Transmembrane protein

Quick info Localization Phosphorylation Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein - conserved

Species:

Leishmania infantum

UniProt:

A4IAD1_LEIIN

TriTrypDb:

LINF_340043900

Length:

174

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Phosphorylation

Amastigote: 169

Expansion

Sequence features

A4IAD1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4IAD1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	72	74	PF00675	0.479
CLV_PCSK_SKI1_1	33	37	PF00082	0.383
CLV_PCSK_SKI1_1	58	62	PF00082	0.369
DEG_SPOP_SBC_1	91	95	PF00917	0.524
DOC_CYCLIN_yCln2_LP_2	23	29	PF00134	0.590
DOC_MAPK_DCC_7	15	25	PF00069	0.593
DOC_MAPK_MEF2A_6	33	40	PF00069	0.579
DOC_MAPK_NFAT4_5	33	41	PF00069	0.577
DOC_PP2B_LxvP_1	23	26	PF13499	0.590
DOC_PP2B_LxvP_1	36	39	PF13499	0.552
DOC_USP7_MATH_1	2	6	PF00917	0.582
DOC_USP7_UBL2_3	144	148	PF12436	0.589
DOC_WW_Pin1_4	154	159	PF00397	0.730
DOC_WW_Pin1_4	96	101	PF00397	0.444
LIG_14-3-3_CanoR_1	15	21	PF00244	0.591
LIG_14-3-3_CanoR_1	52	61	PF00244	0.571
LIG_APCC_ABBAyCdc20_2	98	104	PF00400	0.413
LIG_BRCT_BRCA1_1	4	8	PF00533	0.579
LIG_eIF4E_1	126	132	PF01652	0.650
LIG_FHA_1	17	23	PF00498	0.593
LIG_FHA_1	55	61	PF00498	0.540
LIG_FHA_2	29	35	PF00498	0.579
LIG_GBD_Chelix_1	120	128	PF00786	0.531
LIG_LIR_Gen_1	34	41	PF02991	0.576
LIG_LIR_Nem_3	127	132	PF02991	0.653
LIG_LIR_Nem_3	34	38	PF02991	0.579
LIG_PDZ_Class_3	169	174	PF00595	0.600
LIG_SH2_STAT5	126	129	PF00017	0.640
LIG_SH2_STAT5	59	62	PF00017	0.569
LIG_SH2_STAT5	65	68	PF00017	0.546
LIG_SH3_3	18	24	PF00018	0.594
LIG_UBA3_1	66	74	PF00899	0.427
MOD_CDK_SPK_2	154	159	PF00069	0.662
MOD_CDK_SPxK_1	154	160	PF00069	0.667
MOD_CDK_SPxxK_3	154	161	PF00069	0.451
MOD_GlcNHglycan	136	139	PF01048	0.730
MOD_GlcNHglycan	169	172	PF01048	0.656
MOD_GSK3_1	134	141	PF00069	0.656
MOD_GSK3_1	39	46	PF00069	0.430
MOD_GSK3_1	90	97	PF00069	0.597
MOD_N-GLC_1	154	159	PF02516	0.662
MOD_N-GLC_1	53	58	PF02516	0.435
MOD_NEK2_1	124	129	PF00069	0.420
MOD_NEK2_1	140	145	PF00069	0.477
MOD_Plk_4	116	122	PF00069	0.531
MOD_Plk_4	124	130	PF00069	0.398
MOD_Plk_4	43	49	PF00069	0.434
MOD_ProDKin_1	154	160	PF00069	0.667
MOD_ProDKin_1	96	102	PF00069	0.545
TRG_DiLeu_BaLyEn_6	127	132	PF01217	0.487
TRG_DiLeu_BaLyEn_6	18	23	PF01217	0.470
TRG_ER_diArg_1	133	136	PF00400	0.704
TRG_NLS_MonoExtC_3	158	163	PF00514	0.472
TRG_NLS_MonoExtN_4	158	164	PF00514	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X8E8	Leishmania donovani	68%	100%
A4IAD0	Leishmania infantum	68%	100%
E9B5F3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	100%
E9B5F5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	100%
Q4Q2I0	Leishmania major	56%	100%