LeishMANIAdb
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Serine palmitoyltransferase-like protein

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Serine palmitoyltransferase-like protein
Gene product:
serine palmitoyltransferase-like protein
Species:
Leishmania infantum
UniProt:
A4IAE1_LEIIN
TriTrypDb:
LINF_340044900
Length:
488

Annotations

LeishMANIAdb annotations

A very conserved eukaryotic enzyme involved in sphingolipid biosynthesis. Localization: ER (by homology)

Annotations by Jardim et al.

Phospholipid biosynthesis, Serine palmitoyltransferase-like

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005783 endoplasmic reticulum 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 7
GO:0016020 membrane 2 6

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A4IAE1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAE1

Function

Biological processes
Term Name Level Count
GO:0008152 metabolic process 1 12
GO:0009058 biosynthetic process 2 12
GO:0006066 alcohol metabolic process 3 1
GO:0006629 lipid metabolic process 3 1
GO:0006643 membrane lipid metabolic process 4 1
GO:0006665 sphingolipid metabolic process 4 1
GO:0006670 sphingosine metabolic process 6 1
GO:0006672 ceramide metabolic process 4 1
GO:0006807 nitrogen compound metabolic process 2 1
GO:0008610 lipid biosynthetic process 4 1
GO:0009987 cellular process 1 1
GO:0019751 polyol metabolic process 4 1
GO:0030148 sphingolipid biosynthetic process 5 1
GO:0034311 diol metabolic process 5 1
GO:0034312 diol biosynthetic process 6 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0043603 amide metabolic process 3 1
GO:0043604 amide biosynthetic process 4 1
GO:0044237 cellular metabolic process 2 1
GO:0044238 primary metabolic process 2 1
GO:0044249 cellular biosynthetic process 3 1
GO:0044255 cellular lipid metabolic process 3 1
GO:0044271 cellular nitrogen compound biosynthetic process 4 1
GO:0044281 small molecule metabolic process 2 1
GO:0044283 small molecule biosynthetic process 3 1
GO:0046165 alcohol biosynthetic process 4 1
GO:0046173 polyol biosynthetic process 5 1
GO:0046467 membrane lipid biosynthetic process 4 1
GO:0046512 sphingosine biosynthetic process 5 1
GO:0046513 ceramide biosynthetic process 5 1
GO:0046519 sphingoid metabolic process 5 1
GO:0046520 sphingoid biosynthetic process 6 1
GO:0071704 organic substance metabolic process 2 1
GO:1901564 organonitrogen compound metabolic process 3 1
GO:1901566 organonitrogen compound biosynthetic process 4 1
GO:1901576 organic substance biosynthetic process 3 1
GO:1901615 organic hydroxy compound metabolic process 3 1
GO:1901617 organic hydroxy compound biosynthetic process 4 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0004758 serine C-palmitoyltransferase activity 7 8
GO:0005488 binding 1 12
GO:0016408 C-acyltransferase activity 5 8
GO:0016409 palmitoyltransferase activity 5 8
GO:0016454 C-palmitoyltransferase activity 6 8
GO:0016740 transferase activity 2 12
GO:0016746 acyltransferase activity 3 8
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups 4 8
GO:0019842 vitamin binding 3 12
GO:0030170 pyridoxal phosphate binding 4 12
GO:0036094 small molecule binding 2 12
GO:0043167 ion binding 2 12
GO:0043168 anion binding 3 12
GO:0070279 vitamin B6 binding 3 12
GO:0097159 organic cyclic compound binding 2 12
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 246 248 PF00675 0.215
CLV_NRD_NRD_1 374 376 PF00675 0.303
CLV_NRD_NRD_1 381 383 PF00675 0.281
CLV_NRD_NRD_1 39 41 PF00675 0.381
CLV_NRD_NRD_1 59 61 PF00675 0.332
CLV_PCSK_FUR_1 379 383 PF00082 0.213
CLV_PCSK_KEX2_1 246 248 PF00082 0.212
CLV_PCSK_KEX2_1 374 376 PF00082 0.229
CLV_PCSK_KEX2_1 378 380 PF00082 0.238
CLV_PCSK_KEX2_1 381 383 PF00082 0.215
CLV_PCSK_KEX2_1 39 41 PF00082 0.375
CLV_PCSK_KEX2_1 59 61 PF00082 0.332
CLV_PCSK_PC1ET2_1 378 380 PF00082 0.213
CLV_PCSK_PC7_1 374 380 PF00082 0.213
CLV_PCSK_SKI1_1 165 169 PF00082 0.281
CLV_PCSK_SKI1_1 277 281 PF00082 0.205
CLV_PCSK_SKI1_1 444 448 PF00082 0.210
DEG_APCC_DBOX_1 417 425 PF00400 0.413
DEG_COP1_1 74 84 PF00400 0.578
DOC_CYCLIN_RxL_1 272 283 PF00134 0.454
DOC_MAPK_gen_1 273 280 PF00069 0.417
DOC_PP4_FxxP_1 300 303 PF00568 0.416
DOC_SPAK_OSR1_1 247 251 PF12202 0.384
DOC_USP7_MATH_1 103 107 PF00917 0.613
DOC_USP7_MATH_1 326 330 PF00917 0.493
DOC_USP7_MATH_1 354 358 PF00917 0.434
DOC_USP7_MATH_1 63 67 PF00917 0.542
DOC_USP7_MATH_1 71 75 PF00917 0.536
DOC_WW_Pin1_4 293 298 PF00397 0.458
DOC_WW_Pin1_4 401 406 PF00397 0.391
DOC_WW_Pin1_4 50 55 PF00397 0.511
LIG_14-3-3_CanoR_1 102 112 PF00244 0.542
LIG_14-3-3_CanoR_1 247 255 PF00244 0.391
LIG_14-3-3_CanoR_1 336 344 PF00244 0.402
LIG_14-3-3_CanoR_1 444 453 PF00244 0.451
LIG_BIR_II_1 1 5 PF00653 0.366
LIG_BIR_III_2 402 406 PF00653 0.413
LIG_BRCT_BRCA1_1 13 17 PF00533 0.415
LIG_BRCT_BRCA1_1 282 286 PF00533 0.391
LIG_BRCT_BRCA1_1 65 69 PF00533 0.501
LIG_eIF4E_1 274 280 PF01652 0.413
LIG_FHA_1 249 255 PF00498 0.391
LIG_FHA_1 256 262 PF00498 0.391
LIG_FHA_1 302 308 PF00498 0.434
LIG_FHA_1 338 344 PF00498 0.425
LIG_FHA_1 351 357 PF00498 0.350
LIG_FHA_1 375 381 PF00498 0.389
LIG_FHA_1 471 477 PF00498 0.476
LIG_FHA_1 74 80 PF00498 0.561
LIG_FHA_1 86 92 PF00498 0.509
LIG_FHA_2 122 128 PF00498 0.408
LIG_FHA_2 224 230 PF00498 0.407
LIG_FHA_2 446 452 PF00498 0.456
LIG_FHA_2 466 472 PF00498 0.297
LIG_FHA_2 5 11 PF00498 0.322
LIG_Integrin_RGD_1 192 194 PF01839 0.234
LIG_LIR_Apic_2 239 244 PF02991 0.449
LIG_LIR_Apic_2 298 303 PF02991 0.391
LIG_LIR_Gen_1 116 126 PF02991 0.396
LIG_LIR_Gen_1 176 186 PF02991 0.416
LIG_LIR_Nem_3 116 122 PF02991 0.396
LIG_LIR_Nem_3 148 153 PF02991 0.493
LIG_LIR_Nem_3 176 182 PF02991 0.416
LIG_LIR_Nem_3 194 198 PF02991 0.427
LIG_LIR_Nem_3 283 289 PF02991 0.408
LIG_LIR_Nem_3 83 87 PF02991 0.564
LIG_SH2_CRK 150 154 PF00017 0.391
LIG_SH2_CRK 179 183 PF00017 0.493
LIG_SH2_CRK 241 245 PF00017 0.449
LIG_SH2_CRK 84 88 PF00017 0.578
LIG_SH2_NCK_1 179 183 PF00017 0.493
LIG_SH2_SRC 198 201 PF00017 0.441
LIG_SH2_STAP1 175 179 PF00017 0.434
LIG_SH2_STAT5 195 198 PF00017 0.409
LIG_SH2_STAT5 31 34 PF00017 0.298
LIG_SH2_STAT5 310 313 PF00017 0.391
LIG_SH2_STAT5 342 345 PF00017 0.391
LIG_SH2_STAT5 351 354 PF00017 0.391
LIG_SH2_STAT5 415 418 PF00017 0.429
LIG_SH3_1 42 48 PF00018 0.575
LIG_SH3_3 42 48 PF00018 0.594
LIG_SH3_3 76 82 PF00018 0.525
LIG_SUMO_SIM_anti_2 359 364 PF11976 0.493
LIG_SUMO_SIM_anti_2 404 410 PF11976 0.410
LIG_SUMO_SIM_anti_2 96 102 PF11976 0.594
LIG_TRAF2_1 227 230 PF00917 0.493
LIG_TRAF2_1 53 56 PF00917 0.505
LIG_TYR_ITIM 29 34 PF00017 0.372
LIG_UBA3_1 267 275 PF00899 0.402
LIG_WRC_WIRS_1 119 124 PF05994 0.400
LIG_WRC_WIRS_1 174 179 PF05994 0.408
MOD_CK1_1 121 127 PF00069 0.391
MOD_CK1_1 187 193 PF00069 0.423
MOD_CK1_1 2 8 PF00069 0.397
MOD_CK1_1 224 230 PF00069 0.461
MOD_CK1_1 313 319 PF00069 0.393
MOD_CK1_1 465 471 PF00069 0.446
MOD_CK1_1 50 56 PF00069 0.630
MOD_CK1_1 74 80 PF00069 0.583
MOD_CK1_1 96 102 PF00069 0.517
MOD_CK2_1 103 109 PF00069 0.554
MOD_CK2_1 121 127 PF00069 0.437
MOD_CK2_1 202 208 PF00069 0.481
MOD_CK2_1 223 229 PF00069 0.416
MOD_CK2_1 4 10 PF00069 0.328
MOD_CK2_1 445 451 PF00069 0.402
MOD_CK2_1 465 471 PF00069 0.297
MOD_CK2_1 50 56 PF00069 0.542
MOD_GlcNHglycan 189 192 PF01048 0.279
MOD_GlcNHglycan 291 294 PF01048 0.249
MOD_GlcNHglycan 344 347 PF01048 0.212
MOD_GlcNHglycan 456 459 PF01048 0.231
MOD_GSK3_1 145 152 PF00069 0.500
MOD_GSK3_1 2 9 PF00069 0.339
MOD_GSK3_1 289 296 PF00069 0.393
MOD_GSK3_1 310 317 PF00069 0.402
MOD_GSK3_1 350 357 PF00069 0.391
MOD_LATS_1 334 340 PF00433 0.395
MOD_N-GLC_1 454 459 PF02516 0.281
MOD_NEK2_1 149 154 PF00069 0.399
MOD_NEK2_1 280 285 PF00069 0.402
MOD_NEK2_1 289 294 PF00069 0.413
MOD_NEK2_1 314 319 PF00069 0.402
MOD_NEK2_1 337 342 PF00069 0.391
MOD_NEK2_1 344 349 PF00069 0.375
MOD_NEK2_1 4 9 PF00069 0.354
MOD_PIKK_1 354 360 PF00454 0.479
MOD_PKA_1 374 380 PF00069 0.395
MOD_PKA_2 335 341 PF00069 0.417
MOD_PKA_2 374 380 PF00069 0.459
MOD_Plk_1 280 286 PF00069 0.395
MOD_Plk_1 365 371 PF00069 0.402
MOD_Plk_1 71 77 PF00069 0.610
MOD_Plk_2-3 113 119 PF00069 0.400
MOD_Plk_4 181 187 PF00069 0.411
MOD_Plk_4 202 208 PF00069 0.493
MOD_Plk_4 365 371 PF00069 0.460
MOD_ProDKin_1 293 299 PF00069 0.458
MOD_ProDKin_1 401 407 PF00069 0.391
MOD_ProDKin_1 50 56 PF00069 0.502
MOD_SUMO_for_1 483 486 PF00179 0.538
TRG_DiLeu_BaEn_1 392 397 PF01217 0.458
TRG_DiLeu_BaEn_4 109 115 PF01217 0.431
TRG_DiLeu_BaLyEn_6 274 279 PF01217 0.425
TRG_ENDOCYTIC_2 150 153 PF00928 0.391
TRG_ENDOCYTIC_2 179 182 PF00928 0.470
TRG_ENDOCYTIC_2 31 34 PF00928 0.355
TRG_ENDOCYTIC_2 84 87 PF00928 0.578
TRG_ER_diArg_1 246 248 PF00400 0.414
TRG_ER_diArg_1 373 375 PF00400 0.421
TRG_ER_diArg_1 379 382 PF00400 0.431
TRG_ER_diArg_1 59 61 PF00400 0.514
TRG_NLS_MonoExtC_3 377 382 PF00514 0.413
TRG_NLS_MonoExtN_4 375 382 PF00514 0.395
TRG_Pf-PMV_PEXEL_1 277 281 PF00026 0.182
TRG_Pf-PMV_PEXEL_1 382 386 PF00026 0.319

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0H3C7E9 Caulobacter vibrioides (strain NA1000 / CB15N) 28% 100%
A0A0N1HYL3 Leptomonas seymouri 75% 99%
A0A0S4KPJ9 Bodo saltans 46% 96%
A0A1X0PAD7 Trypanosomatidae 49% 99%
A0A3R7KRA6 Trypanosoma rangeli 49% 99%
A0A3S7X8D9 Leishmania donovani 100% 100%
A1ITK1 Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491) 22% 100%
A1KVF6 Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM 15464 / FAM18) 22% 100%
A4HB93 Leishmania braziliensis 84% 100%
A4VR87 Pseudomonas stutzeri (strain A1501) 25% 100%
A6UYW1 Pseudomonas aeruginosa (strain PA7) 26% 100%
A9HJ57 Gluconacetobacter diazotrophicus (strain ATCC 49037 / DSM 5601 / CCUG 37298 / CIP 103539 / LMG 7603 / PAl5) 27% 100%
A9M251 Neisseria meningitidis serogroup C (strain 053442) 22% 100%
B0U6J0 Xylella fastidiosa (strain M12) 22% 100%
B1I4F9 Desulforudis audaxviator (strain MP104C) 28% 100%
B2AG98 Cupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CCUG 44338 / CIP 107171 / LMG 19424 / R1) 26% 100%
B2I9H7 Xylella fastidiosa (strain M23) 22% 100%
B3PI88 Cellvibrio japonicus (strain Ueda107) 26% 100%
B4ESU4 Proteus mirabilis (strain HI4320) 27% 100%
B4RP93 Neisseria gonorrhoeae (strain NCCP11945) 22% 100%
B5XZ74 Klebsiella pneumoniae (strain 342) 25% 100%
B7K0L9 Rippkaea orientalis (strain PCC 8801) 26% 100%
B7V486 Pseudomonas aeruginosa (strain LESB58) 27% 100%
C4LK80 Corynebacterium kroppenstedtii (strain DSM 44385 / JCM 11950 / CIP 105744 / CCUG 35717) 26% 68%
C8V1D1 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 22% 100%
C9ZLV5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 51% 100%
D4A2H2 Rattus norvegicus 34% 100%
E9B5G5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
O15269 Homo sapiens 35% 100%
O35704 Mus musculus 34% 100%
O54695 Cricetulus griseus 34% 100%
O59682 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 33% 96%
P09950 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 89%
P25045 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 30% 87%
P91079 Caenorhabditis elegans 34% 100%
Q02TR5 Pseudomonas aeruginosa (strain UCBPP-PA14) 27% 100%
Q12F38 Polaromonas sp. (strain JS666 / ATCC BAA-500) 25% 100%
Q2W3L2 Magnetospirillum magneticum (strain AMB-1 / ATCC 700264) 23% 100%
Q3JWR6 Burkholderia pseudomallei (strain 1710b) 28% 100%
Q3SLX9 Thiobacillus denitrificans (strain ATCC 25259) 27% 100%
Q48CS2 Pseudomonas savastanoi pv. phaseolicola (strain 1448A / Race 6) 26% 100%
Q55FL5 Dictyostelium discoideum 33% 100%
Q5F6R6 Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090) 22% 100%
Q5R9T5 Pongo abelii 34% 100%
Q60HD1 Macaca fascicularis 34% 100%
Q6FXE3 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 24% 92%
Q6LPR3 Photobacterium profundum (strain SS9) 23% 100%
Q6XFB3 Leishmania major 96% 100%
Q7RVY5 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) 23% 78%
Q7VWP1 Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251) 26% 100%
Q7W9I4 Bordetella parapertussis (strain 12822 / ATCC BAA-587 / NCTC 13253) 26% 100%
Q7WH76 Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50) 26% 100%
Q87DT2 Xylella fastidiosa (strain Temecula1 / ATCC 700964) 22% 100%
Q88A97 Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000) 25% 100%
Q9I617 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) 27% 100%
Q9K0U0 Neisseria meningitidis serogroup B (strain MC58) 22% 100%
Q9PDM2 Xylella fastidiosa (strain 9a5c) 23% 100%
V5BLV3 Trypanosoma cruzi 51% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS