Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IAE0_LEIIN

TriTrypDb:

LINF_340044800

Length:

348

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4IAE0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAE0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	122	128	PF00089	0.455
CLV_NRD_NRD_1	107	109	PF00675	0.388
CLV_NRD_NRD_1	112	114	PF00675	0.404
CLV_NRD_NRD_1	140	142	PF00675	0.478
CLV_NRD_NRD_1	209	211	PF00675	0.452
CLV_NRD_NRD_1	267	269	PF00675	0.451
CLV_NRD_NRD_1	295	297	PF00675	0.596
CLV_NRD_NRD_1	300	302	PF00675	0.515
CLV_PCSK_FUR_1	293	297	PF00082	0.622
CLV_PCSK_KEX2_1	107	109	PF00082	0.388
CLV_PCSK_KEX2_1	112	114	PF00082	0.404
CLV_PCSK_KEX2_1	140	142	PF00082	0.430
CLV_PCSK_KEX2_1	209	211	PF00082	0.450
CLV_PCSK_KEX2_1	267	269	PF00082	0.451
CLV_PCSK_KEX2_1	295	297	PF00082	0.601
CLV_PCSK_KEX2_1	299	301	PF00082	0.489
CLV_PCSK_PC7_1	108	114	PF00082	0.468
CLV_PCSK_PC7_1	263	269	PF00082	0.486
CLV_PCSK_PC7_1	295	301	PF00082	0.473
CLV_PCSK_SKI1_1	108	112	PF00082	0.398
CLV_PCSK_SKI1_1	119	123	PF00082	0.444
CLV_PCSK_SKI1_1	144	148	PF00082	0.426
CLV_PCSK_SKI1_1	195	199	PF00082	0.477
CLV_PCSK_SKI1_1	267	271	PF00082	0.521
CLV_PCSK_SKI1_1	314	318	PF00082	0.515
DEG_APCC_DBOX_1	234	242	PF00400	0.513
DEG_APCC_DBOX_1	99	107	PF00400	0.410
DOC_CKS1_1	16	21	PF01111	0.548
DOC_CYCLIN_yCln2_LP_2	245	251	PF00134	0.527
DOC_MAPK_gen_1	193	201	PF00069	0.422
DOC_MAPK_gen_1	212	222	PF00069	0.319
DOC_MAPK_gen_1	276	286	PF00069	0.440
DOC_PP1_RVXF_1	117	124	PF00149	0.430
DOC_PP1_RVXF_1	163	169	PF00149	0.427
DOC_PP1_RVXF_1	57	64	PF00149	0.738
DOC_PP4_FxxP_1	16	19	PF00568	0.541
DOC_USP7_MATH_1	224	228	PF00917	0.477
DOC_USP7_MATH_1	240	244	PF00917	0.378
DOC_USP7_MATH_1	4	8	PF00917	0.499
DOC_WW_Pin1_4	15	20	PF00397	0.572
DOC_WW_Pin1_4	35	40	PF00397	0.641
DOC_WW_Pin1_4	45	50	PF00397	0.594
LIG_14-3-3_CanoR_1	156	160	PF00244	0.494
LIG_14-3-3_CanoR_1	212	218	PF00244	0.494
LIG_14-3-3_CanoR_1	221	228	PF00244	0.401
LIG_14-3-3_CanoR_1	230	234	PF00244	0.373
LIG_14-3-3_CanoR_1	29	35	PF00244	0.623
LIG_14-3-3_CanoR_1	318	325	PF00244	0.620
LIG_14-3-3_CanoR_1	42	49	PF00244	0.546
LIG_14-3-3_CterR_2	345	348	PF00244	0.564
LIG_Actin_WH2_2	99	114	PF00022	0.460
LIG_APCC_ABBAyCdc20_2	144	150	PF00400	0.442
LIG_CaM_IQ_9	111	127	PF13499	0.398
LIG_deltaCOP1_diTrp_1	169	174	PF00928	0.452
LIG_deltaCOP1_diTrp_1	292	297	PF00928	0.535
LIG_deltaCOP1_diTrp_1	95	101	PF00928	0.451
LIG_FHA_1	16	22	PF00498	0.571
LIG_FHA_1	4	10	PF00498	0.537
LIG_FHA_1	77	83	PF00498	0.487
LIG_FHA_1	89	95	PF00498	0.365
LIG_FHA_2	156	162	PF00498	0.382
LIG_LIR_Gen_1	242	251	PF02991	0.566
LIG_LIR_Nem_3	242	247	PF02991	0.571
LIG_LIR_Nem_3	333	337	PF02991	0.484
LIG_SH2_NCK_1	53	57	PF00017	0.549
LIG_SH2_STAP1	334	338	PF00017	0.521
LIG_SH2_STAT5	15	18	PF00017	0.520
LIG_SH2_STAT5	244	247	PF00017	0.690
LIG_SH2_STAT5	337	340	PF00017	0.632
LIG_SH2_STAT5	53	56	PF00017	0.515
LIG_SUMO_SIM_par_1	90	95	PF11976	0.355
MOD_CDK_SPxxK_3	35	42	PF00069	0.541
MOD_CK1_1	22	28	PF00069	0.577
MOD_CK1_1	74	80	PF00069	0.453
MOD_CK2_1	14	20	PF00069	0.606
MOD_CK2_1	155	161	PF00069	0.336
MOD_CK2_1	22	28	PF00069	0.496
MOD_CMANNOS	168	171	PF00535	0.442
MOD_CMANNOS	294	297	PF00535	0.410
MOD_GlcNHglycan	222	225	PF01048	0.447
MOD_GlcNHglycan	31	34	PF01048	0.644
MOD_GSK3_1	15	22	PF00069	0.636
MOD_GSK3_1	220	227	PF00069	0.453
MOD_GSK3_1	29	36	PF00069	0.584
MOD_GSK3_1	41	48	PF00069	0.540
MOD_GSK3_1	51	58	PF00069	0.488
MOD_NEK2_1	21	26	PF00069	0.623
MOD_NEK2_1	3	8	PF00069	0.562
MOD_PIKK_1	318	324	PF00454	0.469
MOD_PKA_2	155	161	PF00069	0.362
MOD_PKA_2	220	226	PF00069	0.427
MOD_PKA_2	229	235	PF00069	0.403
MOD_PKA_2	28	34	PF00069	0.658
MOD_PKA_2	41	47	PF00069	0.554
MOD_PKA_2	74	80	PF00069	0.500
MOD_PKB_1	200	208	PF00069	0.398
MOD_Plk_1	224	230	PF00069	0.468
MOD_Plk_2-3	155	161	PF00069	0.362
MOD_Plk_4	155	161	PF00069	0.480
MOD_Plk_4	240	246	PF00069	0.471
MOD_Plk_4	88	94	PF00069	0.449
MOD_ProDKin_1	15	21	PF00069	0.574
MOD_ProDKin_1	35	41	PF00069	0.640
MOD_ProDKin_1	45	51	PF00069	0.592
TRG_DiLeu_BaEn_1	155	160	PF01217	0.402
TRG_DiLeu_BaEn_1	312	317	PF01217	0.504
TRG_DiLeu_BaLyEn_6	273	278	PF01217	0.466
TRG_DiLeu_BaLyEn_6	311	316	PF01217	0.498
TRG_ENDOCYTIC_2	244	247	PF00928	0.641
TRG_ER_diArg_1	106	108	PF00400	0.418
TRG_ER_diArg_1	111	113	PF00400	0.398
TRG_ER_diArg_1	117	120	PF00400	0.366
TRG_ER_diArg_1	140	142	PF00400	0.476
TRG_ER_diArg_1	177	180	PF00400	0.397
TRG_ER_diArg_1	208	210	PF00400	0.474
TRG_ER_diArg_1	294	296	PF00400	0.620
TRG_ER_diArg_1	298	301	PF00400	0.499
TRG_ER_diArg_1	9	12	PF00400	0.548
TRG_Pf-PMV_PEXEL_1	140	145	PF00026	0.481

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILB8	Leptomonas seymouri	58%	100%
A0A1X0PA21	Trypanosomatidae	28%	100%
A0A3Q8IFU3	Leishmania donovani	99%	100%
A4HB92	Leishmania braziliensis	68%	93%
E9B5G4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	98%
Q4Q2H1	Leishmania major	89%	100%