H(+)-transporting two-sector ATPase

Quick info Annotations Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

vacuolar ATP synthase catalytic subunit A - putative

Species:

Leishmania infantum

UniProt:

A4IAD4_LEIIN

TriTrypDb:

LINF_340044200

Length:

610

Annotations

Annotations by Jardim et al.

Acidocalcisome, vacuolar ATP synthase catalytic subunit A

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	12
GO:0033178	proton-transporting two-sector ATPase complex, catalytic domain	3	12
GO:0033180	proton-transporting V-type ATPase, V1 domain	4	12
GO:0098796	membrane protein complex	2	12

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Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A4IAD4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAD4

Function

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Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0009987	cellular process	1	1
GO:0034220	monoatomic ion transmembrane transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1
GO:0098655	monoatomic cation transmembrane transport	4	1
GO:0098660	inorganic ion transmembrane transport	4	1

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005215	transporter activity	1	12
GO:0005216	monoatomic ion channel activity	4	12
GO:0005261	monoatomic cation channel activity	5	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0008324	monoatomic cation transmembrane transporter activity	4	12
GO:0009678	pyrophosphate hydrolysis-driven proton transmembrane transporter activity	5	12
GO:0015075	monoatomic ion transmembrane transporter activity	3	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	291	295	PF00656	0.299
CLV_C14_Caspase3-7	64	68	PF00656	0.392
CLV_NRD_NRD_1	194	196	PF00675	0.314
CLV_NRD_NRD_1	436	438	PF00675	0.270
CLV_PCSK_KEX2_1	194	196	PF00082	0.342
CLV_PCSK_KEX2_1	302	304	PF00082	0.283
CLV_PCSK_KEX2_1	394	396	PF00082	0.283
CLV_PCSK_KEX2_1	432	434	PF00082	0.283
CLV_PCSK_PC1ET2_1	194	196	PF00082	0.342
CLV_PCSK_PC1ET2_1	302	304	PF00082	0.283

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8L6	Leptomonas seymouri	97%	100%
A0A0S4JL32	Bodo saltans	88%	100%
A0A1X0PA64	Trypanosomatidae	90%	100%
A0A3Q8IUV8	Leishmania donovani	100%	100%
A0A422N2Z1	Trypanosoma rangeli	91%	100%
A0B9K2	Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT)	52%	100%
A0PZC6	Clostridium novyi (strain NT)	54%	100%
A0RXK1	Cenarchaeum symbiosum (strain A)	52%	100%
A1QYP3	Borrelia turicatae (strain 91E135)	42%	100%
A1RSF1	Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)	46%	100%

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