Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF501) - putative

Species:

Leishmania infantum

UniProt:

A4IAD9_LEIIN

TriTrypDb:

LINF_340044700

Length:

302

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4IAD9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAD9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	204	206	PF00675	0.451
CLV_PCSK_KEX2_1	204	206	PF00082	0.555
CLV_PCSK_KEX2_1	5	7	PF00082	0.753
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.739
CLV_PCSK_SKI1_1	117	121	PF00082	0.357
CLV_PCSK_SKI1_1	280	284	PF00082	0.484
DOC_CYCLIN_RxL_1	114	121	PF00134	0.336
DOC_MAPK_gen_1	27	36	PF00069	0.508
DOC_MAPK_MEF2A_6	280	288	PF00069	0.463
DOC_PP1_RVXF_1	239	246	PF00149	0.379
DOC_PP4_FxxP_1	245	248	PF00568	0.560
DOC_USP7_MATH_1	146	150	PF00917	0.478
DOC_USP7_MATH_1	171	175	PF00917	0.438
DOC_WW_Pin1_4	118	123	PF00397	0.492
LIG_14-3-3_CanoR_1	204	209	PF00244	0.524
LIG_14-3-3_CanoR_1	216	225	PF00244	0.410
LIG_14-3-3_CanoR_1	241	246	PF00244	0.462
LIG_14-3-3_CanoR_1	280	285	PF00244	0.450
LIG_14-3-3_CanoR_1	6	12	PF00244	0.641
LIG_BIR_II_1	1	5	PF00653	0.793
LIG_Clathr_ClatBox_1	285	289	PF01394	0.442
LIG_FHA_1	221	227	PF00498	0.459
LIG_FHA_1	281	287	PF00498	0.499
LIG_FHA_1	58	64	PF00498	0.391
LIG_FHA_2	35	41	PF00498	0.476
LIG_Integrin_isoDGR_2	54	56	PF01839	0.366
LIG_Integrin_isoDGR_2	57	59	PF01839	0.347
LIG_LIR_Apic_2	244	248	PF02991	0.522
LIG_LIR_Gen_1	215	226	PF02991	0.489
LIG_LIR_Nem_3	13	19	PF02991	0.599
LIG_LIR_Nem_3	215	221	PF02991	0.493
LIG_LIR_Nem_3	235	240	PF02991	0.612
LIG_Pex14_2	128	132	PF04695	0.357
LIG_Pex14_2	221	225	PF04695	0.419
LIG_PTB_Apo_2	239	246	PF02174	0.516
LIG_SH2_NCK_1	19	23	PF00017	0.550
LIG_SH2_PTP2	179	182	PF00017	0.451
LIG_SH2_SRC	19	22	PF00017	0.561
LIG_SH2_STAP1	112	116	PF00017	0.357
LIG_SH2_STAP1	19	23	PF00017	0.550
LIG_SH2_STAT5	179	182	PF00017	0.366
LIG_SH3_3	165	171	PF00018	0.492
LIG_SH3_3	244	250	PF00018	0.507
LIG_SUMO_SIM_par_1	283	289	PF11976	0.529
LIG_TYR_ITIM	177	182	PF00017	0.450
MOD_CK2_1	34	40	PF00069	0.481
MOD_GlcNHglycan	8	11	PF01048	0.645
MOD_GlcNHglycan	91	94	PF01048	0.389
MOD_GSK3_1	204	211	PF00069	0.598
MOD_GSK3_1	212	219	PF00069	0.421
MOD_GSK3_1	265	272	PF00069	0.488
MOD_N-GLC_1	241	246	PF02516	0.476
MOD_NEK2_1	212	217	PF00069	0.522
MOD_NEK2_1	34	39	PF00069	0.493
MOD_NEK2_1	47	52	PF00069	0.269
MOD_NEK2_1	68	73	PF00069	0.357
MOD_PIKK_1	265	271	PF00454	0.557
MOD_PKA_1	204	210	PF00069	0.427
MOD_PKA_1	5	11	PF00069	0.724
MOD_PKA_2	204	210	PF00069	0.490
MOD_PKA_2	5	11	PF00069	0.724
MOD_Plk_1	212	218	PF00069	0.461
MOD_Plk_1	241	247	PF00069	0.553
MOD_Plk_4	171	177	PF00069	0.438
MOD_Plk_4	280	286	PF00069	0.399
MOD_Plk_4	63	69	PF00069	0.357
MOD_ProDKin_1	118	124	PF00069	0.492
MOD_SUMO_rev_2	2	7	PF00179	0.708
TRG_ENDOCYTIC_2	179	182	PF00928	0.403
TRG_ER_diArg_1	204	206	PF00400	0.451
TRG_ER_diArg_1	292	295	PF00400	0.545
TRG_NLS_MonoExtN_4	295	301	PF00514	0.583

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6T1	Leptomonas seymouri	58%	100%
A0A3Q8IIH7	Leishmania donovani	99%	100%
A0A422N2V1	Trypanosoma rangeli	40%	100%
A4HB91	Leishmania braziliensis	74%	100%
C9ZLV6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9B5G3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q2H2	Leishmania major	88%	100%