1	287	289	PF00675	0.622
CLV_NRD_NRD_1	334	336	PF00675	0.671
CLV_NRD_NRD_1	35	37	PF00675	0.662
CLV_NRD_NRD_1	363	365	PF00675	0.737
CLV_NRD_NRD_1	402	404	PF00675	0.721
CLV_NRD_NRD_1	509	511	PF00675	0.458
CLV_PCSK_KEX2_1	149	151	PF00082	0.643
CLV_PCSK_KEX2_1	162	164	PF00082	0.478
CLV_PCSK_KEX2_1	287	289	PF00082	0.622
CLV_PCSK_KEX2_1	334	336	PF00082	0.666
CLV_PCSK_KEX2_1	365	367	PF00082	0.738
CLV_PCSK_KEX2_1	508	510	PF00082	0.484
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.633
CLV_PCSK_PC1ET2_1	162	164	PF00082	0.624
CLV_PCSK_PC1ET2_1	365	367	PF00082	0.738
CLV_PCSK_PC1ET2_1	508	510	PF00082	0.484
CLV_PCSK_SKI1_1	209	213	PF00082	0.645
CLV_PCSK_SKI1_1	24	28	PF00082	0.739
CLV_PCSK_SKI1_1	403	407	PF00082	0.574
CLV_PCSK_SKI1_1	509	513	PF00082	0.516
DEG_Nend_Nbox_1	1	3	PF02207	0.640
DEG_SPOP_SBC_1	312	316	PF00917	0.761
DEG_SPOP_SBC_1	80	84	PF00917	0.697
DEG_SPOP_SBC_1	93	97	PF00917	0.593
DOC_CKS1_1	25	30	PF01111	0.748
DOC_CYCLIN_RxL_1	462	472	PF00134	0.346
DOC_CYCLIN_yCln2_LP_2	413	419	PF00134	0.744
DOC_MAPK_JIP1_4	326	332	PF00069	0.646
DOC_PP2B_LxvP_1	251	254	PF13499	0.474
DOC_USP7_MATH_1	196	200	PF00917	0.775
DOC_USP7_MATH_1	216	220	PF00917	0.685
DOC_USP7_MATH_1	302	306	PF00917	0.675
DOC_USP7_MATH_1	408	412	PF00917	0.672
DOC_USP7_MATH_1	473	477	PF00917	0.525
DOC_USP7_MATH_1	80	84	PF00917	0.673
DOC_USP7_MATH_1	9	13	PF00917	0.703
DOC_USP7_MATH_1	92	96	PF00917	0.570
DOC_USP7_UBL2_3	400	404	PF12436	0.710
DOC_USP7_UBL2_3	508	512	PF12436	0.573
DOC_WW_Pin1_4	139	144	PF00397	0.459
DOC_WW_Pin1_4	192	197	PF00397	0.787
DOC_WW_Pin1_4	24	29	PF00397	0.662
DOC_WW_Pin1_4	294	299	PF00397	0.703
DOC_WW_Pin1_4	313	318	PF00397	0.773
DOC_WW_Pin1_4	367	372	PF00397	0.725
DOC_WW_Pin1_4	447	452	PF00397	0.555
DOC_WW_Pin1_4	469	474	PF00397	0.650
DOC_WW_Pin1_4	81	86	PF00397	0.573
LIG_14-3-3_CanoR_1	191	196	PF00244	0.756
LIG_14-3-3_CanoR_1	497	503	PF00244	0.506
LIG_BRCT_BRCA1_1	174	178	PF00533	0.430
LIG_BRCT_BRCA1_1	99	103	PF00533	0.656
LIG_FHA_1	115	121	PF00498	0.695
LIG_FHA_1	180	186	PF00498	0.529
LIG_FHA_1	386	392	PF00498	0.699
LIG_FHA_1	94	100	PF00498	0.732
LIG_FHA_2	382	388	PF00498	0.709
LIG_FHA_2	451	457	PF00498	0.642
LIG_FHA_2	491	497	PF00498	0.592
LIG_LIR_Gen_1	100	108	PF02991	0.552
LIG_LIR_Nem_3	100	106	PF02991	0.609
LIG_LIR_Nem_3	142	148	PF02991	0.486
LIG_LIR_Nem_3	39	45	PF02991	0.751
LIG_SH2_CRK	145	149	PF00017	0.508
LIG_SH2_SRC	145	148	PF00017	0.601
LIG_SH2_STAP1	445	449	PF00017	0.492
LIG_SH2_STAT5	105	108	PF00017	0.612
LIG_SH2_STAT5	56	59	PF00017	0.591
LIG_SH3_3	22	28	PF00018	0.747
LIG_SH3_3	306	312	PF00018	0.731
LIG_SH3_3	467	473	PF00018	0.575
LIG_SUMO_SIM_anti_2	277	286	PF11976	0.558
LIG_TRAF2_1	419	422	PF00917	0.754
LIG_TRAF2_1	453	456	PF00917	0.553
MOD_CDC14_SPxK_1	297	300	PF00782	0.594
MOD_CDC14_SPxK_1	370	373	PF00782	0.623
MOD_CDK_SPK_2	313	318	PF00069	0.736
MOD_CDK_SPK_2	447	452	PF00069	0.602
MOD_CDK_SPK_2	81	86	PF00069	0.574
MOD_CDK_SPxK_1	294	300	PF00069	0.602
MOD_CDK_SPxK_1	367	373	PF00069	0.675
MOD_CDK_SPxxK_3	24	31	PF00069	0.750
MOD_CDK_SPxxK_3	313	320	PF00069	0.738
MOD_CK1_1	14	20	PF00069	0.644
MOD_CK1_1	97	103	PF00069	0.668
MOD_CK2_1	109	115	PF00069	0.638
MOD_CK2_1	123	129	PF00069	0.612
MOD_CK2_1	450	456	PF00069	0.534
MOD_Cter_Amidation	206	209	PF01082	0.587
MOD_DYRK1A_RPxSP_1	24	28	PF00069	0.752
MOD_GlcNHglycan	125	128	PF01048	0.752
MOD_GlcNHglycan	13	16	PF01048	0.626
MOD_GlcNHglycan	196	199	PF01048	0.662
MOD_GlcNHglycan	214	217	PF01048	0.616
MOD_GlcNHglycan	230	233	PF01048	0.377
MOD_GlcNHglycan	359	362	PF01048	0.815
MOD_GlcNHglycan	408	411	PF01048	0.730
MOD_GlcNHglycan	76	79	PF01048	0.770
MOD_GlcNHglycan	88	91	PF01048	0.667
MOD_GlcNHglycan	96	99	PF01048	0.630
MOD_GSK3_1	190	197	PF00069	0.690
MOD_GSK3_1	20	27	PF00069	0.631
MOD_GSK3_1	212	219	PF00069	0.647
MOD_GSK3_1	381	388	PF00069	0.779
MOD_GSK3_1	469	476	PF00069	0.640
MOD_GSK3_1	59	66	PF00069	0.696
MOD_GSK3_1	67	74	PF00069	0.667
MOD_GSK3_1	7	14	PF00069	0.669
MOD_GSK3_1	80	87	PF00069	0.670
MOD_GSK3_1	93	100	PF00069	0.719
MOD_N-GLC_1	228	233	PF02516	0.450
MOD_N-GLC_1	385	390	PF02516	0.804
MOD_NEK2_1	477	482	PF00069	0.542
MOD_NEK2_1	65	70	PF00069	0.674
MOD_PIKK_1	114	120	PF00454	0.720
MOD_PIKK_1	302	308	PF00454	0.748
MOD_PIKK_1	63	69	PF00454	0.608
MOD_PKA_2	17	23	PF00069	0.730
MOD_PKA_2	190	196	PF00069	0.679
MOD_PKA_2	286	292	PF00069	0.711
MOD_PKA_2	345	351	PF00069	0.677
MOD_PKA_2	496	502	PF00069	0.515
MOD_PKA_2	7	13	PF00069	0.684
MOD_Plk_1	276	282	PF00069	0.651
MOD_Plk_1	71	77	PF00069	0.491
MOD_Plk_2-3	109	115	PF00069	0.604
MOD_Plk_2-3	244	250	PF00069	0.611
MOD_Plk_4	198	204	PF00069	0.715
MOD_Plk_4	276	282	PF00069	0.554
MOD_ProDKin_1	139	145	PF00069	0.452
MOD_ProDKin_1	192	198	PF00069	0.788
MOD_ProDKin_1	24	30	PF00069	0.659
MOD_ProDKin_1	294	300	PF00069	0.702
MOD_ProDKin_1	313	319	PF00069	0.773
MOD_ProDKin_1	367	373	PF00069	0.726
MOD_ProDKin_1	447	453	PF00069	0.561
MOD_ProDKin_1	469	475	PF00069	0.643
MOD_ProDKin_1	81	87	PF00069	0.573
MOD_SUMO_for_1	419	422	PF00179	0.754
MOD_SUMO_rev_2	47	55	PF00179	0.789
TRG_DiLeu_BaEn_4	115	121	PF01217	0.797
TRG_DiLeu_LyEn_5	129	134	PF01217	0.583
TRG_ENDOCYTIC_2	105	108	PF00928	0.553
TRG_ENDOCYTIC_2	145	148	PF00928	0.500
TRG_ENDOCYTIC_2	168	171	PF00928	0.532
TRG_ENDOCYTIC_2	42	45	PF00928	0.716
TRG_ER_diArg_1	334	336	PF00400	0.670
TRG_ER_diArg_1	509	511	PF00400	0.458
TRG_NLS_MonoCore_2	363	368	PF00514	0.832
TRG_NLS_MonoExtC_3	363	368	PF00514	0.832
TRG_NLS_MonoExtC_3	402	407	PF00514	0.724
TRG_NLS_MonoExtC_3	507	512	PF00514	0.446
TRG_NLS_MonoExtN_4	362	369	PF00514	0.732
TRG_NLS_MonoExtN_4	400	407	PF00514	0.717
TRG_Pf-PMV_PEXEL_1	432	436	PF00026	0.717

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5K2	Leptomonas seymouri	37%	89%
A0A3Q8INS4	Leishmania donovani	98%	100%
A4HB95	Leishmania braziliensis	59%	100%
E9B5G7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q2G8	Leishmania major	84%	100%